Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

Xenotransplantation

Volumn 20, Issue 1, 2013, Pages 27-35

  Lutz, Andrew J ^a   Li, Ping ^a   Estrada, Jose L ^a   Sidner, Richard A ^a   Chihara, Ray K ^a   Downey, Susan M ^a   Burlak, Christopher ^a   Wang, Zheng Yu ^a   Reyes, Luz M ^a   Ivary, Bess ^a   Yin, Fuqin ^a   Blankenship, Ross L ^a   Paris, Leela L ^a   Tector, A Joseph ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

humoral; Neu5Gc; pig; xenotransplantation; zinc finger nuclease

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; ZINC FINGER NUCLEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CELL CLONING; CELL NUCLEUS TRANSPLANTATION; CYTIDINE PHOSPHATE N ACETYLNEURAMINIC ACID HYDROXYLASE GENE; CYTOTOXICITY; DNA MODIFICATION; ENZYME DEFICIENCY; FEMALE; GENE; GENE ACTIVITY; GENETIC DISORDER; HUMORAL IMMUNE DEFICIENCY; IMMUNOREACTIVITY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; SOMATIC CELL; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES, HETEROPHILE; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, HETEROPHILE; BASE SEQUENCE; CELLS, CULTURED; DISACCHARIDES; DNA; FEMALE; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; HUMANS; LEUKOCYTES, MONONUCLEAR; MIXED FUNCTION OXYGENASES; NEURAMINIC ACIDS; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 84873465592     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12019     Document Type: Article

References (17)

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