A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease

Human Molecular Genetics

Volumn 24, Issue 22, 2015, Pages 6473-6484

  Beraldi, Rosanna ^a   Chan, Chun Hung ^a   Rogers, Christopher S ^b   Kovács, Attila D ^a   Meyerholz, David K ^c   Trantzas, Constantin ^d   Lambertz, Allyn M ^c   Darbro, Benjamin W ^c   Weber, Krystal L ^a   White, Katherine A M ^a   Rheeden, Richard V ^c   Kruer, Michael C ^a   Dacken, Brian A ^b   Wang, Xiao Jun ^b   Davis, Bryan T ^b   Rohret, Judy A ^b   Struzynski, Jason T ^b   Rohret, Frank A ^b   Weimer, Jill M ^a,e   Pearce, David A ^a,e  

^a SANFORD RESEARCH   (United States)

^b Transova Genetics   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d ProtoKinetics LLC   (United States)

^e UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA TELANGIECTASIA; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOARCHITECTURE; DENDRITE; FEMALE; GAIT; GROWTH RETARDATION; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; ANIMAL; CELL NUCLEUS TRANSPLANTATION; DISEASE MODEL; GENETIC ASSOCIATION STUDY; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; PIG; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATAXIA TELANGIECTASIA; ATAXIA TELANGIECTASIA MUTATED PROTEINS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MUTATION; NUCLEAR TRANSFER TECHNIQUES; PURKINJE CELLS; SWINE;

EID: 84949032534     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv356     Document Type: Article

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