The future of genetic studies of complex human diseases

Science

Volumn 273, Issue 5281, 1996, Pages 1516-1517

  Risch, Neil ^a   Merikangas, Kathleen ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ALZHEIMER DISEASE; BREAST CANCER; CANCER SUSCEPTIBILITY; DISEASE PREDISPOSITION; GENETIC DISORDER; GENETIC LINKAGE; HUNTINGTON CHOREA; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; SCHIZOPHRENIA; SHORT SURVEY;

EID: 0029741063     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.273.5281.1516     Document Type: Short Survey

References (7)

1. N. Risch, Am. J. Hum. Genet. 40, 1 (1987); ibid. 46, 229 (1990).
2. N. Risch, Am. J. Hum. Genet. 40, 1 (1987); ibid. 46, 229 (1990).
3. S = (1 = w)/(2 + w).
4. R. Spielman, R. E. McGinnis, W. J. Ewens, Am. J. Hum. Genet. 52, 506 (1993).
5. 2 = pq(γ + 1)/(pγ + q).
6. E. S. Lander and N. J. Schork, Science 265, 2037 (1994).
7. 2 as for singleton families but now using the heterozygote frequency for parents of affected sib pairs. Using the above formulas, we can calculate sample sizes for the three study designs.