In vivo genome editing using a high-efficiency TALEN system

Nature

Volumn 491, Issue 7422, 2012, Pages 114-118

  Bedell, Victoria M ^a   Wang, Ying ^b   Campbell, Jarryd M ^a   Poshusta, Tanya L ^a   Starker, Colby G ^c   Krug Ii, Randall G ^a   Tan, Wenfang ^c   Penheiter, Sumedha G ^a   Ma, Alvin C ^a,d   Leung, Anskar Y H ^d   Fahrenkrug, Scott C ^c,e   Carlson, Daniel F ^c,e   Voytas, Daniel F ^c   Clark, Karl J ^a   Essner, Jeffrey J ^b   Ekker, Stephen C ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e RECOMBINETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR SCAFFOLD; MORPHOLINO OLIGONUCLEOTIDE; NUCLEASE; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

GENETIC ENGINEERING; GENOME; PERCIFORM;

ARTICLE; DNA DETERMINATION; DNA STRAND BREAKAGE; GENE LOCUS; GENE SEQUENCE; GENE SILENCING; GENETIC VARIABILITY; GERMLINE MICRONUCLEUS; IN VIVO STUDY; INDEL MUTATION; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SOMATIC CELL; ZEBRA FISH;

ALLELES; ANIMALS; ATTACHMENT SITES, MICROBIOLOGICAL; BASE SEQUENCE; CHROMOSOMES; DEOXYRIBONUCLEASES; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA BREAKS; DNA, SINGLE-STRANDED; GENE TARGETING; GENETIC ENGINEERING; GENOME; GENOMICS; GENOTYPE; GERM-LINE MUTATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECOMBINATIONAL DNA REPAIR; RNA, MESSENGER; ZEBRAFISH;

DANIO RERIO; VERTEBRATA;

EID: 84868342049     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11537     Document Type: Article

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