Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

Diabetes

Volumn 61, Issue 7, 2012, Pages 1726-1733

  Rosengren, Anders H ^a   Braun, Matthias ^b,c   Mahdi, Taman ^a   Andersson, Sofia A ^a   Travers, Mary E ^b   Shigeto, Makoto ^b   Zhang, Enming ^a   Almgren, Peter ^a   Ladenvall, Claes ^a   Axelsson, Annika S ^a   Edlund, Anna ^a   Pedersen, Morten Gram ^a   Jonsson, Anna ^a   Ramracheya, Reshma ^b   Tang, Yunzhao ^a,d   Walker, Jonathan N ^b,e   Barrett, Amy ^b   Johnson, Paul R V ^b,e   Lyssenko, Valeriya ^a   McCarthy, Mark I ^b,e,f   Groop, Leif ^a   Salehi, Albert ^a   Gloyn, Anna L ^b,e   Renström, Erik ^a   Rorsman, Patrik ^b,c,e   Eliasson, Lena ^a   more..

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ALBERTA   (Canada)

^d TIANJIN MEDICAL UNIVERSITY   (China)

^e CHURCHILL HOSPITAL   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUCOSE TRANSPORTER 2; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; POTASSIUM CHANNEL KCNQ1; TRANSCRIPTION FACTOR 7 LIKE 2;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; EXOCYTOSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE INTOLERANCE; HIGH RISK PATIENT; HUMAN; HUMAN CELL; INSULIN RELEASE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MOLECULAR DOCKING; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; EXOCYTOSIS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GLUCOSE TRANSPORTER TYPE 2; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; KCNQ1 POTASSIUM CHANNEL; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, ADRENERGIC, ALPHA-2; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TRANSCRIPTION FACTORS;

EID: 84863207933     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1516     Document Type: Article

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