Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Nature Genetics

Volumn 47, Issue 12, 2015, Pages 1415-1425

  Gaulton, Kyle J ^a,b   Ferreira, Teresa ^a   Lee, Yeji ^c   Raimondo, Anne ^d   Mägi, Reedik ^e   Reschen, Michael E ^f   Mahajan, Anubha ^a   Locke, Adam ^c   Rayner, N William ^a,d,g   Robertson, Neil ^a,d   Scott, Robert A ^h   Prokopenko, Inga ⁱ   Scott, Laura J ^c   Green, Todd ^j   Sparso, Thomas ^k   Thuillier, Dorothee ^l   Yengo, Loic ^l   Grallert, Harald ^m,n   Wahl, Simone ^m,n   Frånberg, Mattias ^o,p,q   Strawbridge, Rona J ^o   Kestler, Hans ^r,s   Chheda, Himanshu ^t   Eisele, Lewin ^u   Gustafsson, Stefan ^v   Steinthorsdottir, Valgerdur ^w   Thorleifsson, Gudmar ^w   Qi, Lu ^x,y,z   Karssen, Lennart C ^aa   Van Leeuwen, Elisabeth M ^aa   Willems, Sara M ^h,aa   Li, Man ^ab   Chen, Han ^x,ac   Fuchsberger, Christian ^c   Kwan, Phoenix ^c   Ma, Clement ^c   Linderman, Michael ^ad   Lu, Yingchang ^ad   Thomsen, Soren K ^d   Rundle, Jana K ^d   Beer, Nicola L ^a,d   Van De Bunt, Martijn ^a,d   Chalisey, Anil ^f   Kang, Hyun Min ^c   Voight, Benjamin F ^ae   Abecasis, Gonçalo R ^c   Almgren, Peter ^af   Baldassarre, Damiano ^ag,ah   Balkau, Beverley ^ai,aj   Benediktsson, Rafn ^ak,al   Blüher, Matthias ^am   Boeing, Heiner ^an   Bonnycastle, Lori L ^ao   Bottinger, Erwin P ^ad   Burtt, Noël P ^j   Carey, Jason ^j   Charpentier, Guillaume ^ap   Chines, Peter S ^ao   Cornelis, Marilyn C ^aq   Couper, David J ^ar   Crenshaw, Andrew T ^j   Van Dam, Rob M ^x,as   Doney, Alex S F ^at   Dorkhan, Mozhgan ^af   Edkins, Sarah ^g   Eriksson, Johan G ^t,au,av   Esko, Tonu ^e,j,aw   Eury, Elodie ^ax   Fadista, João ^af   Flannick, Jason ^j   Fontanillas, Pierre ^j   Fox, Caroline ^y,ay   Franks, Paul W ^x,af,az,ba   Gertow, Karl ^o   Gieger, Christian ^m   Gigante, Bruna ^o   Gottesman, Omri ^ad   Grant, George B ^j   Grarup, Niels ^k   Groves, Christopher J ^d   Hassinen, Maija ^bb   Have, Christian T ^k   Herder, Christian ^bc,bd   Holmen, Oddgeir L ^be   Hreidarsson, Astradur B ^al   Humphries, Steve E ^bf   Hunter, David J ^x,y   Jackson, Anne U ^c   Jonsson, Anna ^af   Jørgensen, Marit E ^bg   Jørgensen, Torben ^bh,bi,bj   Kao, Wen Hong L ^ab   Kerrison, Nicola D ^h   Kinnunen, Leena ^au   Klopp, Norman ^m,bk   Kong, Augustine ^w   Kovacs, Peter ^am   Kraft, Peter ^x   Kravic, Jasmina ^af   Langford, Cordelia ^g   Leander, Karin ^o   Liang, Liming ^x   Lichtner, Peter ^m   Lindgren, Cecilia M ^a,j   Lindholm, Eero ^af   Linneberg, Allan ^bh,bi,bl   Liu, Ching Ti ^ac   Lobbens, Stéphane ^ax   Luan, Jian'fan ^h   Lyssenko, Valeriya ^af,bg   Männistö, Satu ^au   McLeod, Olga ^o   Meyer, Julia ^m   Mihailov, Evelin ^e   Mirza, Ghazala ^bm   Mühleisen, Thomas W ^bn,bo   Müller Nurasyid, Martina ^m,bp,bq,br   Navarro, Carmen ^bs,bt,bu   Nöthen, Markus M ^bn   Oskolkov, Nikolay N ^af   Owen, Katharine R ^d,bv   Palli, Domenico ^bw   Pechlivanis, Sonali ^u   Peltonen, Leena ^g,j,t,au   Perry, John R B ^h   Platou, Carl G P ^be,bx   Roden, Michael ^bc,bd,by   Ruderfer, Douglas ^ad   Rybin, Denis ^bz   Van Der Schouw, Yvonne T ^ca   Sennblad, Bengt ^o,p   Sigurosson, Gunnar ^al,cb   Stančáková, Alena ^cc   Steinbach, Gerald ^s   Storm, Petter ^af   Strauch, Konstantin ^m,bq   Stringham, Heather M ^c   Sun, Qi ^x,y   Thorand, Barbara ^m,n   Tikkanen, Emmi ^t   Tonjes, Anke ^am   Trakalo, Joseph ^a   Tremoli, Elena ^ag,ah   Tuomi, Tiinamaija ^t,av,cd   Wennauer, Roman ^aa   Wiltshire, Steven ^a   Wood, Andrew R ^ce   Zeggini, Eleftheria ^g   Dunham, Ian ^cf   Birney, Ewan ^cf   Pasquali, Lorenzo ^cg,ch,ci   Ferrer, Jorge ^i,cj   Loos, Ruth J F ^h,ad   Dupuis, Josée ^ac,ay   Florez, Jose C ^j,y,ck   Boerwinkle, Eric ^cl,cm   Pankow, James S ^cn   Van Duijn, Cornelia ^aa,co   Sijbrands, Eric ^aa   Meigs, James B ^y,ck   Hu, Frank B ^x,y   Thorsteinsdottir, Unnur ^w,ak   Stefansson, Kari ^w,ak   Lakka, Timo A ^bb,cc   Rauramaa, Rainer ^bb,cc   Stumvoll, Michael ^am   Pedersen, Nancy L ^o   Lind, Lars ^cp   Keinanen Kiukaanniemi, Sirkka M ^cq,cr   Korpi Hyövälti, Eeva ^cs   Saaristo, Timo E ^ct,cu   Saltevo, Juha ^cv   Kuusisto, Johanna ^cc   Laakso, Markku ^cc   Metspalu, Andres ^e,cw   Erbel, Raimund ^u   Jöckel, Karl Heinz ^u   Moebus, Susanne ^u   Ripatti, Samuli ^g,t,au   Salomaa, Veikko ^au   Ingelsson, Erik ^a,v   Boehm, Bernhard O ^cx,cy   Bergman, Richard N ^cz   Collins, Francis S ^ao   Mohlke, Karen L ^da   Koistinen, Heikki ^au,cd,db   Tuomilehto, Jaakko ^au,dc,dd,de   Hveem, Kristian ^be   Njølstad, Inger ^df   Deloukas, Panagiotis ^g,dg   Donnelly, Peter J ^a,dh   Frayling, Timothy M ^ce   Hattersley, Andrew T ^ce   De Faire, Ulf ^o   Hamsten, Anders ^o   Illig, Thomas ^m,bk   Peters, Annette ^m,n,br   Cauchi, Stephane ^l   Sladek, Rob ^di,dj   Froguel, Philippe ^i,l,ax   Hansen, Torben ^k,dk   Pedersen, Oluf ^k   Morris, Andrew D ^dl   Palmer, Collin N A ^at   Kathiresan, Sekar ^j,ck   Melander, Olle ^af   Nilsson, Peter M ^af   Groop, Leif C ^t,af   Barroso, Inês ^g,dm,dn   Langenberg, Claudia ^h   Wareham, Nicholas J ^h   O'Callaghan, Christopher A ^f   Gloyn, Anna L ^a,d,bv   Altshuler, David ^j,y,ck   Boehnke, Michael ^c   Teslovich, Tanya M ^c   McCarthy, Mark I ^a,d,bv   Morris, Andrew P ^a,e,do   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF TARTU   (Estonia)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

ⁱ IMPERIAL COLLEGE LONDON   (United Kingdom)

^j BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^k Capital Region   (Denmark)

^l France   (France)

^m INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁿ GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^o KAROLINSKA INSTITUTE   (Sweden)

^p SCIENCE FOR LIFE LABORATORY   (Sweden)

^q STOCKHOLM UNIVERSITY   (Sweden)

^r FRITZ LIPMANN INSTITUTE   (Germany)

^s UNIVERSITY OF ULM   (Germany)

^t UNIVERSITY OF HELSINKI   (Finland)

^u UNIVERSITY HOSPITAL ESSEN   (Germany)

^v UPPSALA UNIVERSITY   (Sweden)

^w DECODE GENETICS   (Iceland)

^x HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^y HARVARD MEDICAL SCHOOL   (United States)

^z TULANE UNIVERSITY   (United States)

^aa ERASMUS MEDICAL CENTER   (Netherlands)

^ab JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^ac BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^ad MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ae UNIVERSITY OF PENNSYLVANIA   (United States)

^af LUND UNIVERSITY   (Sweden)

^ag CENTRO CARDIOLOGICO MONZINO   (Italy)

^ah UNIVERSITY OF MILAN   (Italy)

^ai CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^aj UNIVERSITÉ PARIS SACLAY   (France)

^ak UNIVERSITY OF ICELAND   (Iceland)

^al LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^am UNIVERSITY OF LEIPZIG   (Germany)

^an GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^ao NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^ap CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^aq NORTHWESTERN UNIVERSITY   (United States)

^ar IL   (United States)

^as NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^at UNIVERSITY OF DUNDEE   (United Kingdom)

^au NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^av FOLKHÄLSAN RESEARCH CENTER   (Finland)

^aw BOSTON CHILDREN S HOSPITAL   (United States)

^ax Institut Pasteur de Lille   (France)

^ay FRAMINGHAM HEART STUDY   (United States)

^az LUND UNIVERSITY   (Sweden)

^ba UMEÅ UNIVERSITY   (Sweden)

^bb UNIVERSITY OF EASTERN FINLAND   (Finland)

^bc HEINRICH HEINE UNIVERSITY   (Germany)

^bd LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^be NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^bf UNIVERSITY COLLEGE LONDON   (United Kingdom)

^bg STENO DIABETES CENTER   (Denmark)

^bh Unit for Psychotherapy Education and Research   (Denmark)

^bi UNIVERSITY OF COPENHAGEN   (Denmark)

^bj AALBORG UNIVERSITY   (Denmark)

^bk HANNOVER MEDICAL SCHOOL   (Germany)

^bl Rigshospitalet   (Denmark)

^bm GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^bn UNIVERSITY OF BONN   (Germany)

^bo FORSCHUNGSZENTRUM JÜLICH   (Germany)

^bp LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^bq UNIVERSITY OF MUNICH   (Germany)

^br DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^bs DEPARTMENT OF EPIDEMIOLOGY   (Spain)

^bt CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^bu UNIVERSITY OF MURCIA   (Spain)

^bv CHURCHILL HOSPITAL   (United Kingdom)

^bw CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^bx Levanger Hospital   (Norway)

^by UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^bz BOSTON UNIVERSITY   (United States)

^ca UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^cb ICELANDIC HEART ASSOCIATION   (Iceland)

^cc KUOPIO UNIVERSITY HOSPITAL   (Finland)

^cd HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^ce UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^cf EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^cg HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^ch JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IJC   (Spain)

^ci INSTITUTO DE SALUD CARLOS III   (Spain)

^cj INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^ck MASSACHUSETTS GENERAL HOSPITAL   (United States)

^cl UNIVERSITY OF TEXAS   (United States)

^cm BAYLOR COLLEGE OF MEDICINE   (United States)

^cn UNIVERSITY OF MINNESOTA   (United States)

^co Netherlands Genomics Initiative   (Netherlands)

^cp UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^cq UNIVERSITY OF OULU   (Finland)

^cr OULU UNIVERSITY HOSPITAL   (Finland)

^cs SOUTH OSTROBOTHNIA CENTRAL HOSPITAL   (Finland)

^ct Finnish Diabetes Association   (Finland)

^cu PIRKANMAA HOSPITAL DISTRICT   (Finland)

^cv Central Finland Central Hospital   (Finland)

^cw UNIVERSITY OF TARTU   (Estonia)

^cx UNIVERSITY HOSPITAL ULM   (Germany)

^cy NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^cz CEDARS SINAI MEDICAL CENTER   (United States)

^da UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^db MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^dc HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^dd DANUBE UNIVERSITY KREMS   (Austria)

^de KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^df UNIVERSITY OF TROMSØ   (Norway)

^dg QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^dh UNIVERSITY OF OXFORD   (United Kingdom)

^di CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^dj MCGILL UNIVERSITY   (Canada)

^dk UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^dl UNIVERSITY OF EDINBURGH   (United Kingdom)

^dm UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^dn Institute of Metabolic Science ^*  (United Kingdom)

^do UNIVERSITY OF LIVERPOOL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 3BETA; FOXA2 PROTEIN, HUMAN; MELATONIN 2 RECEPTOR;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENHANCER REGION; GENE CONTROL; GENE MAPPING; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE MAP; HEPG2 CELL LINE; HUMAN; HUMAN CELL; INSULIN RELEASE; LIVER CELL; LOSS OF FUNCTION MUTATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; BINDING SITE; CASE CONTROL STUDY; CHROMOSOMAL MAPPING; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; LIVER; METABOLISM; MOLECULAR GENETICS; PANCREAS ISLET; PATHOLOGY;

BINDING SITES; CASE-CONTROL STUDIES; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; ISLETS OF LANGERHANS; LIVER; MOLECULAR SEQUENCE ANNOTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELATONIN, MT2;

EID: 84948984088     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3437     Document Type: Article

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