The importance of synthetic associations will only be resolved empirically

PLoS Biology

Volumn 9, Issue 1, 2011, Pages

  Goldstein, David B ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COPY NUMBER VARIATION; DIAGNOSTIC VALUE; DISEASE PREDISPOSITION; EFFECT SIZE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN GENOME; LINKAGE ANALYSIS; MUTATIONAL ANALYSIS; PROGNOSIS; SAMPLE SIZE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; EMPIRICAL RESEARCH; GENETIC LINKAGE; NOTE;

EMPIRICAL RESEARCH; GENETIC LINKAGE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS;

EID: 79851487366     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001008     Document Type: Article

References (10)

1. Pritchard J. K (2001) Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 69: 124-137.
2. Reich D. E, Lander E. S (2001) On the allelic spectrum of human disease. Trends Genet 17: 502-510.
3. Manolio T. A, Collins F. S, Cox N. J, Goldstein D. B, Hindorff L. A (2009) Finding the missing heritability of complex diseases. Nature 461: 747-753.
4. Merikangas A. K, Corvin A. P, Gallagher L (2009) Copy-number variants in neurodevelopmental disorders: promises and challenges. Trends Genet 25: 536-544.
5. Dickson S. P, Wang K, Krantz I, Hakonarson H, Goldstein D. B (2010) Rare variants create synthetic genome-wide associations. PLoS Biol 8: e1000294 doi:10.1371/journal.pbio.1000294.
6. Nothen M. M, Nieratschker V, Cichon S, Rietschel M (2010) New findings in the genetics of major psychoses. Dialogues Clin Neurosci 12: 85-93.
7. Teslovich T. M, Musunuru K, Smith A. V, Edmondson A. C, Stylianou I. M (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466: 707-713.
8. Speliotes E. K, Willer C. J, Berndt S. I, Monda K. L, Thorleifsson G (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
9. Lango Allen H, Estrada K, Lettre G, Berndt S. I, Weedon M. N (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467: 832-838.
10. Purcell S. M, Wray N. R, Stone J. L, Visscher P.M, et al. (2009) International Schizophrenia Consortium Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748-752.