Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies

Xenotransplantation

Volumn 17, Issue 6, 2010, Pages 440-448

  Basnet, Nabin B ^a   Ide, Kentaro ^a   Tahara, Hiroyuki ^a   Tanaka, Yuka ^a   Ohdan, Hideki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

complement dependent cytotoxicity; natural antibody; xenoantibody xenoantigen; xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CARBOHYDRATE ANTIGEN; CHROMIUM 51; CYTIDINE MONOPHOSPHO N ACETYLNEURAMINIC ACID HYDROXYLASE; EPITOPE; GALACTOSYLGALACTOSE; GALACTOSYLGALACTOSE BETA 1; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; N GLYCOLOYLNEURAMINIC ACID; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BLOOD GROUP; CELL; CHROMIUM 51 RELEASE; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; FLOW CYTOMETRY; GENOTYPE; HEART; HEMATOPOIETIC CELL; HUMAN; HUMAN EXPERIMENT; IMMUNOHISTOCHEMISTRY; KIDNEY; KNOCKOUT MOUSE; LIVER; LUNG; NONHUMAN; NORMAL HUMAN; PANCREAS; PRIORITY JOURNAL; THYMOCYTE; XENOGENEIC CELL;

ANIMALS; ANTIBODIES; ANTIGENS, HETEROPHILE; CARBOHYDRATE SEQUENCE; COMPLEMENT SYSTEM PROTEINS; EPITOPES; GALACTOSYLTRANSFERASES; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; N-ACETYLNEURAMINIC ACID; NEURAMINIC ACIDS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 78650670892     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2010.00610.x     Document Type: Article

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