The genetic architecture of type 2 diabetes

Nature

Volumn 536, Issue 7614, 2016, Pages 41-47

  Fuchsberger, Christian ^a,b,c   Flannick, Jason ^d,e   Teslovich, Tanya M ^a   Mahajan, Anubha ^f   Agarwala, Vineeta ^d,g   Gaulton, Kyle J ^f   Ma, Clement ^a   Fontanillas, Pierre ^d   Moutsianas, Loukas ^f   McCarthy, Davis J ^f,h   Rivas, Manuel A ^f   Perry, John R B ^f,i,j,k   Sim, Xueling ^a   Blackwell, Thomas W ^a   Robertson, Neil R ^f,l   Rayner, N William ^f,l,m   Cingolani, Pablo ⁿ   Locke, Adam E ^a   Tajes, Juan Fernandez ^f   Highland, Heather M ^o   Dupuis, Josee ^p,q   Chines, Peter S ^r   Lindgren, Cecilia M ^d,f   Hartl, Christopher ^d   Jackson, Anne U ^a   Chen, Han ^p,s   Huyghe, Jeroen R ^a   Van De Bunt, Martijn ^f,l   Pearson, Richard D ^f   Kumar, Ashish ^f,t   Müller Nurasyid, Martina ^u,v,w,x   Grarup, Niels ^y   Stringham, Heather M ^a   Gamazon, Eric R ^z   Lee, Jaehoon ^aa   Chen, Yuhui ^f   Scott, Robert A ^j   Below, Jennifer E ^ab   Chen, Peng ^ac   Huang, Jinyan ^s   Go, Min Jin ^ad   Stitzel, Michael L ^ae   Pasko, Dorota ⁱ   Parker, Stephen C J ^a   Varga, Tibor V ^af   Green, Todd ^d   Beer, Nicola L ^l   Day Williams, Aaron G ^m   Ferreira, Teresa ^f   Fingerlin, Tasha ^ag   Horikoshi, Momoko ^f,l   Hu, Cheng ^ah   Huh, Iksoo ^aa   Ikram, Mohammad Kamran ^ai,aj,ak   Kim, Bong Jo ^ad   Kim, Yongkang ^aa   Kim, Young Jin ^ad   Kwon, Min Seok ^aa   Lee, Juyoung ^ad   Lee, Selyeong ^aa   Lin, Keng Han ^a   Maxwell, Taylor J ^ab   Nagai, Yoshihiko ^n,al   Wang, Xu ^ac   Welch, Ryan P ^a   Yoon, Joon ^aa   Zhang, Weihua ^am,an   Barzilai, Nir ^ao   Voight, Benjamin F ^ap   Han, Bok Ghee ^ad   Jenkinson, Christopher P ^aq,ar   Kuulasmaa, Teemu ^as   Kuusisto, Johanna ^as,at   Manning, Alisa ^d   Ng, Maggie C Y ^au   Palmer, Nicholette D ^au   Balkau, Beverley ^av   Stančáková, Alena ^as   Abboud, Hanna E ^aq   Boeing, Heiner ^aw   Giedraitis, Vilmantas ^ax   Prabhakaran, Dorairaj ^ay   Gottesman, Omri ^az   Scott, James ^ba   Carey, Jason ^d   Kwan, Phoenix ^a   Grant, George ^d   Smith, Joshua D ^bb   Neale, Benjamin M ^d,e   Purcell, Shaun ^d,e,az   Butterworth, Adam S ^j   Howson, Joanna M M ^j   Lee, Heung Man ^bc   Lu, Yingchang ^az   Kwak, Soo Heon ^aa   Zhao, Wei ^bd   Danesh, John ^j,m   Lam, Vincent K L ^bc   Park, Kyong Soo ^aa,be   Saleheen, Danish ^bd,bf   So, Wing Yee ^bc   Tam, Claudia H T ^bc   Afzal, Uzma ^am   Aguilar, David ^bg   Arya, Rector ^aq   Aung, Tin ^ai,aj,ak   Chan, Edmund ^bh   Navarro, Carmen ^bi,bj,bk   Cheng, Ching Yu ^ac,ai,aj,ak   Palli, Domenico ^bl   Correa, Adolfo ^bm   Curran, Joanne E ^bn   Rybin, Denis ^p   Farook, Vidya S ^bo   Fowler, Sharon P ^aq   Freedman, Barry I ^au   Griswold, Michael ^bp   Hale, Daniel Esten ^aq   Hicks, Pamela J ^au   Khor, Chiea Chuen ^ac,ai,aj,bq   Kumar, Satish ^bn   Lehne, Benjamin ^am   Thuillier, Dorothée ^br   Lim, Wei Yen ^ac   Liu, Jianjun ^ac,bq   Van Der Schouw, Yvonne T ^bs   Loh, Marie ^am,bt,bu   Musani, Solomon K ^bp   Puppala, Sobha ^bo   Scott, William R ^am   Yengo, Loic ^br   Tan, Sian Tsung ^an,ba   Taylor, Herman A ^bm   Thameem, Farook ^aq   Wilson, Gregory ^bv   Wong, Tien Yin ^ai,aj,ak   Njolstad, Pal Rasmus ^bw,bx   Levy, Jonathan C ^l   Mangino, Massimo ^k   Bonnycastle, Lori L ^r   Schwarzmayr, Thomas ^u   Fadista, Joao ^af   Surdulescu, Gabriela L ^k   Herder, Christian ^by,bz   Groves, Christopher J ^l   Wieland, Thomas ^u   Bork Jensen, Jette ^y   Brandslund, Ivan ^ca,cb   Christensen, Cramer ^cb   Koistinen, Heikki A ^cc,cd,ce   Doney, Alex S F ^cf   Kinnunen, Leena ^cc   Esko, Tonu ^d,cg,ch,ci   Farmer, Andrew J ^l   Hakaste, Liisa ^cd,cj   Hodgkiss, Dylan ^k   Kravic, Jasmina ^af   Lyssenko, Valeriya ^af   Hollensted, Mette ^y   Jorgensen, Marit E ^ck   Jorgensen, Torben ^cl,cm,cn   Ladenvall, Claes ^af   Justesen, Johanne Marie ^y   Käräjämäki, Annemari ^co,cp   Kriebel, Jennifer ^u,bz   Rathmann, Wolfgang ^by   Lannfelt, Lars ^ax   Lauritzen, Torsten ^cq   Narisu, Narisu ^r   Linneberg, Allan ^cl,cr,cs   Melander, Olle ^ct   Milani, Lili ^cg   Neville, Matt ^l,cu   Orho Melander, Marju ^ct   Qi, Lu ^s,ch   Qi, Qibin ^s,ao   Roden, Michael ^by,bz,cv   Rolandsson, Olov ^cw   Swift, Amy ^r   Rosengren, Anders H ^af   Stirrups, Kathleen ^m   Wood, Andrew R ⁱ   Mihailov, Evelin ^cg   Blancher, Christine ^f   Carneiro, Mauricio O ^d   Maguire, Jared ^d   Poplin, Ryan ^d   Shakir, Khalid ^d   Fennell, Timothy ^d   DePristo, Mark ^d   De Angelis, Martin Hrabé ^u,bz,cx   Deloukas, Panos ^cy,cz   Gjesing, Anette P ^y   Jun, Goo ^a,ab   Nilsson, Peter ^ct   Murphy, Jacquelyn ^d   Onofrio, Robert ^d   Thorand, Barbara ^u,bz   Hansen, Torben ^y,da   Meisinger, Christa ^u,bz   Hu, Frank B ^s   Isomaa, Bo ^cj,db   Karpe, Fredrik ^l,cu   Liang, Liming ^s   Peters, Annette ^u,x,bz   Huth, Cornelia ^u,bz   O'Rahilly, Stephen P ^j   Palmer, Colin N A ^cf   Pedersen, Oluf ^y   Rauramaa, Rainer ^as   Tuomilehto, Jaakko ^cc,cz,dc,dd   Salomaa, Veikko ^cc   Watanabe, Richard M ^de   Syvänen, Ann Christine ^df   Bergman, Richard N ^dg   Bharadwaj, Dwaipayan ^dh   Bottinger, Erwin P ^az   Cho, Yoon Shin ^di   Chandak, Giriraj R ^dj   Chan, Juliana C N ^bc   Chia, Kee Seng ^ac   Daly, Mark J ^e   Ebrahim, Shah B ^ay   Langenberg, Claudia ^j   Elliott, Paul ^am   Jablonski, Kathleen A ^dk   Lehman, Donna M ^aq   Jia, Weiping ^ah   Ma, Ronald C W ^bc   Pollin, Toni I ^dl   Sandhu, Manjinder ^j,m   Tandon, Nikhil ^dm   Froguel, Philippe ^am,br   Barroso, Ines ^j,m   Teo, Yik Ying ^ac,dn   Zeggini, Eleftheria ^m   Loos, Ruth J F ^az   Small, Kerrin S ^k   Ried, Janina S ^u   DeFronzo, Ralph A ^aq   Grallert, Harald ^u,bz   Glaser, Benjamin ^do   Metspalu, Andres ^cg   Wareham, Nicholas J ^j   Walker, Mark ^dp   Banks, Eric ^d   Gieger, Christian ^u   Ingelsson, Erik ^f,df   Im, Hae Kyung ^z   Illig, Thomas ^u,dq   Franks, Paul W ^s,af,cw   Buck, Gemma ^f   Trakalo, Joseph ^f   Buck, David ^f   Prokopenko, Inga ^f,l,am   Mägi, Reedik ^cg   Lind, Lars ^df   Farjoun, Yossi ^d   Owen, Katharine R ^l,cu   Gloyn, Anna L ^f,l,cu   Strauch, Konstantin ^u,w   Tuomi, Tiinamaija ^cd,cj   Kooner, Jaspal Singh ^an,ba,dr   Lee, Jong Young ^ad   Park, Taesung ^aa   Donnelly, Peter ^f,h   Morris, Andrew D ^cf,ds   Hattersley, Andrew T ⁱ   Bowden, Donald W ^au   Collins, Francis S ^r   Atzmon, Gil ^ao,dt   Chambers, John C ^am,an,dr   Spector, Timothy D ^k   Laakso, Markku ^as,at   Strom, Tim M ^u,cx   Bell, Graeme I ^z   Blangero, John ^bn   Duggirala, Ravindranath ^bo   Tai, E Shyong ^ac,ak,bh   McVean, Gilean ^f   Hanis, Craig L ^ab   Wilson, James G ^bm   Seielstad, Mark ^du,dv   Frayling, Timothy M ⁱ   Meigs, James B ^e   Cox, Nancy J ^z   Sladek, Rob ⁿ   Lander, Eric S ^d   Gabriel, Stacey ^d   Burtt, Noël P ^d   Mohlke, Karen L ^dw   Meitinger, Thomas ^u,cx   Groop, Leif ^af,cd   Abecasis, Goncalo ^a   Florez, Jose C ^d,e,ch   Scott, Laura J ^a   Morris, Andrew P ^f,cg,dx   Kang, Hyun Min ^a   Boehnke, Michael ^a   Altshuler, David ^d,e,g,ch   McCarthy, Mark I ^f,l,cu   more..

^a UNIVERSITY OF MICHIGAN   (United States)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c University of Lubeck   (Italy)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^k KING'S COLLEGE LONDON   (United Kingdom)

^l UNIVERSITY OF OXFORD   (United Kingdom)

^m WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

ⁿ MCGILL UNIVERSITY   (Canada)

^o UNIVERSITY OF TEXAS   (United States)

^p BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^q FRAMINGHAM HEART STUDY   (United States)

^r NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^s HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^t UNIVERSITY OF BASEL   (Switzerland)

^u INSTITUTE OF EPIDEMIOLOGY   (Germany)

^v LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^w UNIVERSITY OF MUNICH   (Germany)

^x DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^y Capital Region   (Denmark)

^z UNIVERSITY OF CHICAGO   (United States)

^aa Seoul National University   (South Korea)

^ab UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^ac NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^ad Korea National Institute of Health   (South Korea)

^ae JACKSON LABORATORY   (United States)

^af LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^ag Global Health and Health Disparities   (United States)

^ah SHANGHAI JIAO TONG UNIVERSITY   (China)

^ai SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^aj NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^ak DUKE NUS MEDICAL SCHOOL   (Singapore)

^al MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^am IMPERIAL COLLEGE LONDON   (United Kingdom)

^an EALING HOSPITAL NHS TRUST   (United Kingdom)

^ao ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^ap UNIVERSITY OF PENNSYLVANIA   (United States)

^aq Mays Cancer Center at UT Health San Antonio   (United States)

^ar SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^as UNIVERSITY OF EASTERN FINLAND   (Finland)

^at KUOPIO UNIVERSITY HOSPITAL   (Finland)

^au WAKE FOREST SCHOOL OF MEDICINE   (United States)

^av CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^aw GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^ax UPPSALA UNIVERSITY   (Sweden)

^ay CENTRE FOR CHRONIC DISEASE CONTROL   (India)

^az MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ba NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^bb UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^bc CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^bd UNIVERSITY OF PENNSYLVANIA   (United States)

^be Seoul National University   (South Korea)

^bf Center for Non Communicable Diseases   (Pakistan)

^bg BAYLOR COLLEGE OF MEDICINE   (United States)

^bh Dept Medicine Endocrinol Diabet   (Singapore)

^bi DEPARTMENT OF EPIDEMIOLOGY   (Spain)

^bj UNIVERSITY OF MURCIA   (Spain)

^bk UNIVERSITY OF MURCIA   (Spain)

^bl CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^bm UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^bn University of Texas Rio Grande Valley School of Medicine   (United States)

^bo SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^bp UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^bq GENOME INSTITUTE OF SINGAPORE   (Singapore)

^br UNIV LILLE   (France)

^bs UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^bt UNIVERSITY OF OULU   (Finland)

^bu AGENCY FOR SCIENCE   (Singapore)

^bv JACKSON STATE UNIVERSITY   (United States)

^bw UNIVERSITY OF BERGEN   (Norway)

^bx HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^by HEINRICH HEINE UNIVERSITY   (Germany)

^bz GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^ca UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^cb LILLEBAELT HOSPITAL   (Denmark)

^cc NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^cd UNIVERSITY OF HELSINKI   (Finland)

^ce MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^cf UNIVERSITY OF DUNDEE   (United Kingdom)

^cg UNIVERSITY OF TARTU   (Estonia)

^ch HARVARD MEDICAL SCHOOL   (United States)

^ci BOSTON CHILDREN S HOSPITAL   (United States)

^cj FOLKHÄLSAN RESEARCH CENTER   (Finland)

^ck STENO DIABETES CENTER   (Denmark)

^cl Research Centre for Prevention and Health   (Denmark)

^cm UNIVERSITY OF COPENHAGEN   (Denmark)

^cn AALBORG UNIVERSITY   (Denmark)

^co VAASA CENTRAL HOSPITAL   (Finland)

^cp Vaasa Health Care Center   (Finland)

^cq AARHUS UNIVERSITY   (Denmark)

^cr Rigshospitalet   (Denmark)

^cs UNIVERSITY OF COPENHAGEN   (Denmark)

^ct LUND UNIVERSITY   (Sweden)

^cu OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^cv Department of Orthopedic Surgery   (Germany)

^cw UMEÅ UNIVERSITY   (Sweden)

^cx TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^cy QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^cz KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^da UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^db Hallym University ^*  (Finland)

^dc DANUBE UNIVERSITY KREMS   (Austria)

^dd HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^de UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^df UPPSALA UNIVERSITY   (Sweden)

^dg CEDARS SINAI MEDICAL CENTER   (United States)

^dh CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^di Hallym University   (South Korea)

^dj CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^dk GEORGE WASHINGTON UNIVERSITY   (United States)

^dl UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^dm ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^dn NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^do HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^dp NEWCASTLE UNIVERSITY   (United Kingdom)

^dq HANNOVER MEDICAL SCHOOL   (Germany)

^dr IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^ds UNIVERSITY OF EDINBURGH   (United Kingdom)

^dt UNIVERSITY OF HAIFA   (Israel)

^du UNIVERSITY OF CALIFORNIA   (United States)

^dv BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^dw UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^dx UNIVERSITY OF LIVERPOOL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANCESTRY; DIABETES; GENETIC ANALYSIS; GENETIC STRUCTURE; GENOME; HEALTH RISK; PATHOLOGY; PHYSIOLOGY;

ALLELE; ARTICLE; CONTROLLED STUDY; EUROPEAN; EXOME; GENE SEQUENCE; GENETIC CODE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; DNA MUTATIONAL ANALYSIS; ETHNOLOGY; EUROPE; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; SAMPLE SIZE;

EUROPE;

ALLELES; DIABETES MELLITUS, TYPE 2; DNA MUTATIONAL ANALYSIS; EUROPE; EXOME; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPING TECHNIQUES; HUMANS; SAMPLE SIZE;

EID: 84978128486     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18642     Document Type: Article

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