-
1
-
-
75149178737
-
Familial risks for type 2 diabetes in Sweden
-
Hemminki, K., Li, X., Sundquist, K., & Sundquist, J. Familial risks for type 2 diabetes in Sweden. Diabetes Care 33, 293-297 (2010)
-
(2010)
Diabetes Care
, vol.33
, pp. 293-297
-
-
Hemminki, K.1
Li, X.2
Sundquist, K.3
Sundquist, J.4
-
2
-
-
80054707972
-
Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study
-
Almgren P., et al. Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia 54, 2811-2819 (2011)
-
(2011)
Diabetologia
, vol.54
, pp. 2811-2819
-
-
Almgren, P.1
-
3
-
-
84896495719
-
Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future
-
Kahn, S. E., Cooper, M. E., & Del Prato, S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383, 1068-1083 (2014)
-
(2014)
Lancet
, vol.383
, pp. 1068-1083
-
-
Kahn, S.E.1
Cooper, M.E.2
Del Prato, S.3
-
4
-
-
42349087252
-
Microvascular and macrovascular complications of diabetes
-
Fowler, M. J. Microvascular and macrovascular complications of diabetes. Clin. Diabetes 26, 77-82 (2008)
-
(2008)
Clin. Diabetes
, vol.26
, pp. 77-82
-
-
Fowler, M.J.1
-
5
-
-
84946049571
-
Excess mortality among persons with type 2 diabetes
-
Tancredi M., et al. Excess mortality among persons with type 2 diabetes. N. Engl. J. Med. 373, 1720-1732 (2015)
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 1720-1732
-
-
Tancredi, M.1
-
6
-
-
0033624575
-
The common PPAR? Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler D., et al. The common PPAR? Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26, 76-80 (2000)
-
(2000)
Nat. Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
-
7
-
-
0037317981
-
Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
-
Gloyn A. L., et al. Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52, 568-572 (2003)
-
(2003)
Diabetes
, vol.52
, pp. 568-572
-
-
Gloyn, A.L.1
-
8
-
-
32544451924
-
Variant of transcription factor 7 like 2 (TCF7L2) gene confers risk of type 2 diabetes
-
Grant S. F., et al. Variant of transcription factor 7 like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38, 320-323 (2006)
-
(2006)
Nat. Genet
, vol.38
, pp. 320-323
-
-
Grant, S.F.1
-
9
-
-
40349114743
-
Meta-Analysis of 23 type 2 diabetes linkage studies from the international type 2 diabetes linkage analysis consortium
-
Guan, W., Pluzhnikov, A., Cox, N. J., & Boehnke, M. Meta-Analysis of 23 type 2 diabetes linkage studies from the international type 2 diabetes linkage analysis consortium. Hum. Hered. 66, 35-49 (2008)
-
(2008)
Hum. Hered
, vol.66
, pp. 35-49
-
-
Guan, W.1
Pluzhnikov, A.2
Cox, N.J.3
Boehnke, M.4
-
10
-
-
55449120805
-
Genetic mapping in human disease
-
Altshuler, D., Daly, M. J., & Lander, E. S. Genetic mapping in human disease. Science 322, 881-888 (2008)
-
(2008)
Science
, vol.322
, pp. 881-888
-
-
Altshuler, D.1
Daly, M.J.2
Lander, E.S.3
-
11
-
-
78649842241
-
Genomics, type 2 diabetes, and obesity
-
McCarthy, M. I. Genomics, type 2 diabetes, and obesity. N. Engl. J. Med. 363, 2339-2350 (2010)
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 2339-2350
-
-
McCarthy, M.I.1
-
12
-
-
77951702343
-
Genetic heterogeneity in human disease
-
McClellan, J., & King, M. C. Genetic heterogeneity in human disease. Cell 141, 210-217 (2010)
-
(2010)
Cell
, vol.141
, pp. 210-217
-
-
McClellan, J.1
King, M.C.2
-
13
-
-
65949107547
-
Common genetic variation and human traits
-
Goldstein, D. B. Common genetic variation and human traits. N. Engl. J. Med. 360, 1696-1698 (2009)
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1696-1698
-
-
Goldstein, D.B.1
-
14
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch, N., & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996)
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
15
-
-
0035451780
-
On the allelic spectrum of human disease
-
Reich, D. E., & Lander, E. S. On the allelic spectrum of human disease. Trends Genet. 17, 502-510 (2001)
-
(2001)
Trends Genet
, vol.17
, pp. 502-510
-
-
Reich, D.E.1
Lander, E.S.2
-
16
-
-
79959524146
-
A haplotype map of the human genome
-
International HapMap Consortium
-
International HapMap Consortium. A haplotype map of the human genome. Nature 437 1299-1320 (2005)
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
17
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Diabetes Genetics Initiative
-
Diabetes Genetics Initiative. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 1331-1336 (2007)
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
-
18
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
-
Scott L. J., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341-1345 (2007)
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
-
19
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
Sladek R., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885 (2007)
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
-
20
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
Steinthorsdottir V., et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat. Genet. 39, 770-775 (2007)
-
(2007)
Nat. Genet
, vol.39
, pp. 770-775
-
-
Steinthorsdottir, V.1
-
21
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
Zeggini E., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341 (2007)
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
-
22
-
-
42349106044
-
Meta-Analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Zeggini E., et al. Meta-Analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 40, 638-645 (2008)
-
(2008)
Nat. Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
-
23
-
-
58149345887
-
Practical aspects of imputation-driven meta-Analysis of genome-wide association studies
-
de Bakker P. I., et al. Practical aspects of imputation-driven meta-Analysis of genome-wide association studies. Hum. Mol. Genet. 17, R122-R128 (2008)
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. R122-R128
-
-
De Bakker, P.I.1
-
24
-
-
77955894071
-
METAL: Fast and efficient meta-Analysis of genomewide association scans
-
Willer, C. J., Li, Y., & Abecasis, G. R. METAL: fast and efficient meta-Analysis of genomewide association scans. Bioinformatics 26, 2190-2191 (2010)
-
(2010)
Bioinformatics
, vol.26
, pp. 2190-2191
-
-
Willer, C.J.1
Li, Y.2
Abecasis, G.R.3
-
25
-
-
78049337953
-
Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index
-
Speliotes, E. K., et al. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010)
-
(2010)
Nat. Genet
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
-
26
-
-
77955505564
-
Biological clinical and population relevance of 95 loci for blood lipids
-
Teslovich, T. M., et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010)
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
-
27
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
Voight B. F., et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42, 579-589 (2010)
-
(2010)
Nat. Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
-
28
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
Dupuis J., et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42, 105-116 (2010)
-
(2010)
Nat. Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
-
29
-
-
79251612707
-
Common variants near ATM are associated with glycaemic response to metformin in type 2 diabetes
-
Zhou K., et al. Common variants near ATM are associated with glycaemic response to metformin in type 2 diabetes. Nat. Genet. 43, 117-120 (2011)
-
(2011)
Nat. Genet
, vol.43
, pp. 117-120
-
-
Zhou, K.1
-
30
-
-
75749091912
-
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
-
Saxena R., et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet. 42, 142-148 (2010)
-
(2010)
Nat. Genet
, vol.42
, pp. 142-148
-
-
Saxena, R.1
-
31
-
-
80053405321
-
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
-
Strawbridge R. J., et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 60, 2624-2634 (2011)
-
(2011)
Diabetes
, vol.60
, pp. 2624-2634
-
-
Strawbridge, R.J.1
-
32
-
-
84655162045
-
Meta-Analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians
-
Cho Y. S., et al. Meta-Analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians. Nat. Genet. 44, 67-72 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 67-72
-
-
Cho, Y.S.1
-
33
-
-
80053385333
-
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
-
Kooner J. S., et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat. Genet. 43, 984-989 (2011)
-
(2011)
Nat. Genet
, vol.43
, pp. 984-989
-
-
Kooner, J.S.1
-
34
-
-
77957553197
-
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
-
Yamauchi T., et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat. Genet. 42, 864-868 (2010)
-
(2010)
Nat. Genet
, vol.42
, pp. 864-868
-
-
Yamauchi, T.1
-
35
-
-
84865693681
-
The metabochip a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits
-
Voight, B. F., et al. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 8, e1002793 (2012)
-
(2012)
PLoS Genet
, vol.8
, pp. e1002793
-
-
Voight, B.F.1
-
36
-
-
84868337361
-
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
-
Morris A. P., et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981-990 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 981-990
-
-
Morris, A.P.1
-
37
-
-
84865693929
-
Large-scale association analyses identify new loci influencing glycaemic traits and provide insight into the underlying biological pathways
-
Scott R. A., et al. Large-scale association analyses identify new loci influencing glycaemic traits and provide insight into the underlying biological pathways. Nat. Genet. 44, 991-1005 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 991-1005
-
-
Scott, R.A.1
-
38
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio T. A., et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009)
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
-
39
-
-
65949124249
-
Genomewide association studies-illuminating biologic pathways
-
Hirschhorn, J. N. Genomewide association studies-illuminating biologic pathways. N. Engl. J. Med. 360, 1699-1701 (2009)
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1699-1701
-
-
Hirschhorn, J.N.1
-
40
-
-
77249134594
-
Rare variants create synthetic genome-wide associations
-
Dickson, S. P., Wang, K., Krantz, I., Hakonarson, H., & Goldstein, D. B. Rare variants create synthetic genome-wide associations. PLoS Biol. 8, e1000294 (2010)
-
(2010)
PLoS Biol
, vol.8
, pp. e1000294
-
-
Dickson, S.P.1
Wang, K.2
Krantz, I.3
Hakonarson, H.4
Goldstein, D.B.5
-
41
-
-
44349132708
-
Common and rare variants in multifactorial susceptibility to common diseases
-
Bodmer, W., & Bonilla, C. Common and rare variants in multifactorial susceptibility to common diseases. Nat. Genet. 40, 695-701 (2008)
-
(2008)
Nat. Genet
, vol.40
, pp. 695-701
-
-
Bodmer, W.1
Bonilla, C.2
-
42
-
-
0034969437
-
Are rare variants responsible for susceptibility to complex diseases?
-
Pritchard, J. K. Are rare variants responsible for susceptibility to complex diseases?. Am. J. Hum. Genet. 69, 124-137 (2001)
-
(2001)
Am. J. Hum. Genet
, vol.69
, pp. 124-137
-
-
Pritchard, J.K.1
-
43
-
-
79851487366
-
The importance of synthetic associations will only be resolved empirically
-
Goldstein, D. B. The importance of synthetic associations will only be resolved empirically. PLoS Biol. 9, e1001008 (2011)
-
(2011)
PLoS Biol
, vol.9
, pp. e1001008
-
-
Goldstein, D.B.1
-
44
-
-
79851468862
-
Synthetic associations are unlikely to account for many common disease genome-wide association signals
-
Anderson, C. A., Soranzo, N., Zeggini, E., & Barrett, J. C. Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol. 9, e1000580 (2011)
-
(2011)
PLoS Biol
, vol.9
, pp. e1000580
-
-
Anderson, C.A.1
Soranzo, N.2
Zeggini, E.3
Barrett, J.C.4
-
45
-
-
79851487367
-
Synthetic associations created by rare variants do not explain most GWAS results
-
Wray, N. R., Purcell, S. M., & Visscher, P. M. Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol. 9, e1000579 (2011)
-
(2011)
PLoS Biol
, vol.9
, pp. e1000579
-
-
Wray, N.R.1
Purcell, S.M.2
Visscher, P.M.3
-
46
-
-
77957370404
-
Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups
-
Waters K. M., et al. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet. 6, e1001078 (2010)
-
(2010)
PLoS Genet
, vol.6
, pp. e1001078
-
-
Waters, K.M.1
-
47
-
-
84860333083
-
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
-
Stahl E. A., et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat. Genet. 44, 483-489 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 483-489
-
-
Stahl, E.A.1
-
48
-
-
84888389414
-
Evaluating empirical bounds on complex disease genetic architecture
-
Agarwala, V., Flannick, J., Sunyaev, S., Go, T. D. C., & Altshuler, D. Evaluating empirical bounds on complex disease genetic architecture. Nat. Genet. 45, 1418-1427 (2013)
-
(2013)
Nat. Genet
, vol.45
, pp. 1418-1427
-
-
Agarwala, V.1
Flannick, J.2
Sunyaev, S.3
Go, T.D.C.4
Altshuler, D.5
-
49
-
-
84873085571
-
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
-
Huyghe J. R., et al. Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat. Genet. 45, 197-201 (2013)
-
(2013)
Nat. Genet
, vol.45
, pp. 197-201
-
-
Huyghe, J.R.1
-
50
-
-
84876276050
-
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
-
Albrechtsen A., et al. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia 56, 298-310 (2013)
-
(2013)
Diabetologia
, vol.56
, pp. 298-310
-
-
Albrechtsen, A.1
-
51
-
-
84895858002
-
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
-
Steinthorsdottir V., et al. Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nat. Genet. 46, 294-298 (2014)
-
(2014)
Nat. Genet
, vol.46
, pp. 294-298
-
-
Steinthorsdottir, V.1
-
52
-
-
84920882093
-
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population
-
Estrada K., et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA 311, 2305-2314 (2014)
-
(2014)
JAMA
, vol.311
, pp. 2305-2314
-
-
Estrada, K.1
-
53
-
-
84929200986
-
Identification and functional characterization of G6PC2 coding variants influencing glycaemic traits define an effector transcript at the G6PC2 ABCB11 locus
-
Mahajan A., et al. Identification and functional characterization of G6PC2 coding variants influencing glycaemic traits define an effector transcript at the G6PC2 ABCB11 locus. PLoS Genet. 11, e1004876 (2015)
-
(2015)
PLoS Genet
, vol.11
, pp. e1004876
-
-
Mahajan, A.1
-
54
-
-
84923206532
-
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
-
Wessel J., et al. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat. Commun. 6, 5897 (2015)
-
(2015)
Nat. Commun
, vol.6
, pp. 5897
-
-
Wessel, J.1
-
56
-
-
84857654651
-
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
-
Bonnefond, A., et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat. Genet. 44, 297-301 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 297-301
-
-
Bonnefond, A.1
-
57
-
-
84907013152
-
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
-
Majithia A. R., et al. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc. Natl Acad. Sci. USA 111, 13127-13132 (2014)
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 13127-13132
-
-
Majithia, A.R.1
-
58
-
-
84897407583
-
Loss of function mutations in SLC30A8 protect against type 2 diabetes
-
Flannick J., et al. Loss of function mutations in SLC30A8 protect against type 2 diabetes. Nat. Genet. 46, 357-363 (2014)
-
(2014)
Nat. Genet
, vol.46
, pp. 357-363
-
-
Flannick, J.1
-
59
-
-
77953399221
-
Think zinc: New roles for zinc in the control of insulin secretion
-
Rutter, G. A. Think zinc: new roles for zinc in the control of insulin secretion. Islets 2, 49-50 (2010)
-
(2010)
Islets
, vol.2
, pp. 49-50
-
-
Rutter, G.A.1
-
60
-
-
70349113136
-
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-Associated variants
-
Nicolson T. J., et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-Associated variants. Diabetes 58, 2070-2083 (2009)
-
(2009)
Diabetes
, vol.58
, pp. 2070-2083
-
-
Nicolson, T.J.1
-
61
-
-
84890260477
-
Whole-exome sequencing of 2 000 Danish individuals and the role of rare coding variants in type 2 diabetes
-
Lohmueller, K. E., et al. Whole-exome sequencing of 2, 000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am. J. Hum. Genet. 93, 1072-1086 (2013)
-
(2013)
Am. J. Hum. Genet
, vol.93
, pp. 1072-1086
-
-
Lohmueller, K.E.1
-
62
-
-
84978128486
-
The genetic architecture of type 2 diabetes
-
Fuchsberger C., et al. The genetic architecture of type 2 diabetes. Nature http://dx.doi.org/10.1038/nature18642 (2016)
-
(2016)
Nature
-
-
Fuchsberger, C.1
-
63
-
-
85000613803
-
The power of gene-based rare variant methods to detect disease-Associated variation and test hypotheses about complex disease
-
Moutsianas, L., et al. The power of gene-based rare variant methods to detect disease-Associated variation and test hypotheses about complex disease. PLoS Genet. 11, e1005165 (2015)
-
(2015)
PLoS Genet
, vol.11
, pp. e1005165
-
-
Moutsianas, L.1
-
64
-
-
84893378179
-
Searching for missing heritability: Designing rare variant association studies
-
Zuk O., et al. Searching for missing heritability: designing rare variant association studies. Proc. Natl Acad. Sci. USA 111, E455-E464 (2014)
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E455-E464
-
-
Zuk, O.1
-
65
-
-
84895868553
-
Genome-wide trans-Ancestry meta-Analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
-
Mahajan A., et al. Genome-wide trans-Ancestry meta-Analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet. 46, 234-244 (2014)
-
(2014)
Nat. Genet
, vol.46
, pp. 234-244
-
-
Mahajan, A.1
-
67
-
-
84893716900
-
-
Sigma Type 2 Diabetes Consortium. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
-
Sigma Type 2 Diabetes Consortium. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature 506, 97-101 (2014)
-
(2014)
Nature
, vol.506
, pp. 97-101
-
-
-
68
-
-
84946031456
-
Meta-Analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
-
Ng M. C. Y., et al. Meta-Analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 10, e1004517 (2014)
-
(2014)
PLoS Genet
, vol.10
, pp. e1004517
-
-
Ng, M.C.Y.1
-
69
-
-
84906226932
-
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
-
Moltke I., et al. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature 512, 190-193 (2014)
-
(2014)
Nature
, vol.512
, pp. 190-193
-
-
Moltke, I.1
-
71
-
-
84923946495
-
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
-
Bulik-Sullivan, B. K., et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015)
-
(2015)
Nat. Genet
, vol.47
, pp. 291-295
-
-
Bulik-Sullivan, B.K.1
-
72
-
-
84940728032
-
Genome-wide association and trans-ethnic meta-Analysis for advanced diabetic kidney disease: Family investigation of nephropathy and diabetes (find
-
Iyengar S. K., et al. Genome-wide association and trans-ethnic meta-Analysis for advanced diabetic kidney disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet. 11, e1005352 (2015)
-
(2015)
PLoS Genet
, vol.11
, pp. e1005352
-
-
Iyengar, S.K.1
-
73
-
-
84901378366
-
A central role for GRB10 in regulation of islet function in man
-
Prokopenko I., et al. A central role for GRB10 in regulation of islet function in man. PLoS Genet. 10, e1004235 (2014)
-
(2014)
PLoS Genet
, vol.10
, pp. e1004235
-
-
Prokopenko, I.1
-
74
-
-
84938765668
-
Discovery and fine-mapping of glycaemic and obesity-related trait loci using hhigh-density imputation
-
Horikoshi M., et al. Discovery and fine-mapping of glycaemic and obesity-related trait loci using hhigh-density imputation. PLoS Genet. 11, e1005230 (2015)
-
(2015)
PLoS Genet
, vol.11
, pp. e1005230
-
-
Horikoshi, M.1
-
75
-
-
84991502822
-
A reference panel of 64 976 haplotypes for genotype imputation
-
McCarthy, S., et al. A reference panel of 64 976 haplotypes for genotype imputation. bioRxiv http://dx.doi.org/10.1101/035170 2015)
-
(2015)
BioRxiv
-
-
McCarthy, S.1
-
76
-
-
84901298851
-
Impact of type 2 diabetes susceptibility variants on quantitative glycaemic traits reveals mechanistic heterogeneity
-
Dimas A. S., et al. Impact of type 2 diabetes susceptibility variants on quantitative glycaemic traits reveals mechanistic heterogeneity. Diabetes 63, 2158-2171 (2014)
-
(2014)
Diabetes
, vol.63
, pp. 2158-2171
-
-
Dimas, A.S.1
-
77
-
-
77951858557
-
Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans
-
Ingelsson E., et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes 59, 1266-1275 (2010)
-
(2010)
Diabetes
, vol.59
, pp. 1266-1275
-
-
Ingelsson, E.1
-
78
-
-
84911949202
-
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes independent of obesity
-
Scott, R. A., et al. Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes 63, 4378-4387 (2014)
-
(2014)
Diabetes
, vol.63
, pp. 4378-4387
-
-
Scott, R.A.1
-
79
-
-
84863207933
-
Reduced insulin exocytosis in human pancreatic β cells with gene variants linked to type 2
-
Rosengren A. H., et al. Reduced insulin exocytosis in human pancreatic β cells with gene variants linked to type 2. Diabetes 61, 1726-1733 (2012)
-
(2012)
Diabetes
, vol.61
, pp. 1726-1733
-
-
Rosengren, A.H.1
-
80
-
-
40849083720
-
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
-
Lawlor, D. A., Harbord, R. M., Sterne, J. A., Timpson, N., & Davey Smith, G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat. Med. 27, 1133-1163 (2008)
-
(2008)
Stat. Med
, vol.27
, pp. 1133-1163
-
-
Lawlor, D.A.1
Harbord, R.M.2
Sterne, J.A.3
Timpson, N.4
Davey Smith, G.5
-
81
-
-
84879326263
-
The role of adiposity in cardiometabolic traits: A Mendelian randomization analysis
-
Fall T., et al. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med. 10, e1001474 (2013)
-
(2013)
PLoS Med
, vol.10
, pp. e1001474
-
-
Fall, T.1
-
82
-
-
84962023207
-
Bilirubin as a potential causal factor in type 2 diabetes risk: A Mendelian randomization study
-
Abbasi A., et al. Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study. Diabetes 64, 1459-1469 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 1459-1469
-
-
Abbasi, A.1
-
83
-
-
79952400252
-
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes glucose levels, or insulin resistance
-
De Silva, N. M., et al. Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. Diabetes 60, 1008-1018 (2011)
-
(2011)
Diabetes
, vol.60
, pp. 1008-1018
-
-
De Silva, N.M.1
-
84
-
-
84947210627
-
Cholesterol and risk of type 2 diabetes: A Mendelian randomization study
-
Haase, C. L., Tybjrg-Hansen, A., Nordestgaard, B. G., & Frikke-Schmidt, R. H.D. L. Cholesterol and risk of type 2 diabetes: a Mendelian randomization study. Diabetes 64, 3328-3333 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 3328-3333
-
-
Haase, C.L.1
Tybjrg-Hansen, A.2
Nordestgaard, B.G.3
Frikke-Schmidt, R.H.D.L.4
-
85
-
-
84891540644
-
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes
-
Yaghootkar H., et al. Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 62, 3589-3598 (2013)
-
(2013)
Diabetes
, vol.62
, pp. 3589-3598
-
-
Yaghootkar, H.1
-
86
-
-
84943357645
-
A mendelian randomization study of circulating uric acid and type 2 diabetes
-
Sluijs I., et al. A mendelian randomization study of circulating uric acid and type 2 diabetes. Diabetes 64, 3028-3036 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 3028-3036
-
-
Sluijs, I.1
-
87
-
-
84866122452
-
PTEN mutations as a cause of constitutive insulin sensitivity and obesity
-
Pal A., et al. PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N. Engl. J. Med. 367, 1002-1011 (2012)
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 1002-1011
-
-
Pal, A.1
-
88
-
-
84919958902
-
PTEN deletion in pancreatic a cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance
-
Wang L., et al. PTEN deletion in pancreatic a cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance. Diabetes 64, 147-157 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 147-157
-
-
Wang, L.1
-
89
-
-
84863670156
-
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases
-
Perry J. R. B., et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genetics 8, e1002741 (2012)
-
(2012)
PLoS Genetics
, vol.8
, pp. e1002741
-
-
Perry, J.R.B.1
-
90
-
-
84861614905
-
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycaemic traits and insulin resistance
-
Manning A. K., et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycaemic traits and insulin resistance. Nat. Genet. 44, 659-669 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 659-669
-
-
Manning, A.K.1
-
91
-
-
84946040296
-
Identification of type 2 diabetes subgroups through topological analysis of patient similarity
-
Li L., et al. Identification of type 2 diabetes subgroups through topological analysis of patient similarity. Sci. Transl. Med. 7, 311ra174 (2015)
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 311ra174
-
-
Li, L.1
-
92
-
-
84883464230
-
Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications
-
Bonnefond A., et al. Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nat. Genet. 45, 1040-1043 (2013)
-
(2013)
Nat. Genet
, vol.45
, pp. 1040-1043
-
-
Bonnefond, A.1
-
93
-
-
84867074831
-
A metagenome-wide association study of gut microbiota in type 2 diabetes
-
Qin J., et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55-60 (2012)
-
(2012)
Nature
, vol.490
, pp. 55-60
-
-
Qin, J.1
-
94
-
-
84906708242
-
Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes
-
Walford G. A., et al. Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes. Diabetes Care 37, 2508-2514 (2014)
-
(2014)
Diabetes Care
, vol.37
, pp. 2508-2514
-
-
Walford, G.A.1
-
95
-
-
84864386138
-
Circulating metabolite predictors of glycemia in middle-Aged men and women
-
Wurtz P., et al. Circulating metabolite predictors of glycemia in middle-Aged men and women. Diabetes Care 35, 1749-1756 (2012)
-
(2012)
Diabetes Care
, vol.35
, pp. 1749-1756
-
-
Wurtz, P.1
-
96
-
-
84934435676
-
Epigenome-wide association of DNA methylation markers in peripheral blood from indian asians and europeans with incident type 2 diabetes: A nested case-control study
-
Chambers J. C., et al. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. Lancet Diabetes Endocrinol. 3, 526-534 (2015)
-
(2015)
Lancet Diabetes Endocrinol
, vol.3
, pp. 526-534
-
-
Chambers, J.C.1
-
97
-
-
84981551346
-
Sixty-five common genetic variants and prediction of type 2 diabetes
-
Talmud P. J., et al. Sixty-five common genetic variants and prediction of type 2 diabetes. Diabetes 64, 1830-1840 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 1830-1840
-
-
Talmud, P.J.1
-
98
-
-
84901380958
-
Polygenic type 2 diabetes prediction at the limit of common variant detection
-
Vassy J. L., et al. Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes 63, 2172-2182 (2014)
-
(2014)
Diabetes
, vol.63
, pp. 2172-2182
-
-
Vassy, J.L.1
-
99
-
-
84887110294
-
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
-
Flannick J., et al. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat. Genet. 45, 1380-1385 (2013)
-
(2013)
Nat. Genet
, vol.45
, pp. 1380-1385
-
-
Flannick, J.1
-
100
-
-
84982296068
-
Type 1 diabetes genetic risk score-A novel tool to differentiate monogenic diabetes from t1d (abstract 1746 p
-
Patel, K., Weedon, M. N., Ellard, S., Oram, R. A., & Hattersley, A. T. Type 1 diabetes genetic risk score-A novel tool to differentiate monogenic diabetes from T1D. (Abstract 1746 P) Diabetes 64 (Suppl. 1), A453 (2015)
-
(2015)
Diabetes
, vol.64
, Issue.SUPPL 1
, pp. A453
-
-
Patel, K.1
Weedon, M.N.2
Ellard, S.3
Oram, R.A.4
Hattersley, A.T.5
-
101
-
-
84962090577
-
A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults
-
Oram R. A., et al. A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults. Diabetes Care 39, 337-344 (2016)
-
(2016)
Diabetes Care
, vol.39
, pp. 337-344
-
-
Oram, R.A.1
-
102
-
-
84948984088
-
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
-
Gaulton K. J., et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat. Genet. 47, 1415-1425 (2015)
-
(2015)
Nat. Genet
, vol.47
, pp. 1415-1425
-
-
Gaulton, K.J.1
-
103
-
-
79960930495
-
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction
-
Shea J., et al. Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. Nat. Genet. 43, 801-805 (2011)
-
(2011)
Nat. Genet
, vol.43
, pp. 801-805
-
-
Shea, J.1
-
104
-
-
84964697760
-
Association analysis of 29 956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion
-
Yaghootkar, H., et al. Association analysis of 29, 956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. Diabetes 64, 2279-2285 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 2279-2285
-
-
Yaghootkar, H.1
-
105
-
-
84870502629
-
Bayesian refinement of association signals for 14 loci in 3 common diseases
-
Maller J. B., et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet. 44, 1294-1301 (2012)
-
(2012)
Nat. Genet
, vol.44
, pp. 1294-1301
-
-
Maller, J.B.1
-
106
-
-
84881315517
-
Validating therapeutic targets through human genetics
-
Plenge, R. M., Scolnick, E. M., & Altshuler, D. Validating therapeutic targets through human genetics. Nat. Rev. Drug Discov. 12, 581-594 (2013)
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 581-594
-
-
Plenge, R.M.1
Scolnick, E.M.2
Altshuler, D.3
-
107
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium
-
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489 57-74 (2012)
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
108
-
-
84923362619
-
Integrative analysis of 111 reference human epigenomes
-
Roadmap Epigenomics Consortium et a.l.
-
Roadmap Epigenomics Consortium, et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317-330 (2015)
-
(2015)
Nature
, vol.518
, pp. 317-330
-
-
-
109
-
-
84929001104
-
Human genomics the genotype-Tissue expression (gtex) pilot analysis: Multitissue gene regulation in humans
-
GTEx Consortium
-
GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348 648-660 (2015)
-
(2015)
Science
, vol.348
, pp. 648-660
-
-
-
110
-
-
84865822182
-
Systematic localization of common disease-Associated variation in regulatory DNA
-
Maurano M. T., et al. Systematic localization of common disease-Associated variation in regulatory DNA. Science 337, 1190-1195 (2012)
-
(2012)
Science
, vol.337
, pp. 1190-1195
-
-
Maurano, M.T.1
-
111
-
-
84873086126
-
Chromatin marks identify critical cell types for fine mapping complex trait variants
-
Trynka G., et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat. Genet. 45, 124-130 (2012)
-
(2012)
Nat. Genet
, vol.45
, pp. 124-130
-
-
Trynka, G.1
-
112
-
-
84887072795
-
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
-
Parker S. C. J., et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc. Natl Acad. Sci. USA 110, 17921-17926 (2013)
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 17921-17926
-
-
Parker, S.C.J.1
-
113
-
-
84895806401
-
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-Associated variants
-
Pasquali L., et al. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-Associated variants. Nat. Genet. 46, 136-143 (2014)
-
(2014)
Nat. Genet
, vol.46
, pp. 136-143
-
-
Pasquali, L.1
-
114
-
-
84934325147
-
Genetic variation determines PPAR? Function and anti-diabetic drug response in vivo
-
Soccio Raymond, E., et al. Genetic variation determines PPAR? function and anti-diabetic drug response in vivo. Cell 162, 33-44 (2015)
-
(2015)
Cell
, vol.162
, pp. 33-44
-
-
Soccio Raymond, E.1
-
115
-
-
77649086970
-
A map of open chromatin in human pancreatic islets
-
Gaulton K. J., et al. A map of open chromatin in human pancreatic islets. Nat. Genet. 42, 255-259 (2010)
-
(2010)
Nat. Genet
, vol.42
, pp. 255-259
-
-
Gaulton, K.J.1
-
116
-
-
78049446282
-
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
-
Stitzel M. L., et al. Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab. 12, 443-455 (2010)
-
(2010)
Cell Metab
, vol.12
, pp. 443-455
-
-
Stitzel, M.L.1
-
117
-
-
84867070330
-
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific dynamically regulated, and abnormally expressed in type 2 diabetes
-
Morán, I., et al. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 16, 435-448 (2012)
-
(2012)
Cell Metab
, vol.16
, pp. 435-448
-
-
Morán, I.1
-
118
-
-
84872833195
-
The miRNA profile of human pancreatic islets and Beta-Cells and relationship to type 2 diabetes pathogenesis
-
van de Bunt M., et al. The miRNA profile of human pancreatic islets and Beta-Cells and relationship to type 2 diabetes pathogenesis. PLoS ONE 8, e55272 (2013)
-
(2013)
PLoS ONE
, vol.8
, pp. e55272
-
-
Van De Bunt, M.1
-
119
-
-
84907222786
-
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
-
Fadista J., et al. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc. Natl Acad. Sci. USA 111, 13924-13929 (2014)
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 13924-13929
-
-
Fadista, J.1
-
120
-
-
84953234597
-
Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycaemic traits to their downstream effectors
-
van de Bunt M., et al. Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycaemic traits to their downstream effectors. PLoS Genet. 11, e1005694 (2015)
-
(2015)
PLoS Genet
, vol.11
, pp. e1005694
-
-
Van De Bunt, M.1
-
121
-
-
84883706987
-
Cell-Type allelic, and genetic signatures in the human pancreatic beta cell transcriptome
-
Nica, A. C., et al. Cell-Type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome. Genome Res. 23, 1554-1562 (2013)
-
(2013)
Genome Res
, vol.23
, pp. 1554-1562
-
-
Nica, A.C.1
-
122
-
-
84897452599
-
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion
-
Dayeh T., et al. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet. 10, e1004160 (2014)
-
(2014)
PLoS Genet
, vol.10
, pp. e1004160
-
-
Dayeh, T.1
-
123
-
-
84858800629
-
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
-
Volkmar M., et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J. 31, 1405-1426 (2012)
-
(2012)
EMBO J.
, vol.31
, pp. 1405-1426
-
-
Volkmar, M.1
-
124
-
-
84906707442
-
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
-
Nilsson E., et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes 63, 2962-2976 (2014)
-
(2014)
Diabetes
, vol.63
, pp. 2962-2976
-
-
Nilsson, E.1
-
125
-
-
84923339459
-
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
-
Yuan W., et al. An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat. Commun. 5, 5719 (2014)
-
(2014)
Nat. Commun
, vol.5
, pp. 5719
-
-
Yuan, W.1
-
126
-
-
84906672321
-
ADCY5 couples glucose to insulin secretion in human islets
-
Hodson D. J., et al. ADCY5 couples glucose to insulin secretion in human islets. Diabetes 63, 3009-3021 (2014)
-
(2014)
Diabetes
, vol.63
, pp. 3009-3021
-
-
Hodson, D.J.1
-
127
-
-
84940830979
-
FTO obesity variant circuitry and adipocyte browning in humans
-
Claussnitzer M., et al. FTO obesity variant circuitry and adipocyte browning in humans. N. Engl. J. Med. 373, 895-907 (2015)
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 895-907
-
-
Claussnitzer, M.1
-
128
-
-
84961999748
-
Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies
-
Locke, J. M., Hysenaj, G., Wood, A. R., Weedon, M. N., & Harries, L. W. Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes 64, 1484-1491 (2015)
-
(2015)
Diabetes
, vol.64
, pp. 1484-1491
-
-
Locke, J.M.1
Hysenaj, G.2
Wood, A.R.3
Weedon, M.N.4
Harries, L.W.5
-
129
-
-
84893763903
-
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell
-
Kulzer Jennifer, R., et al. A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. Am. J. Hum. Genet. 94, 186-197 (2014)
-
(2014)
Am. J. Hum. Genet
, vol.94
, pp. 186-197
-
-
Kulzer Jennifer, R.1
-
130
-
-
76249098866
-
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX SOX4, and IRX3
-
Ragvin, A., et al. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc. Natl Acad. Sci. USA 107, 775-780 (2010)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 775-780
-
-
Ragvin, A.1
-
131
-
-
84897855294
-
Obesity-Associated variants within FTO form long-range functional connections with IRX3
-
Smemo S., et al. Obesity-Associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-375 (2014)
-
(2014)
Nature
, vol.507
, pp. 371-375
-
-
Smemo, S.1
-
132
-
-
84866107469
-
Genetic risk factors for type 2 diabetes: A trans-regulatory genetic architecture?
-
Elbein Steven, C., et al. Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?. Am. J. Hum. Genet. 91, 466-477 (2012)
-
(2012)
Am. J. Hum. Genet
, vol.91
, pp. 466-477
-
-
Elbein Steven, C.1
-
133
-
-
79957607662
-
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
-
Small K. S., et al. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat. Genet. 43, 561-564 (2011)
-
(2011)
Nat. Genet
, vol.43
, pp. 561-564
-
-
Small, K.S.1
-
134
-
-
33746075560
-
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
-
Florez J. C., et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N. Engl. J. Med. 355, 241-250 (2006)
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 241-250
-
-
Florez, J.C.1
-
135
-
-
84876542426
-
Allele-specific transcriptional activity at type 2 diabetes-Associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus
-
Fogarty, M. P., Panhuis, T. M., Vadlamudi, S., Buchkovich, M. L., & Mohlke, K. L. Allele-specific transcriptional activity at type 2 diabetes-Associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus. Diabetes 62, 1756-1762 (2013)
-
(2013)
Diabetes
, vol.62
, pp. 1756-1762
-
-
Fogarty, M.P.1
Panhuis, T.M.2
Vadlamudi, S.3
Buchkovich, M.L.4
Mohlke, K.L.5
-
136
-
-
84907584433
-
Identification of a regulatory variant that binds, foxa1 and foxa2 at the cdc123/camk1d type 2 diabetes, gwas locus
-
Fogarty, M. P., Cannon, M. E., Vadlamudi, S., Gaulton, K. J., & Mohlke, K. L. Identification of a regulatory variant that binds, FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes, GWAS locus. PLoS Genet. 10, e1004633 (2014)
-
(2014)
PLoS Genet
, vol.10
, pp. e1004633
-
-
Fogarty, M.P.1
Cannon, M.E.2
Vadlamudi, S.3
Gaulton, K.J.4
Mohlke, K.L.5
-
137
-
-
84874427659
-
Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets
-
Travers M. E., et al. Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets. Diabetes 62, 987-992 (2013)
-
(2013)
Diabetes
, vol.62
, pp. 987-992
-
-
Travers, M.E.1
-
138
-
-
84892689100
-
Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms
-
Claussnitzer M., et al. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell 156, 343-358 (2014)
-
(2014)
Cell
, vol.156
, pp. 343-358
-
-
Claussnitzer, M.1
-
139
-
-
80052375980
-
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice
-
Wei F. Y., et al. Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice. J. Clin. Invest. 121, 3598-3608 (2011)
-
(2011)
J. Clin. Invest
, vol.121
, pp. 3598-3608
-
-
Wei, F.Y.1
-
140
-
-
82255191640
-
GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus
-
McCulloch L. J., et al. GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol. Genet. Metab. 104, 648-653 (2011)
-
(2011)
Mol. Genet. Metab
, vol.104
, pp. 648-653
-
-
McCulloch, L.J.1
-
141
-
-
70349980881
-
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
-
Beer N. L., et al. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum. Mol. Genet. 18, 4081-4088 (2009)
-
(2009)
Hum. Mol. Genet
, vol.18
, pp. 4081-4088
-
-
Beer, N.L.1
-
142
-
-
76749108047
-
Rfx6 directs islet formation and insulin production in mice and humans
-
Smith S. B., et al. Rfx6 directs islet formation and insulin production in mice and humans. Nature 463, 775-780 (2010)
-
(2010)
Nature
, vol.463
, pp. 775-780
-
-
Smith, S.B.1
-
143
-
-
80053481600
-
The Lin28/let 7 axis regulates glucose metabolism
-
Zhu H., et al. The Lin28/let 7 axis regulates glucose metabolism. Cell 147, 81-94 (2011)
-
(2011)
Cell
, vol.147
, pp. 81-94
-
-
Zhu, H.1
-
144
-
-
84928393220
-
Igf2bp2/imp2 deficient mice resist obesity through enhanced translation of ucp1 mRNA and other mRNAs encoding mitochondrial proteins
-
Dai N., et al. IGF2BP2/IMP2 Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding mitochondrial proteins. Cell Metab. 21, 609-621 (2015)
-
(2015)
Cell Metab
, vol.21
, pp. 609-621
-
-
Dai, N.1
-
145
-
-
84872014037
-
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems
-
Mercader J. M., et al. Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems. PLoS Genet. 8, e1003046 (2012)
-
(2012)
PLoS Genet
, vol.8
, pp. e1003046
-
-
Mercader, J.M.1
-
146
-
-
84878699515
-
Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes
-
Taneera J., et al. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. Mol. Cell. Endocrinol. 375, 35-42 (2013)
-
(2013)
Mol. Cell. Endocrinol
, vol.375
, pp. 35-42
-
-
Taneera, J.1
-
147
-
-
84920615192
-
High-Throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic beta-cell function
-
Burns S. M., et al. High-Throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic beta-cell function. Cell Metab. 21, 126-137 (2015)
-
(2015)
Cell Metab
, vol.21
, pp. 126-137
-
-
Burns, S.M.1
-
148
-
-
84982269181
-
Genetics portal for type 2 diabetes debuts
-
The American Diabetes Association
-
The American Diabetes Association. Genetics portal for type 2 diabetes debuts. Diabetes Dispatch http://www.diabetesdispatchextra.org/genetics-portal-for-Type-2-diabetes-debuts (2015)
-
(2015)
Diabetes Dispatch
-
-
-
149
-
-
84976904305
-
ClinVar: Public archive of interpretations of clinically relevant variants
-
Landrum, M. J., et al. ClinVar: public archive of interpretations of clinically relevant variants. Nucleic Acids Res. 44, D862-D868 (2016)
-
(2016)
Nucleic Acids Res
, vol.44
, pp. D862-D868
-
-
Landrum, M.J.1
-
150
-
-
0037903275
-
Human gene mutation database (hgmd): 2003 update
-
Stenson P. D., et al. Human Gene Mutation Database (HGMD): 2003 update. Hum. Mutat. 21, 577-581 (2003)
-
(2003)
Hum. Mutat
, vol.21
, pp. 577-581
-
-
Stenson, P.D.1
-
151
-
-
84947613905
-
Human genotype-phenotype databases: Aims, challenges and opportunities
-
Brookes, A. J., & Robinson, P. N. Human genotype-phenotype databases: aims, challenges and opportunities. Nat. Rev. Genet. 16, 702-715 (2015)
-
(2015)
Nat. Rev. Genet
, vol.16
, pp. 702-715
-
-
Brookes, A.J.1
Robinson, P.N.2
-
152
-
-
84975795680
-
An integrated map of genetic variation from 1 092 human genomes
-
1000 Genomes Project Consortium
-
Genomes Project Consortium. An integrated map of genetic variation from 1, 092 human genomes. Nature 491, 56-65 (2012)
-
(2012)
Nature
, vol.491
, pp. 56-65
-
-
-
153
-
-
84946100079
-
The ucsc genome browser database: 2015 update
-
Rosenbloom K. R., et al. The UCSC Genome Browser database: 2015 update. Nucleic Acids Res. 43, D670-D681 (2015)
-
(2015)
Nucleic Acids Res
, vol.43
, pp. D670-D681
-
-
Rosenbloom, K.R.1
-
154
-
-
84858779229
-
HaploReg: A resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
-
Ward, L. D., & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930-D934 (2012)
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D930-D934
-
-
Ward, L.D.1
Kellis, M.2
-
157
-
-
84930920556
-
Pharma firms join NIH on drug development
-
Reardon, S. Pharma firms join NIH on drug development. Nature http://dx.doi.org/10.1038/nature.2014.14672 (2014)
-
(2014)
Nature
-
-
Reardon, S.1
-
158
-
-
84941940944
-
Using human genetics to make new medicines
-
Barrett, J. C., Dunham, I., & Birney, E. Using human genetics to make new medicines. Nat. Rev. Genet. 16, 561-562 (2015)
-
(2015)
Nat. Rev. Genet
, vol.16
, pp. 561-562
-
-
Barrett, J.C.1
Dunham, I.2
Birney, E.3
-
159
-
-
84857237851
-
The innovative medicines initiative: A European response to the innovation challenge
-
Goldman, M. The innovative medicines initiative: a European response to the innovation challenge. Clin. Pharmacol. Ther. 91, 418-425 (2012)
-
(2012)
Clin. Pharmacol. Ther
, vol.91
, pp. 418-425
-
-
Goldman, M.1
-
160
-
-
0003927248
-
-
2nd edn (Wiley
-
Kimball, R., Ross, M., Thornthwaite, W., Mundy, J., & Becker, K The Data Warehouse Lifecycle Toolkitc 2nd edn (Wiley 2008)
-
(2008)
The Data Warehouse Lifecycle Toolkit
-
-
Kimball, R.1
Ross, M.2
Thornthwaite, W.3
Mundy, J.4
Becker, K.5
-
161
-
-
41249098723
-
Consent for genetics studies among clinical trial participants: Findings from action for health in diabetes (look ahead)
-
Espeland, M. A., et al. Consent for genetics studies among clinical trial participants: findings from Action for Health in Diabetes (Look AHEAD). Clin. Trials 3, 443-456 (2006)
-
(2006)
Clin. Trials
, vol.3
, pp. 443-456
-
-
Espeland, M.A.1
-
162
-
-
84922273141
-
Partitioning heritability of regulatory and cell-Type-specific variants across 11 common diseases
-
Gusev A., et al. Partitioning heritability of regulatory and cell-Type-specific variants across 11 common diseases. Am. J. Hum. Genet. 95, 535-552 (2014)
-
(2014)
Am. J. Hum. Genet
, vol.95
, pp. 535-552
-
-
Gusev, A.1
-
163
-
-
84891790401
-
The nhgri gwas catalog a curated resource of snp-Trait associations
-
Welter, D., et al. The NHGRI GWAS Catalog, a curated resource of SNP-Trait associations. Nucleic Acids Res. 42, D1001-D1006 (2014)
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D1001-D1006
-
-
Welter, D.1
-
164
-
-
84962476739
-
Loss of function mutations in the cell-cycle control gene CDKN2A impact on glucose homeostasis in humans
-
Pal A., et al. Loss of function mutations in the cell-cycle control gene CDKN2A impact on glucose homeostasis in humans. Diabetes 65, 527-533 (2015)
-
(2015)
Diabetes
, vol.65
, pp. 527-533
-
-
Pal, A.1
-
165
-
-
84897837023
-
KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia
-
Torekov S. S., et al. KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia. Diabetes 63, 1315-1325 (2014).
-
(2014)
Diabetes
, vol.63
, pp. 1315-1325
-
-
Torekov, S.S.1
|