Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

Science

Volumn 321, Issue 5897, 2008, Pages 1837-1841

  Rogers, Christopher S ^a   Stoltz, David A ^a   Meyerholz, David K ^a   Ostedgaard, Lynda S ^a   Rokhlina, Tatiana ^a   Taft, Peter J ^a   Rogan, Mark P ^a   Pezzulo, Alejandro A ^a   Karp, Philip H ^a   Itani, Omar A ^a   Kabel, Amanda C ^a   Wohlford Lenane, Christine L ^a   Davis, Greg J ^a   Hanfland, Robert A ^a   Smith, Tony L ^a   Samuel, Melissa ^b   Wax, David ^b   Murphy, Clifton N ^b   Rieke, August ^b   Whitworth, Kristin ^b   Uc, Aliye ^a   Starner, Timothy D ^a   Brogden, Kim A ^c   Shilyansky, Joel ^a   McCray Jr , Paul B ^a   Zabner, Joseph ^a   Prather, Randall S ^b   Welsh, Michael J ^a   more..

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSMEMBRANE CONDUCTANCE REGULATOR;

DISEASE TREATMENT; ENDOCRINE SYSTEM; GENE EXPRESSION; PHYSIOLOGICAL RESPONSE; PIG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY CIRRHOSIS; CFTR GENE; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; ENTEROPATHY; FEMALE; GALLBLADDER DISEASE; GENE; GENE DISRUPTION; LIVER DISEASE; LUNG DISEASE; MALE; MECONIUM ILEUS; NEWBORN; NONHUMAN; PANCREAS INJURY; PRIORITY JOURNAL; SWINE;

ANIMALS; ANIMALS, NEWBORN; CHLORIDES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE MODELS, ANIMAL; FEMALE; GALLBLADDER; ILEUS; INTESTINES; ION TRANSPORT; LIVER; LIVER CIRRHOSIS, BILIARY; LUNG; MALE; PANCREAS, EXOCRINE; RECOMBINATION, GENETIC; SWINE;

MUS; SUIDAE;

EID: 52949154301     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1163600     Document Type: Article

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29. We thank A. Arias, E. Bagnall, J. Bartlett, B. Bauer, T. Bohnert, E. Burnight, K. Dobbs, C. Dohrn, L. Dowell, L. Gakhar, D. Guilliams, Y. Hao, S. C. Isom, S. Jones, S. Korte, B. Kussman, J. Launspach, M. Linville, E. Mahan, T. Mayhew, C. McHughes, K. Munson, M. Parker, C. Randak, S. Ramachandran, J. Ross, A. Small, L. Spate, D. Vermeer, E. Walters, and J. Whyte for excellent assistance. We thank our patients with CF for inspiration, and we also thank Cystic Fibrosis Foundation Therapeutics and R. Bridges for the gift of GlyH-101. This work was supported by the National Heart Lung and Blood Institute (grant HL51670), the National Institute of Diabetes and Digestive and Kidney Diseases (grant DK54759), Food for the 21st Century, the Cystic Fibrosis Foundation, and HHMI. C.S.R. was supported by NIH training grant HL07638. D.A.S. is a Parker B. Francis Fellow and was supported by the National Institute of Allergy and Infectious Diseases (grant AI076671). M.J.W. is an Investigator of the HHMI. C.S.R., R.S.P., M.J.W., and the University of Iowa Foundation have applied for a patent related to the work reported in this paper, and C.S.R. and M.J.W. are founders of Exemplar Genetics, a company that is licensing materials and technology related to this work. C.S.R. is currently Director of Research and Development at Exemplar Genetics.