Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Nature Genetics

Volumn 46, Issue 3, 2014, Pages 234-244

  Mahajan, Anubha ^a   Go, Min Jin ^b   Zhang, Weihua ^c   Below, Jennifer E ^d   Gaulton, Kyle J ^a   Ferreira, Teresa ^a   Horikoshi, Momoko ^a,e   Johnson, Andrew D ^f   Ng, Maggie C Y ^g   Prokopenko, Inga ^a,e,h   Saleheen, Danish ^i,j   Wang, Xu ^k   Zeggini, Eleftheria ^l   Abecasis, Goncalo R ^m   Adair, Linda S ⁿ   Almgren, Peter ^o   Atalay, Mustafa ^p   Aung, Tin ^k,q   Baldassarre, Damiano ^r,s   Balkau, Beverley ^t,u   Bao, Yuqian ^v   Barnett, Anthony H ^w,x   Barroso, Ines ^i,l,y   Basit, Abdul ^z   Been, Latonya F ^aa   Beilby, John ^ab,ac,ad   Bell, Graeme I ^ae,af   Benediktsson, Rafn ^ag,ah   Bergman, Richard N ^ai   OBoehm, Bernhard ^aj,ak   Boerwinkle, Eric ^al,am   Bonnycastle, Lori L ^an   Burtt, Noël ^ao   Cai, Qiuyin ^ap   Campbell, Harry ^aq   Carey, Jason ^ao   Cauchi, Stephane ^ar   Caulfield, Mark ^as   Chan, Juliana C N ^at   Chang, Li Ching ^au   Chang, Tien Jyun ^av   Chang, Yi Cheng ^av   Charpentier, Guillaume ^aw   Chen, Chien Hsiun ^au,ax   Chen, Han ^ay   Chen, Yuan Tsong ^au   Chia, Kee Seng ^k   Chidambaram, Manickam ^az   Chines, Peter S ^an   Cho, Nam H ^ba   Cho, Young Min ^bb   Chuang, Lee Ming ^av,bc   Collins, Francis S ^an   Cornelis, Marilyn C ^bd   Couper, David J ⁿ   Crenshaw, Andrew T ^ao   Van Dam, Rob M ^k,bd   Danesh, John ⁱ   Das, Debashish ^be   De Faire, Ulf ^bf   Dedoussis, George ^bg   Deloukas, Panos ^l   Dimas, Antigone S ^a,bh,bi,bj   Dina, Christian ^bj,bk   Doney, Alex S F ^bl   Donnelly, Peter J ^a,bm   Dorkhan, Mozhgan ^o   Van Duijn, Cornelia ^bn,bo   Dupuis, Josée ^f,ay   Edkins, Sarah ^l   Elliott, Paul ^c   Emilsson, Valur ^bp   Erbel, Raimund ^bq   Eriksson, Johan G ^br,bt   Escobedo, Jorge ^bu   Esko, Tonu ^bv,by   Eury, Elodie ^ar   Florez, Jose C ^bx,ca   Fontanillas, Pierre ^ao   Forouhi, Nita G ^y   Forsen, Tom ^bs,cb   Fox, Caroline ^f,bz   Fraser, Ross M ^aq   Frayling, Timothy M ^cc   Froguel, Philippe ^h,ar   Frossard, Philippe ^j   Gao, Yutang ^cd   Gertow, Karl ^bf,ce   Gieger, Christian ^cf   Gigante, Bruna ^bf   Grallert, Harald ^cf,ci   Grant, George B ^ao   Groop, Leif C ^o   Groves, Christopher J ^e   Grundberg, Elin ^cg,ch,cj   Guiducci, Candace ^ao   Hamsten, Anders ^bf,ce   Han, Bok Ghee ^b   Hara, Kazuo ^ck   Hassanali, Neelam ^e   Hattersley, Andrew T ^cc   Hayward, Caroline ^aq   Hedman, Asa K ^a   Herder, Christian ^cl   Hofman, Albert ^bn   Holmen, Oddgeir L ^cm   Hovingh, Kees ^cn   Hreidarsson, Astradur B ^ah   Hu, Cheng ^v   Hu, Frank B ^bd,bz   Hui, Jennie ^ab,ad   Humphries, Steve E ^co   Hunt, Sarah E ^l   Hunter, David J ^bd,bz   Hveem, Kristian ^cm   Hydrie, Zafar I ^z   Ikegami, Hiroshi ^cp   Illig, Thomas ^cf,cq   Ingelsson, Erik ^a,cr   Islam, Muhammed ^cs   Isomaa, Bo ^bt,ct   Jackson, Anne U ^m   Jafar, Tazeen ^cs   James, Alan ^ab,cu,cv   Jia, Weiping ^v   Jöckel, Karl Heinz ^bq   Jonsson, Anna ^o   Jowett, Jeremy B M ^cw   Kadowaki, Takashi ^ck   Kang, Hyun Min ^m   Kanoni, Stavroula ^l   Kao, Wen Hong L ^cx   Kathiresan, Sekar ^ao,ca   Kato, Norihiro ^cy   Katulanda, Prasad ^e,cz   Keinanen Kiukaanniemi, Sirkka M ^da,db   Kelly, Ann M ^w,x   Khan, Hassan ⁱ   Khaw, Kay Tee ⁱ   Khor, Chiea Chuen ^k,q,dc   Kim, Hyung Lae ^dd   Kim, Sangsoo ^de   Kim, Young Jin ^b   Kinnunen, Leena ^br   Klopp, Norman ^cf,cq   Kong, Augustine ^df   Korpi Hyövälti, Eeva ^dg   Kowlessur, Sudhir ^dh   Kraft, Peter ^bd   Kravic, Jasmina ^o   Kristensen, Malene M ^cw   Krithika, S ^di   Kumar, Ashish ^a   Kumate, Jesus ^bu   Kuusisto, Johanna ^p   Kwak, Soo Heon ^bb   Laakso, Markku ^p   Lagou, Vasiliki ^a   Lakka, Timo A ^p   Langenberg, Claudia ^y   Langford, Cordelia ^l   Lawrence, Robert ^ad   Leander, Karin ^bf   Lee, Jen Mai ^k   Lee, Nanette R ^dj   Li, Man ^cx   Li, Xinzhong ^dk   Li, Yun ^n,dl   Liang, Junbin ^dm   Liju, Samuel ^az   Lim, Wei Yen ^k   Lind, Lars ^cr   Lindgren, Cecilia M ^a,ao   Lindholm, Eero ^o   Liu, Ching Ti ^ay   Liu, Jian Jun ^dc   Lobbens, Stéphane ^ar   Long, Jirong ^ap   Loos, Ruth J F ^y,dn   Lu, Wei ^do   Luan, Jianan ^y   Lyssenko, Valeriya ^o   WMa, Ronald C ^at   Maeda, Shiro ^bc   Mägi, Reedik ^bv   Männistö, Satu ^br   Matthews, David R ^e   Meigs, James B ^bz,ca,dn   Melander, Olle ^o   Metspalu, Andres ^bv,bw   Meyer, Julia ^cf   Mirza, Ghazala ^a   Mihailov, Evelin ^bv   Moebus, Susanne ^bq   Mohan, Viswanathan ^az,ct,ek   Mohlke, Karen L ^dl   Morris, Andrew D ^bl   WMühleisen, Thomas ^dp   Müller Nurasyid, Martina ^cf,cg,dq,eo   Musk, Bill ^ab,ad,cv   Nakamura, Jiro ^dr   Nakashima, Eitaro ^dr,ds   Navarro, Pau ^aq   Ng, Peng Keat ^k   Nica, Alexandra C ^bh   Nilsson, Peter M ^o   Njølstad, Inger ^dt   Nöthen, Markus M ^dp   Ohnaka, Keizo ^du   Ong, Twee Hee ^k   Owen, Katharine R ^e,dv   Palmer, Colin N A ^bl   Pankow, James S ^dw   Park, Kyong Soo ^bb   Parkin, Melissa ^ao   Pechlivanis, Sonali ^bq   Pedersen, Nancy L ^bf   Peltonen, Leena ^{l,ao,br,bs,ep}   Perry, John R B ^a,cc   Peters, Annette ^cf   Pinidiyapathirage, Janani M ^dx   Platou, Carl G P ^cm,dy   Potter, Simon ^l   Price, Jackie F ^aq   Qi, Lu ^bd,bz   Radha, Venkatesan ^az   Rallidis, Loukianos ^dz   Rasheed, Asif ^j   Rathmann, Wolfgang ^cl   Rauramaa, Rainer ^p,ea   Raychaudhuri, Soumya ^ao,bs,bz,eb   Rayner, N William ^a,e   Rees, Simon D ^w,x   Rehnberg, Emil ^bf   Ripatti, Samuli ^l,br,bs   Robertson, Neil ^a,e   Roden, Michael ^cl   Rossin, Elizabeth J ^ao,bx,ec   Rudan, Igor ^aq   Rybin, Denis ^ed   Saaristo, Timo E ^ee,ef,eq   Salomaa, Veikko ^br   Saltevo, Juha ^eg   Samuel, Maria ^j   KSanghera, Dharambir ^aa   Saramies, Jouko ^eh   Scott, James ^dk   Scott, Laura J ^m   Scott, Robert A ^y   Segrè, Ayellet V ^ao,bz,ca   Sehmi, Joban ^be,dk   Sennblad, Bengt ^bf,ce   Shah, Nabi ^j   Shah, Sonia ^co   Shera, A Samad ^ei   Shu, Xiao Ou ^ap   Shuldiner, Alan R ^ej   Sigurosson, Gunnar ^ah,bp   Sijbrands, Eric ^bn   Silveira, Angela ^bf,ce   Sim, Xueling ^k,m   Sivapalaratnam, Suthesh ^cn   Small, Kerrin S ^l,cj   So, Wing Yee ^at   Stančáková, Alena ^p   Stefansson, Kari ^ag,df   Steinbach, Gerald ^el   Steinthorsdottir, Valgerdur ^df   Stirrups, Kathleen ^l   Strawbridge, Rona J ^bf,ce   Stringham, Heather M ^m   Sun, Qi ^bd,bz   Suo, Chen ^k   Syvänen, Ann Christine ^em   Takayanagi, Ryoichi ^du   Takeuchi, Fumihiko ^cy   Tay, Wan Ting ^q   Teslovich, Tanya M ^m   Thorand, Barbara ^cf   Thorleifsson, Gudmar ^df   Thorsteinsdottir, Unnur ^ag,df   Tikkanen, Emmi ^br,bs   Trakalo, Joseph ^a   Tremoli, Elena ^r,s   Trip, Mieke D ^cn   Tsai, Fuu Jen ^ax   Tuomi, Tiinamaija ^bt,en   Tuomilehto, Jaakko ^br,eo,eq   Uitterlinden, Andre G ^bn,bo   Valladares Salgado, Adan ^er   Vedantam, Sailaja ^bx,by   Veglia, Fabrizio ^r   Voight, Benjamin F ^ao,es   Wang, Congrong ^v   Wareham, Nicholas J ^y   Wennauer, Roman ^bn   Wickremasinghe, Ananda R ^dx   Wilsgaard, Tom ^dt   Wilson, James F ^aq   Wiltshire, Steven ^a   Winckler, Wendy ^ao   Wong, Tien Yin ^k,q,et   Wood, Andrew R ^cc   Wu, Jer Yuarn ^au,ax   Wu, Ying ^dl   Yamamoto, Ken ^eu   Yamauchi, Toshimasa ^ck   Yang, Mingyu ^dm   Yengo, Loic ^ar,ev   Yokota, Mitsuhiro ^ew   Young, Robin ⁱ   Zabaneh, Delilah ^co   Zhang, Fan ^dm   Zhang, Rong ^v   Zheng, Wei ^ap   Zimmet, Paul Z ^cw   Altshuler, David ^ao,bz,ca   Bowden, Donald W ^g,bz   Cho, Yoon Shin ^ex   Cox, Nancy J ^ae,af   Cruz, Miguel ^er   Hanis, Craig L ^al   Kooner, Jaspal ^be,dk,ey   Lee, Jong Young ^b   Seielstad, Mark ^dc,ez,fa   Teo, Yik Ying ^k,dc   Boehnke, Michael ^m   Parra, Esteban J ^di   Chambers, John C ^c,be,ey   Tai, E Shyong ^k,fb   McCarthy, Mark I ^a,e,dv   Morris, Andrew P ^a,fc   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Korea National Institute of Health   (South Korea)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f FRAMINGHAM HEART STUDY   (United States)

^g WAKE FOREST SCHOOL OF MEDICINE   (United States)

^h HAMMERSMITH HOSPITAL   (United Kingdom)

ⁱ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^j Center for Non Communicable Diseases Pakistan   (Pakistan)

^k NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^l WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^m UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

ⁿ IL   (United States)

^o LUND UNIVERSITY HOSPITAL   (Sweden)

^p UNIVERSITY OF EASTERN FINLAND   (Finland)

^q SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^r CENTRO CARDIOLOGICO MONZINO   (Italy)

^s UNIVERSITY OF MILAN   (Italy)

^t INSERM   (France)

^u UNIVERSITÉ PARIS SACLAY   (France)

^v SHANGHAI JIAO TONG UNIVERSITY   (China)

^w UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^x UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^y ADDENBROOKE S HOSPITAL   (United Kingdom)

^z BAQAI MEDICAL UNIVERSITY   (Pakistan)

^aa UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^ab SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^ac PATHWEST LABORATORY MEDICINE   (Australia)

^ad UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ae UNIVERSITY OF CHICAGO   (United States)

^af UNIVERSITY OF CHICAGO   (United States)

^ag UNIVERSITY OF ICELAND   (Iceland)

^ah LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^ai CEDARS SINAI MEDICAL CENTER   (United States)

^aj UNIVERSITY HOSPITAL ULM   (Germany)

^ak NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^al UNIVERSITY OF TEXAS   (United States)

^am BAYLOR COLLEGE OF MEDICINE   (United States)

^an NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^ao MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^ap VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^aq UNIVERSITY OF EDINBURGH   (United Kingdom)

^ar CNRS   (France)

^as QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^at CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^au INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^av NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^aw CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^ax CHINA MEDICAL UNIVERSITY   (Taiwan)

^ay BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^az MADRAS DIABETES RESEARCH FOUNDATION   (India)

^ba Ajou University School of Medicine   (South Korea)

^bb Seoul National University College of Medicine   (South Korea)

^bc NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^bd HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^be EALING HOSPITAL NHS TRUST   (United Kingdom)

^bf KAROLINSKA INSTITUTE   (Sweden)

^bg HAROKOPIO UNIVERSITY   (Greece)

^bh UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^bi BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^bj L INSTITUT DU THORAX   (France)

^bk UNIVERSITÉ DE NANTES   (France)

^bl UNIVERSITY OF DUNDEE   (United Kingdom)

^bm UNIVERSITY OF OXFORD   (United Kingdom)

^bn ERASMUS MEDICAL CENTER   (Netherlands)

^bo Center for Medical System Biology   (Netherlands)

^bp ICELANDIC HEART ASSOCIATION   (Iceland)

^bq UNIVERSITY HOSPITAL ESSEN   (Germany)

^br NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^bs UNIVERSITY OF HELSINKI   (Finland)

^bt FOLKHÄLSAN RESEARCH CENTER   (Finland)

^bu INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^bv UNIVERSITY OF TARTU   (Estonia)

^bw UNIVERSITY OF TARTU   (Estonia)

^bx BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^by BOSTON CHILDREN S HOSPITAL   (United States)

^bz HARVARD MEDICAL SCHOOL   (United States)

^ca MASSACHUSETTS GENERAL HOSPITAL   (United States)

^cb Vaasa Health Care Centre   (Finland)

^cc UNIVERSITY OF EXETER   (United Kingdom)

^cd SHANGHAI CANCER INSTITUTE   (China)

^ce KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^cf INSTITUTE OF EPIDEMIOLOGY   (Germany)

^cg UNIVERSITY OF MUNICH   (Germany)

^ch TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ci GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^cj KING'S COLLEGE LONDON   (United Kingdom)

^ck UNIVERSITY OF TOKYO   (Japan)

^cl HEINRICH HEINE UNIVERSITY   (Germany)

^cm NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^cn UNIVERSITY OF AMSTERDAM   (Netherlands)

^co UNIVERSITY COLLEGE LONDON   (United Kingdom)

^cp KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^cq HANNOVER MEDICAL SCHOOL   (Germany)

^cr UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^cs AGA KHAN UNIVERSITY   (Pakistan)

^ct Center for Molecular Medicine Karolinska University Hospital Solna ^*  (India)

^cu West Australian Sleep Disorders Research Institute   (Australia)

^cv UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^cw BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^cx JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^cy NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^cz UNIVERSITY OF COLOMBO   (Sri Lanka)

^da UNIVERSITY OF OULU   (Finland)

^db OULU UNIVERSITY HOSPITAL   (Finland)

^dc GENOME INSTITUTE OF SINGAPORE   (Singapore)

^dd Ewha Womans University School of Medicine   (South Korea)

^de Soongsil University   (South Korea)

^df DECODE GENETICS   (Iceland)

^dg SOUTH OSTROBOTHNIA CENTRAL HOSPITAL   (Finland)

^dh Ministry of Health   (Mauritius)

^di UNIVERSITY OF TORONTO   (Canada)

^dj UNIVERSITY OF SAN CARLOS   (Philippines)

^dk NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^dl UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^dm BGI SHENZHEN   (China)

^dn MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^do Shanghai Institute of Preventive Medicine   (China)

^dp UNIVERSITY OF BONN   (Germany)

^dq LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^dr NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^ds CHUBU ROSAI HOSPITAL   (Japan)

^dt UNIVERSITY OF TROMSØ   (Norway)

^du KYUSHU UNIVERSITY   (Japan)

^dv CHURCHILL HOSPITAL   (United Kingdom)

^dw UNIVERSITY OF MINNESOTA   (United States)

^dx UNIVERSITY OF KELANIYA   (Sri Lanka)

^dy Levanger Hospital   (Norway)

^dz NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^ea KUOPIO UNIVERSITY HOSPITAL   (Finland)

^eb LABORATORY FOR MOLECULAR MEDICINE   (United States)

^ec HARVARD UNIVERSITY   (United States)

^ed BOSTON UNIVERSITY   (United States)

^ee Finnish Diabetes Association   (Finland)

^ef PIRKANMAA HOSPITAL DISTRICT   (Finland)

^eg Central Finland Central Hospital   (Finland)

^eh SOUTH KARELIA CENTRAL HOSPITAL   (Finland)

^ei Diabetic Association Pakistan   (Pakistan)

^ej UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^ek GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^el UNIVERSITY OF ULM   (Germany)

^em UPPSALA UNIVERSITY   (Sweden)

^en HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^eo INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^ep DANUBE UNIVERSITY KREMS   (Austria)

^eq KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^er HOSPITAL DE ESPECIALIDADES   (Mexico)

^es UNIVERSITY OF PENNSYLVANIA   (United States)

^et UNIVERSITY OF MELBOURNE   (Australia)

^eu KYUSHU UNIVERSITY   (Japan)

^ev UNIV LILLE   (France)

^ew AICHI GAKUIN UNIVERSITY   (Japan)

^ex Hallym University   (South Korea)

^ey IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^ez UNIVERSITY OF CALIFORNIA   (United States)

^fa BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^fb DUKE NUS MEDICAL SCHOOL   (Singapore)

^fc UNIVERSITY OF LIVERPOOL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ALLELE; ARTICLE; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; ENHANCER REGION; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN RESISTANCE; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HISPANIC AMERICANS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84895868553     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2897     Document Type: Article

References (51)

1. Zeggini, E. et al. Meta-Analysis of genome-wide association data and large-scale replication identified additional susceptibility loci for type 2 diabetes. Nat. Genet. 40, 638-645 (2008
2. Kong, A. et al. Parental origin of sequence variants associated with complex diseases. Nature 462, 868-874 (2009
3. Dupuis, J. et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42, 105-116 (2010
4. Voight, B.F. et al. Twelve type 2 diabetes susceptibility loci identified through large scale association analysis. Nat. Genet. 42, 579-589 (2010
5. Morris, A.P. et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981-990 (2012
6. Rosenberg, N.A. et al. Genome-wide association studies in diverse populations. Nat. Rev. Genet. 11, 356-366 (2010
7. Qi, L. et al. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum. Mol. Genet. 19, 2706-2715 (2010
8. Tsai, F-J. et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 6, e1000847 (2010
9. Shu, X.O. et al. Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 6, e1001127 (2010
10. Yamauchi, T. et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat. Genet. 42, 864-868 (2010
11. Cho, Y.S. et al. Meta-Analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians. Nat. Genet. 44, 67-72 (2012
12. Li, H. et al. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 62, 291-298 (2013
13. Kooner, J.S. et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat. Genet. 43, 984-989 (2011
14. Tabassum, R et al. Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes 62, 977-986 (2013
15. Parra, E.J. et al. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-Analysis of a Mexican-American samples from Starr County, Texas. Diabetologia 54, 2038-2046 (2011
16. Palmer, N.D. et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE 7, e29202 (2012
17. Waters, K.M. et al. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet. 6, e1001078 (2010
18. Saxena, R. et al. Large-scale gene-centric meta-Analysis across 39 studies identifies type 2 diabetes loci. Am. J. Hum. Genet. 90, 410-425 (2012); erratum 90, 753 (2012
19. Cooper, R.S., Tayo, B. & Zhu, X. Genome-wide association studies: Implications for multi-ethnic samples. Hum. Mol. Genet. 17, R151-R155 (2008
20. Zaitlen, N., Pasaniuc, B., Gur, T., Ziv, E. & Halperin, E. Leveraging genetic variability across populations for the identification of causal variants. Am. J. Hum. Genet. 86, 23-33 (2010
21. Franceschini, N. et al. Discovery and fine-mapping of serum protein loci through transethnic meta-Analysis. Am. J. Hum. Genet. 91, 744-753 (2012
22. The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007
23. The International HapMap Consortium. Integrating common and rare genetic variation in diverse human populations. Nature 467, 52-58 (2010
24. Dickson, S.P., Wang, K., Krantz, I., Hakonarson, H. & Goldstein, D.B. Rare variants create synthetic genome-wide associations. PLoS Biol. 8, e1000294 (2010
25. The 1000 Genomes Project Consortium. A map of human genome variation from population scale sequencing. Nature 467, 1061-1073 (2010
26. Voight, B.F. et al. The Metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 8, e1002793 (2012
27. Bradfield, J.P. et al. A genome-wide meta-Analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet. 7, e1002293 (2011
28. Cervin, C. et al. Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes. Diabetes 57, 1433-1437 (2008
29. Grant, S.F., Hakonarson, H. & Schwartz, S. Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults? Endocr. Rev. 31, 183-193 (2010
30. Scott, R.A. et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat. Genet. 44, 991-1005 (2012
31. Richards, J.B. et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 5, e1000768 (2009
32. Speliotes, E.K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010
33. Heid, I.M. et al. Meta-Analysis identifies 12 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet. 42, 949-960 (2010
34. Teslovich, T.M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010
35. Ng, P.C. & Henikoff, S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 31, 3812-3814 (2003
36. The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012
37. Lee, E.K. et al. RNA-binding protein HuD controls insulin translation. Mol. Cell 45, 826-835 (2012
38. Trynka, G. et al. Chromatin marks identify critical cell types for fine-mapping complex trait variants. Nat. Genet. 45, 124-130 (2013
39. Morris, A.P. Transethnic meta-Analysis of genomewide association studies. Genet. Epidemiol. 35, 809-822 (2011
40. Wang, X. et al. Comparing methods for performing trans-ethnic meta-Analysis of genome-wide association studies. Hum. Mol. Genet. 22, 2303-2311 (2013
41. Maller, J.B. et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet. 44, 1294-1301 (2012
42. Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369-375 (2012
43. Fogarty, M.P., Panhuis, T.M., Vadlamudi, S., Buchkovich, M.L. & Mohlke, K.L. Allele-specific transcriptional activity at type 2 diabetes-Associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus. Diabetes 62, 1756-1762 (2013
44. Nicolson, T.J. et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-Associated variants. Diabetes 58, 2070-2083 (2009
45. The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56-65 (2012
46. Sung, Y.J., Wang, L., Rankinen, T., Bouchard, C. & Rao, D.C. Performance of genotype imputations using data from the 1000 Genomes Project. Hum. Hered. 73, 18-25 (2012
47. Zheng, H.F., Ladouceur, M., Greenwood, C.M. & Richards, J.B. Effect of genome-wide genotyping and reference panels on rare variant imputation. J. Genet. Genomics 39, 545-550 (2012
48. Nelson, S.C et al. Imputation-based genomic coverage assessments of current human genotyping arrays. G3 (Bethesda) 3, 1795-1880 (2013
49. Stahl, E.A. et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat. Genet. 44, 483-489 (2012
50. Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999
51. Ioannidis, J.P. et al. Heterogeneity in meta-Analyses of genome-wide association investigations. PLoS ONE 2, e841 (2007.