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Volumn 12, Issue 4, 2015, Pages 747-768

Cannabinoids and Epilepsy

Author keywords

cannabidiol; cannabinoids; cannabis; Epilepsy; seizures; THC

Indexed keywords

CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABIS; DRONABINOL; ENDOCANNABINOID; ANTICONVULSIVE AGENT;

EID: 84973890794     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-015-0375-5     Document Type: Review
Times cited : (175)

References (338)
  • 1
    • 16344387731 scopus 로고    scopus 로고
    • Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    • PID: 15816939
    • Fisher RS, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005;46:470-472.
    • (2005) Epilepsia , vol.46 , pp. 470-472
    • Fisher, R.S.1
  • 2
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • COI: 1:STN:280:DC%2BD3c7gs1KqtQ%3D%3D, PID: 10660394
    • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314-319.
    • (2000) N Engl J Med , vol.342 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 3
    • 0036265042 scopus 로고    scopus 로고
    • Refractory epilepsy: a progressive, intractable but preventable condition?
    • PID: 11945093
    • Kwan P, Brodie MJ. Refractory epilepsy: a progressive, intractable but preventable condition? Seizure 2002;11:77-84.
    • (2002) Seizure , vol.11 , pp. 77-84
    • Kwan, P.1    Brodie, M.J.2
  • 4
    • 80052592003 scopus 로고    scopus 로고
    • Drug-resistant epilepsy
    • COI: 1:CAS:528:DC%2BC3MXhtFKhsLnE, PID: 21899452
    • Kwan P, Schachter SC, Brodie MJ. Drug-resistant epilepsy. N Engl J Med 2011; 365:919-926.
    • (2011) N Engl J Med , vol.365 , pp. 919-926
    • Kwan, P.1    Schachter, S.C.2    Brodie, M.J.3
  • 5
    • 0033550997 scopus 로고    scopus 로고
    • Risk factors for sudden unexpected death in epilepsy: a case–control study
    • COI: 1:STN:280:DyaK1M7ptFOksg%3D%3D, PID: 10093982
    • Nilsson L, et al. Risk factors for sudden unexpected death in epilepsy: a case–control study. Lancet 1999;353:888-893.
    • (1999) Lancet , vol.353 , pp. 888-893
    • Nilsson, L.1
  • 6
    • 0035957118 scopus 로고    scopus 로고
    • Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study
    • COI: 1:STN:280:DC%2BD3M7ps1KgsQ%3D%3D, PID: 11222798
    • Walczak TS, et al. Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology 2001;56:519-525.
    • (2001) Neurology , vol.56 , pp. 519-525
    • Walczak, T.S.1
  • 7
    • 0033586952 scopus 로고    scopus 로고
    • Patients with refractory seizures
    • COI: 1:STN:280:DyaK1M3kslKkuw%3D%3D, PID: 10332020
    • Devinsky O. Patients with refractory seizures. N Engl J Med 1999;340:1565-1570.
    • (1999) N Engl J Med , vol.340 , pp. 1565-1570
    • Devinsky, O.1
  • 8
    • 40949099179 scopus 로고    scopus 로고
    • Quality-of-life trajectories in epilepsy: a review of the literature
    • PID: 18158270
    • Jacoby A, Baker GA. Quality-of-life trajectories in epilepsy: a review of the literature. Epilepsy Behav 2008;12:557-571.
    • (2008) Epilepsy Behav , vol.12 , pp. 557-571
    • Jacoby, A.1    Baker, G.A.2
  • 9
    • 84880326639 scopus 로고    scopus 로고
    • The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs
    • COI: 1:CAS:528:DC%2BC3sXpt1CgsLw%3D, PID: 23646969
    • Rogawski MA. The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs. Epilepsia 2013;54(Suppl. 2):33-40.
    • (2013) Epilepsia , vol.54 , pp. 33-40
    • Rogawski, M.A.1
  • 10
    • 0034100739 scopus 로고    scopus 로고
    • Is there a role for therapeutic drug monitoring of new anticonvulsants?
    • COI: 1:CAS:528:DC%2BD3cXisVent74%3D, PID: 10749516
    • Perucca E. Is there a role for therapeutic drug monitoring of new anticonvulsants? Clin Pharmacokinet 2000;38:191-204.
    • (2000) Clin Pharmacokinet , vol.38 , pp. 191-204
    • Perucca, E.1
  • 11
    • 84902304606 scopus 로고    scopus 로고
    • Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
    • COI: 1:CAS:528:DC%2BC2cXpslKgtL8%3D, PID: 24854329
    • Devinsky O, et al. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia 2014;55:791-802.
    • (2014) Epilepsia , vol.55 , pp. 791-802
    • Devinsky, O.1
  • 12
    • 84902171176 scopus 로고    scopus 로고
    • Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology
    • PID: 24778283
    • Koppel BS, et al. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2014;82:1556-63.
    • (2014) Neurology , vol.82 , pp. 1556-1563
    • Koppel, B.S.1
  • 15
    • 57149125651 scopus 로고    scopus 로고
    • Phytochemical and genetic analyses of ancient cannabis from Central Asia
    • COI: 1:CAS:528:DC%2BD1cXhsVCgt7zE, PID: 19036842
    • Russo EB, et al. Phytochemical and genetic analyses of ancient cannabis from Central Asia. J Exp Bot 2008;59:4171-4182.
    • (2008) J Exp Bot , vol.59 , pp. 4171-4182
    • Russo, E.B.1
  • 16
    • 84947769162 scopus 로고    scopus 로고
    • The therapeutic use of Cannabis sativa L. in Arabic medicine
    • Lozano I. The therapeutic use of Cannabis sativa L. in Arabic medicine. J Cannabis Ther 2001;1:63-70.
    • (2001) J Cannabis Ther , vol.1 , pp. 63-70
    • Lozano, I.1
  • 17
    • 84918584560 scopus 로고    scopus 로고
    • Cannabis, cannabidiol, and epilepsy—from receptors to clinical response
    • PID: 25282526
    • Szaflarski JP, Bebin EM. Cannabis, cannabidiol, and epilepsy—from receptors to clinical response. Epilepsy Behav 2014;41:277-282.
    • (2014) Epilepsy Behav , vol.41 , pp. 277-282
    • Szaflarski, J.P.1    Bebin, E.M.2
  • 18
    • 0004222283 scopus 로고
    • On the preparations of the Indian hemp, or Gunjah
    • O’Shaughnessy WB. On the preparations of the Indian hemp, or Gunjah. Prov Med J Retrosp Med Sci 1843;5:363-369.
    • (1843) Prov Med J Retrosp Med Sci , vol.5 , pp. 363-369
    • O’Shaughnessy, W.B.1
  • 19
    • 84973857108 scopus 로고
    • Epilepsy: its symptoms, treatment, and relation to other chronic convulsive diseases. J
    • Reynolds JR. Epilepsy: its symptoms, treatment, and relation to other chronic convulsive diseases. J. Churchill (Ed.) London, 1861.
    • (1861) Churchill (Ed.) London
    • Reynolds, J.R.1
  • 20
    • 84973931158 scopus 로고
    • Epilepsy and other chronic convulsive disorders
    • Gowers W. Epilepsy and other chronic convulsive disorders. Churchill (Ed.) London, 1881.
    • (1881) Churchill (Ed.) London
    • Gowers, W.1
  • 21
    • 33947489961 scopus 로고
    • Isolation, structure, and partial synthesis of an active constituent of hashish
    • COI: 1:CAS:528:DyaF2cXkt1GhtLs%3D
    • Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964;86:1646-1647.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 22
    • 0015221354 scopus 로고
    • The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish
    • Gaoni Y, Mechoulam R. The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish. J Am Chem Soc 1971;9:217-224.
    • (1971) J Am Chem Soc , vol.9 , pp. 217-224
    • Gaoni, Y.1    Mechoulam, R.2
  • 23
    • 0342946669 scopus 로고
    • Isolation of cannabinol, cannabidiol, and quebrachitrol from red oil of Minnesota wild hemp
    • COI: 1:CAS:528:DyaH3cXktlarsg%3D%3D
    • Adams R, Pease DC, Clark JH. Isolation of cannabinol, cannabidiol, and quebrachitrol from red oil of Minnesota wild hemp. J Am Chem Soc 1940;62: 2194-2196.
    • (1940) J Am Chem Soc , vol.62 , pp. 2194-2196
    • Adams, R.1    Pease, D.C.2    Clark, J.H.3
  • 24
    • 0013768939 scopus 로고
    • The structure of cannabidiol
    • COI: 1:STN:280:DyaF1c%2FlsVentA%3D%3D, PID: 5879214
    • Michoulam R, Shvo Y., Hashish, I. The structure of cannabidiol. Tetrahedron 1963; 19:2073-2078.
    • (1963) Tetrahedron , vol.19 , pp. 2073-2078
    • Michoulam, R.1    Shvo, Y.2    Hashish, I.3
  • 25
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • COI: 1:CAS:528:DyaK3cXls1Ghu7w%3D, PID: 2165569
    • Matsuda LA, et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1
  • 26
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • COI: 1:CAS:528:DyaK3sXmsVWiurk%3D, PID: 7689702
    • Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 27
    • 0026088941 scopus 로고
    • Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices
    • COI: 1:STN:280:DyaK3M3hsl2ntQ%3D%3D, PID: 1673717
    • Llano I, et al. Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J Physiol 1991;434:183-213.
    • (1991) J Physiol , vol.434 , pp. 183-213
    • Llano, I.1
  • 28
    • 0026707813 scopus 로고
    • A responses in hippocampal pyramidal cells
    • COI: 1:CAS:528:DyaK38Xmt1Krtbk%3D, PID: 1403103
    • A responses in hippocampal pyramidal cells. J Neurosci 1992;12:4122-4132.
    • (1992) J Neurosci , vol.12 , pp. 4122-4132
    • Pitler, T.A.1    Alger, B.E.2
  • 29
    • 0035053627 scopus 로고    scopus 로고
    • Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
    • COI: 1:CAS:528:DC%2BD3MXis1KjtrY%3D, PID: 11301030
    • Kreitzer AC, Regehr WG. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 2001;29:717-727.
    • (2001) Neuron , vol.29 , pp. 717-727
    • Kreitzer, A.C.1    Regehr, W.G.2
  • 30
    • 0035888999 scopus 로고    scopus 로고
    • Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids
    • COI: 1:STN:280:DC%2BD3MrktFemtg%3D%3D, PID: 11588204
    • Kreitzer AC, Regehr WG. Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J Neurosci 2001;21:RC174.
    • (2001) J Neurosci , vol.21 , pp. RC174
    • Kreitzer, A.C.1    Regehr, W.G.2
  • 31
    • 0035899302 scopus 로고    scopus 로고
    • Presynaptic specificity of endocannabinoid signaling in the hippocampus
    • COI: 1:CAS:528:DC%2BD3MXmsVeisr8%3D, PID: 11516401
    • Wilson RI, Kunos G, Nicoll RA. Presynaptic specificity of endocannabinoid signaling in the hippocampus. Neuron 2001;31:453-462.
    • (2001) Neuron , vol.31 , pp. 453-462
    • Wilson, R.I.1    Kunos, G.2    Nicoll, R.A.3
  • 32
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • COI: 1:CAS:528:DyaK3sXpvVKntg%3D%3D, PID: 1470919
    • Devane WA, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992;258:1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1
  • 33
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • COI: 1:CAS:528:DyaK2MXmsl2ks7Y%3D, PID: 7605349
    • Mechoulam R, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995;50:83-90.
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1
  • 34
    • 0028970517 scopus 로고
    • 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain
    • COI: 1:CAS:528:DyaK2MXosVyqtLk%3D, PID: 7575630
    • Sugiura T, et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 1995;215:89-97.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 89-97
    • Sugiura, T.1
  • 35
    • 0036867665 scopus 로고    scopus 로고
    • Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
    • COI: 1:CAS:528:DC%2BD38Xps12ksrw%3D, PID: 12498988
    • Alger BE. Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids. Prog Neurobiol 2002;68:247-286.
    • (2002) Prog Neurobiol , vol.68 , pp. 247-286
    • Alger, B.E.1
  • 36
    • 0141653887 scopus 로고    scopus 로고
    • Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids
    • COI: 1:CAS:528:DC%2BD3sXnsFamtbc%3D, PID: 14502290
    • Brown SP, Brenowitz SD, Regehr WG. Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids. Nat Neurosci 2003;6:1048-1057.
    • (2003) Nat Neurosci , vol.6 , pp. 1048-1057
    • Brown, S.P.1    Brenowitz, S.D.2    Regehr, W.G.3
  • 37
    • 0034930170 scopus 로고    scopus 로고
    • Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals
    • COI: 1:CAS:528:DC%2BD3MXltVehs74%3D, PID: 11448511
    • Maejima T, Ohno-Shosaku T, Kano M. Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals. Neurosci Res 2001;40:205-210.
    • (2001) Neurosci Res , vol.40 , pp. 205-210
    • Maejima, T.1    Ohno-Shosaku, T.2    Kano, M.3
  • 38
    • 9344228468 scopus 로고    scopus 로고
    • Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons
    • COI: 1:CAS:528:DC%2BD2cXhtVKls7%2FO, PID: 15564588
    • Melis M, et al. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci 2004;24:10707-10715.
    • (2004) J Neurosci , vol.24 , pp. 10707-10715
    • Melis, M.1
  • 39
    • 51349141952 scopus 로고    scopus 로고
    • Endocannabinoid signaling as a synaptic circuit breaker in neurological disease
    • COI: 1:CAS:528:DC%2BD1cXhtVyms7vM, PID: 18776886
    • Katona I, Freund TF. Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nat Med 2008;14:923-930.
    • (2008) Nat Med , vol.14 , pp. 923-930
    • Katona, I.1    Freund, T.F.2
  • 40
    • 0028589390 scopus 로고
    • Formation and inactivation of endogenous cannabinoid anandamide in central neurons
    • PID: 7990962
    • Di Marzo V, et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 1994;372:686-691.
    • (1994) Nature , vol.372 , pp. 686-691
    • Di Marzo, V.1
  • 41
    • 0032459475 scopus 로고    scopus 로고
    • Biochemistry of the endogenous ligands of cannabinoid receptors
    • PID: 9974173
    • Di Marzo V, Deutsch DG. Biochemistry of the endogenous ligands of cannabinoid receptors. Neurobiol Dis 1998;5:386-404.
    • (1998) Neurobiol Dis , vol.5 , pp. 386-404
    • Di Marzo, V.1    Deutsch, D.G.2
  • 42
    • 0032401036 scopus 로고    scopus 로고
    • Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
    • PID: 9881850
    • Di Marzo V, et al. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci 1998;21:521-528.
    • (1998) Trends Neurosci , vol.21 , pp. 521-528
    • Di Marzo, V.1
  • 43
    • 0036019386 scopus 로고    scopus 로고
    • Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
    • COI: 1:CAS:528:DC%2BD38Xlt1Kksr8%3D, PID: 12052034
    • Sugiura T, et al. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids 2002;66:173-192.
    • (2002) Prostaglandins Leukot Essent Fatty Acids , vol.66 , pp. 173-192
    • Sugiura, T.1
  • 44
    • 0030870722 scopus 로고    scopus 로고
    • A second endogenous cannabinoid that modulates long-term potentiation
    • COI: 1:CAS:528:DyaK2sXls1Gqs7w%3D, PID: 9285589
    • Stella N, Schweitzer P, Piomelli D. A second endogenous cannabinoid that modulates long-term potentiation. Nature 1997;388:773-778.
    • (1997) Nature , vol.388 , pp. 773-778
    • Stella, N.1    Schweitzer, P.2    Piomelli, D.3
  • 45
    • 0033921628 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
    • COI: 1:CAS:528:DC%2BD3cXkslKmu7c%3D, PID: 11060760
    • Pertwee RG. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. Expert Opin Investig Drugs 2000;9:1553-1571.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 1553-1571
    • Pertwee, R.G.1
  • 46
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients - RIO-North America: A randomized controlled trial
    • COI: 1:CAS:528:DC%2BD28XhsFOrs7g%3D, PID: 16478899
    • Pi-Sunyer F, et al. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients - RIO-North America: A randomized controlled trial. JAMA 2006;295:761-775.
    • (2006) JAMA , vol.295 , pp. 761-775
    • Pi-Sunyer, F.1
  • 47
    • 36749075981 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation
    • Cahill K, Ussher M. Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database Syst Rev 2007:CD005353.
    • (2007) Cochrane Database Syst Rev , pp. CD005353
    • Cahill, K.1    Ussher, M.2
  • 48
    • 0030857066 scopus 로고    scopus 로고
    • Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor
    • COI: 1:CAS:528:DyaK2sXksVSgurw%3D, PID: 9204917
    • Glass M,. Felder CC. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J Neurosci 1997;17:5327-5333.
    • (1997) J Neurosci , vol.17 , pp. 5327-5333
    • Glass, M.1    Felder, C.C.2
  • 49
    • 0026603679 scopus 로고
    • Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
    • COI: 1:CAS:528:DyaK38Xkt1SgsL0%3D, PID: 1315042
    • Mackie K, Hille B. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc Natl Acad Sci U S A 1992;89:3825-3829.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 3825-3829
    • Mackie, K.1    Hille, B.2
  • 50
    • 0026577311 scopus 로고
    • Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism
    • COI: 1:CAS:528:DyaK38Xks1arsL0%3D, PID: 1327374
    • Caulfield MP, Brown DA. Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism. Br J Pharmacol 1992;106:231-232.
    • (1992) Br J Pharmacol , vol.106 , pp. 231-232
    • Caulfield, M.P.1    Brown, D.A.2
  • 51
    • 0030746408 scopus 로고    scopus 로고
    • Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
    • COI: 1:CAS:528:DyaK2sXltl2is7Y%3D, PID: 9242259
    • Twitchell W, Brown S, Mackie K. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 1997;78:43-50.
    • (1997) J Neurophysiol , vol.78 , pp. 43-50
    • Twitchell, W.1    Brown, S.2    Mackie, K.3
  • 52
    • 84901749087 scopus 로고    scopus 로고
    • Presynaptic calcium channel inhibition underlies CB(1) cannabinoid receptor-mediated suppression of GABA release
    • COI: 1:CAS:528:DC%2BC2cXps12qsbY%3D, PID: 24899717
    • Szabo GG, et al. Presynaptic calcium channel inhibition underlies CB(1) cannabinoid receptor-mediated suppression of GABA release. J Neurosci 2014;34:7958-7963.
    • (2014) J Neurosci , vol.34 , pp. 7958-7963
    • Szabo, G.G.1
  • 53
    • 0027875020 scopus 로고
    • Cannabinoids modulate potassium current in cultured hippocampal neurons
    • COI: 1:CAS:528:DyaK2cXhsFemsL4%3D, PID: 8081716
    • Deadwyler SA, et al. Cannabinoids modulate potassium current in cultured hippocampal neurons. Receptors Channels 1993;1:121-134.
    • (1993) Receptors Channels , vol.1 , pp. 121-134
    • Deadwyler, S.A.1
  • 54
    • 0029071194 scopus 로고
    • Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process
    • COI: 1:CAS:528:DyaK2MXlslanurc%3D, PID: 7538581
    • Deadwyler SA, et al. Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process. J Pharmacol Exp Ther 1995;273:734-743.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 734-743
    • Deadwyler, S.A.1
  • 55
    • 0029044912 scopus 로고
    • Role of cyclic AMP dependent protein kinase in cannabinoid receptor modulation of potassium "A-current" in cultured rat hippocampal neurons
    • COI: 1:CAS:528:DyaK2MXlsF2mtbg%3D, PID: 7776835
    • Hampson RE, et al. Role of cyclic AMP dependent protein kinase in cannabinoid receptor modulation of potassium "A-current" in cultured rat hippocampal neurons. Life Sci 1995;56:2081-2088.
    • (1995) Life Sci , vol.56 , pp. 2081-2088
    • Hampson, R.E.1
  • 56
    • 0034058480 scopus 로고    scopus 로고
    • Protein kinase-dependent phosphorylation and cannabinoid receptor modulation of potassium A current (IA) in cultured rat hippocampal neurons
    • COI: 1:CAS:528:DC%2BD3cXhvFCns7o%3D, PID: 10764212
    • Mu J, et al. Protein kinase-dependent phosphorylation and cannabinoid receptor modulation of potassium A current (IA) in cultured rat hippocampal neurons. Pflugers Arch 2000;439:541-546.
    • (2000) Pflugers Arch , vol.439 , pp. 541-546
    • Mu, J.1
  • 57
    • 0028928974 scopus 로고
    • Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes
    • COI: 1:CAS:528:DyaK2MXjvF2msrY%3D, PID: 7777206
    • Henry DJ, Chavkin C. Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes. Neurosci Lett 1995;186:91-94.
    • (1995) Neurosci Lett , vol.186 , pp. 91-94
    • Henry, D.J.1    Chavkin, C.2
  • 58
    • 0028823316 scopus 로고
    • Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
    • COI: 1:CAS:528:DyaK2MXovFWhtbY%3D, PID: 7472417
    • Mackie K, et al. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor. J Neurosci 1995;15:6552-6561.
    • (1995) J Neurosci , vol.15 , pp. 6552-6561
    • Mackie, K.1
  • 59
    • 0032696104 scopus 로고    scopus 로고
    • Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system
    • COI: 1:CAS:528:DyaK1MXntFChtLs%3D, PID: 10525080
    • McAllister SD, et al. Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system. J Pharmacol Exp Ther 1999;291:618-626.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 618-626
    • McAllister, S.D.1
  • 60
    • 33645227423 scopus 로고    scopus 로고
    • G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties
    • COI: 1:CAS:528:DC%2BD28XivFWhs78%3D, PID: 16537522
    • Photowala H, et al. G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties. Proc Natl Acad Sci U S A 2006;103:4281-4286.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4281-4286
    • Photowala, H.1
  • 61
    • 0035499974 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic cannabinoid receptors
    • COI: 1:CAS:528:DC%2BD3MXotFSmsbk%3D, PID: 11698100
    • Schlicker E, Kathmann M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 2001;22:565-572.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 565-572
    • Schlicker, E.1    Kathmann, M.2
  • 62
    • 33745706730 scopus 로고    scopus 로고
    • Endocannabinoid-mediated synaptic plasticity in the CNS
    • COI: 1:CAS:528:DC%2BD28XosVeisbg%3D, PID: 16776579
    • Chevaleyre V, Takahashi KA, Castillo PE. Endocannabinoid-mediated synaptic plasticity in the CNS. Annu Rev Neurosci 2006;29:37-76.
    • (2006) Annu Rev Neurosci , vol.29 , pp. 37-76
    • Chevaleyre, V.1    Takahashi, K.A.2    Castillo, P.E.3
  • 63
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • COI: 1:CAS:528:DC%2BD3sXosFOktrY%3D, PID: 14595399
    • Piomelli D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 2003;4:873-884.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 64
    • 0345621691 scopus 로고    scopus 로고
    • Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
    • COI: 1:CAS:528:DyaK1MXjsFahtb8%3D, PID: 10341254
    • Katona I, et al. Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci 1999; 19:4544-4558.
    • (1999) J Neurosci , vol.19 , pp. 4544-4558
    • Katona, I.1
  • 65
    • 0033452718 scopus 로고    scopus 로고
    • Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
    • COI: 1:STN:280:DC%2BD3c%2Fmt1Crug%3D%3D, PID: 10594647
    • Marsicano G, Lutz B. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur J Neurosci 1999;11: 4213-4225.
    • (1999) Eur J Neurosci , vol.11 , pp. 4213-4225
    • Marsicano, G.1    Lutz, B.2
  • 66
    • 84926213695 scopus 로고    scopus 로고
    • Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling
    • COI: 1:CAS:528:DC%2BC2cXitVCksr%2FJ, PID: 25485758
    • Dudok B, et al. Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling. Nat Neurosci 2015;18:75-86.
    • (2015) Nat Neurosci , vol.18 , pp. 75-86
    • Dudok, B.1
  • 67
    • 33644934527 scopus 로고    scopus 로고
    • The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum
    • COI: 1:CAS:528:DC%2BD28XivFKmur4%3D, PID: 16540577
    • Kawamura Y, et al. The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum. J Neurosci 2006;26:2991-3001.
    • (2006) J Neurosci , vol.26 , pp. 2991-3001
    • Kawamura, Y.1
  • 68
    • 33744974528 scopus 로고    scopus 로고
    • Molecular composition of the endocannabinoid system at glutamatergic synapses
    • COI: 1:CAS:528:DC%2BD28XlsVOjsb4%3D, PID: 16723519
    • Katona I, et al. Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci 2006;26:5628-5637.
    • (2006) J Neurosci , vol.26 , pp. 5628-5637
    • Katona, I.1
  • 69
    • 40249107796 scopus 로고    scopus 로고
    • Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex
    • PID: 17684555
    • Lafourcade M, et al. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS One 2007;2:e709.
    • (2007) PLoS One , vol.2
    • Lafourcade, M.1
  • 70
    • 34447635408 scopus 로고    scopus 로고
    • Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus
    • COI: 1:CAS:528:DC%2BD2sXhtFOksrrL, PID: 17492633
    • Wittmann G, et al. Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J Comp Neurol 2007;503:270-279.
    • (2007) J Comp Neurol , vol.503 , pp. 270-279
    • Wittmann, G.1
  • 71
    • 0035141529 scopus 로고    scopus 로고
    • Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens
    • COI: 1:CAS:528:DC%2BD3MXmtVOhtQ%3D%3D, PID: 11150326
    • Robbe D, et al. Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens. J Neurosci 2001;21:109-116.
    • (2001) J Neurosci , vol.21 , pp. 109-116
    • Robbe, D.1
  • 72
    • 27844525479 scopus 로고    scopus 로고
    • Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    • COI: 1:CAS:528:DC%2BD2MXht1ejsrfJ, PID: 16199061
    • Elsohly MA, Slade D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci 2005;78:539-548.
    • (2005) Life Sci , vol.78 , pp. 539-548
    • Elsohly, M.A.1    Slade, D.2
  • 74
    • 0035048803 scopus 로고    scopus 로고
    • Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716
    • COI: 1:STN:280:DC%2BD3M3itVGitA%3D%3D, PID: 11296091
    • Huestis MA, et al. Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716. Arch Gen Psychiatry 2001;58:322-328.
    • (2001) Arch Gen Psychiatry , vol.58 , pp. 322-328
    • Huestis, M.A.1
  • 75
    • 0030036308 scopus 로고    scopus 로고
    • Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism
    • COI: 1:CAS:528:DyaK28XlsFKrsbs%3D
    • Lichtman AH, Martin BR. Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology (Berl) 1996;126: 125-131.
    • (1996) Psychopharmacology (Berl) , vol.126 , pp. 125-131
    • Lichtman, A.H.1    Martin, B.R.2
  • 76
    • 0031593783 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide
    • COI: 1:CAS:528:DyaK1cXnvFOksrY%3D
    • Mallet PE, Beninger RJ. The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. Psychopharmacology (Berl) 1998;140:11-19.
    • (1998) Psychopharmacology (Berl) , vol.140 , pp. 11-19
    • Mallet, P.E.1    Beninger, R.J.2
  • 77
    • 0034871808 scopus 로고    scopus 로고
    • Differential effects of delta 9-THC on spatial reference and working memory in mice
    • COI: 1:CAS:528:DC%2BD3MXns1Whs7o%3D
    • Varvel SA, et al. Differential effects of delta 9-THC on spatial reference and working memory in mice. Psychopharmacology (Berl) 2001;157:142-150.
    • (2001) Psychopharmacology (Berl) , vol.157 , pp. 142-150
    • Varvel, S.A.1
  • 78
    • 0036138804 scopus 로고    scopus 로고
    • SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice
    • PID: 11817511
    • Da S, Takahashi RN. SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:321-325.
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry , vol.26 , pp. 321-325
    • Da, S.1    Takahashi, R.N.2
  • 79
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • COI: 1:CAS:528:DC%2BD28XitFSitL4%3D, PID: 16306385
    • Pagotto U, et al. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 2006;27:73-100.
    • (2006) Endocr Rev , vol.27 , pp. 73-100
    • Pagotto, U.1
  • 80
    • 0035979606 scopus 로고    scopus 로고
    • Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity
    • COI: 1:CAS:528:DC%2BD3MXmtFWis78%3D, PID: 11514075
    • Abood ME, et al. Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity. Neurosci Lett 2001;309:197-201.
    • (2001) Neurosci Lett , vol.309 , pp. 197-201
    • Abood, M.E.1
  • 81
    • 0035437865 scopus 로고    scopus 로고
    • Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity
    • PID: 11517236
    • van der Stelt M, et al. Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. J Neurosci 2001;21:6475-6479.
    • (2001) J Neurosci , vol.21 , pp. 6475-6479
    • van der Stelt, M.1
  • 82
    • 0142151067 scopus 로고    scopus 로고
    • Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
    • COI: 1:CAS:528:DC%2BD3sXpsVWltbc%3D, PID: 14578199
    • El-Remessy AB, et al. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. Am J Pathol 2003;163:1997-2008.
    • (2003) Am J Pathol , vol.163 , pp. 1997-2008
    • El-Remessy, A.B.1
  • 83
    • 0036156353 scopus 로고    scopus 로고
    • Cannabinoids and brain injury: therapeutic implications
    • COI: 1:CAS:528:DC%2BD38XhsFaitbs%3D, PID: 11815270
    • Mechoulam R, Panikashvili D, Shohami E. Cannabinoids and brain injury: therapeutic implications. Trends Mol Med 2002;8:58-61.
    • (2002) Trends Mol Med , vol.8 , pp. 58-61
    • Mechoulam, R.1    Panikashvili, D.2    Shohami, E.3
  • 84
    • 33846066404 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
    • COI: 1:CAS:528:DC%2BD2sXls1WmsQ%3D%3D, PID: 17140550
    • Gilbert GL, et al. Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity. Brain Res 2007;1128:61-69.
    • (2007) Brain Res , vol.1128 , pp. 61-69
    • Gilbert, G.L.1
  • 85
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • COI: 1:CAS:528:DyaK1MXitlGnur0%3D, PID: 10191316
    • Nagayama T, et al. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci 1999;19:2987-2995.
    • (1999) J Neurosci , vol.19 , pp. 2987-2995
    • Nagayama, T.1
  • 86
    • 36949015383 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors
    • COI: 1:CAS:528:DC%2BD2sXhsVSlsL3J, PID: 17965746
    • Zani A, et al. Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors. Br J Pharmacol 2007;152:1301-1311.
    • (2007) Br J Pharmacol , vol.152 , pp. 1301-1311
    • Zani, A.1
  • 87
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • COI: 1:CAS:528:DyaK1cXks1SltL0%3D, PID: 9653176
    • Hampson AJ, et al. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 1998;95:8268-8273.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8268-8273
    • Hampson, A.J.1
  • 88
    • 0030795910 scopus 로고    scopus 로고
    • Anandamide suppresses nitric oxide and TNF-alpha responses to Theiler's virus or endotoxin in astrocytes
    • COI: 1:CAS:528:DyaK2sXks1Cis7w%3D, PID: 9223079
    • Molina-Holgado F, Lledo A, Guaza C. Anandamide suppresses nitric oxide and TNF-alpha responses to Theiler's virus or endotoxin in astrocytes. Neuroreport 1997;8:1929-1933.
    • (1997) Neuroreport , vol.8 , pp. 1929-1933
    • Molina-Holgado, F.1    Lledo, A.2    Guaza, C.3
  • 89
    • 0037085572 scopus 로고    scopus 로고
    • Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures
    • COI: 1:CAS:528:DC%2BD38XitFCgtLo%3D, PID: 11891798
    • Molina-Holgado F, et al. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. J Neurosci Res 2002;67:829-836.
    • (2002) J Neurosci Res , vol.67 , pp. 829-836
    • Molina-Holgado, F.1
  • 90
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    • COI: 1:CAS:528:DyaK2sXhslansA%3D%3D, PID: 9042110
    • Shohami E, et al. Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J Neuroimmunol 1997;72:169-177.
    • (1997) J Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1
  • 91
    • 0033986604 scopus 로고    scopus 로고
    • Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells
    • COI: 1:STN:280:DC%2BD3c%2Fmt1Orsg%3D%3D, PID: 10594923
    • Puffenbarger RA, Boothe AC, Cabral GA. Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells. Glia 2000;29:58-69.
    • (2000) Glia , vol.29 , pp. 58-69
    • Puffenbarger, R.A.1    Boothe, A.C.2    Cabral, G.A.3
  • 92
    • 0035676046 scopus 로고    scopus 로고
    • Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation
    • COI: 1:CAS:528:DC%2BD38Xmtlyku7o%3D, PID: 11727767
    • Cabral GA, Harmon KN, Carlisle SJ. Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation. Adv Exp Med Biol 2001;493:207-214.
    • (2001) Adv Exp Med Biol , vol.493 , pp. 207-214
    • Cabral, G.A.1    Harmon, K.N.2    Carlisle, S.J.3
  • 93
    • 29244478635 scopus 로고    scopus 로고
    • Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
    • PID: 16343349
    • Ehrhart J, et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2005;2:29.
    • (2005) J Neuroinflammation , vol.2 , pp. 29
    • Ehrhart, J.1
  • 94
    • 0033803432 scopus 로고    scopus 로고
    • The cannabinoid system and cytokine network
    • COI: 1:CAS:528:DC%2BD3cXntVSmsrw%3D, PID: 10998193
    • Klein TW, et al. The cannabinoid system and cytokine network. Proc Soc Exp Biol Med 2000;225:1-8.
    • (2000) Proc Soc Exp Biol Med , vol.225 , pp. 1-8
    • Klein, T.W.1
  • 95
    • 0041842648 scopus 로고    scopus 로고
    • Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia
    • COI: 1:CAS:528:DC%2BD3sXlvF2msbc%3D, PID: 12878687
    • Molina-Holgado F, et al. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J Neurosci 2003;23:6470-6474.
    • (2003) J Neurosci , vol.23 , pp. 6470-6474
    • Molina-Holgado, F.1
  • 96
    • 38349087528 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors in human brain inflammation
    • COI: 1:CAS:528:DC%2BD1cXovFCktg%3D%3D, PID: 17934510
    • Benito C, et al. Cannabinoid CB2 receptors in human brain inflammation. Br J Pharmacol 2008;153:277-285.
    • (2008) Br J Pharmacol , vol.153 , pp. 277-285
    • Benito, C.1
  • 97
    • 44249117614 scopus 로고    scopus 로고
    • Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
    • PID: 18354058
    • De Petrocellis L, et al. Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 2008;325:1007-1015.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 1007-1015
    • De Petrocellis, L.1
  • 98
    • 79960328574 scopus 로고    scopus 로고
    • Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    • PID: 21175579
    • De Petrocellis L, et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol 2011;163:1479-1494.
    • (2011) Br J Pharmacol , vol.163 , pp. 1479-1494
    • De Petrocellis, L.1
  • 99
    • 46749129338 scopus 로고    scopus 로고
    • TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons
    • COI: 1:CAS:528:DC%2BD1cXns1ynsr0%3D, PID: 18550765
    • Qin N, et al. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 2008;28:6231-6238.
    • (2008) J Neurosci , vol.28 , pp. 6231-6238
    • Qin, N.1
  • 100
    • 78651369895 scopus 로고    scopus 로고
    • The role of inflammation in epilepsy
    • COI: 1:CAS:528:DC%2BC3MXjs1OmtA%3D%3D, PID: 21135885
    • Vezzani A, et al. The role of inflammation in epilepsy. Nat Rev Neurol 2011;7:31-40.
    • (2011) Nat Rev Neurol , vol.7 , pp. 31-40
    • Vezzani, A.1
  • 101
    • 84864305538 scopus 로고    scopus 로고
    • Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?
    • PID: 22368518
    • Walker L, Sills GJ. Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy? Epilepsy Curr 2012;12:8-12.
    • (2012) Epilepsy Curr , vol.12 , pp. 8-12
    • Walker, L.1    Sills, G.J.2
  • 102
    • 84875235637 scopus 로고    scopus 로고
    • Glia and epilepsy: excitability and inflammation
    • COI: 1:CAS:528:DC%2BC3sXkt1aisw%3D%3D, PID: 23298414
    • Devinsky O, et al. Glia and epilepsy: excitability and inflammation. Trends Neurosci 2013;36:174-184.
    • (2013) Trends Neurosci , vol.36 , pp. 174-184
    • Devinsky, O.1
  • 103
    • 0031981037 scopus 로고    scopus 로고
    • Comparative receptor binding analyses of cannabinoid agonists and antagonists
    • COI: 1:CAS:528:DyaK1cXisVCqsLY%3D, PID: 9536023
    • Thomas BF, et al. Comparative receptor binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther 1998;285:285-292.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 285-292
    • Thomas, B.F.1
  • 104
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • COI: 1:CAS:528:DC%2BD3MXotlChsbk%3D, PID: 11606325
    • Bisogno T, et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 2001;134:845-852.
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1
  • 105
    • 36448995830 scopus 로고    scopus 로고
    • GPR55: a new member of the cannabinoid receptor clan?
    • COI: 1:CAS:528:DC%2BD2sXhtlCrsbnJ, PID: 17876300
    • Pertwee RG. GPR55: a new member of the cannabinoid receptor clan? Br J Pharmacol 2007;152:984-986.
    • (2007) Br J Pharmacol , vol.152 , pp. 984-986
    • Pertwee, R.G.1
  • 106
    • 76749110725 scopus 로고    scopus 로고
    • Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
    • COI: 1:CAS:528:DC%2BC3cXltVCkt7s%3D, PID: 19906779
    • Jones NA, et al. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. J Pharmacol Exp Ther 2010;332:569-577.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 569-577
    • Jones, N.A.1
  • 107
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • COI: 1:CAS:528:DC%2BD2MXhtFKmsbrE, PID: 16258853
    • Russo EB, et al. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 2005;30:1037-1043.
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1
  • 108
    • 59549106886 scopus 로고    scopus 로고
    • The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    • COI: 1:CAS:528:DC%2BD1MXjvFOntbg%3D, PID: 19204413
    • Ahrens J, et al. The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. Pharmacology 2009;83:217-222.
    • (2009) Pharmacology , vol.83 , pp. 217-222
    • Ahrens, J.1
  • 109
    • 47049091502 scopus 로고    scopus 로고
    • Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol
    • COI: 1:CAS:528:DC%2BD1cXmsFeqsr4%3D, PID: 18390906
    • Ross HR, Napier I, Connor M. Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol. J Biol Chem 2008;283: 16124-16134.
    • (2008) J Biol Chem , vol.283 , pp. 16124-16134
    • Ross, H.R.1    Napier, I.2    Connor, M.3
  • 110
    • 33645239301 scopus 로고    scopus 로고
    • Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells
    • COI: 1:CAS:528:DC%2BD28XivVOgtrc%3D, PID: 16386766
    • Drysdale AJ, et al. Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells. Neuropharmacology 2006;50:621-631.
    • (2006) Neuropharmacology , vol.50 , pp. 621-631
    • Drysdale, A.J.1
  • 111
    • 60849124534 scopus 로고    scopus 로고
    • Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels
    • COI: 1:CAS:528:DC%2BD1MXisV2hurw%3D, PID: 19228959
    • Ryan D, et al. Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels. J Neurosci 2009;29:2053-2063.
    • (2009) J Neurosci , vol.29 , pp. 2053-2063
    • Ryan, D.1
  • 112
    • 85027927333 scopus 로고    scopus 로고
    • The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells
    • COI: 1:CAS:528:DC%2BC3MXps1Wit70%3D, PID: 21533611
    • Rimmerman N, et al. The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells. Cell Mol Neurobiol 2011; 31:921-930.
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 921-930
    • Rimmerman, N.1
  • 113
    • 61349143694 scopus 로고    scopus 로고
    • The enigmatic pharmacology of GPR55
    • COI: 1:CAS:528:DC%2BD1MXivVGgurg%3D, PID: 19233486
    • Ross RA. The enigmatic pharmacology of GPR55. Trends Pharmacol Sci 2009;30: 156-163.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 156-163
    • Ross, R.A.1
  • 114
    • 35649015179 scopus 로고    scopus 로고
    • The orphan receptor GPR55 is a novel cannabinoid receptor
    • COI: 1:CAS:528:DC%2BD2sXhtlCrsbnI, PID: 17876302
    • Ryberg E, et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 2007;152:1092-1101.
    • (2007) Br J Pharmacol , vol.152 , pp. 1092-1101
    • Ryberg, E.1
  • 115
    • 40649102938 scopus 로고    scopus 로고
    • GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    • COI: 1:CAS:528:DC%2BD1cXis1yisr0%3D, PID: 18263732
    • Lauckner JE, et al. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci U S A 2008;105:2699-2704.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2699-2704
    • Lauckner, J.E.1
  • 116
    • 34548591720 scopus 로고    scopus 로고
    • Identification of GPR55 as a lysophosphatidylinositol receptor
    • COI: 1:CAS:528:DC%2BD2sXhtVGitr%2FP, PID: 17765871
    • Oka S, et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochem Biophys Res Commun 2007;362:928-934.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 928-934
    • Oka, S.1
  • 117
    • 84875548200 scopus 로고    scopus 로고
    • Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses
    • COI: 1:CAS:528:DC%2BC3sXmsVelt78%3D, PID: 23472002
    • Sylantyev S, et al. Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. Proc Natl Acad Sci U S A 2013;110:5193-5198.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 5193-5198
    • Sylantyev, S.1
  • 118
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression
    • COI: 1:CAS:528:DC%2BD28XlsVGksbo%3D, PID: 16672367
    • Carrier EJ, Auchampach JA, Hillard CJ. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci U S A 2006;103:7895-7900.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 119
    • 79952535110 scopus 로고    scopus 로고
    • Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
    • COI: 1:CAS:528:DC%2BC3MXjtFKisLc%3D, PID: 21266173
    • Pandolfo P, et al. Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum. Eur J Pharmacol 2011;655:38-45.
    • (2011) Eur J Pharmacol , vol.655 , pp. 38-45
    • Pandolfo, P.1
  • 120
    • 77952640781 scopus 로고    scopus 로고
    • Adenosine-cannabinoid receptor interactions. Implications for striatal function
    • COI: 1:CAS:528:DC%2BC3cXpslyrur8%3D, PID: 20590556
    • Ferre S, et al. Adenosine-cannabinoid receptor interactions. Implications for striatal function. Br J Pharmacol 2010;160:443-453.
    • (2010) Br J Pharmacol , vol.160 , pp. 443-453
    • Ferre, S.1
  • 121
    • 77249107540 scopus 로고    scopus 로고
    • Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
    • PID: 19847654
    • De Petrocellis L, Di Marzo V. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. J Neuroimmune Pharmacol 2010;5:103-121.
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 103-121
    • De Petrocellis, L.1    Di Marzo, V.2
  • 122
    • 80051664599 scopus 로고    scopus 로고
    • Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
    • COI: 1:CAS:528:DC%2BC3MXhtVagtbjI, PID: 21238581
    • Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med 2011;51:1054-1061.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1054-1061
    • Booz, G.W.1
  • 123
    • 0012352186 scopus 로고    scopus 로고
    • Neuroprotective antioxidants from marijuana
    • COI: 1:CAS:528:DC%2BD3cXks1ShsLg%3D, PID: 10863546
    • Hampson AJ, et al. Neuroprotective antioxidants from marijuana. Ann N Y Acad Sci 2000;899:274-282.
    • (2000) Ann N Y Acad Sci , vol.899 , pp. 274-282
    • Hampson, A.J.1
  • 124
    • 58149269741 scopus 로고    scopus 로고
    • Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor
    • PID: 18641283
    • Liou GI, et al. Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. Invest Ophthalmol Vis Sci 2008;49:5526-5531.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 5526-5531
    • Liou, G.I.1
  • 125
    • 34547870158 scopus 로고    scopus 로고
    • Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism
    • COI: 1:CAS:528:DC%2BD2sXhtVWnt7rP, PID: 17437545
    • Hayakawa K, et al. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem 2007;102:1488-1496.
    • (2007) J Neurochem , vol.102 , pp. 1488-1496
    • Hayakawa, K.1
  • 126
    • 69949148000 scopus 로고    scopus 로고
    • Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism
    • COI: 1:CAS:528:DC%2BD1MXhtlOqtbrP, PID: 19721229
    • Hayakawa K, et al. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol Pharm Bull 2009;32:1538-1544.
    • (2009) Biol Pharm Bull , vol.32 , pp. 1538-1544
    • Hayakawa, K.1
  • 127
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • COI: 1:CAS:528:DC%2BD2cXjtValtrw%3D, PID: 15030397
    • Iuvone T, et al. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 2004;89:134-141.
    • (2004) J Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1
  • 128
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • COI: 1:CAS:528:DC%2BD28XjvFSgs7o%3D, PID: 16490313
    • Esposito G, et al. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 2006;399:91-95.
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1
  • 129
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
    • COI: 1:CAS:528:DC%2BD2sXovFehs7g%3D, PID: 17592514
    • Esposito G, et al. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 2007;151:1272-1279.
    • (2007) Br J Pharmacol , vol.151 , pp. 1272-1279
    • Esposito, G.1
  • 130
    • 67349196005 scopus 로고    scopus 로고
    • Differential changes in GPR55 during microglial cell activation
    • COI: 1:CAS:528:DC%2BD1MXnt1Okurk%3D, PID: 19464294
    • Pietr M, et al. Differential changes in GPR55 during microglial cell activation. FEBS Lett 2009;583:2071-2076.
    • (2009) FEBS Lett , vol.583 , pp. 2071-2076
    • Pietr, M.1
  • 131
    • 51549099779 scopus 로고    scopus 로고
    • The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain
    • COI: 1:CAS:528:DC%2BD1cXhtFCgur3K, PID: 18502582
    • Staton PC, et al. The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 2008;139: 225-236.
    • (2008) Pain , vol.139 , pp. 225-236
    • Staton, P.C.1
  • 132
    • 0031830516 scopus 로고    scopus 로고
    • An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
    • COI: 1:CAS:528:DyaK1cXltFWktbw%3D, PID: 9721036
    • Ben-Shabat S, et al. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol 1998;353: 23-31.
    • (1998) Eur J Pharmacol , vol.353 , pp. 23-31
    • Ben-Shabat, S.1
  • 133
    • 59849116161 scopus 로고    scopus 로고
    • Synergy research: approaching a new generation of phytopharmaceuticals
    • COI: 1:CAS:528:DC%2BD1MXkt12qtbg%3D, PID: 19211237
    • Wagner H, Ulrich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine 2009;16:97-110.
    • (2009) Phytomedicine , vol.16 , pp. 97-110
    • Wagner, H.1    Ulrich-Merzenich, G.2
  • 134
    • 0033118863 scopus 로고    scopus 로고
    • From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis
    • COI: 1:CAS:528:DyaK1MXitFajs7o%3D, PID: 10331283
    • Mechoulam R, Ben-Shabat S. From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis. Nat Prod Rep 1999;16:131-143.
    • (1999) Nat Prod Rep , vol.16 , pp. 131-143
    • Mechoulam, R.1    Ben-Shabat, S.2
  • 135
    • 79960306559 scopus 로고    scopus 로고
    • Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
    • COI: 1:CAS:528:DC%2BC3MXps1Sjtb4%3D, PID: 21749363
    • Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol 2011;163:1344-1364.
    • (2011) Br J Pharmacol , vol.163 , pp. 1344-1364
    • Russo, E.B.1
  • 136
    • 0015817954 scopus 로고
    • Pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaE2cXptFaltA%3D%3D, PID: 4358666
    • Karniol IG, Carlini EA. Pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol. Psychopharmacologia 1973;33:53-70.
    • (1973) Psychopharmacologia , vol.33 , pp. 53-70
    • Karniol, I.G.1    Carlini, E.A.2
  • 137
    • 84871534813 scopus 로고    scopus 로고
    • Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment
    • COI: 1:CAS:528:DC%2BC2cXhs1OgtbjN, PID: 23042808
    • Englund A, et al. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol 2013;27:19-27.
    • (2013) J Psychopharmacol , vol.27 , pp. 19-27
    • Englund, A.1
  • 138
    • 28844489930 scopus 로고    scopus 로고
    • A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
    • COI: 1:CAS:528:DC%2BD2MXhtlSjsbnJ, PID: 16209908
    • Russo E, Guy GW. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med Hypotheses 2006;66:234-246.
    • (2006) Med Hypotheses , vol.66 , pp. 234-246
    • Russo, E.1    Guy, G.W.2
  • 139
    • 79960323467 scopus 로고    scopus 로고
    • Cannabis with high cannabidiol content is associated with fewer psychotic experiences
    • PID: 21592732
    • Schubart CD, et al. Cannabis with high cannabidiol content is associated with fewer psychotic experiences. Schizophr Res 2011;130:216-221.
    • (2011) Schizophr Res , vol.130 , pp. 216-221
    • Schubart, C.D.1
  • 140
    • 46049087489 scopus 로고    scopus 로고
    • Synergism between natural products and antibiotics against infectious diseases
    • COI: 1:CAS:528:DC%2BD1cXhtlSrs73K, PID: 18599280
    • Hemaiswarya S, Kruthiventi AK, Doble M. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine 2008;15:639-652.
    • (2008) Phytomedicine , vol.15 , pp. 639-652
    • Hemaiswarya, S.1    Kruthiventi, A.K.2    Doble, M.3
  • 141
    • 84868669789 scopus 로고    scopus 로고
    • Quantitative methods for assessing drug synergism
    • PID: 22737266
    • Tallarida RJ. Quantitative methods for assessing drug synergism. Genes Cancer 2011; 2:1003-1008.
    • (2011) Genes Cancer , vol.2 , pp. 1003-1008
    • Tallarida, R.J.1
  • 142
    • 83555174546 scopus 로고    scopus 로고
    • Phytocannabinoids as novel therapeutic agents in CNS disorders
    • COI: 1:CAS:528:DC%2BC3MXhs1CiurzM, PID: 21924288
    • Hill AJ, et al. Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacol Ther 2012;133:79-97.
    • (2012) Pharmacol Ther , vol.133 , pp. 79-97
    • Hill, A.J.1
  • 143
    • 82655173268 scopus 로고    scopus 로고
    • Experimental models of seizures and epilepsies
    • COI: 1:CAS:528:DC%2BC38XivVOksrs%3D, PID: 22137429
    • Raol YH, Brooks-Kayal AR. Experimental models of seizures and epilepsies. Prog Mol Biol Transl Sci 2012;105:57-82.
    • (2012) Prog Mol Biol Transl Sci , vol.105 , pp. 57-82
    • Raol, Y.H.1    Brooks-Kayal, A.R.2
  • 144
    • 79955677603 scopus 로고    scopus 로고
    • Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    • PID: 21292505
    • Loscher W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure 2011;20:359-368.
    • (2011) Seizure , vol.20 , pp. 359-368
    • Loscher, W.1
  • 145
    • 84906280998 scopus 로고    scopus 로고
    • The challenge and promise of anti-epileptic therapy development in animal models
    • PID: 25127174
    • Simonato M, et al. The challenge and promise of anti-epileptic therapy development in animal models. Lancet Neurol 2014;13:949-960.
    • (2014) Lancet Neurol , vol.13 , pp. 949-960
    • Simonato, M.1
  • 146
    • 0141865717 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    • COI: 1:CAS:528:DC%2BD3sXnslSjs78%3D, PID: 14526074
    • Marsicano G, et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 2003;302:84-88.
    • (2003) Science , vol.302 , pp. 84-88
    • Marsicano, G.1
  • 147
    • 0141742514 scopus 로고    scopus 로고
    • The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BD3sXnslGktbw%3D, PID: 12954810
    • Wallace MJ, et al. The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther 2003;307: 129-137.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 129-137
    • Wallace, M.J.1
  • 148
    • 34548098084 scopus 로고    scopus 로고
    • Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage
    • COI: 1:CAS:528:DC%2BD2sXpslKrsbk%3D, PID: 17545313
    • Karanian DA, et al. Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage. J Pharmacol Exp Ther 2007;322: 1059-1066.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1059-1066
    • Karanian, D.A.1
  • 149
    • 23944432405 scopus 로고    scopus 로고
    • Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity
    • COI: 1:CAS:528:DC%2BD2MXpvVKgu7Y%3D, PID: 16120783
    • Karanian DA, et al. Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. J Neurosci 2005;25:7813-7820.
    • (2005) J Neurosci , vol.25 , pp. 7813-7820
    • Karanian, D.A.1
  • 150
    • 84862065791 scopus 로고    scopus 로고
    • Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase—dual targets of the endocannabinoid system to protect against seizure pathology
    • COI: 1:CAS:528:DC%2BC38XhsFOqtbnM, PID: 22270809
    • Naidoo V, et al. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase—dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics 2012;9:801-813.
    • (2012) Neurotherapeutics , vol.9 , pp. 801-813
    • Naidoo, V.1
  • 151
    • 33847321509 scopus 로고    scopus 로고
    • Endocannabinoids block status epilepticus in cultured hippocampal neurons
    • COI: 1:CAS:528:DC%2BD2sXhvVGgu7k%3D, PID: 17174949
    • Deshpande LS, et al. Endocannabinoids block status epilepticus in cultured hippocampal neurons. Eur J Pharmacol 2007;558:52-59.
    • (2007) Eur J Pharmacol , vol.558 , pp. 52-59
    • Deshpande, L.S.1
  • 152
    • 33746913292 scopus 로고    scopus 로고
    • The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    • COI: 1:CAS:528:DC%2BD28XovFKnurw%3D, PID: 16908411
    • Monory K, et al. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 2006;51:455-466.
    • (2006) Neuron , vol.51 , pp. 455-466
    • Monory, K.1
  • 153
    • 78650987060 scopus 로고    scopus 로고
    • AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity
    • COI: 1:CAS:528:DC%2BC3MXisFantg%3D%3D, PID: 21203567
    • Guggenhuber S, et al. AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. PLoS One 2010;5:e15707.
    • (2010) PLoS One , vol.5
    • Guggenhuber, S.1
  • 154
    • 84908454413 scopus 로고    scopus 로고
    • Seizing an opportunity for the endocannabinoid system
    • PID: 25346637
    • Alger BE. Seizing an opportunity for the endocannabinoid system. Epilepsy Curr 2014; 14:272-276.
    • (2014) Epilepsy Curr , vol.14 , pp. 272-276
    • Alger, B.E.1
  • 155
    • 34247895508 scopus 로고    scopus 로고
    • Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy
    • COI: 1:CAS:528:DC%2BD2sXlt1Sjtro%3D, PID: 17433556
    • Falenski KW, et al. Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy. Neuroscience 2007;146:1232-1244.
    • (2007) Neuroscience , vol.146 , pp. 1232-1244
    • Falenski, K.W.1
  • 156
    • 61849166674 scopus 로고    scopus 로고
    • Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus
    • COI: 1:CAS:528:DC%2BD1MXjt1Slt7o%3D, PID: 19368833
    • Falenski KW, et al. Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Brain Res 2009;1262:64-72.
    • (2009) Brain Res , vol.1262 , pp. 64-72
    • Falenski, K.W.1
  • 157
    • 77956533692 scopus 로고    scopus 로고
    • Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy
    • PID: 20498848
    • Bhaskaran MD, Smith BN. Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. PLoS One 2010;5:e10683.
    • (2010) PLoS One , vol.5
    • Bhaskaran, M.D.1    Smith, B.N.2
  • 158
    • 84860696786 scopus 로고    scopus 로고
    • Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain
    • COI: 1:CAS:528:DC%2BC38Xptl2it7Y%3D, PID: 22509801
    • Sayers KW, et al. Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. Epilepsia 2012;53:897-907.
    • (2012) Epilepsia , vol.53 , pp. 897-907
    • Sayers, K.W.1
  • 159
    • 41149147486 scopus 로고    scopus 로고
    • Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus
    • COI: 1:CAS:528:DC%2BD1cXjvFCjsL8%3D, PID: 18354002
    • Ludanyi A, et al. Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. J Neurosci 2008;28:2976-2990.
    • (2008) J Neurosci , vol.28 , pp. 2976-2990
    • Ludanyi, A.1
  • 160
    • 77951589098 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BC3cXntVOkurY%3D, PID: 19817812
    • Romigi A, et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. Epilepsia 2010;51:768-772.
    • (2010) Epilepsia , vol.51 , pp. 768-772
    • Romigi, A.1
  • 161
    • 77954390291 scopus 로고    scopus 로고
    • Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BC3cXptFWgsLY%3D, PID: 20592220
    • Wyeth MS, et al. Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci 2010;30:8993-9006.
    • (2010) J Neurosci , vol.30 , pp. 8993-9006
    • Wyeth, M.S.1
  • 162
    • 84885119880 scopus 로고    scopus 로고
    • Loss of cholecystokinin-containing terminals in temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BC2cXjtlCjtg%3D%3D, PID: 24051276
    • Sun C, et al. Loss of cholecystokinin-containing terminals in temporal lobe epilepsy. Neurobiol Dis 2014;62:44-55.
    • (2014) Neurobiol Dis , vol.62 , pp. 44-55
    • Sun, C.1
  • 163
    • 84858175915 scopus 로고    scopus 로고
    • Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy
    • COI: 1:CAS:528:DC%2BC3MXhsFejsrzP, PID: 22076136
    • Karlocai MR, et al. Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy. PLoS One 2011;6:e27196.
    • (2011) PLoS One , vol.6
    • Karlocai, M.R.1
  • 164
    • 77954529991 scopus 로고    scopus 로고
    • Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans
    • PID: 20618415
    • Magloczky Z, et al. Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans. Epilepsia 2010;51(Suppl. 3):115-120.
    • (2010) Epilepsia , vol.51 , pp. 115-120
    • Magloczky, Z.1
  • 165
    • 0043023379 scopus 로고    scopus 로고
    • Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures
    • COI: 1:CAS:528:DC%2BD3sXmslOmurY%3D, PID: 12925275
    • Chen K, et al. Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron 2003;39:599-611.
    • (2003) Neuron , vol.39 , pp. 599-611
    • Chen, K.1
  • 166
    • 33846152922 scopus 로고    scopus 로고
    • Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures
    • PID: 17202471
    • Chen K, et al. Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. J Neurosci 2007;27: 46-58.
    • (2007) J Neurosci , vol.27 , pp. 46-58
    • Chen, K.1
  • 168
    • 84861528229 scopus 로고    scopus 로고
    • Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures
    • COI: 1:CAS:528:DC%2BC38Xnsl2qu7s%3D, PID: 22386872
    • Manna SS, Umathe SN. Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. Epilepsy Res 2012;100:113-124.
    • (2012) Epilepsy Res , vol.100 , pp. 113-124
    • Manna, S.S.1    Umathe, S.N.2
  • 169
    • 33748535430 scopus 로고    scopus 로고
    • Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model
    • COI: 1:CAS:528:DC%2BD28Xps1Omur0%3D, PID: 16930590
    • Luszczki JJ, et al. Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model. Eur J Pharmacol 2006;547:65-74.
    • (2006) Eur J Pharmacol , vol.547 , pp. 65-74
    • Luszczki, J.J.1
  • 170
    • 73649113131 scopus 로고    scopus 로고
    • Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    • COI: 1:CAS:528:DC%2BC3cXjvVSjtw%3D%3D, PID: 19751793
    • Luszczki JJ, et al. Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:18-25.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry , vol.34 , pp. 18-25
    • Luszczki, J.J.1
  • 171
    • 79251642782 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice
    • COI: 1:CAS:528:DC%2BC3MXjsFGju7c%3D, PID: 21238473
    • Luszczki JJ, et al. Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacol Biochem Behav 2011;98:261-267.
    • (2011) Pharmacol Biochem Behav , vol.98 , pp. 261-267
    • Luszczki, J.J.1
  • 172
    • 82455210955 scopus 로고    scopus 로고
    • Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice
    • COI: 1:CAS:528:DC%2BC3MXhsVSksbnO, PID: 21777642
    • Luszczki JJ, et al. Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1870-1876.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 1870-1876
    • Luszczki, J.J.1
  • 173
    • 84867019421 scopus 로고    scopus 로고
    • Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model
    • COI: 1:CAS:528:DC%2BC38XhsVCjsr7L, PID: 22789660
    • Andres-Mach M, et al. Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Prog Neuropsychopharmacol Biol Psychiatry 2012;39: 301-309.
    • (2012) Prog Neuropsychopharmacol Biol Psychiatry , vol.39 , pp. 301-309
    • Andres-Mach, M.1
  • 174
    • 84890120086 scopus 로고    scopus 로고
    • Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice
    • COI: 1:CAS:528:DC%2BC3sXhsleitL3M, PID: 24161913
    • Luszczki JJ, et al. Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice. Eur J Pharmacol 2013;720:247-254.
    • (2013) Eur J Pharmacol , vol.720 , pp. 247-254
    • Luszczki, J.J.1
  • 175
    • 84903278372 scopus 로고    scopus 로고
    • Effects of WIN 55,212-2 (a non-selective cannabinoid CB1 and CB 2 receptor agonist) on the protective action of various classical antiepileptic drugs in the mouse 6 Hz psychomotor seizure model
    • COI: 1:CAS:528:DC%2BC2cXivF2mtbo%3D, PID: 24549572
    • Florek-Luszczki M, et al. Effects of WIN 55,212-2 (a non-selective cannabinoid CB1 and CB 2 receptor agonist) on the protective action of various classical antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. J Neural Transm 2014;121: 707-715.
    • (2014) J Neural Transm , vol.121 , pp. 707-715
    • Florek-Luszczki, M.1
  • 176
    • 84913554913 scopus 로고    scopus 로고
    • Influence of WIN 55,212-2 on the anticonvulsant and acute neurotoxic potential of clobazam and lacosamide in the maximal electroshock-induced seizure model and chimney test in mice
    • COI: 1:CAS:528:DC%2BC2cXhsl2lt7%2FM, PID: 25458536
    • Florek-Luszczki M, Zagaja M, Luszczki JJ. Influence of WIN 55,212-2 on the anticonvulsant and acute neurotoxic potential of clobazam and lacosamide in the maximal electroshock-induced seizure model and chimney test in mice. Epilepsy Res 2014;108:1728-1733.
    • (2014) Epilepsy Res , vol.108 , pp. 1728-1733
    • Florek-Luszczki, M.1    Zagaja, M.2    Luszczki, J.J.3
  • 177
    • 84921324520 scopus 로고    scopus 로고
    • Effects of WIN 55,212-2 (a synthetic cannabinoid CB1 and CB2 receptor agonist) on the anticonvulsant activity of various novel antiepileptic drugs against 6Hz-induced psychomotor seizures in mice
    • COI: 1:CAS:528:DC%2BC2MXht12qtrg%3D, PID: 25592741
    • Florek-Luszczki M, et al. Effects of WIN 55,212-2 (a synthetic cannabinoid CB1 and CB2 receptor agonist) on the anticonvulsant activity of various novel antiepileptic drugs against 6Hz-induced psychomotor seizures in mice. Pharmacol Biochem Behav 2015; 130:53-58.
    • (2015) Pharmacol Biochem Behav , vol.130 , pp. 53-58
    • Florek-Luszczki, M.1
  • 178
    • 0016198745 scopus 로고
    • The effect of withdrawal from cannabis on pentylenetetrazol convulsive threshold in mice
    • COI: 1:CAS:528:DyaE2MXkslWlu74%3D, PID: 4476083
    • Chesher GB, Jackson DM. The effect of withdrawal from cannabis on pentylenetetrazol convulsive threshold in mice. Psychopharmacologia 1974;40: 129-135.
    • (1974) Psychopharmacologia , vol.40 , pp. 129-135
    • Chesher, G.B.1    Jackson, D.M.2
  • 179
    • 0016592826 scopus 로고
    • Interaction of delta9-tetrahydrocannabinol and cannabidiol with phenobarbitone in protecting mice from electrically induced convulsions
    • COI: 1:CAS:528:DyaE2MXmtVWrs7c%3D, PID: 239178
    • Chesher GB, Jackson DM, Malor RM. Interaction of delta9-tetrahydrocannabinol and cannabidiol with phenobarbitone in protecting mice from electrically induced convulsions. J Pharm Pharmacol 1975;27:608-609.
    • (1975) J Pharm Pharmacol , vol.27 , pp. 608-609
    • Chesher, G.B.1    Jackson, D.M.2    Malor, R.M.3
  • 180
    • 84936113447 scopus 로고    scopus 로고
    • NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies)
    • National Toxicology Program. NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 1996;446:1-317.
    • (1996) Natl Toxicol Program Tech Rep Ser , vol.446 , pp. 1-317
  • 181
    • 84870498540 scopus 로고    scopus 로고
    • Cannabidivarin is anticonvulsant in mouse and rat
    • COI: 1:CAS:528:DC%2BC38XhvVWns7rE, PID: 22970845
    • Hill AJ, et al. Cannabidivarin is anticonvulsant in mouse and rat. Br J Pharmacol 2012;167:1629-1642.
    • (2012) Br J Pharmacol , vol.167 , pp. 1629-1642
    • Hill, A.J.1
  • 182
    • 0027196816 scopus 로고
    • Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study
    • COI: 1:CAS:528:DyaK3sXkvVGru74%3D, PID: 8395305
    • Oviedo A, Glowa J, Herkenham M. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain Res 1993;616:293-302.
    • (1993) Brain Res , vol.616 , pp. 293-302
    • Oviedo, A.1    Glowa, J.2    Herkenham, M.3
  • 183
    • 0028084259 scopus 로고
    • Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment
    • COI: 1:STN:280:DyaK2c7lvFKlsA%3D%3D, PID: 8115426
    • Rodriguez de Fonseca F, et al. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. Pharmacol Biochem Behav 1994;47:33-40.
    • (1994) Pharmacol Biochem Behav , vol.47 , pp. 33-40
    • Rodriguez de Fonseca, F.1
  • 184
    • 0029829841 scopus 로고    scopus 로고
    • Effects of chronic treatment with delta9-tetrahydrocannabinol on cannabinoid-stimulated [35S]GTPgammaS autoradiography in rat brain
    • COI: 1:CAS:528:DyaK28Xns1Sitr4%3D, PID: 8987831
    • Sim LJ, et al. Effects of chronic treatment with delta9-tetrahydrocannabinol on cannabinoid-stimulated [35S]GTPgammaS autoradiography in rat brain. J Neurosci 1996;16:8057-8066.
    • (1996) J Neurosci , vol.16 , pp. 8057-8066
    • Sim, L.J.1
  • 185
    • 0343724969 scopus 로고    scopus 로고
    • Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice
    • COI: 1:CAS:528:DyaK28XkslKnsg%3D%3D, PID: 8720487
    • Fan F, et al. Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice. Brain Res 1996;706:13-20.
    • (1996) Brain Res , vol.706 , pp. 13-20
    • Fan, F.1
  • 186
    • 0030959336 scopus 로고    scopus 로고
    • Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions
    • COI: 1:CAS:528:DyaK2sXislemsrY%3D, PID: 9191083
    • Romero J, et al. Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions. Brain Res Mol Brain Res 1997;46:100-108.
    • (1997) Brain Res Mol Brain Res , vol.46 , pp. 100-108
    • Romero, J.1
  • 187
    • 0344878843 scopus 로고    scopus 로고
    • Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice
    • COI: 1:CAS:528:DyaK1cXjvFeksr4%3D, PID: 9649978
    • Romero J, et al. Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice. Drug Alcohol Depend 1998;50:241-249.
    • (1998) Drug Alcohol Depend , vol.50 , pp. 241-249
    • Romero, J.1
  • 188
    • 0032469925 scopus 로고    scopus 로고
    • Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTP gamma S binding and cannabinoid receptor mRNA levels in the basal ganglia and the cerebellum of adult male rats chronically exposed to delta 9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaK1MXhvVOjtLo%3D, PID: 10096037
    • Romero J, et al. Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTP gamma S binding and cannabinoid receptor mRNA levels in the basal ganglia and the cerebellum of adult male rats chronically exposed to delta 9-tetrahydrocannabinol. J Mol Neurosci 1998;11:109-119.
    • (1998) J Mol Neurosci , vol.11 , pp. 109-119
    • Romero, J.1
  • 189
    • 0031669975 scopus 로고    scopus 로고
    • Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to delta9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaK1cXmsVGntLk%3D, PID: 9776133
    • Romero J, et al. Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to delta9-tetrahydrocannabinol. Synapse 1998;30:298-308.
    • (1998) Synapse , vol.30 , pp. 298-308
    • Romero, J.1
  • 190
    • 0032570042 scopus 로고    scopus 로고
    • Effects of long-term exposure to delta9-THC on expression of cannabinoid receptor (CB1) mRNA in different rat brain regions
    • COI: 1:CAS:528:DyaK1cXnt1eitLg%3D, PID: 9813289
    • Zhuang S, et al. Effects of long-term exposure to delta9-THC on expression of cannabinoid receptor (CB1) mRNA in different rat brain regions. Brain Res Mol Brain Res 1998;62:141-149.
    • (1998) Brain Res Mol Brain Res , vol.62 , pp. 141-149
    • Zhuang, S.1
  • 191
    • 0032771955 scopus 로고    scopus 로고
    • Internalization and recycling of the CB1 cannabinoid receptor
    • COI: 1:CAS:528:DyaK1MXkslOqsrg%3D, PID: 10428044
    • Hsieh C, et al. Internalization and recycling of the CB1 cannabinoid receptor. J Neurochem 1999;73:493-501.
    • (1999) J Neurochem , vol.73 , pp. 493-501
    • Hsieh, C.1
  • 192
    • 0033528652 scopus 로고    scopus 로고
    • Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudateputamen
    • COI: 1:CAS:528:DyaK1MXhvFGhs78%3D, PID: 10101241
    • Corchero J, et al. Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudateputamen. Brain Res Mol Brain Res 1999;67:148-157.
    • (1999) Brain Res Mol Brain Res , vol.67 , pp. 148-157
    • Corchero, J.1
  • 193
    • 0032589999 scopus 로고    scopus 로고
    • Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain
    • COI: 1:CAS:528:DyaK1MXns1ehu70%3D, PID: 10582605
    • Breivogel CS, et al. Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain. J Neurochem 1999;73:2447-2459.
    • (1999) J Neurochem , vol.73 , pp. 2447-2459
    • Breivogel, C.S.1
  • 194
    • 0037449471 scopus 로고    scopus 로고
    • The effects of delta9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors
    • COI: 1:CAS:528:DC%2BD3sXotVek, PID: 12524139
    • Breivogel CS, et al. The effects of delta9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors. Eur J Pharmacol 2003;459:139-150.
    • (2003) Eur J Pharmacol , vol.459 , pp. 139-150
    • Breivogel, C.S.1
  • 195
    • 38749093701 scopus 로고    scopus 로고
    • Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
    • COI: 1:CAS:528:DC%2BD1cXhsFShtLg%3D, PID: 17967938
    • McKinney DL, et al. Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol. J Pharmacol Exp Ther 2008;324:664-673.
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 664-673
    • McKinney, D.L.1
  • 196
    • 0036784515 scopus 로고    scopus 로고
    • Effect of chronic administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxaz inyl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) or delta(9)-tetrahydrocannabinol on cannabinoid receptor adaptation in mice
    • COI: 1:CAS:528:DC%2BD38XnsV2qsr8%3D, PID: 12235230
    • Sim-Selley LJ, Martin BR. Effect of chronic administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxaz inyl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) or delta(9)-tetrahydrocannabinol on cannabinoid receptor adaptation in mice. J Pharmacol Exp Ther 2002;303:36-44.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 36-44
    • Sim-Selley, L.J.1    Martin, B.R.2
  • 197
    • 0742271034 scopus 로고    scopus 로고
    • Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids
    • COI: 1:CAS:528:DC%2BD2cXhvVGlsro%3D, PID: 14977366
    • Sim-Selley LJ. Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids. Crit Rev Neurobiol 2003;15:91-119.
    • (2003) Crit Rev Neurobiol , vol.15 , pp. 91-119
    • Sim-Selley, L.J.1
  • 198
    • 33747626926 scopus 로고    scopus 로고
    • Prolonged recovery rate of CB1 receptor adaptation after cessation of long-term cannabinoid administration
    • COI: 1:CAS:528:DC%2BD28Xps1Smsbo%3D, PID: 16760363
    • Sim-Selley LJ, et al. Prolonged recovery rate of CB1 receptor adaptation after cessation of long-term cannabinoid administration. Mol Pharmacol 2006;70:986-996.
    • (2006) Mol Pharmacol , vol.70 , pp. 986-996
    • Sim-Selley, L.J.1
  • 199
    • 2542442555 scopus 로고    scopus 로고
    • Signaling pathways involved in the development of cannabinoid tolerance
    • COI: 1:CAS:528:DC%2BD2cXksVelsLg%3D, PID: 15165748
    • Martin BR, Sim-Selley LJ, Selley DE. Signaling pathways involved in the development of cannabinoid tolerance. Trends Pharmacol Sci 2004;25:325-330.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 325-330
    • Martin, B.R.1    Sim-Selley, L.J.2    Selley, D.E.3
  • 200
    • 33846928453 scopus 로고    scopus 로고
    • Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain
    • COI: 1:CAS:528:DC%2BD2sXhvVGmsL0%3D, PID: 17222515
    • Villares J. Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain. Neuroscience 2007;145:323-334.
    • (2007) Neuroscience , vol.145 , pp. 323-334
    • Villares, J.1
  • 201
    • 0035313310 scopus 로고    scopus 로고
    • Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons
    • COI: 1:CAS:528:DC%2BD3MXjslCls7w%3D, PID: 11264316
    • Coutts AA, et al. Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons. J Neurosci 2001;21:2425-2433.
    • (2001) J Neurosci , vol.21 , pp. 2425-2433
    • Coutts, A.A.1
  • 202
    • 27744574366 scopus 로고    scopus 로고
    • Delta(9)-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture
    • COI: 1:CAS:528:DC%2BD2MXht1ejs77K, PID: 16157354
    • Lundberg DJ, Daniel AR, Thayer SA. Delta(9)-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture. Neuropharmacology 2005;49:1170-1177.
    • (2005) Neuropharmacology , vol.49 , pp. 1170-1177
    • Lundberg, D.J.1    Daniel, A.R.2    Thayer, S.A.3
  • 203
    • 79956133857 scopus 로고    scopus 로고
    • Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons
    • COI: 1:CAS:528:DC%2BC3MXmsFagtLs%3D, PID: 21324315
    • Deshpande LS, Blair RE, DeLorenzo RJ. Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons. Exp Neurol 2011;229:264-273.
    • (2011) Exp Neurol , vol.229 , pp. 264-273
    • Deshpande, L.S.1    Blair, R.E.2    DeLorenzo, R.J.3
  • 204
    • 0022509199 scopus 로고
    • Cannabinoid pharmacology
    • COI: 1:CAS:528:DyaL28XlsVGnur8%3D, PID: 3529128
    • Dewey WL. Cannabinoid pharmacology. Pharmacol Rev 1986;38:151-178.
    • (1986) Pharmacol Rev , vol.38 , pp. 151-178
    • Dewey, W.L.1
  • 205
    • 0027368524 scopus 로고
    • Development of behavioral tolerance to delta 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain
    • COI: 1:CAS:528:DyaK2cXltFI%3D, PID: 8278434
    • Abood ME, et al. Development of behavioral tolerance to delta 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain. Pharmacol Biochem Behav 1993;46:575-579.
    • (1993) Pharmacol Biochem Behav , vol.46 , pp. 575-579
    • Abood, M.E.1
  • 206
    • 0016615865 scopus 로고
    • Acute and chronic effects of beta9-tetrahydrocannabinol on seizures in the gerbil
    • PID: 1126373
    • Ten Ham M, Loskota WJ, Lomax P. Acute and chronic effects of beta9-tetrahydrocannabinol on seizures in the gerbil. Eur J Pharmacol 1975;31:148-152.
    • (1975) Eur J Pharmacol , vol.31 , pp. 148-152
    • Ten Ham, M.1    Loskota, W.J.2    Lomax, P.3
  • 207
    • 0017835175 scopus 로고
    • Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled rats
    • COI: 1:CAS:528:DyaL3cXhslCmsLo%3D, PID: 624268
    • Corcoran ME, McCaughran JA, Jr., Wada JA, Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled rats. Epilepsia 1978;19: 47-55.
    • (1978) Epilepsia , vol.19 , pp. 47-55
    • Corcoran, M.E.1    McCaughran, J.A.2    Wada, J.A.3
  • 208
    • 0020083061 scopus 로고
    • Effects of marihuana cannabinoids on seizure activity in cobalt-epileptic rats
    • COI: 1:CAS:528:DyaL38XhvFegtrk%3D, PID: 6280204
    • Colasanti BK, Lindamood C, 3rd, Craig CR. Effects of marihuana cannabinoids on seizure activity in cobalt-epileptic rats. Pharmacol Biochem Behav 1982;16: 573-578.
    • (1982) Pharmacol Biochem Behav , vol.16 , pp. 573-578
    • Colasanti, B.K.1    Lindamood, C.2    Craig, C.R.3
  • 209
    • 0018866833 scopus 로고
    • Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice
    • COI: 1:CAS:528:DyaL3cXktlOjurc%3D, PID: 6301593
    • Karler R, Turkanis SA. Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice. Br J Pharmacol 1980;68:479-484.
    • (1980) Br J Pharmacol , vol.68 , pp. 479-484
    • Karler, R.1    Turkanis, S.A.2
  • 210
    • 67650680323 scopus 로고    scopus 로고
    • Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy
    • COI: 1:CAS:528:DC%2BD1MXptVCitbc%3D, PID: 19540252
    • Blair RE, et al. Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. Neuropharmacology 2009;57:208-218.
    • (2009) Neuropharmacology , vol.57 , pp. 208-218
    • Blair, R.E.1
  • 211
    • 0017095185 scopus 로고
    • Clinical studies of cannabis tolerance and dependence
    • COI: 1:STN:280:DyaE2s7jt12jsQ%3D%3D, PID: 798533
    • Jones RT, Benowitz N, Bachman J. Clinical studies of cannabis tolerance and dependence. Ann N Y Acad Sci 1976;282:221-239.
    • (1976) Ann N Y Acad Sci , vol.282 , pp. 221-239
    • Jones, R.T.1    Benowitz, N.2    Bachman, J.3
  • 212
    • 0019605335 scopus 로고
    • Clinical relevance of cannabis tolerance and dependence
    • COI: 1:STN:280:DyaL38%2FltlGhuw%3D%3D, PID: 6271820
    • Jones RT, Benowitz NL, Herning RI. Clinical relevance of cannabis tolerance and dependence. J Clin Pharmacol 1981;21(8-9 Suppl.):143S-152S.
    • (1981) J Clin Pharmacol , vol.21 , pp. 143S-152S
    • Jones, R.T.1    Benowitz, N.L.2    Herning, R.I.3
  • 213
    • 0032586698 scopus 로고    scopus 로고
    • Responses to oral delta9-tetrahydrocannabinol in frequent and infrequent marijuana users
    • COI: 1:CAS:528:DyaK1MXjtFSlsr0%3D, PID: 10340534
    • Kirk JM, de Wit H. Responses to oral delta9-tetrahydrocannabinol in frequent and infrequent marijuana users. Pharmacol Biochem Behav 1999;63:137-142.
    • (1999) Pharmacol Biochem Behav , vol.63 , pp. 137-142
    • Kirk, J.M.1    de Wit, H.2
  • 214
    • 0036453750 scopus 로고    scopus 로고
    • Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans
    • COI: 1:CAS:528:DC%2BD38XptFehsro%3D
    • Hart CL, et al. Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans. Psychopharmacology (Berl) 2002;164:407-415.
    • (2002) Psychopharmacology (Berl) , vol.164 , pp. 407-415
    • Hart, C.L.1
  • 215
    • 0016596168 scopus 로고
    • Marijuana consumption and tolerance to physiological and subjective effects
    • COI: 1:STN:280:DyaE28%2FoslSnsQ%3D%3D, PID: 1200773
    • Babor TF, et al. Marijuana consumption and tolerance to physiological and subjective effects. Arch Gen Psychiatry 1975;32:1548-1552.
    • (1975) Arch Gen Psychiatry , vol.32 , pp. 1548-1552
    • Babor, T.F.1
  • 216
    • 0017690077 scopus 로고
    • Tolerance to marijuana: heart rate and subjective "high"
    • COI: 1:CAS:528:DyaE1cXksFWgtA%3D%3D, PID: 913022
    • Nowlan R, Cohen S. Tolerance to marijuana: heart rate and subjective "high". Clin Pharmacol Ther 1977;22:550-556.
    • (1977) Clin Pharmacol Ther , vol.22 , pp. 550-556
    • Nowlan, R.1    Cohen, S.2
  • 217
    • 0029111498 scopus 로고
    • Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A
    • COI: 1:STN:280:DyaK28%2FlvFyksA%3D%3D, PID: 7498260
    • Aceto MD, et al. Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A. Eur J Pharmacol 1995;282:R1-R2.
    • (1995) Eur J Pharmacol , vol.282 , pp. R1-R2
    • Aceto, M.D.1
  • 218
    • 0029643521 scopus 로고
    • Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist
    • COI: 1:CAS:528:DyaK2MXmvF2nu78%3D, PID: 8566091
    • Tsou K, Patrick SL, Walker JM. Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. Eur J Pharmacol 1995;280:R13-R15.
    • (1995) Eur J Pharmacol , vol.280 , pp. R13-R15
    • Tsou, K.1    Patrick, S.L.2    Walker, J.M.3
  • 219
    • 0039534405 scopus 로고    scopus 로고
    • Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal
    • COI: 1:CAS:528:DyaK2sXkt1aku7w%3D, PID: 9197270
    • Rodriguez de Fonseca F, et al. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science 1997;276:2050-2054.
    • (1997) Science , vol.276 , pp. 2050-2054
    • Rodriguez de Fonseca, F.1
  • 220
    • 0015738789 scopus 로고
    • Tolerance to and dependence on cannabis
    • COI: 1:CAS:528:DyaE2cXksFykurw%3D
    • Kaymakcalan S. Tolerance to and dependence on cannabis. Bull Narc 1973;25:39–47.
    • (1973) Bull Narc , vol.25 , pp. 39-47
    • Kaymakcalan, S.1
  • 221
    • 0022993379 scopus 로고
    • Dependence on tetrahydrocannabinol in rhesus monkeys
    • COI: 1:CAS:528:DyaL2sXht1yqsg%3D%3D, PID: 3021952
    • Beardsley PM, Balster RL, Harris LS. Dependence on tetrahydrocannabinol in rhesus monkeys. J Pharmacol Exp Ther 1986;239:311-319.
    • (1986) J Pharmacol Exp Ther , vol.239 , pp. 311-319
    • Beardsley, P.M.1    Balster, R.L.2    Harris, L.S.3
  • 222
    • 33748194119 scopus 로고    scopus 로고
    • The cannabis withdrawal syndrome
    • PID: 16612207
    • Budney AJ, Hughes JR. The cannabis withdrawal syndrome. Curr Opin Psychiatry 2006;19:233-238.
    • (2006) Curr Opin Psychiatry , vol.19 , pp. 233-238
    • Budney, A.J.1    Hughes, J.R.2
  • 223
    • 0021720565 scopus 로고
    • Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice
    • COI: 1:CAS:528:DyaL2MXnt1yjtQ%3D%3D, PID: 6098847
    • Karler R, et al. Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice. Neuropharmacology 1984;23:1315-1320.
    • (1984) Neuropharmacology , vol.23 , pp. 1315-1320
    • Karler, R.1
  • 224
    • 0022600570 scopus 로고
    • Prolonged CNS hyperexcitability in mice after a single exposure to delta-9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaL28XktVSmsbg%3D, PID: 3012403
    • Karler R, Calder LD, Turkanis SA. Prolonged CNS hyperexcitability in mice after a single exposure to delta-9-tetrahydrocannabinol. Neuropharmacology 1986;25:441-446.
    • (1986) Neuropharmacology , vol.25 , pp. 441-446
    • Karler, R.1    Calder, L.D.2    Turkanis, S.A.3
  • 225
    • 84871839209 scopus 로고    scopus 로고
    • Seizure exacerbation in two patients with focal epilepsy following marijuana cessation
    • PID: 23159379
    • Hegde M, et al. Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. Epilepsy Behav 2012;25:563-566.
    • (2012) Epilepsy Behav , vol.25 , pp. 563-566
    • Hegde, M.1
  • 226
    • 0025049969 scopus 로고
    • Complex partial seizure symptoms affected by marijuana abuse
    • COI: 1:STN:280:DyaK3M%2FgvFShsg%3D%3D, PID: 2211545
    • Ellison JM, Gelwan E, Ogletree J. Complex partial seizure symptoms affected by marijuana abuse. J Clin Psychiatry 1990;51:439-440.
    • (1990) J Clin Psychiatry , vol.51 , pp. 439-440
    • Ellison, J.M.1    Gelwan, E.2    Ogletree, J.3
  • 227
    • 0015948729 scopus 로고
    • Failure to obtain "cannabis-directed behavior" and abstinence syndrome in rats chronically treated with cannabis sativa extracts
    • COI: 1:STN:280:DyaE2c3nt1Wgtg%3D%3D, PID: 4407690
    • Leite JR, Carlini EA. Failure to obtain "cannabis-directed behavior" and abstinence syndrome in rats chronically treated with cannabis sativa extracts. Psychopharmacologia 1974;36:133-145.
    • (1974) Psychopharmacologia , vol.36 , pp. 133-145
    • Leite, J.R.1    Carlini, E.A.2
  • 228
    • 80051985532 scopus 로고    scopus 로고
    • Abuse potential and psychoactive effects of delta-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine
    • COI: 1:CAS:528:DC%2BC3MXhtVCrtrzM, PID: 21542664
    • Robson P. Abuse potential and psychoactive effects of delta-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine. Expert Opin Drug Saf 2011;10:675-685.
    • (2011) Expert Opin Drug Saf , vol.10 , pp. 675-685
    • Robson, P.1
  • 229
    • 4344582253 scopus 로고    scopus 로고
    • Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients
    • COI: 1:CAS:528:DC%2BD2cXnt1Sks7w%3D, PID: 15327042
    • Wade DT, et al. Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Mult Scler 2004;10:434-441.
    • (2004) Mult Scler , vol.10 , pp. 434-441
    • Wade, D.T.1
  • 230
    • 34548483175 scopus 로고    scopus 로고
    • Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine
    • COI: 1:CAS:528:DC%2BD2sXhtVelsL%2FK, PID: 17712817
    • Russo EB, Guy GW, Robson PJ. Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. Chem Biodivers 2007; 4:1729-1743.
    • (2007) Chem Biodivers , vol.4 , pp. 1729-1743
    • Russo, E.B.1    Guy, G.W.2    Robson, P.J.3
  • 231
    • 36849070991 scopus 로고    scopus 로고
    • Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial
    • COI: 1:CAS:528:DC%2BD2sXhtlakt7jL, PID: 18035205
    • Rog DJ, Nurmikko TJ, Young CA. Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial. Clin Ther 2007;29: 2068-2079.
    • (2007) Clin Ther , vol.29 , pp. 2068-2079
    • Rog, D.J.1    Nurmikko, T.J.2    Young, C.A.3
  • 232
    • 33749427038 scopus 로고    scopus 로고
    • Combined cannabinoid therapy via an oromucosal spray
    • COI: 1:CAS:528:DC%2BD28XhtFams7jF
    • Perez J. Combined cannabinoid therapy via an oromucosal spray. Drugs Today (Barc) 2006;42:495-503.
    • (2006) Drugs Today (Barc) , vol.42 , pp. 495-503
    • Perez, J.1
  • 233
    • 84874980235 scopus 로고    scopus 로고
    • Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report
    • COI: 1:STN:280:DC%2BC3s%2FnvVCmuw%3D%3D, PID: 23095052
    • Crippa JA, et al. Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report. J Clin Pharm Ther 2013;38:162-164.
    • (2013) J Clin Pharm Ther , vol.38 , pp. 162-164
    • Crippa, J.A.1
  • 234
    • 84896781775 scopus 로고    scopus 로고
    • Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial
    • COI: 1:CAS:528:DC%2BC2cXntlWhtbc%3D, PID: 24430917
    • Allsop DJ, et al. Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial. JAMA Psychiatry 2014;71:281-291.
    • (2014) JAMA Psychiatry , vol.71 , pp. 281-291
    • Allsop, D.J.1
  • 235
    • 84938937531 scopus 로고    scopus 로고
    • Cannabinoid replacement therapy (CRT): Nabiximols (Sativex) as a novel treatment for cannabis withdrawal
    • COI: 1:CAS:528:DC%2BC2MXptFKrsLc%3D, PID: 25777582
    • Allsop DJ, Lintzeris N, Copeland J, Dunlop A, McGregor IS. Cannabinoid replacement therapy (CRT): Nabiximols (Sativex) as a novel treatment for cannabis withdrawal. Clin Pharmacol Ther 2015;97:571-574.
    • (2015) Clin Pharmacol Ther , vol.97 , pp. 571-574
    • Allsop, D.J.1    Lintzeris, N.2    Copeland, J.3    Dunlop, A.4    McGregor, I.S.5
  • 236
    • 0014102236 scopus 로고
    • Grand mal convulsions subsequent to marijuana use
    • COI: 1:STN:280:DyaK3c7is1ajtA%3D%3D, PID: 5006458
    • Keeler MH, Reifler CB. Grand mal convulsions subsequent to marijuana use. Case report. Dis Nerv Syst 1967;28:474-475.
    • (1967) Case report. Dis Nerv Syst , vol.28 , pp. 474-475
    • Keeler, M.H.1    Reifler, C.B.2
  • 237
    • 80053638478 scopus 로고    scopus 로고
    • Severe toxicity following synthetic cannabinoid ingestion
    • COI: 1:CAS:528:DC%2BC3MXht1Oqt73O
    • Lapoint J, et al. Severe toxicity following synthetic cannabinoid ingestion. Clin Toxicol (Phila) 2011;49:760-764.
    • (2011) Clin Toxicol (Phila) , vol.49 , pp. 760-764
    • Lapoint, J.1
  • 238
    • 84871250328 scopus 로고    scopus 로고
    • Synthetic cannabis and respiratory depression
    • COI: 1:CAS:528:DC%2BC38XhvVCksrvM, PID: 23234589
    • Jinwala FN, Gupta M. Synthetic cannabis and respiratory depression. J Child Adolesc Psychopharmacol 2012;22:459-462.
    • (2012) J Child Adolesc Psychopharmacol , vol.22 , pp. 459-462
    • Jinwala, F.N.1    Gupta, M.2
  • 239
    • 84886095592 scopus 로고    scopus 로고
    • Acute intoxication by synthetic cannabinoids—four case reports
    • COI: 1:CAS:528:DC%2BC3sXnvFSgsrc%3D, PID: 23696237
    • Hermanns-Clausen M, et al. Acute intoxication by synthetic cannabinoids—four case reports. Drug Test Anal 2013;5:790-794.
    • (2013) Drug Test Anal , vol.5 , pp. 790-794
    • Hermanns-Clausen, M.1
  • 240
    • 84873974367 scopus 로고    scopus 로고
    • Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings
    • PID: 22971158
    • Hermanns-Clausen M, et al. Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings. Addiction 2013;108: 534-544.
    • (2013) Addiction , vol.108 , pp. 534-544
    • Hermanns-Clausen, M.1
  • 241
    • 84877103777 scopus 로고    scopus 로고
    • First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201
    • PID: 22936123
    • McQuade D, et al. First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201. Eur J Clin Pharmacol 2013; 69:373-376.
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 373-376
    • McQuade, D.1
  • 242
    • 84863477865 scopus 로고    scopus 로고
    • Spicy seizure
    • PID: 22627260
    • Pant S, et al. Spicy seizure. Am J Med Sci 2012;344:67-68.
    • (2012) Am J Med Sci , vol.344 , pp. 67-68
    • Pant, S.1
  • 243
    • 84871330231 scopus 로고    scopus 로고
    • Internet highs—seizures after consumption of synthetic cannabinoids purchased online
    • PID: 22824736
    • Tofighi B, Lee JD. Internet highs—seizures after consumption of synthetic cannabinoids purchased online. J Addict Med 2012;6:240-241.
    • (2012) J Addict Med , vol.6 , pp. 240-241
    • Tofighi, B.1    Lee, J.D.2
  • 244
    • 84863450726 scopus 로고    scopus 로고
    • The secret "spice": an undetectable toxic cause of seizure
    • PID: 23983854
    • de Havenon A, et al. The secret "spice": an undetectable toxic cause of seizure. Neurohospitalist 2011;1:182-186.
    • (2011) Neurohospitalist , vol.1 , pp. 182-186
    • de Havenon, A.1
  • 245
    • 84908879029 scopus 로고    scopus 로고
    • Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications
    • COI: 1:CAS:528:DC%2BC2cXhsVynt7nE, PID: 25220897
    • Castaneto MS, et al. Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend 2014;144:12-41.
    • (2014) Drug Alcohol Depend , vol.144 , pp. 12-41
    • Castaneto, M.S.1
  • 246
    • 0002467306 scopus 로고
    • Anti-epileptic action of marijuana-active substances
    • Davis JP, Ramsey HH. Anti-epileptic action of marijuana-active substances. Fed Proc Am Soc Exp Biol 1949;8:284.
    • (1949) Fed Proc Am Soc Exp Biol , vol.8 , pp. 284
    • Davis, J.P.1    Ramsey, H.H.2
  • 247
    • 0016858146 scopus 로고
    • Anticonvulsant nature of marihuana smoking
    • COI: 1:STN:280:DyaE28%2Fgsl2qsQ%3D%3D, PID: 808653
    • Consroe PF, Wood GC, Buchsbaum H. Anticonvulsant nature of marihuana smoking. JAMA 1975;234:306-307.
    • (1975) JAMA , vol.234 , pp. 306-307
    • Consroe, P.F.1    Wood, G.C.2    Buchsbaum, H.3
  • 248
    • 3242813125 scopus 로고    scopus 로고
    • On the application of cannabis in paediatrics and epileptology
    • COI: 1:CAS:528:DC%2BD2cXlsFCjtbg%3D, PID: 15159680
    • Lorenz R. On the application of cannabis in paediatrics and epileptology. Neuro Endocrinol Lett 2004;25:40-44.
    • (2004) Neuro Endocrinol Lett , vol.25 , pp. 40-44
    • Lorenz, R.1
  • 249
    • 34347331251 scopus 로고    scopus 로고
    • Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature
    • PID: 17609644
    • Mortati K, Dworetzky B, Devinsky O. Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature. Rev Neurol Dis 2007;4:103-106.
    • (2007) Rev Neurol Dis , vol.4 , pp. 103-106
    • Mortati, K.1    Dworetzky, B.2    Devinsky, O.3
  • 250
    • 0035168639 scopus 로고    scopus 로고
    • Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy
    • COI: 1:CAS:528:DC%2BD38Xht1OqurY%3D, PID: 11737161
    • Gordon E, Devinsky O. Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy. Epilepsia 2001;42:1266-1272.
    • (2001) Epilepsia , vol.42 , pp. 1266-1272
    • Gordon, E.1    Devinsky, O.2
  • 251
    • 84902352281 scopus 로고    scopus 로고
    • The case for medical marijuana in epilepsy
    • PID: 24854149
    • Maa E, Figi P. The case for medical marijuana in epilepsy. Epilepsia 2014;55: 783-786.
    • (2014) Epilepsia , vol.55 , pp. 783-786
    • Maa, E.1    Figi, P.2
  • 252
    • 1242305688 scopus 로고    scopus 로고
    • Differential effects of medical marijuana based on strain and route of administration: a three-year observational study
    • Corral VJ. Differential effects of medical marijuana based on strain and route of administration: a three-year observational study. J Cannabis Ther 2001;1:43-59.
    • (2001) J Cannabis Ther , vol.1 , pp. 43-59
    • Corral, V.J.1
  • 253
    • 84890128006 scopus 로고    scopus 로고
    • Cannabis and other illicit drug use in epilepsy patients
    • COI: 1:STN:280:DC%2BC3s3oslKjtg%3D%3D, PID: 23311572
    • Hamerle M, et al. Cannabis and other illicit drug use in epilepsy patients. Eur J Neurol, 2014;21:167-170.
    • (2014) Eur J Neurol , vol.21 , pp. 167-170
    • Hamerle, M.1
  • 255
    • 11244306629 scopus 로고
    • Marijuana and epilepsy: activation of symptoms by delta-9-THC
    • Plenum Press, New York
    • Feeney D, Spiker M. Marijuana and epilepsy: activation of symptoms by delta-9-THC. In: C.S and S.RC (Eds.). The therapeutic potential of marihuana. Plenum Press, New York, 1976.
    • (1976) The therapeutic potential of marihuana
    • Feeney, D.1    Spiker, M.2
  • 256
    • 0024452359 scopus 로고
    • Seizures associated with recreational drug abuse
    • COI: 1:STN:280:DyaL1MzksVCjsA%3D%3D, PID: 2788249
    • Alldredge BK, Lowenstein DH, Simon RP. Seizures associated with recreational drug abuse. Neurology 1989;39:1037-1039.
    • (1989) Neurology , vol.39 , pp. 1037-1039
    • Alldredge, B.K.1    Lowenstein, D.H.2    Simon, R.P.3
  • 257
    • 0026714343 scopus 로고
    • Marijuana use and the risk of new onset seizures
    • COI: 1:STN:280:DyaK3s%2Fjt12ntA%3D%3D, PID: 1413377
    • Brust JC, et al. Marijuana use and the risk of new onset seizures. Trans Am Clin Climatol Assoc 1992;103:176-181.
    • (1992) Trans Am Clin Climatol Assoc , vol.103 , pp. 176-181
    • Brust, J.C.1
  • 258
    • 2942555598 scopus 로고    scopus 로고
    • Marijuana use and epilepsy: prevalence in patients of a tertiary care epilepsy center
    • COI: 1:STN:280:DC%2BD2c3osVClug%3D%3D, PID: 15184622
    • Gross DW, et al. Marijuana use and epilepsy: prevalence in patients of a tertiary care epilepsy center. Neurology 2004;62:2095-2097.
    • (2004) Neurology , vol.62 , pp. 2095-2097
    • Gross, D.W.1
  • 259
    • 84887809109 scopus 로고    scopus 로고
    • Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
    • PID: 24237632
    • Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy Behav 2013;29:574-577.
    • (2013) Epilepsy Behav , vol.29 , pp. 574-577
    • Porter, B.E.1    Jacobson, C.2
  • 260
    • 84964227461 scopus 로고    scopus 로고
    • Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy
    • PID: 25845492
    • Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy Behav 2015;45: 49–52.
    • (2015) Epilepsy Behav , vol.45 , pp. 49-52
    • Press, C.A.1    Knupp, K.G.2    Chapman, K.E.3
  • 261
    • 0018150536 scopus 로고
    • Toward drugs derived from cannabis
    • COI: 1:CAS:528:DyaE1cXhvVaht74%3D, PID: 351429
    • Mechoulam R, Carlini EA. Toward drugs derived from cannabis. Naturwissenschaften 1978;65:174-179.
    • (1978) Naturwissenschaften , vol.65 , pp. 174-179
    • Mechoulam, R.1    Carlini, E.A.2
  • 262
    • 0018947105 scopus 로고
    • Chronic administration of cannabidiol to healthy volunteers and epileptic patients
    • COI: 1:STN:280:DyaL3M%2FhsVSrtQ%3D%3D, PID: 7413719
    • Cunha JM, et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 1980;21:175-185.
    • (1980) Pharmacology , vol.21 , pp. 175-185
    • Cunha, J.M.1
  • 263
    • 0023041272 scopus 로고
    • Anticonvulsant effect of cannabidiol
    • COI: 1:STN:280:DyaL28%2FpslWltQ%3D%3D, PID: 3941934
    • Ames FR, Cridland S. Anticonvulsant effect of cannabidiol. S Afr Med J 1986; 69:14.
    • (1986) S Afr Med J , vol.69 , pp. 14
    • Ames, F.R.1    Cridland, S.2
  • 265
    • 60249089708 scopus 로고    scopus 로고
    • Treatment of Lennox-Gastaut syndrome: overview and recent findings
    • PID: 19337447
    • van Rijckevorsel K. Treatment of Lennox-Gastaut syndrome: overview and recent findings. Neuropsychiatr Dis Treat 2008;4:1001-1019.
    • (2008) Neuropsychiatr Dis Treat , vol.4 , pp. 1001-1019
    • van Rijckevorsel, K.1
  • 266
    • 79953726784 scopus 로고    scopus 로고
    • The core Dravet syndrome phenotype
    • PID: 21463272
    • Dravet C. The core Dravet syndrome phenotype. Epilepsia 2011;52(Suppl. 2):3-9.
    • (2011) Epilepsia , vol.52 , pp. 3-9
    • Dravet, C.1
  • 267
    • 84921690349 scopus 로고    scopus 로고
    • Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia's survey
    • PID: 25413126
    • Mathern GW, Beninsig L, Nehlig A. Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia's survey. Epilepsia 2015;56:1-6.
    • (2015) Epilepsia , vol.56 , pp. 1-6
    • Mathern, G.W.1    Beninsig, L.2    Nehlig, A.3
  • 268
    • 84906931759 scopus 로고    scopus 로고
    • Adverse health effects of marijuana use
    • PID: 25162899
    • Volkow ND, Compton WM, Weiss SR. Adverse health effects of marijuana use. N Engl J Med 2014;371:879.
    • (2014) N Engl J Med , vol.371 , pp. 879
    • Volkow, N.D.1    Compton, W.M.2    Weiss, S.R.3
  • 269
    • 84908151689 scopus 로고    scopus 로고
    • Characterizing cannabis-induced psychosis: a study with prepulse inhibition of the startle reflex
    • PID: 25175914
    • Morales-Munoz I, et al. Characterizing cannabis-induced psychosis: a study with prepulse inhibition of the startle reflex. Psychiatry Res 2014;220:535-540.
    • (2014) Psychiatry Res , vol.220 , pp. 535-540
    • Morales-Munoz, I.1
  • 270
    • 0033663635 scopus 로고    scopus 로고
    • The effects of adolescent cannabis use on educational attainment: a review
    • COI: 1:STN:280:DC%2BD3M7jsFKnsQ%3D%3D, PID: 11219366
    • Lynskey M, Hall W. The effects of adolescent cannabis use on educational attainment: a review. Addiction 2000;95:1621-1630.
    • (2000) Addiction , vol.95 , pp. 1621-1630
    • Lynskey, M.1    Hall, W.2
  • 271
    • 79954549233 scopus 로고    scopus 로고
    • An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions
    • PID: 21321675
    • Crean RD, Crane NA, Mason BJ. An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med 2011;5: 1-8.
    • (2011) J Addict Med , vol.5 , pp. 1-8
    • Crean, R.D.1    Crane, N.A.2    Mason, B.J.3
  • 272
    • 84884551746 scopus 로고    scopus 로고
    • Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function
    • PID: 23847550
    • Lisdahl KM, et al. Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. Front Psychiatry 2013;4:53.
    • (2013) Front Psychiatry , vol.4 , pp. 53
    • Lisdahl, K.M.1
  • 273
    • 84884827741 scopus 로고    scopus 로고
    • Preliminary evidence for a sex-specific relationship between amount of cannabis use and neurocognitive performance in young adult cannabis users
    • PID: 23962414
    • Crane NA, Schuster RM, Gonzalez R. Preliminary evidence for a sex-specific relationship between amount of cannabis use and neurocognitive performance in young adult cannabis users. J Int Neuropsychol Soc 2013;19:1009-1015.
    • (2013) J Int Neuropsychol Soc , vol.19 , pp. 1009-1015
    • Crane, N.A.1    Schuster, R.M.2    Gonzalez, R.3
  • 274
    • 84964312464 scopus 로고    scopus 로고
    • Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence
    • PID: 25208190
    • Jacobus J, et al. Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence. J Stud Alcohol Drugs 2014; 75:729-743.
    • (2014) J Stud Alcohol Drugs , vol.75 , pp. 729-743
    • Jacobus, J.1
  • 275
    • 84899476917 scopus 로고    scopus 로고
    • Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users
    • PID: 24741043
    • Gilman JM, et al. Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. J Neurosci 2014;34: 5529-5538.
    • (2014) J Neurosci , vol.34 , pp. 5529-5538
    • Gilman, J.M.1
  • 276
    • 84898601930 scopus 로고    scopus 로고
    • Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity
    • COI: 1:CAS:528:DC%2BC3sXhslWlsbvJ
    • Gruber SA, et al. Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity. Psychopharmacology (Berl) 2014;231:1455-1465.
    • (2014) Psychopharmacology (Berl) , vol.231 , pp. 1455-1465
    • Gruber, S.A.1
  • 277
    • 84898620219 scopus 로고    scopus 로고
    • Miswiring the brain: Delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway
    • COI: 1:CAS:528:DC%2BC2cXhtVOgsr7E, PID: 24469251
    • Tortoriello G, et al. Miswiring the brain: Delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J 2014;33:668-685.
    • (2014) EMBO J , vol.33 , pp. 668-685
    • Tortoriello, G.1
  • 278
    • 84888329823 scopus 로고    scopus 로고
    • Adolescent cannabinoid exposure permanently suppresses cortical oscillations in adult mice
    • PID: 23822952
    • Raver SM, Haughwout SP, Keller A. Adolescent cannabinoid exposure permanently suppresses cortical oscillations in adult mice. Neuropsychopharmacology 2013;38:2338-2347.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2338-2347
    • Raver, S.M.1    Haughwout, S.P.2    Keller, A.3
  • 279
    • 84905367356 scopus 로고    scopus 로고
    • Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms
    • COI: 1:CAS:528:DC%2BC2cXht1OqsbvN, PID: 25036610
    • Raver SM, Keller A. Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms. Neuropharmacology 2014;86:161-173.
    • (2014) Neuropharmacology , vol.86 , pp. 161-173
    • Raver, S.M.1    Keller, A.2
  • 280
    • 84887569562 scopus 로고    scopus 로고
    • Functional connectivity and cannabis use in high-risk adolescents
    • PID: 24200211
    • Houck JM, Bryan AD, Feldstein Ewing SW. Functional connectivity and cannabis use in high-risk adolescents. Am J Drug Alcohol Abuse 2013;39:414-423.
    • (2013) Am J Drug Alcohol Abuse , vol.39 , pp. 414-423
    • Houck, J.M.1    Bryan, A.D.2    Feldstein Ewing, S.W.3
  • 281
    • 84902201152 scopus 로고    scopus 로고
    • Effects of cannabis on cognition in patients with MS: a psychometric and MRI study
    • PID: 24789863
    • Pavisian B, et al. Effects of cannabis on cognition in patients with MS: a psychometric and MRI study. Neurology 2014;82:1879-1887.
    • (2014) Neurology , vol.82 , pp. 1879-1887
    • Pavisian, B.1
  • 282
    • 1542361268 scopus 로고    scopus 로고
    • A phase I, open label, four-way crossover study to compare the pharmacokinetic profiles of a single dose of 20 mg of a cannabis based medicine extract (CBME) administered on 3 different areas of the buccal mucosa and to investigate the pharmacokinetics of CBME per oral in healthy male and female volunteers (GWPK0112)
    • COI: 1:CAS:528:DC%2BD2cXisFKrsLo%3D
    • Guy GW, Robson PJ. A phase I, open label, four-way crossover study to compare the pharmacokinetic profiles of a single dose of 20 mg of a cannabis based medicine extract (CBME) administered on 3 different areas of the buccal mucosa and to investigate the pharmacokinetics of CBME per oral in healthy male and female volunteers (GWPK0112). J Cannabis Ther 2003;3:79-120.
    • (2003) J Cannabis Ther , vol.3 , pp. 79-120
    • Guy, G.W.1    Robson, P.J.2
  • 284
    • 0027401508 scopus 로고
    • Characterization of cannabidiol-mediated cytochrome P450 inactivation
    • COI: 1:CAS:528:DyaK3sXisVKqtr4%3D, PID: 8466552
    • Bornheim LM, et al. Characterization of cannabidiol-mediated cytochrome P450 inactivation. Biochem Pharmacol 1993;45:1323-1331.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1323-1331
    • Bornheim, L.M.1
  • 285
    • 80054732392 scopus 로고    scopus 로고
    • Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6
    • COI: 1:CAS:528:DC%2BC38XhtlSks7k%3D, PID: 21821735
    • Yamaori S, et al. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos 2011;39:2049-2056.
    • (2011) Drug Metab Dispos , vol.39 , pp. 2049-2056
    • Yamaori, S.1
  • 286
    • 80051794688 scopus 로고    scopus 로고
    • Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
    • COI: 1:CAS:528:DC%2BC3MXptVaitbo%3D, PID: 21704641
    • Jiang R, et al. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sci 2011;89:165-170.
    • (2011) Life Sci , vol.89 , pp. 165-170
    • Jiang, R.1
  • 287
    • 79953287136 scopus 로고    scopus 로고
    • Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety
    • COI: 1:CAS:528:DC%2BC3MXktF2jt7s%3D, PID: 21356216
    • Yamaori S, et al. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. Life Sci 2011;88:730-736.
    • (2011) Life Sci , vol.88 , pp. 730-736
    • Yamaori, S.1
  • 288
    • 84880409258 scopus 로고    scopus 로고
    • Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19
    • COI: 1:CAS:528:DC%2BC3sXhsF2ktrvF, PID: 23318708
    • Jiang R, et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Metab Pharmacokinet 2013;28:332-338.
    • (2013) Drug Metab Pharmacokinet , vol.28 , pp. 332-338
    • Jiang, R.1
  • 289
    • 84893293360 scopus 로고    scopus 로고
    • Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review
    • COI: 1:CAS:528:DC%2BC2cXhvVylu7Y%3D, PID: 24160757
    • Stout SM, Cimino NM. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev 2014;46:86-95.
    • (2014) Drug Metab Rev , vol.46 , pp. 86-95
    • Stout, S.M.1    Cimino, N.M.2
  • 290
    • 0038714895 scopus 로고    scopus 로고
    • Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs
    • COI: 1:CAS:528:DC%2BD3sXmslamtbs%3D, PID: 12878435
    • Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003;2: 473-481.
    • (2003) Lancet Neurol , vol.2 , pp. 473-481
    • Patsalos, P.N.1    Perucca, E.2
  • 291
    • 77950094856 scopus 로고    scopus 로고
    • Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
    • COI: 1:CAS:528:DC%2BC3cXjvFKmtL4%3D, PID: 20117100
    • Yamaori S, et al. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes. Biochem Pharmacol 2010;79:1691-1698.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1691-1698
    • Yamaori, S.1
  • 292
    • 84973920243 scopus 로고    scopus 로고
    • The effect of Epidiolex (Cannabidiol) on serum levels of concomminant anti-epileptic drugs in children and young adults with treatment-resistant epilepsy in an expanded access program
    • Seattle: WA
    • Friedman D, et al. The effect of Epidiolex (Cannabidiol) on serum levels of concomminant anti-epileptic drugs in children and young adults with treatment-resistant epilepsy in an expanded access program. In: American Epilepsy Society, Seattle, WA, 2014.
    • American Epilepsy Society , pp. 2014
    • Friedman, D.1
  • 293
    • 84923675964 scopus 로고    scopus 로고
    • Placebo effect of medication cost in Parkinson disease: a randomized double-blind study
    • PID: 25632091
    • Espay AJ, et al. Placebo effect of medication cost in Parkinson disease: a randomized double-blind study. Neurology 2015;84:794-802.
    • (2015) Neurology , vol.84 , pp. 794-802
    • Espay, A.J.1
  • 294
    • 84880283477 scopus 로고    scopus 로고
    • Placebo effects in children: a review
    • PID: 23598811
    • Weimer K, et al. Placebo effects in children: a review. Pediatr Res 2013;74:96-102.
    • (2013) Pediatr Res , vol.74 , pp. 96-102
    • Weimer, K.1
  • 295
    • 34249804779 scopus 로고    scopus 로고
    • Placebo response in asthma: a robust and objective phenomenon
    • PID: 17451796
    • Kemeny ME, et al. Placebo response in asthma: a robust and objective phenomenon. J Allergy Clin Immunol 2007;119:1375-1381.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1375-1381
    • Kemeny, M.E.1
  • 296
    • 50949123608 scopus 로고    scopus 로고
    • Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy
    • PID: 18700812
    • Rheims S, et al. Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy. PLoS Med 2008;5: e166.
    • (2008) PLoS Med , vol.5
    • Rheims, S.1
  • 297
    • 0024312464 scopus 로고
    • Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome. The Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome
    • Anon. Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome. The Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome. Epilepsia 1989;30:422-429.
    • (1989) Epilepsia , vol.30 , pp. 422-429
  • 298
    • 84893503263 scopus 로고    scopus 로고
    • THC:CBD spray and MS spasticity symptoms: data from latest studies
    • COI: 1:CAS:528:DC%2BC2cXhs1Chu74%3D, PID: 24457846
    • Rekand T. THC:CBD spray and MS spasticity symptoms: data from latest studies. Eur Neurol 2014;71(Suppl. 1):4-9.
    • (2014) Eur Neurol , vol.71 , pp. 4-9
    • Rekand, T.1
  • 299
    • 55349089895 scopus 로고    scopus 로고
    • Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice
    • COI: 1:CAS:528:DC%2BD1cXhtlSgsb3L, PID: 18575801
    • Naderi N, et al. Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice. J Neural Transm 2008;115:1501-1511.
    • (2008) J Neural Transm , vol.115 , pp. 1501-1511
    • Naderi, N.1
  • 300
    • 79961208134 scopus 로고    scopus 로고
    • Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat
    • COI: 1:CAS:528:DC%2BC3MXltFCntrk%3D, PID: 21516342
    • Naderi N, et al. Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat. Neurochem Res 2011;36:1520-1525.
    • (2011) Neurochem Res , vol.36 , pp. 1520-1525
    • Naderi, N.1
  • 301
    • 84876958493 scopus 로고    scopus 로고
    • Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats
    • COI: 1:CAS:528:DC%2BC3sXhsVOls70%3D, PID: 23352737
    • Vilela LR, et al. Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats. Epilepsy Res 2013;104:195-202.
    • (2013) Epilepsy Res , vol.104 , pp. 195-202
    • Vilela, L.R.1
  • 302
    • 84924288379 scopus 로고    scopus 로고
    • Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs
    • COI: 1:CAS:528:DC%2BC2MXhsFSisb4%3D, PID: 25769371
    • Shubina L, Aliev R, Kitchigina V. Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs. Epilepsy Res 2015;111:33-44.
    • (2015) Epilepsy Res , vol.111 , pp. 33-44
    • Shubina, L.1    Aliev, R.2    Kitchigina, V.3
  • 303
    • 79959941041 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice
    • PID: 21627644
    • Wendt H, et al. Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice. Epilepsia 2011;52:e62-e65.
    • (2011) Epilepsia , vol.52 , pp. e62-e65
    • Wendt, H.1
  • 304
    • 0035964576 scopus 로고    scopus 로고
    • Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects
    • COI: 1:CAS:528:DC%2BD3MXnsVSluro%3D, PID: 11779037
    • Wallace MJ, et al. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. Eur J Pharmacol 2001;428:51-57.
    • (2001) Eur J Pharmacol , vol.428 , pp. 51-57
    • Wallace, M.J.1
  • 305
    • 84919444053 scopus 로고    scopus 로고
    • Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2
    • COI: 1:CAS:528:DC%2BC2cXhvFOhu7vL, PID: 25448777
    • Payandemehr B, et al. Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. Prog Neuropsychopharmacol Biol Psychiatry 2015;57:140-145.
    • (2015) Prog Neuropsychopharmacol Biol Psychiatry , vol.57 , pp. 140-145
    • Payandemehr, B.1
  • 306
    • 77955338455 scopus 로고    scopus 로고
    • WAG/Rij rats show a reduced expression of CB(1) receptors in thalamic nuclei and respond to the CB(1) receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges
    • PID: 20132294
    • van Rijn CM, et al. WAG/Rij rats show a reduced expression of CB(1) receptors in thalamic nuclei and respond to the CB(1) receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia 2010;51:1511-1521.
    • (2010) Epilepsia , vol.51 , pp. 1511-1521
    • van Rijn, C.M.1
  • 307
    • 84883284124 scopus 로고    scopus 로고
    • CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations
    • COI: 1:CAS:528:DC%2BC3sXhtFSmt7%2FN, PID: 23860329
    • Citraro R, et al. CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Res 2013; 106:74-82.
    • (2013) Epilepsy Res , vol.106 , pp. 74-82
    • Citraro, R.1
  • 308
    • 0035060264 scopus 로고    scopus 로고
    • Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice
    • COI: 1:CAS:528:DC%2BD38Xht1Oqt7s%3D, PID: 11442148
    • Lambert DM, et al. Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 2001;42:321-327.
    • (2001) Epilepsia , vol.42 , pp. 321-327
    • Lambert, D.M.1
  • 309
    • 5344277612 scopus 로고    scopus 로고
    • Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid
    • COI: 1:CAS:528:DC%2BD2cXhtVSjtrbK, PID: 15461672
    • Sheerin AH, et al. Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid. Epilepsia 2004;45:1184-1188.
    • (2004) Epilepsia , vol.45 , pp. 1184-1188
    • Sheerin, A.H.1
  • 310
    • 0037064266 scopus 로고    scopus 로고
    • Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
    • COI: 1:CAS:528:DC%2BD38XnsVagt7o%3D, PID: 12359270
    • Wallace MJ, Martin BR, DeLorenzo RJ. Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. Eur J Pharmacol 2002;452:295-301.
    • (2002) Eur J Pharmacol , vol.452 , pp. 295-301
    • Wallace, M.J.1    Martin, B.R.2    DeLorenzo, R.J.3
  • 311
    • 3242687074 scopus 로고    scopus 로고
    • The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice
    • COI: 1:CAS:528:DC%2BD2cXmtVCjtbs%3D, PID: 15275828
    • Shafaroodi H, et al. The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice. Neuropharmacology 2004;47:390-400.
    • (2004) Neuropharmacology , vol.47 , pp. 390-400
    • Shafaroodi, H.1
  • 312
    • 50649102129 scopus 로고    scopus 로고
    • The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice
    • COI: 1:CAS:528:DC%2BD1cXhtVynsLfF, PID: 18502613
    • Bahremand A, et al. The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice. Epilepsy Res 2008;81:44-51.
    • (2008) Epilepsy Res , vol.81 , pp. 44-51
    • Bahremand, A.1
  • 313
    • 64149109740 scopus 로고    scopus 로고
    • Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice
    • COI: 1:CAS:528:DC%2BD1MXkslKmt7Y%3D, PID: 19223154
    • Bahremand A, et al. Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. Epilepsy Res 2009;84:110-119.
    • (2009) Epilepsy Res , vol.84 , pp. 110-119
    • Bahremand, A.1
  • 314
    • 80155182048 scopus 로고    scopus 로고
    • Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period
    • COI: 1:CAS:528:DC%2BC3MXhs1GjsrrN, PID: 22019959
    • Rudenko V, et al. Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period. Pharmacol Biochem Behav 2012;100:474-484.
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 474-484
    • Rudenko, V.1
  • 315
    • 84909983227 scopus 로고    scopus 로고
    • Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats
    • Di Maio R, Cannon JR, Timothy Greenamyre J. Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats. Neurobiol Dis 2014;73C:356-365.
    • (2014) Neurobiol Dis , vol.73C , pp. 356-365
    • Di Maio, R.1    Cannon, J.R.2    Timothy, G.J.3
  • 316
    • 67650976331 scopus 로고    scopus 로고
    • Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat
    • COI: 1:CAS:528:DC%2BD1MXptVaksrg%3D, PID: 19595742
    • Rizzo V, et al. Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat. Neurosci Lett 2009;462:135-139.
    • (2009) Neurosci Lett , vol.462 , pp. 135-139
    • Rizzo, V.1
  • 317
    • 84899677342 scopus 로고    scopus 로고
    • Modulation of pilocarpine-induced seizures by cannabinoid receptor 1
    • PID: 24752144
    • Kow RL, et al. Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. PLoS One 2014;9:e95922.
    • (2014) PLoS One , vol.9
    • Kow, R.L.1
  • 318
    • 67649967402 scopus 로고    scopus 로고
    • The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats
    • COI: 1:CAS:528:DC%2BD1MXpt1Olt7k%3D, PID: 19453709
    • Kozan R, Ayyildiz M, Agar E. The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats. Epilepsia 2009;50:1760-1767.
    • (2009) Epilepsia , vol.50 , pp. 1760-1767
    • Kozan, R.1    Ayyildiz, M.2    Agar, E.3
  • 319
    • 79251637742 scopus 로고    scopus 로고
    • The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats
    • COI: 1:CAS:528:DC%2BC3MXht1yksLc%3D, PID: 21177076
    • Cakil D, et al. The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats. Epilepsy Res 2011;93:128-137.
    • (2011) Epilepsy Res , vol.93 , pp. 128-137
    • Cakil, D.1
  • 320
    • 79953182386 scopus 로고    scopus 로고
    • Endocannabinoid system protects against cryptogenic seizures
    • PID: 21441624
    • van Rijn CM, et al. Endocannabinoid system protects against cryptogenic seizures. Pharmacol Rep 2011;63:165-168.
    • (2011) Pharmacol Rep , vol.63 , pp. 165-168
    • van Rijn, C.M.1
  • 321
    • 80053917610 scopus 로고    scopus 로고
    • Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy
    • COI: 1:CAS:528:DC%2BC3MXhtlCiu73O, PID: 21733658
    • Vinogradova LV, Shatskova AB, van Rijn CM. Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy. Epilepsy Res 2011;96:250-256.
    • (2011) Epilepsy Res , vol.96 , pp. 250-256
    • Vinogradova, L.V.1    Shatskova, A.B.2    van Rijn, C.M.3
  • 322
    • 34948881750 scopus 로고    scopus 로고
    • Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice
    • COI: 1:CAS:528:DC%2BD2sXhtFGrsL3I, PID: 17870135
    • Gholizadeh S, et al. Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. Neuropharmacology 2007;53:763-770.
    • (2007) Neuropharmacology , vol.53 , pp. 763-770
    • Gholizadeh, S.1
  • 323
    • 77954521453 scopus 로고    scopus 로고
    • The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat
    • COI: 1:CAS:528:DC%2BC3cXhtVegs7fE, PID: 20618417
    • Dudek FE, et al. The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat. Epilepsia 2010;51(Suppl. 3):126-130.
    • (2010) Epilepsia , vol.51 , pp. 126-130
    • Dudek, F.E.1
  • 324
    • 67349209246 scopus 로고    scopus 로고
    • Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model
    • COI: 1:CAS:528:DC%2BD1MXnt1eqs78%3D, PID: 19369036
    • Echegoyen J, et al. Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model. Epilepsy Res 2009;85:123-127.
    • (2009) Epilepsy Res , vol.85 , pp. 123-127
    • Echegoyen, J.1
  • 325
    • 0016222412 scopus 로고
    • Comparison among four vehicles and four routes for administering delta9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaE2cXks1ynur4%3D, PID: 4851104
    • Sofia RD, Kubena RK, Barry, H, 3rd. Comparison among four vehicles and four routes for administering delta9-tetrahydrocannabinol. J Pharm Sci 1974;63:939-941.
    • (1974) J Pharm Sci , vol.63 , pp. 939-941
    • Sofia, R.D.1    Kubena, R.K.2    Barry, H.3
  • 326
    • 0016219361 scopus 로고
    • Anticonvulsant effects of cannabinoids in mice: drug interactions within cannabinoids and cannabinoid interactions with phenytoin
    • COI: 1:CAS:528:DyaE2MXkslWltLY%3D, PID: 4850601
    • Chesher GB, Jackson DM. Anticonvulsant effects of cannabinoids in mice: drug interactions within cannabinoids and cannabinoid interactions with phenytoin. Psychopharmacologia 1974;37:255-264.
    • (1974) Psychopharmacologia , vol.37 , pp. 255-264
    • Chesher, G.B.1    Jackson, D.M.2
  • 327
    • 0016675230 scopus 로고
    • Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaE28XhtlShsr4%3D, PID: 1222370
    • Johnson DD, et al. Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol. Can J Physiol Pharmacol 1975;53:1007-1013.
    • (1975) Can J Physiol Pharmacol , vol.53 , pp. 1007-1013
    • Johnson, D.D.1
  • 328
    • 0016813850 scopus 로고
    • Effects of tetrahydrocannabinols on kindled amygdaloid seizures and photogenic seizures in Senegalese baboons, Papio papio
    • COI: 1:STN:280:DyaE28%2FktlKjtQ%3D%3D, PID: 810346
    • Wada JA, Osawa T, Corcoran ME. Effects of tetrahydrocannabinols on kindled amygdaloid seizures and photogenic seizures in Senegalese baboons, Papio papio. Epilepsia 1975;16:439-448.
    • (1975) Epilepsia , vol.16 , pp. 439-448
    • Wada, J.A.1    Osawa, T.2    Corcoran, M.E.3
  • 329
    • 0015927103 scopus 로고
    • 9 -Tetrahydrocannabinol effect on audiogenic seizure susceptibility
    • COI: 1:CAS:528:DyaE3sXkt1Ohtrw%3D, PID: 4709834
    • Boggan WO, Steele RA, Freedman DX. 9 -Tetrahydrocannabinol effect on audiogenic seizure susceptibility. Psychopharmacologia 1973;29:101-106.
    • (1973) Psychopharmacologia , vol.29 , pp. 101-106
    • Boggan, W.O.1    Steele, R.A.2    Freedman, D.X.3
  • 330
    • 0015699219 scopus 로고
    • Acute antiepileptic effects of 9-tetrahydrocannabinol in rats with kindled seizures
    • COI: 1:CAS:528:DyaE3sXlt1Wqt78%3D, PID: 4354188
    • Corcoran ME, McCaughran JA, Jr., Wada JA. Acute antiepileptic effects of 9-tetrahydrocannabinol in rats with kindled seizures. Exp Neurol 1973;40:471-483.
    • (1973) Exp Neurol , vol.40 , pp. 471-483
    • Corcoran, M.E.1    McCaughran, J.A.2    Wada, J.A.3
  • 331
    • 0016742767 scopus 로고
    • Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats
    • COI: 1:STN:280:DyaE28%2FktlKitQ%3D%3D, PID: 1183427
    • Wada JA, et al. Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats. Epilepsia 1975;16:503-510.
    • (1975) Epilepsia , vol.16 , pp. 503-510
    • Wada, J.A.1
  • 332
    • 0018387160 scopus 로고
    • An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats
    • COI: 1:CAS:528:DyaL3cXhsFOkt7w%3D, PID: 477630
    • Turkanis SA, et al. An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats. Epilepsia 1979;20:351-363.
    • (1979) Epilepsia , vol.20 , pp. 351-363
    • Turkanis, S.A.1
  • 333
    • 0015543610 scopus 로고
    • Effect of cannabidiol and of other cannabis sativa compounds on hippocampal seizure discharges
    • COI: 1:CAS:528:DyaE3sXpt1KisQ%3D%3D, PID: 4714680
    • Izquierdo I, Orsingher OA, Berardi AC. Effect of cannabidiol and of other cannabis sativa compounds on hippocampal seizure discharges. Psychopharmacologia 1973;28:95-102.
    • (1973) Psychopharmacologia , vol.28 , pp. 95-102
    • Izquierdo, I.1    Orsingher, O.A.2    Berardi, A.C.3
  • 334
    • 0018274907 scopus 로고
    • Cannabis and epilepsy
    • COI: 1:CAS:528:DyaL3cXlt1Wiuw%3D%3D, PID: 756847
    • Karler R, Turkanis SA. Cannabis and epilepsy. Adv Biosci 1978;22-23:619-641.
    • (1978) Adv Biosci , vol.22-23 , pp. 619-641
    • Karler, R.1    Turkanis, S.A.2
  • 335
    • 0019929137 scopus 로고
    • Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice
    • COI: 1:CAS:528:DyaL3sXkt1I%3D, PID: 6129147
    • Consroe P, et al. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. Eur J Pharmacol 1982;83:293-298.
    • (1982) Eur J Pharmacol , vol.83 , pp. 293-298
    • Consroe, P.1
  • 336
    • 84877349075 scopus 로고    scopus 로고
    • The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice
    • PID: 23644464
    • Shirazi-zand Z, et al. The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice. Epilepsy Behav 2013;28:1-7.
    • (2013) Epilepsy Behav , vol.28 , pp. 1-7
    • Shirazi-zand, Z.1
  • 337
    • 84884550462 scopus 로고    scopus 로고
    • Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
    • COI: 1:CAS:528:DC%2BC3sXhsV2ntrnN, PID: 23902406
    • Hill TD, et al. Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. Br J Pharmacol 2013;170:679-692.
    • (2013) Br J Pharmacol , vol.170 , pp. 679-692
    • Hill, T.D.1
  • 338
    • 84860685529 scopus 로고    scopus 로고
    • Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
    • PID: 22520455
    • Jones NA, et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure 2012;21:344-352.
    • (2012) Seizure , vol.21 , pp. 344-352
    • Jones, N.A.1


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