A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants

Science

Volumn 316, Issue 5829, 2007, Pages 1341-1345

  Scott, Laura J ^a   Mohlke, Karen L ^b   Bonnycastle, Lori L ^c   Willer, Cristen J ^a   Li, Yun ^a   Duren, William L ^a   Erdos, Michael R ^c   Stringham, Heather M ^a   Chines, Peter S ^c   Jackson, Anne U ^a   Prokunina Olsson, Ludmila ^c   Ding, Chia Jen ^a   Swift, Amy J ^c   Narisu, ^c   Hu, Tianle ^a   Pruim, Randall ^d   Xiao, Rui ^a   Li, Xiao Yi ^a   Conneely, Karen N ^a   Riebow, Nancy L ^c   Sprau, Andrew G ^c   Tong, Maurine ^c   White, Peggy P ^a   Hetrick, Kurt N ^e   Barnhart, Michael W ^e   Bark, Craig W ^e   Goldstein, Janet L ^e   Watkins, Lee ^e   Xiang, Fang ^a   Saramies, Jouko ^f   Buchanan, Thomas A ^g   Watanabe, Richard M ^g   Valle, Timo T ^h   Kinnunen, Leena ^h,i   Abecasis, Gonçalo R ^a   Pugh, Elizabeth W ^e   Doheny, Kimberly F ^e   Bergman, Richard N ^g   Tuomilehto, Jaakko ^h,i,j   Collins, Francis S ^c   Boehnke, Michael ^a   more..

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d CALVIN COLLEGE   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Savitaipale Health Center   (Finland)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

ⁱ UNIVERSITY OF HELSINKI   (Finland)

^j SOUTH OSTROBOTHNIA CENTRAL HOSPITAL   (Finland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

SPACER DNA;

CHROMOSOME; DIABETES; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC MARKER; GENETIC VARIATION; GENOMICS; GENOTYPE; HEALTH RISK;

ARTICLE; AUTOSOME; CDKAL1 GENE; CDKN2A GENE; CDKN2B GENE; CHROMOSOME 11P; CONTROLLED STUDY; DISEASE PREDISPOSITION; FINLAND; FTO GENE; GENE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HHEX GENE; HUMAN; HUMAN GENOME; IGF2BP2 GENE; KCNJ11 GENE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PPARG GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLC3PA8 GENE; TCF7L2 GENE;

CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; DIABETES MELLITUS, TYPE 2; DNA, INTERGENIC; FEMALE; FINLAND; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOTYPE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INTRONS; LOGISTIC MODELS; MALE; META-ANALYSIS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EURASIA; EUROPE; FINLAND; NORTHERN EUROPE; SCANDINAVIA;

EID: 34249885875     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142382     Document Type: Article

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33. We thank the Finnish citizens who generously participated in this study; our colleagues from the DGI, WTCCC, and UKT2D for sharing prepublication data from their studies; S. Enloe of FUSION and E. Kwasnik, J. Gearhart, J. Romm, M. Zilka, C. Ongaco, A. Robinson, R. King, B. Craig, and E. Hsu of CIDR for expert technical work; and D. Leja of NHGRI for expert assistance with a figure. Support for this research was provided by NIH grants DK062370 (M.B.), DK072193 (K.L.M.), HL084729 (G.R.A.), HG002651 (G.R.A.), and U54 DA021519; National Human Genome Research Institute Intramural project number 1 Z01 HG000024 (F.S.C.); a postdoctoral fellowship award from the American Diabetes Association (C.J.W.); a Wenner-Gren Fellowship (L.P.O.); and a Calvin Research Fellowship (R.P.). Genome-wide genotyping was performed by the Johns Hopkins University Genetic Resources Core Facility (GRCF) SNP Center at CIDR with support from CIDR NIH (contract N01-HG-65403) and the GRCF SNP Center.