Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

Science

Volumn 350, Issue 6264, 2015, Pages 1101-1104

  Yang, Luhan ^a,b,c   Güell, Marc ^a,b,c   Niu, Dong ^a,d   George, Haydy ^a   Lesha, Emal ^a   Grishin, Dennis ^a   Aach, John ^a   Shrock, Ellen ^a   Xu, Weihong ^e   Poci, Jürgen ^a   Cortazio, Rebeca ^a   Wilkinson, Robert A ^e   Fishman, Jay A ^e   Church, George ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c EGenesis Biosciences   (United States)

^d ZHEJIANG UNIVERSITY   (China)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE; GENOME; PIG; VIRUS;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; CONTROLLED STUDY; CRISPR CAS SYSTEM; ENDOGENOUS RETROVIRUS; GENE DOSAGE; GENE INACTIVATION; GENOME; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY EPITHELIUM; NONHUMAN; PORCINE ENDOGENOUS RETROVIRUS; PRIORITY JOURNAL; STRUCTURAL GENE; VIRAL CLEARANCE; VIRUS TRANSMISSION; XENOTRANSPLANTATION; ANIMAL; CELL LINE; EPITHELIUM CELL; GENE TARGETING; GENETICS; HEK293 CELL LINE; KIDNEY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PIG; PROCEDURES; RETROVIRIDAE INFECTIONS; TRANSMISSION; VIROLOGY; VIRUS INACTIVATION; XENOGRAFT;

PORCINE ENDOGENOUS RETROVIRUS; SUS;

ANIMALS; BASE SEQUENCE; CELL LINE; CRISPR-CAS SYSTEMS; ENDOGENOUS RETROVIRUSES; EPITHELIAL CELLS; GENE DOSAGE; GENE TARGETING; GENES, POL; HEK293 CELLS; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; RETROVIRIDAE INFECTIONS; SWINE; TRANSPLANTATION, HETEROLOGOUS; VIRUS INACTIVATION;

EID: 84948447883     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad1191     Document Type: Article

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