Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice

Journal of Clinical Investigation

Volumn 121, Issue 9, 2011, Pages 3598-3608

  Wei, Fan Yan ^a   Suzuki, Takeo ^b   Watanabe, Sayaka ^a   Kimura, Satoshi ^b   Kaitsuka, Taku ^a   Fujimura, Atsushi ^c   Matsui, Hideki ^c   Atta, Mohamed ^d   Michiue, Hiroyuki ^c   Fontecave, Marc ^d   Yamagata, Kazuya ^a   Suzuki, Tsutomu ^b   Tomizawa, Kazuhito ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIO N6 THREONYLCARBAMOYLADENOSINE; ADENOSINE; CYCLIN DEPENDENT KINASE 5; PROTEIN CDKA11; TRANSFER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CODON; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; UPREGULATION;

ADENOSINE; ANIMALS; CELL LINE; CYCLIN-DEPENDENT KINASE 5; DIABETES MELLITUS, TYPE 2; GENES, REPORTER; GLUCAGON; GLUCOSE; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEIC ACID CONFORMATION; PROINSULIN; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; RNA, TRANSFER, AMINO ACYL; THREONINE;

EID: 80052375980     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58056     Document Type: Article

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