Atherosclerosis: Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant

Science Translational Medicine

Volumn 5, Issue 166, 2013, Pages

  Al Mashhadi, Rozh H ^a   Sørensen, Charlotte B ^b   Kragh, Peter M ^b   Christoffersen, Christina ^c   Mortensen, Martin B ^a   Tolbod, Lars P ^a   Thim, Troels ^a   Du, Yutao ^b   Li, Juan ^b,g   Liu, Ying ^b   Moldt, Brian ^b   Schmidt, Mette ^d   Vajta, Gabor ^b,e   Larsen, Torben ^b   Purup, Stig ^b   Bolund, Lars ^b,f   Nielsen, Lars B ^c,d   Callesen, Henrik ^b   Falk, Erling ^a   Mikkelsen, Jacob Giehm ^b   Bentzon, Jacob F ^a   more..

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Rigshospitalet   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e CENTRAL QUEENSLAND UNIVERSITY   (Australia)

^f BGI SHENZHEN   (China)

^g NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; MUTANT PROTEIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; DNA; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PCSK9 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; AUTOSOMAL DOMINANT DISORDER; CELL NUCLEUS TRANSPLANTATION; CLONING; DISEASE MODEL; DNA MODIFICATION; DNA TRANSPOSITION; FAMILIAL HYPERCHOLESTEROLEMIA; GAIN OF FUNCTION MUTATION; GENETIC STRAIN; LIPID DIET; MINIPIG; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC CELL; TRANSLATIONAL RESEARCH; ANIMAL; FEMALE; GENETICS; HUMAN; HYPERCHOLESTEROLEMIA; LIVER; MALE; METABOLISM; MUTATION; PHENOTYPE; SWINE; TRANSGENE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATHEROSCLEROSIS; CLONING, ORGANISM; DISEASE MODELS, ANIMAL; DNA; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; HYPERLIPOPROTEINEMIA TYPE II; LIVER; MALE; MUTATION; PHENOTYPE; PROPROTEIN CONVERTASES; RECEPTORS, LDL; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SWINE; SWINE, MINIATURE; TRANSGENES;

MLCS; MLOWN;

EID: 84872013355     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3004853     Document Type: Article

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