-
1
-
-
63149090431
-
Parkinson's disease: From monogenic forms to genetic susceptibility factors
-
Lesage, S. & Brice, A. Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet 18, R48-59 (2009).
-
(2009)
Hum Mol Genet
, vol.18
, pp. R48-R59
-
-
Lesage, S.1
Brice, A.2
-
2
-
-
0036151884
-
Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset
-
Bonifati, V. et al. Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. Annals of neurology 51, 253-256 (2002).
-
(2002)
Annals of Neurology
, vol.51
, pp. 253-256
-
-
Bonifati, V.1
-
3
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608 (1998).
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
-
4
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente, E. M. et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160 (2004).
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
-
5
-
-
0141891953
-
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
-
Goldberg, M. S. et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 278, 43628-43635 (2003).
-
(2003)
J Biol Chem
, vol.278
, pp. 43628-43635
-
-
Goldberg, M.S.1
-
6
-
-
70349923087
-
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
-
Kitada, T., Tong, Y., Gautier, C. A. & Shen, J. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem 111, 696-702 (2009).
-
(2009)
J Neurochem
, vol.111
, pp. 696-702
-
-
Kitada, T.1
Tong, Y.2
Gautier, C.A.3
Shen, J.4
-
7
-
-
84898033899
-
Species-dependent neuropathology in transgenic SOD1 pigs
-
Yang, H. Q. et al. Species-dependent neuropathology in transgenic SOD1 pigs. Cell Res 24, 464-481 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 464-481
-
-
Yang, H.Q.1
-
8
-
-
84885468845
-
A transgenic minipig model of Huntington's Disease
-
Baxa, M. et al. A transgenic minipig model of Huntington's Disease. J Huntington's Dis 2, 47-68 (2013).
-
(2013)
J Huntington's Dis
, vol.2
, pp. 47-68
-
-
Baxa, M.1
-
9
-
-
84897594300
-
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
-
Hai, T., Teng, F., Guo, R., Li, W. & Zhou, Q. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res 24, 372-375 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 372-375
-
-
Hai, T.1
Teng, F.2
Guo, R.3
Li, W.4
Zhou, Q.5
-
10
-
-
84921602939
-
Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos
-
Whitworth, K. M. et al. Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos. Biol Reprod 91, 78 (2014).
-
(2014)
Biol Reprod
, vol.91
, pp. 78
-
-
Whitworth, K.M.1
-
11
-
-
84938537178
-
CRISPR/Cas9: A powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
-
Tu, Z., Yang, W., Yan, S., Guo, X. & Li, X. J. CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases. Mol Neurodegener 10, 35 (2015).
-
(2015)
Mol Neurodegener
, vol.10
, pp. 35
-
-
Tu, Z.1
Yang, W.2
Yan, S.3
Guo, X.4
Li, X.J.5
-
12
-
-
52649172321
-
Familial parkinsonism with digenic Parkin and PINK1 mutations
-
Funayama, M. et al. Familial parkinsonism with digenic Parkin and PINK1 mutations. Movement Disord 23, 1461-1465 (2008).
-
(2008)
Movement Disord
, vol.23
, pp. 1461-1465
-
-
Funayama, M.1
-
13
-
-
84883779087
-
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
-
Li, W., Teng, F., Li, T. & Zhou, Q. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nature Biotechnol 31, 684-686 (2013).
-
(2013)
Nature Biotechnol
, vol.31
, pp. 684-686
-
-
Li, W.1
Teng, F.2
Li, T.3
Zhou, Q.4
-
14
-
-
84897530474
-
Dual sgRNAs facilitate CRISPR/Cas9-mediated mouse genome targeting
-
Zhou, J. K. et al. Dual sgRNAs facilitate CRISPR/Cas9-mediated mouse genome targeting. FEBS J 281, 1717-1725 (2014).
-
(2014)
FEBS J
, vol.281
, pp. 1717-1725
-
-
Zhou, J.K.1
-
15
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821 (2012).
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
16
-
-
84930503842
-
Advances in CRISPR-Cas9 genome engineering: Lessons learned from RNA interference
-
Barrangou, R. et al. Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res 43, 3407-3419 (2015).
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 3407-3419
-
-
Barrangou, R.1
-
17
-
-
55849122639
-
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
-
Henchcliffe, C. & Beal, M. F. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Prac Neuro 4, 600-609 (2008).
-
(2008)
Nat Clin Prac Neuro
, vol.4
, pp. 600-609
-
-
Henchcliffe, C.1
Beal, M.F.2
-
18
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nature Biotechnol 31, 822-826 (2013).
-
(2013)
Nature Biotechnol
, vol.31
, pp. 822-826
-
-
Fu, Y.1
-
19
-
-
84923112396
-
Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios
-
Besenbacher, S. et al. Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios. Nature Commun 6, 5969 (2015).
-
(2015)
Nature Commun
, vol.6
, pp. 5969
-
-
Besenbacher, S.1
-
20
-
-
84898889321
-
CasOT: A genome-wide Cas9/gRNA off-target searching tool
-
Xiao, A. et al. CasOT: a genome-wide Cas9/gRNA off-target searching tool. Bioinformatics 30, 1180-1182 (2014).
-
(2014)
Bioinformatics
, vol.30
, pp. 1180-1182
-
-
Xiao, A.1
-
21
-
-
84930153818
-
Off-target mutations are rare in Cas9-modified mice
-
Iyer, V. et al. Off-target mutations are rare in Cas9-modified mice. Nat Methods 12, 479 (2015).
-
(2015)
Nat Methods
, vol.12
, pp. 479
-
-
Iyer, V.1
-
22
-
-
84923241422
-
Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans
-
Chen, X. et al. Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Sci Rep 4, 7581 (2014).
-
(2014)
Sci Rep
, vol.4
, pp. 7581
-
-
Chen, X.1
-
23
-
-
84940107277
-
Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
-
Wang, J. et al. Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication. World J Gastroentero 21, 9554-9565 (2015).
-
(2015)
World J Gastroentero
, vol.21
, pp. 9554-9565
-
-
Wang, J.1
-
24
-
-
84939815032
-
Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs
-
Wang, X. et al. Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs. Sci Rep 5, 13348 (2015).
-
(2015)
Sci Rep
, vol.5
-
-
Wang, X.1
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