IGF2BP2/IMP2-deficient mice resist obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding mitochondrial proteins

Cell Metabolism

Volumn 21, Issue 4, 2015, Pages 609-621

  Dai, Ning ^a,b   Zhao, Liping ^a,b   Wrighting, Diedra ^a,b,c   Krämer, Dana ^d   Majithia, Amit ^a,b,c   Wang, Yanqun ^a   Cracan, Valentin ^a,b   Borges Rivera, Diego ^a,b,c   Mootha, Vamsi K ^a,b   Nahrendorf, Matthias ^a,b   Thorburn, David R ^f,g   Minichiello, Liliana ^d,e   Altshuler, David ^a,b,c   Avruch, Joseph ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f ROYAL CHILDREN'S HOSPITAL   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; MESSENGER RNA; POLYPEPTIDE; PROTEIN IMP2; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; IGF2BP2 PROTEIN, MOUSE; ION CHANNEL; MITOCHONDRIAL PROTEIN; UCP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; COLD EXPOSURE; CONTROLLED STUDY; CORE TEMPERATURE; DIET INDUCED OBESITY; ENERGY EXPENDITURE; ENERGY METABOLISM; FATTY LIVER; FOOD INTAKE; GLUCOSE TOLERANCE; HYPOLIPEMIA; INSULIN SENSITIVITY; LEAN BODY WEIGHT; LIFESPAN; LIPID ABSORPTION; MOUSE; NONHUMAN; NUTRITION; OBESITY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN RNA BINDING; RNA TRANSLATION; WEANING; WILD TYPE; ANALYSIS OF VARIANCE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; INSULIN RESISTANCE; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SEQUENCE ANALYSIS; THERMOREGULATION;

MUS;

ADIPOSE TISSUE, BROWN; ANALYSIS OF VARIANCE; ANIMALS; BASE SEQUENCE; BODY TEMPERATURE REGULATION; ENERGY METABOLISM; GENE EXPRESSION REGULATION; INSULIN RESISTANCE; ION CHANNELS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OBESITY; RNA-BINDING PROTEINS; SEQUENCE ANALYSIS, RNA; UNCOUPLING PROTEIN 1;

EID: 84928393220     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.03.006     Document Type: Article

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