Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

Nature Genetics

Volumn 45, Issue 9, 2013, Pages 1040-1043

  Bonnefond, Amélie ^a,b,c   Skrobek, Boris ^a,b,c   Lobbens, Stéphane ^a,b,c   Eury, Elodie ^a,b,c   Thuillier, Dorothée ^a,b,c   Cauchi, Stéphane ^a,b,c   Lantieri, Olivier ^d   Balkau, Beverley ^e,f   Riboli, Elio ^g   Marre, Michel ^e,h   Charpentier, Guillaume ⁱ   Yengo, Loïc ^a,b,c   Froguel, Philippe ^a,b,c,j,k  

^a CNRS   (France)

^b UNIV LILLE   (France)

^c France   (France)

^d IRSA Institut Inter Régional Pour la Santé   (France)

^e INSERM   (France)

^f UNIVERSITÉ PARIS SACLAY   (France)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

^h BICHAT HOSPITAL   (France)

ⁱ CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^j HAMMERSMITH HOSPITAL   (United Kingdom)

^k HAMAD BIN KHALIFA UNIVERSITY   (Qatar)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; BLOOD ANALYSIS; CHROMOSOME CLONAL MOSAIC EVENT; CHROMOSOME MOSAICISM; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CARRIER; DNA DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; VASCULAR DISEASE;

AGED; BODY MASS INDEX; CASE-CONTROL STUDIES; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; MOSAICISM; ODDS RATIO; PROSPECTIVE STUDIES;

EID: 84883464230     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2700     Document Type: Article

References (25)

1. Forsberg, L.A. et al. Age-related somatic structural changes in the nuclear genome of human blood cells. Am. J. Hum. Genet. 90, 217-228 (2012).
2. Jacobs, K.B. et al. Detectable clonal mosaicism and its relationship to aging and cancer. Nat. Genet. 44, 651-658 (2012).
3. Laurie, C.C. et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat. Genet. 44, 642-650 (2012).
4. Morley, J.E. Diabetes and aging: epidemiologic overview. Clin. Geriatr. Med. 24, 395-405 (2008).
5. Curtis, R., Geesaman, B.J. & DiStefano, P.S. Ageing and metabolism: drug discovery opportunities. Nat. Rev. Drug Discov. 4, 569-580 (2005).
6. Geesaman, B.J. Genetics of aging: implications for drug discovery and development. Am. J. Clin. Nutr. 83, 466S-469S (2006).
7. Campbell, P.T. et al. Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults. Diabetes Care 35, 835-844 (2012).
8. Cohen, D.H. & Leroith, D. Obesity, type 2 diabetes and cancer: the insulin and insulin-like growth factor connection. Endocr. Relat. Cancer 19, F27-F45 (2012).
9. Johnson, J.A. et al. Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence. Diabetologia 55, 1607-1618 (2012).
10. Renehan, A.G. et al. Diabetes and cancer (2): evaluating the impact of diabetes on mortality in patients with cancer. Diabetologia 55, 1619-1632 (2012).
11. Castillo, J.J. et al. Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies. Blood 119, 4845-4850 (2012).
12. Youssoufian, H. & Pyeritz, R.E. Mechanisms and consequences of somatic mosaicism in humans. Nat. Rev. Genet. 3, 748-758 (2002).
13. Dumanski, J.P. & Piotrowski, A. Structural genetic variation in the context of somatic mosaicism. Methods Mol. Biol. 838, 249-272 (2012).
14. Pawlikowska, L. et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8, 460-472 (2009).
15. Voight, B.F. et al. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 8, e1002793 (2012).
16. Martin, L.J. et al. A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. Diabetes 51, 3568-3572 (2002).
17. Sladek, R. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885 (2007).
18. Balkau, B. An epidemiologic survey from a network of French Health Examination Centres, (D.E.S.I.R.): epidemiologic data on the insulin resistance syndrome. Rev. Epidemiol. Sante Publique 44, 373-375 (1996).
19. Meyre, D. et al. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 53, 803-811 (2004).
20. Murphy, N. et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE 7, e39361 (2012).
21. ADA. Diabetes care standards, guidelines, and related documents. Diabetes Care 32 (suppl. 1), S1-S2 (2009).
22. Staaf, J. et al. Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios. BMC Bioinformatics 9, 409 (2008).
23. Diskin, S.J. et al. Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms. Nucleic Acids Res. 36, e126 (2008).
24. Peiffer, D.A. et al. High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping. Genome Res. 16, 1136-1148 (2006).
25. Rodríguez-Santiago, B. et al. Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome. Am. J. Hum. Genet. 87, 129-138 (2010).