메뉴 건너뛰기




Volumn 135, Issue 9, 2016, Pages 1093-1105

Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE;

EID: 84978712593     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-016-1710-6     Document Type: Review
Times cited : (41)

References (160)
  • 1
    • 84872046675 scopus 로고    scopus 로고
    • The runners-up
    • (2012) Breakthrough of the year. The runners-up. Science 338: 1525-1532
    • Science , vol.338 , pp. 1525-1532
  • 2
    • 84872013355 scopus 로고    scopus 로고
    • Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant
    • Al-Mashhadi RH, Sorensen CB, Kragh PM et al (2013) Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med 5:166ra161
    • (2013) Sci Transl Med , vol.5 , pp. 166ra161
    • Al-Mashhadi, R.H.1    Sorensen, C.B.2    Kragh, P.M.3
  • 3
    • 84871941957 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association (2013) Diagnosis and classification of diabetes mellitus. Diabetes Care 36(Suppl 1):S67–S74
    • (2013) Diabetes Care , vol.36 , pp. S67-S74
    • American Diabetes Association1
  • 4
    • 84891722219 scopus 로고    scopus 로고
    • Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair
    • COI: 1:CAS:528:DC%2BC2cXosVCiug%3D%3D, PID: 24179142
    • Auer TO, Duroure K, De Cian A, Concordet JP, Del Bene F (2014) Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res 24:142–153
    • (2014) Genome Res , vol.24 , pp. 142-153
    • Auer, T.O.1    Duroure, K.2    De Cian, A.3    Concordet, J.P.4    Del Bene, F.5
  • 5
    • 0032964105 scopus 로고    scopus 로고
    • Production of goats by somatic cell nuclear transfer
    • COI: 1:CAS:528:DyaK1MXivFWrsbY%3D, PID: 10331804
    • Baguisi A, Behboodi E, Melican DT et al (1999) Production of goats by somatic cell nuclear transfer. Nat Biotechnol 17:456–461
    • (1999) Nat Biotechnol , vol.17 , pp. 456-461
    • Baguisi, A.1    Behboodi, E.2    Melican, D.T.3
  • 6
    • 84893713866 scopus 로고    scopus 로고
    • Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer
    • COI: 1:CAS:528:DC%2BC2cXotlSmtA%3D%3D, PID: 24430555
    • Bao L, Chen H, Jong U et al (2014) Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer. Sci China Life Sci 57:263–268
    • (2014) Sci China Life Sci , vol.57 , pp. 263-268
    • Bao, L.1    Chen, H.2    Jong, U.3
  • 7
    • 84899134190 scopus 로고    scopus 로고
    • CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity
    • COI: 1:CAS:528:DC%2BC2cXntFGntbc%3D, PID: 24766887
    • Barrangou R, Marraffini LA (2014) CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity. Mol Cell 54:234–244
    • (2014) Mol Cell , vol.54 , pp. 234-244
    • Barrangou, R.1    Marraffini, L.A.2
  • 8
    • 34047118522 scopus 로고    scopus 로고
    • CRISPR provides acquired resistance against viruses in prokaryotes
    • COI: 1:CAS:528:DC%2BD2sXjtlWntb8%3D, PID: 17379808
    • Barrangou R, Fremaux C, Deveau H et al (2007) CRISPR provides acquired resistance against viruses in prokaryotes. Science 315:1709–1712
    • (2007) Science , vol.315 , pp. 1709-1712
    • Barrangou, R.1    Fremaux, C.2    Deveau, H.3
  • 9
    • 78650670892 scopus 로고    scopus 로고
    • Deficiency of N-glycolylneuraminic acid and Galalpha1-3Galbeta1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies
    • PID: 21158945
    • Basnet NB, Ide K, Tahara H, Tanaka Y, Ohdan H (2010) Deficiency of N-glycolylneuraminic acid and Galalpha1-3Galbeta1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies. Xenotransplantation 17:440–448
    • (2010) Xenotransplantation , vol.17 , pp. 440-448
    • Basnet, N.B.1    Ide, K.2    Tahara, H.3    Tanaka, Y.4    Ohdan, H.5
  • 10
    • 84868342049 scopus 로고    scopus 로고
    • In vivo genome editing using a high-efficiency TALEN system
    • COI: 1:CAS:528:DC%2BC38Xhtlylsr3K, PID: 23000899
    • Bedell VM, Wang Y, Campbell JM et al (2012) In vivo genome editing using a high-efficiency TALEN system. Nature 491:114–118
    • (2012) Nature , vol.491 , pp. 114-118
    • Bedell, V.M.1    Wang, Y.2    Campbell, J.M.3
  • 11
    • 84949032534 scopus 로고    scopus 로고
    • A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease
    • COI: 1:CAS:528:DC%2BC28XntVWjt70%3D, PID: 26374845
    • Beraldi R, Chan CH, Rogers CS et al (2015) A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease. Hum Mol Genet 24:6473–6484
    • (2015) Hum Mol Genet , vol.24 , pp. 6473-6484
    • Beraldi, R.1    Chan, C.H.2    Rogers, C.S.3
  • 13
    • 0036021389 scopus 로고    scopus 로고
    • Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases
    • COI: 1:CAS:528:DC%2BD38XmsF2ru7c%3D, PID: 12136019
    • Bibikova M, Golic M, Golic KG, Carroll D (2002) Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161:1169–1175
    • (2002) Genetics , vol.161 , pp. 1169-1175
    • Bibikova, M.1    Golic, M.2    Golic, K.G.3    Carroll, D.4
  • 14
    • 0037510038 scopus 로고    scopus 로고
    • Enhancing gene targeting with designed zinc finger nucleases
    • COI: 1:CAS:528:DC%2BD3sXksVymsrk%3D, PID: 12730594
    • Bibikova M, Beumer K, Trautman JK, Carroll D (2003) Enhancing gene targeting with designed zinc finger nucleases. Science 300:764
    • (2003) Science , vol.300 , pp. 764
    • Bibikova, M.1    Beumer, K.2    Trautman, J.K.3    Carroll, D.4
  • 15
    • 72149110399 scopus 로고    scopus 로고
    • Breaking the code of DNA binding specificity of TAL-type III effectors
    • COI: 1:CAS:528:DC%2BD1MXhsFensbnL, PID: 19933107
    • Boch J, Scholze H, Schornack S et al (2009) Breaking the code of DNA binding specificity of TAL-type III effectors. Science 326:1509–1512
    • (2009) Science , vol.326 , pp. 1509-1512
    • Boch, J.1    Scholze, H.2    Schornack, S.3
  • 16
    • 23844505202 scopus 로고    scopus 로고
    • Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
    • COI: 1:CAS:528:DC%2BD2MXps1Cju7g%3D, PID: 16079334
    • Bolotin A, Quinquis B, Sorokin A, Ehrlich SD (2005) Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin. Microbiology 151:2551–2561
    • (2005) Microbiology , vol.151 , pp. 2551-2561
    • Bolotin, A.1    Quinquis, B.2    Sorokin, A.3    Ehrlich, S.D.4
  • 17
    • 49649114086 scopus 로고    scopus 로고
    • Small CRISPR RNAs guide antiviral defense in prokaryotes
    • COI: 1:CAS:528:DC%2BD1cXpslWrur0%3D, PID: 18703739
    • Brouns SJ, Jore MM, Lundgren M et al (2008) Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321:960–964
    • (2008) Science , vol.321 , pp. 960-964
    • Brouns, S.J.1    Jore, M.M.2    Lundgren, M.3
  • 18
    • 84879686686 scopus 로고    scopus 로고
    • Whole-rat conditional gene knockout via genome editing
    • COI: 1:CAS:528:DC%2BC3sXptValsLc%3D, PID: 23749298
    • Brown AJ, Fisher DA, Kouranova E et al (2013) Whole-rat conditional gene knockout via genome editing. Nat Methods 10:638–640
    • (2013) Nat Methods , vol.10 , pp. 638-640
    • Brown, A.J.1    Fisher, D.A.2    Kouranova, E.3
  • 19
    • 0035498405 scopus 로고    scopus 로고
    • Transgenic pigs produced using in vitro matured oocytes infected with a retroviral vector
    • COI: 1:CAS:528:DC%2BD38XntFSrtg%3D%3D, PID: 11808636
    • Cabot RA, Kuhholzer B, Chan AW et al (2001) Transgenic pigs produced using in vitro matured oocytes infected with a retroviral vector. Anim Biotechnol 12:205–214
    • (2001) Anim Biotechnol , vol.12 , pp. 205-214
    • Cabot, R.A.1    Kuhholzer, B.2    Chan, A.W.3
  • 21
    • 84867911474 scopus 로고    scopus 로고
    • Efficient TALEN-mediated gene knockout in livestock
    • COI: 1:CAS:528:DC%2BC38XhvVSltL3K, PID: 23027955
    • Carlson DF, Tan W, Lillico SG et al (2012b) Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci USA 109:17382–17387
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17382-17387
    • Carlson, D.F.1    Tan, W.2    Lillico, S.G.3
  • 22
    • 3042604477 scopus 로고    scopus 로고
    • Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer
    • PID: 11964188
    • Chang K, Qian J, Jiang M et al (2002) Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer. BMC Biotechnol 2:5
    • (2002) BMC Biotechnol , vol.2 , pp. 5
    • Chang, K.1    Qian, J.2    Jiang, M.3
  • 23
    • 84876409836 scopus 로고    scopus 로고
    • Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos
    • COI: 1:CAS:528:DC%2BC3sXltFCms7o%3D, PID: 23528705
    • Chang N, Sun C, Gao L et al (2013) Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res 23:465–472
    • (2013) Cell Res , vol.23 , pp. 465-472
    • Chang, N.1    Sun, C.2    Gao, L.3
  • 24
    • 28644446730 scopus 로고    scopus 로고
    • Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
    • COI: 1:CAS:528:DC%2BD2MXht1yisrrI, PID: 16311604
    • Chen G, Qian H, Starzl T et al (2005) Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 11:1295–1298
    • (2005) Nat Med , vol.11 , pp. 1295-1298
    • Chen, G.1    Qian, H.2    Starzl, T.3
  • 25
    • 84936765320 scopus 로고    scopus 로고
    • Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
    • COI: 1:CAS:528:DC%2BC2MXhsVyhs7zE, PID: 25859012
    • Chen Y, Zheng Y, Kang Y et al (2015) Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Hum Mol Genet 24:3764–3774
    • (2015) Hum Mol Genet , vol.24 , pp. 3764-3774
    • Chen, Y.1    Zheng, Y.2    Kang, Y.3
  • 26
    • 78951479577 scopus 로고    scopus 로고
    • Targeting DNA double-strand breaks with TAL effector nucleases
    • COI: 1:CAS:528:DC%2BC3cXhsFOnt7jP, PID: 20660643
    • Christian M, Cermak T, Doyle EL et al (2010) Targeting DNA double-strand breaks with TAL effector nucleases. Genetics 186:757–761
    • (2010) Genetics , vol.186 , pp. 757-761
    • Christian, M.1    Cermak, T.2    Doyle, E.L.3
  • 27
    • 0032557605 scopus 로고    scopus 로고
    • Cloned transgenic calves produced from nonquiescent fetal fibroblasts
    • COI: 1:CAS:528:DyaK1cXjt1Gqt78%3D, PID: 9596577
    • Cibelli JB, Stice SL, Golueke PJ et al (1998) Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 280:1256–1258
    • (1998) Science , vol.280 , pp. 1256-1258
    • Cibelli, J.B.1    Stice, S.L.2    Golueke, P.J.3
  • 28
    • 0024574093 scopus 로고
    • Expression of human anti-hemophilic factor IX in the milk of transgenic sheep
    • COI: 1:CAS:528:DyaL1MXltFSjsr8%3D
    • Clark AJ, Bessos H, Bishop JO et al (1989) Expression of human anti-hemophilic factor IX in the milk of transgenic sheep. Bio/Technology 7:487–492
    • (1989) Bio/Technology , vol.7 , pp. 487-492
    • Clark, A.J.1    Bessos, H.2    Bishop, J.O.3
  • 29
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • COI: 1:CAS:528:DC%2BC3sXit1ygtb8%3D, PID: 23287718
    • Cong L, Ran FA, Cox D et al (2013) Multiplex genome engineering using CRISPR/Cas systems. Science 339:819–823
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1    Ran, F.A.2    Cox, D.3
  • 30
    • 84951278691 scopus 로고    scopus 로고
    • The role of genetically engineered pigs in xenotransplantation research
    • PID: 26365762
    • Cooper DK, Ekser B, Ramsoondar J, Phelps C, Ayares D (2016) The role of genetically engineered pigs in xenotransplantation research. J Pathol 238:288–299
    • (2016) J Pathol , vol.238 , pp. 288-299
    • Cooper, D.K.1    Ekser, B.2    Ramsoondar, J.3    Phelps, C.4    Ayares, D.5
  • 31
    • 38849103093 scopus 로고    scopus 로고
    • DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases
    • COI: 1:CAS:528:DC%2BD1cXhtVGhtL0%3D, PID: 18026168
    • Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, Cathomen T (2008) DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol Ther 16:352–358
    • (2008) Mol Ther , vol.16 , pp. 352-358
    • Cornu, T.I.1    Thibodeau-Beganny, S.2    Guhl, E.3    Alwin, S.4    Eichtinger, M.5    Joung, J.K.6    Cathomen, T.7
  • 32
    • 0036009120 scopus 로고    scopus 로고
    • Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs
    • COI: 1:CAS:528:DC%2BD38XhvVWjtrs%3D, PID: 11875425
    • Dai Y, Vaught TD, Boone J et al (2002) Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 20:251–255
    • (2002) Nat Biotechnol , vol.20 , pp. 251-255
    • Dai, Y.1    Vaught, T.D.2    Boone, J.3
  • 33
    • 84898657735 scopus 로고    scopus 로고
    • Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs
    • PID: 24691380
    • Davis BT, Wang XJ, Rohret JA et al (2014) Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs. PLoS One 9:e93457
    • (2014) PLoS One , vol.9
    • Davis, B.T.1    Wang, X.J.2    Rohret, J.A.3
  • 34
    • 0033119609 scopus 로고    scopus 로고
    • Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14
    • COI: 1:STN:280:DyaK1M3jtlSlsQ%3D%3D, PID: 10218695
    • Edwards AO, Miedziak A, Vrabec T, Verhoeven J, Acott TS, Weleber RG, Donoso LA (1999) Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14. Am J Ophthalmol 127:426–435
    • (1999) Am J Ophthalmol , vol.127 , pp. 426-435
    • Edwards, A.O.1    Miedziak, A.2    Vrabec, T.3    Verhoeven, J.4    Acott, T.S.5    Weleber, R.G.6    Donoso, L.A.7
  • 35
    • 84930753871 scopus 로고    scopus 로고
    • Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/beta4GalNT2 genes
    • PID: 25728481
    • Estrada JL, Martens G, Li P et al (2015) Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/beta4GalNT2 genes. Xenotransplantation 22:194–202
    • (2015) Xenotransplantation , vol.22 , pp. 194-202
    • Estrada, J.L.1    Martens, G.2    Li, P.3
  • 36
    • 84978438340 scopus 로고    scopus 로고
    • DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
    • COI: 1:CAS:528:DC%2BC28XmvFOqsro%3D, PID: 27136078
    • Gao F, Shen XZ, Jiang F, Wu Y, Han C (2016) DNA-guided genome editing using the Natronobacterium gregoryi Argonaute. Nat Biotechnol 34:768–773
    • (2016) Nat Biotechnol , vol.34 , pp. 768-773
    • Gao, F.1    Shen, X.Z.2    Jiang, F.3    Wu, Y.4    Han, C.5
  • 37
    • 80052279739 scopus 로고    scopus 로고
    • Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome
    • COI: 1:CAS:528:DC%2BC3MXht1Sqt7fM, PID: 21897845
    • Garrels W, Mates L, Holler S et al (2011) Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome. PLoS One 6:e23573
    • (2011) PLoS One , vol.6
    • Garrels, W.1    Mates, L.2    Holler, S.3
  • 38
    • 67749106611 scopus 로고    scopus 로고
    • Knockout rats via embryo microinjection of zinc-finger nucleases
    • COI: 1:CAS:528:DC%2BD1MXovVChtrY%3D, PID: 19628861
    • Geurts AM, Cost GJ, Freyvert Y et al (2009) Knockout rats via embryo microinjection of zinc-finger nucleases. Science 325:433
    • (2009) Science , vol.325 , pp. 433
    • Geurts, A.M.1    Cost, G.J.2    Freyvert, Y.3
  • 39
    • 0026729799 scopus 로고
    • Production of human tissue plasminogen activator in transgenic mouse milk. 1987
    • COI: 1:STN:280:DyaK3s%2FksVWrug%3D%3D, PID: 1422049
    • Gordon K, Lee E, Vitale JA, Smith AE, Westphal H, Hennighausen L (1992) Production of human tissue plasminogen activator in transgenic mouse milk. 1987. Biotechnology 24:425–428
    • (1992) Biotechnology , vol.24 , pp. 425-428
    • Gordon, K.1    Lee, E.2    Vitale, J.A.3    Smith, A.E.4    Westphal, H.5    Hennighausen, L.6
  • 40
    • 84893768157 scopus 로고    scopus 로고
    • A novel gene delivery method transduces porcine pancreatic duct epithelial cells
    • COI: 1:CAS:528:DC%2BC3sXhvVShu7vF, PID: 24257348
    • Griffin MA, Restrepo MS, Abu-El-Haija M et al (2014) A novel gene delivery method transduces porcine pancreatic duct epithelial cells. Gene Ther 21:123–130
    • (2014) Gene Ther , vol.21 , pp. 123-130
    • Griffin, M.A.1    Restrepo, M.S.2    Abu-El-Haija, M.3
  • 42
    • 84897111753 scopus 로고    scopus 로고
    • Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets
    • COI: 1:CAS:528:DC%2BC3sXhsleiurbP, PID: 24183914
    • Guo JJ, Stoltz DA, Zhu V, Volk KA, Segar JL, McCray PB Jr, Roghair RD (2014) Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets. J Cyst Fibros 13:251–259
    • (2014) J Cyst Fibros , vol.13 , pp. 251-259
    • Guo, J.J.1    Stoltz, D.A.2    Zhu, V.3    Volk, K.A.4    Segar, J.L.5    McCray, P.B.6    Roghair, R.D.7
  • 43
    • 84897594300 scopus 로고    scopus 로고
    • One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
    • COI: 1:CAS:528:DC%2BC2cXhsl2gsLk%3D, PID: 24481528
    • Hai T, Teng F, Guo R, Li W, Zhou Q (2014) One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res 24:372–375
    • (2014) Cell Res , vol.24 , pp. 372-375
    • Hai, T.1    Teng, F.2    Guo, R.3    Li, W.4    Zhou, Q.5
  • 44
    • 34247897112 scopus 로고    scopus 로고
    • Cone rod dystrophies
    • PID: 17270046
    • Hamel CP (2007) Cone rod dystrophies. Orphanet J Rare Dis 2:7
    • (2007) Orphanet J Rare Dis , vol.2 , pp. 7
    • Hamel, C.P.1
  • 45
    • 0021930664 scopus 로고
    • Production of transgenic rabbits, sheep and pigs by microinjection
    • COI: 1:CAS:528:DyaL2MXkvF2lsLs%3D, PID: 3892305
    • Hammer RE, Pursel VG, Rexroad CE Jr et al (1985) Production of transgenic rabbits, sheep and pigs by microinjection. Nature 315:680–683
    • (1985) Nature , vol.315 , pp. 680-683
    • Hammer, R.E.1    Pursel, V.G.2    Rexroad, C.E.3
  • 46
    • 33751537273 scopus 로고    scopus 로고
    • Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets
    • COI: 1:CAS:528:DC%2BD28Xht1enu7rK, PID: 17080303
    • Hao YH, Yong HY, Murphy CN et al (2006) Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets. Transgenic Res 15:739–750
    • (2006) Transgenic Res , vol.15 , pp. 739-750
    • Hao, Y.H.1    Yong, H.Y.2    Murphy, C.N.3
  • 47
    • 77956498326 scopus 로고    scopus 로고
    • Sequence- and structure-specific RNA processing by a CRISPR endonuclease
    • COI: 1:CAS:528:DC%2BC3cXhtFajs7vN, PID: 20829488
    • Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna JA (2010) Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science 329:1355–1358
    • (2010) Science , vol.329 , pp. 1355-1358
    • Haurwitz, R.E.1    Jinek, M.2    Wiedenheft, B.3    Zhou, K.4    Doudna, J.A.5
  • 48
    • 79961079857 scopus 로고    scopus 로고
    • Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
    • COI: 1:CAS:528:DC%2BC3MXpsFyku7o%3D, PID: 21730124
    • Hauschild J, Petersen B, Santiago Y et al (2011) Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci USA 108:12013–12017
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12013-12017
    • Hauschild, J.1    Petersen, B.2    Santiago, Y.3
  • 49
    • 81155162423 scopus 로고    scopus 로고
    • Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer
    • COI: 1:CAS:528:DC%2BC3MXht1amtbrE, PID: 21674562
    • Hickey RD, Lillegard JB, Fisher JE et al (2011) Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer. Hepatology 54:1351–1359
    • (2011) Hepatology , vol.54 , pp. 1351-1359
    • Hickey, R.D.1    Lillegard, J.B.2    Fisher, J.E.3
  • 50
    • 84901477570 scopus 로고    scopus 로고
    • Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease
    • COI: 1:CAS:528:DC%2BC2cXhtFWitbjI, PID: 24879068
    • Hickey RD, Mao SA, Glorioso J et al (2014) Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease. Stem Cell Res 13:144–153
    • (2014) Stem Cell Res , vol.13 , pp. 144-153
    • Hickey, R.D.1    Mao, S.A.2    Glorioso, J.3
  • 51
    • 79960836456 scopus 로고    scopus 로고
    • Genetic engineering of human pluripotent cells using TALE nucleases
    • COI: 1:CAS:528:DC%2BC3MXos1Srs7o%3D, PID: 21738127
    • Hockemeyer D, Wang H, Kiani S et al (2011) Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol 29:731–734
    • (2011) Nat Biotechnol , vol.29 , pp. 731-734
    • Hockemeyer, D.1    Wang, H.2    Kiani, S.3
  • 52
    • 0346242741 scopus 로고    scopus 로고
    • Efficient transgenesis in farm animals by lentiviral vectors
    • COI: 1:CAS:528:DC%2BD3sXosFajtLs%3D, PID: 14566324
    • Hofmann A, Kessler B, Ewerling S et al (2003) Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep 4:1054–1060
    • (2003) EMBO Rep , vol.4 , pp. 1054-1060
    • Hofmann, A.1    Kessler, B.2    Ewerling, S.3
  • 53
    • 84951299418 scopus 로고    scopus 로고
    • Genetically modified pig models for neurodegenerative disorders
    • COI: 1:CAS:528:DC%2BC28XitVCgtg%3D%3D, PID: 26446984
    • Holm IE, Alstrup AK, Luo Y (2016) Genetically modified pig models for neurodegenerative disorders. J Pathol 238:267–287
    • (2016) J Pathol , vol.238 , pp. 267-287
    • Holm, I.E.1    Alstrup, A.K.2    Luo, Y.3
  • 54
    • 84906096394 scopus 로고    scopus 로고
    • RAG1/2 knockout pigs with severe combined immunodeficiency
    • COI: 1:CAS:528:DC%2BC2cXhtFyqs7%2FO, PID: 24973446
    • Huang J, Guo X, Fan N et al (2014) RAG1/2 knockout pigs with severe combined immunodeficiency. J Immunol 193:1496–1503
    • (2014) J Immunol , vol.193 , pp. 1496-1503
    • Huang, J.1    Guo, X.2    Fan, N.3
  • 55
    • 84874617789 scopus 로고    scopus 로고
    • Efficient genome editing in zebrafish using a CRISPR-Cas system
    • COI: 1:CAS:528:DC%2BC3sXhsFCkurk%3D, PID: 23360964
    • Hwang WY, Fu Y, Reyon D et al (2013) Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol 31:227–229
    • (2013) Nat Biotechnol , vol.31 , pp. 227-229
    • Hwang, W.Y.1    Fu, Y.2    Reyon, D.3
  • 56
    • 0023600057 scopus 로고
    • Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product
    • COI: 1:CAS:528:DyaL1cXhsVCgs78%3D, PID: 3316184
    • Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A (1987) Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol 169:5429–5433
    • (1987) J Bacteriol , vol.169 , pp. 5429-5433
    • Ishino, Y.1    Shinagawa, H.2    Makino, K.3    Amemura, M.4    Nakata, A.5
  • 57
    • 0036267740 scopus 로고    scopus 로고
    • Identification of genes that are associated with DNA repeats in prokaryotes
    • COI: 1:CAS:528:DC%2BD38XivFyls7w%3D, PID: 11952905
    • Jansen R, Embden JD, Gaastra W, Schouls LM (2002) Identification of genes that are associated with DNA repeats in prokaryotes. Mol Microbiol 43:1565–1575
    • (2002) Mol Microbiol , vol.43 , pp. 1565-1575
    • Jansen, R.1    Embden, J.D.2    Gaastra, W.3    Schouls, L.M.4
  • 58
    • 84882788354 scopus 로고    scopus 로고
    • Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
    • COI: 1:CAS:528:DC%2BC3sXhtlKqu7nP, PID: 23918387
    • Jao LE, Wente SR, Chen W (2013) Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci USA 110:13904–13909
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 13904-13909
    • Jao, L.E.1    Wente, S.R.2    Chen, W.3
  • 59
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • COI: 1:CAS:528:DC%2BC38XhtFOqsb3L, PID: 22745249
    • Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337:816–821
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3    Hauer, M.4    Doudna, J.A.5    Charpentier, E.6
  • 60
    • 84962689480 scopus 로고    scopus 로고
    • Production of alpha1, 3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology
    • PID: 27051344
    • Kang JT, Kwon DK, Park AR et al (2016) Production of alpha1, 3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology. J Vet Sci 17:89–96
    • (2016) J Vet Sci , vol.17 , pp. 89-96
    • Kang, J.T.1    Kwon, D.K.2    Park, A.R.3
  • 62
    • 0030032063 scopus 로고    scopus 로고
    • Hybrid restriction enzymes: zinc finger fusions to FokI cleavage domain
    • COI: 1:CAS:528:DyaK28Xptl2luw%3D%3D, PID: 8577732
    • Kim YG, Cha J, Chandrasegaran S (1996) Hybrid restriction enzymes: zinc finger fusions to FokI cleavage domain. Proc Natl Acad Sci USA 93:1156–1160
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1156-1160
    • Kim, Y.G.1    Cha, J.2    Chandrasegaran, S.3
  • 63
    • 67049137904 scopus 로고    scopus 로고
    • First US approval for a transgenic animal drug
    • COI: 1:CAS:528:DC%2BD1MXktFaksLo%3D, PID: 19352350
    • Kling J (2009) First US approval for a transgenic animal drug. Nat Biotechnol 27:302–304
    • (2009) Nat Biotechnol , vol.27 , pp. 302-304
    • Kling, J.1
  • 64
    • 79952398547 scopus 로고    scopus 로고
    • Fresh from the biologic pipeline—2010
    • COI: 1:CAS:528:DC%2BC3MXivFWlu7s%3D, PID: 21390016
    • Kling J (2011) Fresh from the biologic pipeline—2010. Nat Biotechnol 29:197–200
    • (2011) Nat Biotechnol , vol.29 , pp. 197-200
    • Kling, J.1
  • 65
    • 84862577098 scopus 로고    scopus 로고
    • Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis
    • COI: 1:CAS:528:DC%2BC38Xnt12qurc%3D
    • Klymiuk N, Mundhenk L, Kraehe K et al (2012) Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis. J Mol Med (Berl) 90:597–608
    • (2012) J Mol Med (Berl) , vol.90 , pp. 597-608
    • Klymiuk, N.1    Mundhenk, L.2    Kraehe, K.3
  • 66
    • 2442567900 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations
    • COI: 1:CAS:528:DC%2BD2cXksFaksL0%3D, PID: 15123792
    • Kolber-Simonds D, Lai L, Watt SR et al (2004) Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 101:7335–7340
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7335-7340
    • Kolber-Simonds, D.1    Lai, L.2    Watt, S.R.3
  • 67
    • 84897923883 scopus 로고    scopus 로고
    • Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy
    • COI: 1:CAS:528:DC%2BC3sXhtlKmtbfL, PID: 23977029
    • Kostic C, Lillico SG, Crippa SV et al (2013) Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy. PLoS One 8:e71363
    • (2013) PLoS One , vol.8
    • Kostic, C.1    Lillico, S.G.2    Crippa, S.V.3
  • 68
    • 29944439836 scopus 로고    scopus 로고
    • Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin
    • COI: 1:CAS:528:DC%2BD28XitFels70%3D, PID: 16402026
    • Kraft TW, Allen D, Petters RM, Hao Y, Peng YW, Wong F (2005) Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin. Mol Vis 11:1246–1256
    • (2005) Mol Vis , vol.11 , pp. 1246-1256
    • Kraft, T.W.1    Allen, D.2    Petters, R.M.3    Hao, Y.4    Peng, Y.W.5    Wong, F.6
  • 69
    • 33645693598 scopus 로고    scopus 로고
    • Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer
    • COI: 1:CAS:528:DC%2BD28Xjt1ykurY%3D, PID: 16604463
    • Kurome M, Ueda H, Tomii R, Naruse K, Nagashima H (2006) Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer. Transgenic Res 15:229–240
    • (2006) Transgenic Res , vol.15 , pp. 229-240
    • Kurome, M.1    Ueda, H.2    Tomii, R.3    Naruse, K.4    Nagashima, H.5
  • 70
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    • COI: 1:CAS:528:DC%2BD2MXptVSg, PID: 15619628
    • Kuwaki K, Tseng YL, Dor FJ et al (2005) Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 11:29–31
    • (2005) Nat Med , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3
  • 71
    • 0037039771 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • COI: 1:CAS:528:DC%2BD38Xht1Gqtbw%3D, PID: 11778012
    • Lai L, Kolber-Simonds D, Park KW et al (2002) Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295:1089–1092
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 72
    • 0031443141 scopus 로고    scopus 로고
    • Sperm-mediated gene transfer: production of pigs transgenic for a human regulator of complement activation
    • COI: 1:CAS:528:DyaK1cXht1aktg%3D%3D
    • Lavitrano M, Forni M, Varzi V et al (1997) Sperm-mediated gene transfer: production of pigs transgenic for a human regulator of complement activation. Transpl Proc 29:3508–3509
    • (1997) Transpl Proc , vol.29 , pp. 3508-3509
    • Lavitrano, M.1    Forni, M.2    Varzi, V.3
  • 73
    • 70350728470 scopus 로고    scopus 로고
    • Production of recombinant human von Willebrand factor in the milk of transgenic pigs
    • COI: 1:CAS:528:DC%2BD1MXhsFahsLzN, PID: 19521054
    • Lee HG, Lee HC, Kim SW et al (2009) Production of recombinant human von Willebrand factor in the milk of transgenic pigs. J Reprod Dev 55:484–490
    • (2009) J Reprod Dev , vol.55 , pp. 484-490
    • Lee, H.G.1    Lee, H.C.2    Kim, S.W.3
  • 74
    • 84900993129 scopus 로고    scopus 로고
    • Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency
    • COI: 1:CAS:528:DC%2BC2cXnsVWrtb4%3D, PID: 24799706
    • Lee K, Kwon DN, Ezashi T et al (2014a) Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency. Proc Natl Acad Sci USA 111:7260–7265
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 7260-7265
    • Lee, K.1    Kwon, D.N.2    Ezashi, T.3
  • 75
    • 84902168933 scopus 로고    scopus 로고
    • Recombinant human factor IX produced from transgenic porcine milk
    • PID: 24955355
    • Lee MH, Lin YS, Tu CF, Yen CH (2014b) Recombinant human factor IX produced from transgenic porcine milk. Biomed Res Int 2014:315375
    • (2014) Biomed Res Int , vol.2014 , pp. 315375
    • Lee, M.H.1    Lin, Y.S.2    Tu, C.F.3    Yen, C.H.4
  • 76
    • 64749108482 scopus 로고    scopus 로고
    • Inhibition of porcine reproductive and respiratory syndrome virus replication by adenovirus-mediated RNA interference both in porcine alveolar macrophages and swine
    • COI: 1:CAS:528:DC%2BD1MXltVKrtrw%3D, PID: 19428607
    • Li G, Jiang P, Li Y et al (2009) Inhibition of porcine reproductive and respiratory syndrome virus replication by adenovirus-mediated RNA interference both in porcine alveolar macrophages and swine. Antivir Res 82:157–165
    • (2009) Antivir Res , vol.82 , pp. 157-165
    • Li, G.1    Jiang, P.2    Li, Y.3
  • 77
    • 84860736700 scopus 로고    scopus 로고
    • High-efficiency TALEN-based gene editing produces disease-resistant rice
    • COI: 1:CAS:528:DC%2BC38XmsFyjs7g%3D, PID: 22565958
    • Li T, Liu B, Spalding MH, Weeks DP, Yang B (2012) High-efficiency TALEN-based gene editing produces disease-resistant rice. Nat Biotechnol 30:390–392
    • (2012) Nat Biotechnol , vol.30 , pp. 390-392
    • Li, T.1    Liu, B.2    Spalding, M.H.3    Weeks, D.P.4    Yang, B.5
  • 78
    • 84890853920 scopus 로고    scopus 로고
    • RNAi-based inhibition of porcine reproductive and respiratory syndrome virus replication in transgenic pigs
    • COI: 1:CAS:528:DC%2BC2cXhs1Grsr4%3D, PID: 24333125
    • Li L, Li Q, Bao Y et al (2014) RNAi-based inhibition of porcine reproductive and respiratory syndrome virus replication in transgenic pigs. J Biotechnol 171:17–24
    • (2014) J Biotechnol , vol.171 , pp. 17-24
    • Li, L.1    Li, Q.2    Bao, Y.3
  • 79
    • 84922755847 scopus 로고    scopus 로고
    • Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection
    • COI: 1:CAS:528:DC%2BC2MXhvFSksLzF, PID: 25178170
    • Li P, Estrada JL, Burlak C et al (2015) Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection. Xenotransplantation 22:20–31
    • (2015) Xenotransplantation , vol.22 , pp. 20-31
    • Li, P.1    Estrada, J.L.2    Burlak, C.3
  • 80
    • 84892942429 scopus 로고    scopus 로고
    • Live pigs produced from genome edited zygotes
    • PID: 24108318
    • Lillico SG, Proudfoot C, Carlson DF et al (2013) Live pigs produced from genome edited zygotes. Sci Rep 3:2847
    • (2013) Sci Rep , vol.3 , pp. 2847
    • Lillico, S.G.1    Proudfoot, C.2    Carlson, D.F.3
  • 81
    • 54849418868 scopus 로고    scopus 로고
    • Expression of functional recombinant human factor IX in milk of mice
    • COI: 1:CAS:528:DC%2BD1cXht1Ont7zP, PID: 18688573
    • Lisauskas SF, Cunha NB, Vianna GR et al (2008) Expression of functional recombinant human factor IX in milk of mice. Biotechnol Lett 30:2063–2069
    • (2008) Biotechnol Lett , vol.30 , pp. 2063-2069
    • Lisauskas, S.F.1    Cunha, N.B.2    Vianna, G.R.3
  • 82
    • 84896142186 scopus 로고    scopus 로고
    • TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys
    • COI: 1:CAS:528:DC%2BC2cXisFCjtr4%3D, PID: 24529597
    • Liu H, Chen Y, Niu Y et al (2014) TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell 14:323–328
    • (2014) Cell Stem Cell , vol.14 , pp. 323-328
    • Liu, H.1    Chen, Y.2    Niu, Y.3
  • 83
    • 84957589085 scopus 로고    scopus 로고
    • Production of transgenic-cloned pigs expressing large quantities of recombinant human lysozyme in milk
    • PID: 25955256
    • Lu D, Liu S, Shang S et al (2015) Production of transgenic-cloned pigs expressing large quantities of recombinant human lysozyme in milk. PLoS One 10:e0123551
    • (2015) PLoS One , vol.10
    • Lu, D.1    Liu, S.2    Shang, S.3
  • 84
    • 84873465592 scopus 로고    scopus 로고
    • Double knockout pigs deficient in N-glycolylneuraminic acid and galactose alpha-1,3-galactose reduce the humoral barrier to xenotransplantation
    • PID: 23384142
    • Lutz AJ, Li P, Estrada JL et al (2013) Double knockout pigs deficient in N-glycolylneuraminic acid and galactose alpha-1,3-galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation 20:27–35
    • (2013) Xenotransplantation , vol.20 , pp. 27-35
    • Lutz, A.J.1    Li, P.2    Estrada, J.L.3
  • 85
    • 79956157571 scopus 로고    scopus 로고
    • Evolution and classification of the CRISPR-Cas systems
    • COI: 1:CAS:528:DC%2BC3MXlvVagt7Y%3D, PID: 21552286
    • Makarova KS, Haft DH, Barrangou R et al (2011) Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol 9:467–477
    • (2011) Nat Rev Microbiol , vol.9 , pp. 467-477
    • Makarova, K.S.1    Haft, D.H.2    Barrangou, R.3
  • 86
    • 84875252985 scopus 로고    scopus 로고
    • Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs
    • COI: 1:CAS:528:DC%2BC3sXmslequrs%3D, PID: 23431169
    • Matsunari H, Nagashima H, Watanabe M et al (2013) Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci USA 110:4557–4562
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4557-4562
    • Matsunari, H.1    Nagashima, H.2    Watanabe, M.3
  • 87
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: differences between mouse and human immunology
    • COI: 1:CAS:528:DC%2BD2cXhsVCktbk%3D, PID: 14978070
    • Mestas J, Hughes CC (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172:2731–2738
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 88
    • 33847682924 scopus 로고    scopus 로고
    • Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
    • COI: 1:CAS:528:DC%2BD2sXjtVWls74%3D, PID: 17360608
    • Moehle EA, Rock JM, Lee YL et al (2007) Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc Natl Acad Sci USA 104:3055–3060
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3055-3060
    • Moehle, E.A.1    Rock, J.M.2    Lee, Y.L.3
  • 89
    • 16444385662 scopus 로고    scopus 로고
    • Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
    • COI: 1:CAS:528:DC%2BD2MXit1Sntb8%3D, PID: 15791728
    • Mojica FJ, Diez-Villasenor C, Garcia-Martinez J, Soria E (2005) Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol Evol 60:174–182
    • (2005) J Mol Evol , vol.60 , pp. 174-182
    • Mojica, F.J.1    Diez-Villasenor, C.2    Garcia-Martinez, J.3    Soria, E.4
  • 90
    • 84861361409 scopus 로고    scopus 로고
    • Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs)
    • COI: 1:CAS:528:DC%2BC38XotFKrs7g%3D, PID: 22655075
    • Moore FE, Reyon D, Sander JD et al (2012) Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). PLoS One 7:e37877
    • (2012) PLoS One , vol.7
    • Moore, F.E.1    Reyon, D.2    Sander, J.D.3
  • 91
    • 0028363417 scopus 로고
    • The porcine mammary gland as a bioreactor for complex proteins
    • COI: 1:CAS:528:DyaK2cXmslyqsb4%3D, PID: 8010672
    • Morcol T, Akers RM, Johnson JL et al (1994) The porcine mammary gland as a bioreactor for complex proteins. Ann N Y Acad Sci 721:218–233
    • (1994) Ann N Y Acad Sci , vol.721 , pp. 218-233
    • Morcol, T.1    Akers, R.M.2    Johnson, J.L.3
  • 92
    • 72149090954 scopus 로고    scopus 로고
    • A simple cipher governs DNA recognition by TAL effectors
    • COI: 1:CAS:528:DC%2BD1MXhsFensbjP, PID: 19933106
    • Moscou MJ, Bogdanove AJ (2009) A simple cipher governs DNA recognition by TAL effectors. Science 326:1501
    • (2009) Science , vol.326 , pp. 1501
    • Moscou, M.J.1    Bogdanove, A.J.2
  • 94
    • 84894081986 scopus 로고    scopus 로고
    • Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
    • COI: 1:CAS:528:DC%2BC2cXhs1ajtLY%3D, PID: 24486104
    • Niu Y, Shen B, Cui Y et al (2014) Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156:836–843
    • (2014) Cell , vol.156 , pp. 836-843
    • Niu, Y.1    Shen, B.2    Cui, Y.3
  • 95
    • 76749147849 scopus 로고    scopus 로고
    • Primary immunodeficiencies
    • PID: 20042228
    • Notarangelo LD (2010) Primary immunodeficiencies. J Allergy Clin Immunol 125:S182–S194
    • (2010) J Allergy Clin Immunol , vol.125 , pp. S182-S194
    • Notarangelo, L.D.1
  • 96
    • 0035543868 scopus 로고    scopus 로고
    • Effect of DNA concentration on transgenesis rates in mice and pigs
    • COI: 1:CAS:528:DC%2BD38XmtlSltQ%3D%3D, PID: 11817540
    • Nottle MB, Haskard KA, Verma PJ et al (2001) Effect of DNA concentration on transgenesis rates in mice and pigs. Transgenic Res 10:523–531
    • (2001) Transgenic Res , vol.10 , pp. 523-531
    • Nottle, M.B.1    Haskard, K.A.2    Verma, P.J.3
  • 97
    • 0030771837 scopus 로고    scopus 로고
    • Transgenic pigs produce functional human factor VIII in milk
    • COI: 1:CAS:528:DyaK2sXmsFKjtLk%3D, PID: 9335047
    • Paleyanda RK, Velander WH, Lee TK et al (1997) Transgenic pigs produce functional human factor VIII in milk. Nat Biotechnol 15:971–975
    • (1997) Nat Biotechnol , vol.15 , pp. 971-975
    • Paleyanda, R.K.1    Velander, W.H.2    Lee, T.K.3
  • 98
    • 0030851707 scopus 로고    scopus 로고
    • Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
    • COI: 1:CAS:528:DyaK2sXmsFKjt74%3D, PID: 9335046
    • Petters RM, Alexander CA, Wells KD et al (1997) Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat Biotechnol 15:965–970
    • (1997) Nat Biotechnol , vol.15 , pp. 965-970
    • Petters, R.M.1    Alexander, C.A.2    Wells, K.D.3
  • 99
    • 0034622122 scopus 로고    scopus 로고
    • A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes
    • COI: 1:CAS:528:DC%2BD3cXkvFSqu70%3D, PID: 10889272
    • Phelan JK, Bok D (2000) A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes. Mol Vis 6:116–124
    • (2000) Mol Vis , vol.6 , pp. 116-124
    • Phelan, J.K.1    Bok, D.2
  • 100
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • COI: 1:CAS:528:DC%2BD3sXjsF2rtA%3D%3D, PID: 12493821
    • Phelps CJ, Koike C, Vaught TD et al (2003) Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299:411–414
    • (2003) Science , vol.299 , pp. 411-414
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 101
    • 0034618722 scopus 로고    scopus 로고
    • Cloned pigs produced by nuclear transfer from adult somatic cells
    • COI: 1:STN:280:DC%2BD3cvkt12rug%3D%3D, PID: 10993078
    • Polejaeva IA, Chen SH, Vaught TD et al (2000) Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 407:86–90
    • (2000) Nature , vol.407 , pp. 86-90
    • Polejaeva, I.A.1    Chen, S.H.2    Vaught, T.D.3
  • 102
    • 84877079632 scopus 로고    scopus 로고
    • Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model
    • COI: 1:CAS:528:DC%2BC3sXktFyhs7g%3D, PID: 23511247
    • Potash AE, Wallen TJ, Karp PH et al (2013) Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model. Mol Ther 21:947–953
    • (2013) Mol Ther , vol.21 , pp. 947-953
    • Potash, A.E.1    Wallen, T.J.2    Karp, P.H.3
  • 103
    • 77950521498 scopus 로고    scopus 로고
    • Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications
    • COI: 1:CAS:528:DC%2BC3cXksFGlug%3D%3D, PID: 20068556
    • Radecke S, Radecke F, Cathomen T, Schwarz K (2010) Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications. Mol Ther 18:743–753
    • (2010) Mol Ther , vol.18 , pp. 743-753
    • Radecke, S.1    Radecke, F.2    Cathomen, T.3    Schwarz, K.4
  • 104
    • 67651160600 scopus 로고    scopus 로고
    • Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs
    • PID: 19566656
    • Ramsoondar J, Vaught T, Ball S et al (2009) Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs. Xenotransplantation 16:164–180
    • (2009) Xenotransplantation , vol.16 , pp. 164-180
    • Ramsoondar, J.1    Vaught, T.2    Ball, S.3
  • 105
    • 77951829073 scopus 로고    scopus 로고
    • Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function
    • COI: 1:CAS:528:DC%2BC3cXmtFegtrw%3D, PID: 20185813
    • Renner S, Fehlings C, Herbach N et al (2010) Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59:1228–1238
    • (2010) Diabetes , vol.59 , pp. 1228-1238
    • Renner, S.1    Fehlings, C.2    Herbach, N.3
  • 106
    • 84864300391 scopus 로고    scopus 로고
    • Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass
    • COI: 1:CAS:528:DC%2BC38XhtFOgu7zO, PID: 22492530
    • Renner S, Romisch-Margl W, Prehn C et al (2012) Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass. Diabetes 61:2166–2175
    • (2012) Diabetes , vol.61 , pp. 2166-2175
    • Renner, S.1    Romisch-Margl, W.2    Prehn, C.3
  • 107
    • 84876517346 scopus 로고    scopus 로고
    • Permanent neonatal diabetes in INS(C94Y) transgenic pigs
    • COI: 1:CAS:528:DC%2BC3sXhtVSnurnI, PID: 23274907
    • Renner S, Braun-Reichhart C, Blutke A et al (2013) Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes 62:1505–1511
    • (2013) Diabetes , vol.62 , pp. 1505-1511
    • Renner, S.1    Braun-Reichhart, C.2    Blutke, A.3
  • 108
    • 84874235716 scopus 로고    scopus 로고
    • CFTR-deficient pigs display peripheral nervous system defects at birth
    • COI: 1:CAS:528:DC%2BC3sXjvV2jsbw%3D, PID: 23382208
    • Reznikov LR, Dong Q, Chen JH et al (2013) CFTR-deficient pigs display peripheral nervous system defects at birth. Proc Natl Acad Sci USA 110:3083–3088
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3083-3088
    • Reznikov, L.R.1    Dong, Q.2    Chen, J.H.3
  • 109
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
    • COI: 1:CAS:528:DyaK3cXhvFarur0%3D, PID: 2475911
    • Riordan JR, Rommens JM, Kerem B et al (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066–1073
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riordan, J.R.1    Rommens, J.M.2    Kerem, B.3
  • 110
    • 41849148289 scopus 로고    scopus 로고
    • Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer
    • COI: 1:CAS:528:DC%2BD1cXkt1Cnu7k%3D, PID: 18324337
    • Rogers CS, Hao Y, Rokhlina T et al (2008a) Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest 118:1571–1577
    • (2008) J Clin Invest , vol.118 , pp. 1571-1577
    • Rogers, C.S.1    Hao, Y.2    Rokhlina, T.3
  • 111
    • 52949154301 scopus 로고    scopus 로고
    • Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    • COI: 1:CAS:528:DC%2BD1cXhtFCrtLrP, PID: 18818360
    • Rogers CS, Stoltz DA, Meyerholz DK et al (2008b) Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321:1837–1841
    • (2008) Science , vol.321 , pp. 1837-1841
    • Rogers, C.S.1    Stoltz, D.A.2    Meyerholz, D.K.3
  • 112
    • 84858858553 scopus 로고    scopus 로고
    • Generation of an inbred miniature pig model of retinitis pigmentosa
    • COI: 1:CAS:528:DC%2BC38XjtVKrtLk%3D, PID: 22247487
    • Ross JW, Fernandez de Castro JP, Zhao J et al (2012) Generation of an inbred miniature pig model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 53:501–507
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 501-507
    • Ross, J.W.1    Fernandez de Castro, J.P.2    Zhao, J.3
  • 113
    • 79961192836 scopus 로고    scopus 로고
    • Targeted gene disruption in somatic zebrafish cells using engineered TALENs
    • COI: 1:CAS:528:DC%2BC3MXpvVOlsrc%3D, PID: 21822241
    • Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR (2011) Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol 29:697–698
    • (2011) Nat Biotechnol , vol.29 , pp. 697-698
    • Sander, J.D.1    Cade, L.2    Khayter, C.3    Reyon, D.4    Peterson, R.T.5    Joung, J.K.6    Yeh, J.R.7
  • 114
    • 33747038352 scopus 로고    scopus 로고
    • Belated approval of first recombinant protein from animal
    • COI: 1:CAS:528:DC%2BD28XnvVygs7s%3D, PID: 16900113
    • Schmidt C (2006) Belated approval of first recombinant protein from animal. Nat Biotechnol 24:877
    • (2006) Nat Biotechnol , vol.24 , pp. 877
    • Schmidt, C.1
  • 115
    • 84957877798 scopus 로고    scopus 로고
    • Production of human apolipoprotein(a) transgenic NIBS miniature pigs by somatic cell nuclear transfer
    • COI: 1:CAS:528:DC%2BC28XhtFCgt7zM, PID: 26411321
    • Shimatsu Y, Horii W, Nunoya T, Iwata A, Fan J, Ozawa M (2016) Production of human apolipoprotein(a) transgenic NIBS miniature pigs by somatic cell nuclear transfer. Exp Anim 65:37–43
    • (2016) Exp Anim , vol.65 , pp. 37-43
    • Shimatsu, Y.1    Horii, W.2    Nunoya, T.3    Iwata, A.4    Fan, J.5    Ozawa, M.6
  • 116
    • 0023646640 scopus 로고
    • Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice
    • COI: 1:STN:280:DyaL2s3oslahtA%3D%3D, PID: 3614356
    • Simons JP, McClenaghan M, Clark AJ (1987) Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice. Nature 328:530–532
    • (1987) Nature , vol.328 , pp. 530-532
    • Simons, J.P.1    McClenaghan, M.2    Clark, A.J.3
  • 117
    • 84952943845 scopus 로고    scopus 로고
    • Rationally engineered Cas9 nucleases with improved specificity
    • COI: 1:CAS:528:DC%2BC2MXitV2nt7nE, PID: 26628643
    • Slaymaker IM, Gao L, Zetsche B, Scott DA, Yan WX, Zhang F (2016) Rationally engineered Cas9 nucleases with improved specificity. Science 351:84–88
    • (2016) Science , vol.351 , pp. 84-88
    • Slaymaker, I.M.1    Gao, L.2    Zetsche, B.3    Scott, D.A.4    Yan, W.X.5    Zhang, F.6
  • 118
    • 0034283804 scopus 로고    scopus 로고
    • Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
    • COI: 1:CAS:528:DC%2BD3cXmvVSntrc%3D, PID: 10954606
    • Smith J, Bibikova M, Whitby FG, Reddy AR, Chandrasegaran S, Carroll D (2000) Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Res 28:3361–3369
    • (2000) Nucleic Acids Res , vol.28 , pp. 3361-3369
    • Smith, J.1    Bibikova, M.2    Whitby, F.G.3    Reddy, A.R.4    Chandrasegaran, S.5    Carroll, D.6
  • 119
    • 81555204465 scopus 로고    scopus 로고
    • Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
    • PID: 21873315
    • Sommer JR, Estrada JL, Collins EB et al (2011) Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration. Br J Ophthalmol 95:1749–1754
    • (2011) Br J Ophthalmol , vol.95 , pp. 1749-1754
    • Sommer, J.R.1    Estrada, J.L.2    Collins, E.B.3
  • 120
    • 77950874526 scopus 로고    scopus 로고
    • Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation
    • COI: 1:CAS:528:DC%2BC3cXjtFynt7k%3D, PID: 20047559
    • Song KH, Kang YJ, Jin UH et al (2010) Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation. Biochem J 427:179–188
    • (2010) Biochem J , vol.427 , pp. 179-188
    • Song, K.H.1    Kang, Y.J.2    Jin, U.H.3
  • 121
    • 84881167672 scopus 로고    scopus 로고
    • Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs
    • COI: 1:CAS:528:DC%2BC3sXht1Wltb%2FP, PID: 23835472
    • Song J, Zhong J, Guo X et al (2013) Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs. Cell Res 23:1059–1062
    • (2013) Cell Res , vol.23 , pp. 1059-1062
    • Song, J.1    Zhong, J.2    Guo, X.3
  • 122
    • 33947679772 scopus 로고    scopus 로고
    • Mechanisms of disease: genetic causes of familial hypercholesterolemia
    • COI: 1:CAS:528:DC%2BD2sXjsVCjtbw%3D, PID: 17380167
    • Soutar AK, Naoumova RP (2007) Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med 4:214–225
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. 214-225
    • Soutar, A.K.1    Naoumova, R.P.2
  • 123
    • 84878578719 scopus 로고    scopus 로고
    • Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs
    • COI: 1:CAS:528:DC%2BC3sXpsFWkt7Y%3D, PID: 23676501
    • Stoltz DA, Rokhlina T, Ernst SE et al (2013) Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest 123:2685–2693
    • (2013) J Clin Invest , vol.123 , pp. 2685-2693
    • Stoltz, D.A.1    Rokhlina, T.2    Ernst, S.E.3
  • 124
    • 84863297206 scopus 로고    scopus 로고
    • Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease
    • COI: 1:CAS:528:DC%2BC38XjtlKqur8%3D, PID: 22301904
    • Sun N, Liang J, Abil Z, Zhao H (2012) Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease. Mol BioSyst 8:1255–1263
    • (2012) Mol BioSyst , vol.8 , pp. 1255-1263
    • Sun, N.1    Liang, J.2    Abil, Z.3    Zhao, H.4
  • 125
    • 84872194963 scopus 로고    scopus 로고
    • Knockout mice created by TALEN-mediated gene targeting
    • COI: 1:CAS:528:DC%2BC3sXltVCksg%3D%3D, PID: 23302927
    • Sung YH, Baek IJ, Kim DH et al (2013) Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol 31:23–24
    • (2013) Nat Biotechnol , vol.31 , pp. 23-24
    • Sung, Y.H.1    Baek, I.J.2    Kim, D.H.3
  • 126
    • 84862560337 scopus 로고    scopus 로고
    • Il2rg gene-targeted severe combined immunodeficiency pigs
    • COI: 1:CAS:528:DC%2BC38XosFeqsbk%3D, PID: 22704516
    • Suzuki S, Iwamoto M, Saito Y et al (2012) Il2rg gene-targeted severe combined immunodeficiency pigs. Cell Stem Cell 10:753–758
    • (2012) Cell Stem Cell , vol.10 , pp. 753-758
    • Suzuki, S.1    Iwamoto, M.2    Saito, Y.3
  • 127
    • 84857662538 scopus 로고    scopus 로고
    • Swine as models in biomedical research and toxicology testing
    • COI: 1:STN:280:DC%2BC383mvVOrsw%3D%3D
    • Swindle MM, Makin A, Herron AJ, Clubb FJ Jr, Frazier KS (2012) Swine as models in biomedical research and toxicology testing. Vet Pathol 49:344–356
    • (2012) Vet Pathol , vol.49 , pp. 344-356
    • Swindle, M.M.1    Makin, A.2    Herron, A.J.3    Clubb, F.J.4    Frazier, K.S.5
  • 128
    • 79961196358 scopus 로고    scopus 로고
    • Knockout rats generated by embryo microinjection of TALENs
    • COI: 1:CAS:528:DC%2BC3MXpvVOlurY%3D, PID: 21822240
    • Tesson L, Usal C, Menoret S et al (2011) Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol 29:695–696
    • (2011) Nat Biotechnol , vol.29 , pp. 695-696
    • Tesson, L.1    Usal, C.2    Menoret, S.3
  • 129
    • 84953708487 scopus 로고    scopus 로고
    • Genome editing through large insertion leads to the skipping of targeted exon
    • Uddin B, Chen NP, Panic M, Schiebel E (2015) Genome editing through large insertion leads to the skipping of targeted exon. BMC Genom 16:1082
    • (2015) BMC Genom , vol.16 , pp. 1082
    • Uddin, B.1    Chen, N.P.2    Panic, M.3    Schiebel, E.4
  • 130
    • 70349981719 scopus 로고    scopus 로고
    • Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs
    • COI: 1:CAS:528:DC%2BD1MXhtVWrsrbF, PID: 19357985
    • Umeyama K, Watanabe M, Saito H et al (2009) Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs. Transgenic Res 18:697–706
    • (2009) Transgenic Res , vol.18 , pp. 697-706
    • Umeyama, K.1    Watanabe, M.2    Saito, H.3
  • 131
    • 0032730944 scopus 로고    scopus 로고
    • Transgenic pigs as bioreactors: a comparison of gamma-carboxylation of glutamic acid in recombinant human protein C and factor IX by the mammary gland
    • PID: 10596756
    • Van Cott KE, Butler SP, Russell CG et al (1999) Transgenic pigs as bioreactors: a comparison of gamma-carboxylation of glutamic acid in recombinant human protein C and factor IX by the mammary gland. Genet Anal 15:155–160
    • (1999) Genet Anal , vol.15 , pp. 155-160
    • Van Cott, K.E.1    Butler, S.P.2    Russell, C.G.3
  • 132
    • 84902533278 scopus 로고    scopus 로고
    • Unravelling the structural and mechanistic basis of CRISPR-Cas systems
    • PID: 24909109
    • van der Oost J, Westra ER, Jackson RN, Wiedenheft B (2014) Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nat Rev Microbiol 12:479–492
    • (2014) Nat Rev Microbiol , vol.12 , pp. 479-492
    • van der Oost, J.1    Westra, E.R.2    Jackson, R.N.3    Wiedenheft, B.4
  • 133
    • 0027062770 scopus 로고
    • High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C
    • COI: 1:CAS:528:DyaK3sXpsFGjtA%3D%3D
    • Velander WH, Johnson JL, Page RL et al (1992a) High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C. Proc Natl Acad Sci USA 89:12003–12007
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 12003-12007
    • Velander, W.H.1    Johnson, J.L.2    Page, R.L.3
  • 134
    • 0026693703 scopus 로고
    • Production of biologically active human protein C in the milk of transgenic mice
    • COI: 1:CAS:528:DyaK38XmsV2qtrc%3D, PID: 1416618
    • Velander WH, Page RL, Morcol T et al (1992b) Production of biologically active human protein C in the milk of transgenic mice. Ann N Y Acad Sci 665:391–403
    • (1992) Ann N Y Acad Sci , vol.665 , pp. 391-403
    • Velander, W.H.1    Page, R.L.2    Morcol, T.3
  • 135
    • 79952240166 scopus 로고    scopus 로고
    • Atherosclerosis and thrombosis: insights from large animal models
    • PID: 21274431
    • Vilahur G, Padro T, Badimon L (2011) Atherosclerosis and thrombosis: insights from large animal models. J Biomed Biotechnol 2011:907575
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 907575
    • Vilahur, G.1    Padro, T.2    Badimon, L.3
  • 136
    • 0032560827 scopus 로고    scopus 로고
    • Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei
    • COI: 1:CAS:528:DyaK1cXkvFKnsbs%3D, PID: 9690471
    • Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R (1998) Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 394:369–374
    • (1998) Nature , vol.394 , pp. 369-374
    • Wakayama, T.1    Perry, A.C.2    Zuccotti, M.3    Johnson, K.R.4    Yanagimachi, R.5
  • 137
    • 0025981089 scopus 로고
    • High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine
    • COI: 1:CAS:528:DyaK3MXhsFynt7o%3D, PID: 1705703
    • Wall RJ, Pursel VG, Shamay A, McKnight RA, Pittius CW, Hennighausen L (1991) High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine. Proc Natl Acad Sci USA 88:1696–1700
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1696-1700
    • Wall, R.J.1    Pursel, V.G.2    Shamay, A.3    McKnight, R.A.4    Pittius, C.W.5    Hennighausen, L.6
  • 138
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • COI: 1:CAS:528:DC%2BC3sXmvF2nt7w%3D, PID: 23643243
    • Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R (2013) One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153:910–918
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6    Jaenisch, R.7
  • 139
    • 84949814888 scopus 로고    scopus 로고
    • Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors
    • COI: 1:CAS:528:DC%2BC2MXhsl2gsbfE, PID: 26551060
    • Wang J, Exline CM, DeClercq JJ et al (2015a) Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors. Nat Biotechnol 33:1256–1263
    • (2015) Nat Biotechnol , vol.33 , pp. 1256-1263
    • Wang, J.1    Exline, C.M.2    DeClercq, J.J.3
  • 140
    • 84939815032 scopus 로고    scopus 로고
    • Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs
    • COI: 1:CAS:528:DC%2BC2MXhsVKhtrvI, PID: 26293209
    • Wang X, Zhou J, Cao C et al (2015b) Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs. Sci Rep 5:13348
    • (2015) Sci Rep , vol.5 , pp. 13348
    • Wang, X.1    Zhou, J.2    Cao, C.3
  • 141
    • 84941208123 scopus 로고    scopus 로고
    • Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA
    • COI: 1:CAS:528:DC%2BC2MXhtFKjurnL, PID: 25653176
    • Wang Y, Du Y, Shen B et al (2015c) Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. Sci Rep 5:8256
    • (2015) Sci Rep , vol.5 , pp. 8256
    • Wang, Y.1    Du, Y.2    Shen, B.3
  • 142
    • 84957592496 scopus 로고    scopus 로고
    • One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system
    • COI: 1:CAS:528:DC%2BC28Xitlymurs%3D, PID: 26857844
    • Wang X, Cao C, Huang J et al (2016) One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system. Sci Rep 6:20620
    • (2016) Sci Rep , vol.6 , pp. 20620
    • Wang, X.1    Cao, C.2    Huang, J.3
  • 143
    • 84885151931 scopus 로고    scopus 로고
    • Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA
    • COI: 1:CAS:528:DC%2BC3sXhs1egs7%2FK, PID: 24130776
    • Watanabe M, Nakano K, Matsunari H et al (2013) Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA. PLoS One 8:e76478
    • (2013) PLoS One , vol.8
    • Watanabe, M.1    Nakano, K.2    Matsunari, H.3
  • 144
    • 84874628805 scopus 로고    scopus 로고
    • Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
    • COI: 1:CAS:528:DC%2BC3sXltVGgt7s%3D, PID: 23426636
    • Wefers B, Meyer M, Ortiz O, Hrabe de Angelis M, Hansen J, Wurst W, Kuhn R (2013) Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci USA 110:3782–3787
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3782-3787
    • Wefers, B.1    Meyer, M.2    Ortiz, O.3    Hrabe de Angelis, M.4    Hansen, J.5    Wurst, W.6    Kuhn, R.7
  • 145
    • 83655161317 scopus 로고    scopus 로고
    • Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII
    • COI: 1:CAS:528:DC%2BC38Xit1Snuw%3D%3D, PID: 22023023
    • Wei J, Ouyang H, Wang Y et al (2012) Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII. FEBS J 279:91–99
    • (2012) FEBS J , vol.279 , pp. 91-99
    • Wei, J.1    Ouyang, H.2    Wang, Y.3
  • 147
    • 84859640267 scopus 로고    scopus 로고
    • Transgenic swine: expression of human CD39 protects against myocardial injury
    • COI: 1:CAS:528:DC%2BC38XisFKgsbg%3D, PID: 22269791
    • Wheeler DG, Joseph ME, Mahamud SD et al (2012) Transgenic swine: expression of human CD39 protects against myocardial injury. J Mol Cell Cardiol 52:958–961
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 958-961
    • Wheeler, D.G.1    Joseph, M.E.2    Mahamud, S.D.3
  • 148
    • 84921602939 scopus 로고    scopus 로고
    • Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos
    • PID: 25100712
    • Whitworth KM, Lee K, Benne JA et al (2014) Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos. Biol Reprod 91:78
    • (2014) Biol Reprod , vol.91 , pp. 78
    • Whitworth, K.M.1    Lee, K.2    Benne, J.A.3
  • 149
    • 80052846931 scopus 로고    scopus 로고
    • Vascular endothelium-specific overexpression of human catalase in cloned pigs
    • COI: 1:CAS:528:DC%2BC3MXhtFKrt7%2FK, PID: 21170678
    • Whyte JJ, Samuel M, Mahan E et al (2011a) Vascular endothelium-specific overexpression of human catalase in cloned pigs. Transgenic Res 20:989–1001
    • (2011) Transgenic Res , vol.20 , pp. 989-1001
    • Whyte, J.J.1    Samuel, M.2    Mahan, E.3
  • 150
    • 79251529218 scopus 로고    scopus 로고
    • Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs
    • COI: 1:CAS:528:DC%2BC3MXpvV2lsw%3D%3D, PID: 21268178
    • Whyte JJ, Zhao J, Wells KD et al (2011b) Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs. Mol Reprod Dev 78:2
    • (2011) Mol Reprod Dev , vol.78 , pp. 2
    • Whyte, J.J.1    Zhao, J.2    Wells, K.D.3
  • 151
    • 0031044215 scopus 로고    scopus 로고
    • Viable offspring derived from fetal and adult mammalian cells
    • COI: 1:CAS:528:DyaK2sXhsFamsLs%3D, PID: 9039911
    • Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810–813
    • (1997) Nature , vol.385 , pp. 810-813
    • Wilmut, I.1    Schnieke, A.E.2    McWhir, J.3    Kind, A.J.4    Campbell, K.H.5
  • 152
    • 84891662454 scopus 로고    scopus 로고
    • Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer
    • COI: 1:CAS:528:DC%2BC3sXhtFWjur3E, PID: 23857557
    • Wu Z, Xu Z, Zou X et al (2013) Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer. Transgenic Res 22:1107–1118
    • (2013) Transgenic Res , vol.22 , pp. 1107-1118
    • Wu, Z.1    Xu, Z.2    Zou, X.3
  • 153
    • 84892934410 scopus 로고    scopus 로고
    • Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs
    • PID: 24358349
    • Xin J, Yang H, Fan N et al (2013) Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs. PLoS One 8:e84250
    • (2013) PLoS One , vol.8
    • Xin, J.1    Yang, H.2    Fan, N.3
  • 154
    • 85027921901 scopus 로고    scopus 로고
    • Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning
    • COI: 1:CAS:528:DC%2BC3MXmvFOgt74%3D, PID: 21502977
    • Yang D, Yang H, Li W et al (2011) Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res 21:979–982
    • (2011) Cell Res , vol.21 , pp. 979-982
    • Yang, D.1    Yang, H.2    Li, W.3
  • 155
    • 84948447883 scopus 로고    scopus 로고
    • Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
    • COI: 1:CAS:528:DC%2BC2MXhvFamtLrM, PID: 26456528
    • Yang L, Guell M, Niu D et al (2015) Genome-wide inactivation of porcine endogenous retroviruses (PERVs). Science 350:1101–1104
    • (2015) Science , vol.350 , pp. 1101-1104
    • Yang, L.1    Guell, M.2    Niu, D.3
  • 156
    • 80555150663 scopus 로고    scopus 로고
    • Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle
    • COI: 1:CAS:528:DC%2BC3MXhsVags7%2FF, PID: 21912434
    • Yu S, Luo J, Song Z, Ding F, Dai Y, Li N (2011) Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle. Cell Res 21:1638–1640
    • (2011) Cell Res , vol.21 , pp. 1638-1640
    • Yu, S.1    Luo, J.2    Song, Z.3    Ding, F.4    Dai, Y.5    Li, N.6
  • 158
    • 84925679860 scopus 로고    scopus 로고
    • Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9
    • Zhang L, Jia R, Palange NJ et al (2015) Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9. PLoS One 10:e0120396
    • (2015) PLoS One , vol.10
    • Zhang, L.1    Jia, R.2    Palange, N.J.3
  • 159
    • 84942133460 scopus 로고    scopus 로고
    • Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk
    • COI: 1:CAS:528:DC%2BC2MXhsFeisbbP, PID: 26387706
    • Zhao J, Xu W, Ross JW et al (2015) Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk. Sci Rep 5:14176
    • (2015) Sci Rep , vol.5 , pp. 14176
    • Zhao, J.1    Xu, W.2    Ross, J.W.3
  • 160
    • 84954219694 scopus 로고    scopus 로고
    • Efficient generation of gene-modified pigs harboring precise orthologous human mutation via CRISPR/Cas9-induced homology-directed repair in zygotes
    • COI: 1:CAS:528:DC%2BC2MXitVGiu7jP, PID: 26442986
    • Zhou X, Wang L, Du Y et al (2016) Efficient generation of gene-modified pigs harboring precise orthologous human mutation via CRISPR/Cas9-induced homology-directed repair in zygotes. Hum Mutat 37:110–118
    • (2016) Hum Mutat , vol.37 , pp. 110-118
    • Zhou, X.1    Wang, L.2    Du, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.