Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes

Human Mutation

Volumn 37, Issue 1, 2016, Pages 110-118

  Zhou, Xiaoyang ^a   Wang, Lulu ^a   Du, Yinan ^b   Xie, Fei ^a   Li, Liang ^a   Liu, Yu ^a   Liu, Chuanhong ^a   Wang, Shiqiang ^a   Zhang, Shibing ^a   Huang, Xingxu ^b   Wang, Yong ^a   Wei, Hong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAITECH UNIVERSITY   (China)

Author keywords

CRISPR Cas9; Disease model; Homology directed repair; Model organism; Pigs; SOX10

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR CAS9 PROTEIN; DNA FRAGMENT; GENOMIC DNA; TRANSCRIPTION FACTOR SOX10; UNCLASSIFIED DRUG; GUIDE RNA; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR SOX;

ALLELE; ANIMAL CELL; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CODON; CONTROLLED STUDY; DNA BINDING; DNA END JOINING REPAIR; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; HAPLOIDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INDEL MUTATION; MOSAICISM; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SILENT MUTATION; ZYGOTE; AMINO ACID SEQUENCE; ANIMAL; CRISPR CAS SYSTEM; GENE ORDER; GENE TARGETING; GENETICS; HOMOLOGOUS RECOMBINATION; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; SEQUENCE ALIGNMENT; TRANSGENIC ANIMAL;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CRISPR-CAS SYSTEMS; GENE ORDER; GENE TARGETING; HOMOLOGOUS RECOMBINATION; MOLECULAR SEQUENCE DATA; MOSAICISM; MUTATION; OLIGONUCLEOTIDES; RNA, GUIDE; SEQUENCE ALIGNMENT; SOXE TRANSCRIPTION FACTORS; ZYGOTE;

EID: 84954219694     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.22913     Document Type: Article

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