Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets

Journal of Cystic Fibrosis

Volumn 13, Issue 3, 2014, Pages 251-259

  Guo, Jinny J ^a   Stoltz, David A ^a   Zhu, Vivian ^a   Volk, Kenneth A ^a   Segar, Jeffrey L ^a   McCray, Paul B ^a   Roghair, Robert D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cystic fibrosis transmembrane conductance regulator; Endoplasmic reticulum; Inositol triphosphate receptor; Vascular smooth muscle cell

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; RYANODINE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA CONSTRICTION; ARTICLE; BLOOD VESSEL TONE; CALCIUM SIGNALING; CELL FUNCTION; CONTROLLED STUDY; CYSTIC FIBROSIS; GENOTYPE; MUSCLE FUNCTION; MYOGRAPHY; NONHUMAN; PIGLET; VASCULAR SMOOTH MUSCLE; WILD TYPE; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SWINE; VASOCONSTRICTION;

ANIMALS; AORTA; CALCIUM SIGNALING; CELLS, CULTURED; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; GENOTYPE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MUSCLE, SMOOTH, VASCULAR; MYOGRAPHY; SWINE; VASOCONSTRICTION;

EID: 84897111753     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2013.10.009     Document Type: Article

References (45)

1. Bobadilla J.L., Macek M., Fine J.P., Farrell P.M. Cystic fibrosis: a worldwide analysis of CFTR mutations-correlation with incidence data and application to screening. Hum Mutat 2002, 19:575-606.
2. Cheng S.H., Gregory R.J., Marshall J., Paul S., Souza D.W., White G.A., et al. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell 1990, 63:827-834.
3. Kopito R.R. Biosynthesis and degradation of CFTR. Physiol Rev 1999, 79:S167-S173.
4. Lieberman J., Rodbard S. Low blood pressure in young adults with cystic fibrosis: an effect of chronic salt loss in sweat?. Ann Intern Med 1975, 82:806-808.
5. Fraser K.L., Tullis D.E., Sasson Z., Hyland R.H., Thornley K.S., Hanly P.J. Pulmonary hypertension and cardiac function in adult cystic fibrosis: role of hypoxemia. Chest 1999, 115:1321-1328.
6. Baño-Rodrigo A., Salcedo-Posadas A., Villa-Asensi J.R., Tamariz-Martel A., Lopez-Neyra A., Blanco-Iglesias E. Right ventricular dysfunction in adolescents with mild cystic fibrosis. J Cyst Fibros 2012, 11:274-280.
7. Super M., Irtiza-Ali A., Roberts S.A., Schwarz M., Young M., Smith A., et al. Blood pressure and the cystic fibrosis gene: evidence for lower pressure rises with age in female carriers. Hypertension 2004, 44:878-883.
8. Rosenthal A., Button L.N., Khaw K.T. Blood volume changes in patients with cystic fibrosis. Pediatrics 1977, 59:588-594.
9. Brown M.B., McCarty N.A., Millard-Stafford M. High-sweat Na+ in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat. Am J Physiol Regul Integr Comp Physiol 2011, 301:R1177-R1185.
10. Hull J.H., Ansley L., Bolton C.E., Sharman J.E., Knight R.K., Cockcroft J.R., et al. The effect of exercise on large artery haemodynamics in cystic fibrosis. J Cyst Fibros 2011, 10:121-127.
11. Buehler T., Steinmann M., Singer F., Regamey N., Casaulta C., Schoeni M.H., et al. Increased arterial stiffness in children with cystic fibrosis. Eur Respir J 2012, 39:1536-1537.
12. McGrath L.T., McCall D., Hanratty C.G., Brennan S., Devine A., McCauley D.F., et al. Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum. Clin Sci (Lond) 2001, 101:507-513.
13. Michoud M.C., Robert R., Hassan M., Moynihan B., Haston C., Govindaraju V., et al. Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle. Am J Respir Cell Mol Biol 2009, 40:217-222.
14. Stoltz D.A., Rokhlina T., Ernst S.E., Pezzulo A.A., Ostedgaard L.S., Karp P.H., et al. Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest 2013, 123:2685-2693.
15. Sutko J.L., Airey J.A., Welch W., Ruest L. The pharmacology of ryanodine and related compounds. Pharmacol Rev 1997, 49:53-98.
16. Orie N.N., Fry C.H., Clapp L.H. Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism. Cardiovasc Res 2006, 69:107-115.
17. Maruyama T., Kanaji T., Nakade S., Kanno T., Mikoshiba K. 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J Biochem 1997, 122:498-505.
18. Roghair R.D., Segar J.L., Sharma R.V., Zimmerman M.C., Jagadeesha D.K., Segar E.M., et al. Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension. Am J Physiol Regul Integr Comp Physiol 2005, 289:R1169-R1176.
19. Roghair R.D., Volk K.A., Lamb F.S., Segar J.L. Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. Am J Physiol Regul Integr Comp Physiol 2012, 303:R513-R519.
20. Grynkiewicz G., Poenie M., Tsien R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985, 260:3440-3450.
21. Rootwelt T., Løberg E.M., Moen A., Oyasaeter S., Saugstad O.D. Hypoxemia and reoxygenation with 21% or 100% oxygen in newborn pigs: changes in blood pressure, base deficit, and hypoxanthine and brain morphology. Pediatr Res 1992, 32:107-113.
22. Lu M., Leng Q., Egan M.E., Caplan M.J., Boulpaep E.L., Giebisch G.H., et al. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 2006, 116:797-807.
23. Lamhonwah A.M., Bear C.E., Huan L.J., Kim Chiaw P., Ackerley C.A., Tein I. Cystic fibrosis transmembrane conductance regulator in human muscle: dysfunction causes abnormal metabolic recovery in exercise. Ann Neurol 2010, 67:802-808.
24. Robert R., Thoreau V., Norez C., Cantereau A., Kitzis A., Mettey Y., et al. Regulation of the cystic fibrosis transmembrane conductance regulator channel by beta-adrenergic agonists and vasoactive intestinal peptide in rat smooth muscle cells and its role in vasorelaxation. J Biol Chem 2004, 279:21160-21168.
25. Robert R., Savineau J.P., Norez C., Becq F., Guibert C. Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries. Eur Respir J 2007, 30:857-864.
26. Robert R., Norez C., Becq F. Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells. J Physiol 2005, 568:483-495.
27. Martins J.R., Kongsuphol P., Sammels E., Dahimène S., Aldehni F., Clarke L.A., et al. F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis. Biochim Biophys Acta 1812, 2011:1385-1392.
28. Balghi H., Robert R., Rappaz B., Zhang X., Wohlhuter-Haddad A., Evagelidis A., et al. Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways. FASEB J 2011, 25:4274-4291.
29. Narayanan J., Imig M., Roman R.J., Harder D.R. Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol. Am J Physiol 1994, 266:H1840-H1845.
30. Stathopulos P.B., Seo M.D., Enomoto M., Amador F.J., Ishiyama N., Ikura M. Themes and variations in ER/SR calcium release channels: structure and function. Physiology 2012, 27:331-342.
31. Meyerholz D.K., Stoltz D.A., Namati E., Ramachandran S., Pezzulo A.A., Smith A.R., et al. Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med 2010, 182:1251-1261.
32. Barriere H., Bagdany M., Bossard F., Okiyoneda T., Wojewodka G., Gruenert D., et al. Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles. Mol Biol Cell 2009, 20:3125-3141.
33. Rogan M.P., Reznikov L.R., Pezzulo A.A., Gansemer N.D., Samuel M., Prather R.S., et al. Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A 2010, 107:20571-20575.
34. Koklu E., Ozturk M.A., Kurtoglu S., Akcakus M., Yikilmaz A., Gunes T. Aortic intima-media thickness, serum IGF-I, IGFBP-3, and leptin levels in intrauterine growth-restricted newborns of healthy mothers. Pediatr Res 2007, 62:704-709.
35. Wang J., Best P.M. Characterization of the potassium channel from frog skeletal muscle sarcoplasmic reticulum membrane. J Physiol 1994, 477:279-290.
36. Rousseau E., Roberson M., Meissner G. Properties of single chloride selective channel from sarcoplasmic reticulum. Eur Biophys J 1988, 16:143-151.
37. Gillespie D., Fill M. Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study. Biophys J 2008, 95:3706-3714.
38. Hybiske K., Fu Z., Schwarzer C., Tseng J., Do J., Huang N., et al. Effects of cystic fibrosis transmembrane conductance regulator and DeltaF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia. Am J Physiol Lung Cell Mol Physiol 2007, 293:L1250-L1260.
39. Knot H.J., Nelson M.T. Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol 1998, 508:199-209.
40. Tousson A., Van Tine B.A., Naren A.P., Shaw G.M., Schwiebert L.M. Characterization of CFTR expression and chloride channel activity in human endothelia. Am J Physiol 1998, 275:C1555-C1564.
41. Divangahi M., Balghi H., Danialou G., Comtois A.S., Demoule A., Ernest S., et al. Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice. PLoS Genet 2009, 5:e1000586.
42. Sellers Z.M., De Arcangelis V., Xiang Y., Best P.M. Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate. J Physiol 2010, 588:2417-2429.
43. Bartoszewski R., Rab A., Jurkuvenaite A., Mazur M., Wakefield J., Collawn J.F., et al. Activation of the unfolded protein response by deltaF508 CFTR. Am J Respir Cell Mol Biol 2008, 39:448-457.
44. Ribeiro C.M., Boucher R.C. Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses. Proc Am Thorac Soc 2010, 7:387-394.
45. Roghair R., McCray P., Welsh M., Santillan D., Santillan M., Stoltz D.A. Direct cardiovascular effects of the CFTR δF508 mutation. Pulmonology 2012, 47:288.