CB1 cannabinoid receptors and on-demand defense against excitotoxicity

Science

Volumn 302, Issue 5642, 2003, Pages 84-88

  Marsicano, Giovanni ^a   Goodenough, Sharon ^a,b   Monory, Krisztina ^a   Hermann, Heike ^a   Eder, Matthias ^a   Cannich, Astrid ^a   Azad, Shahnaz C ^a,c   Cascio, Maria Grazia ^d   Ortega Gutiérrez, Silvia ^e   Van der Stelt, Mario ^d   López Rodríguez, Maria Luz ^e   Casanova, Emilio ^f   Schütz, Günther ^f   Zieglgänsberger, Walter ^a   Di Marzo, Vincenzo ^d   Behl, Christian ^a,b   Lutz, Beat ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d CNR   (Italy)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; MUTAGENESIS; TOXICITY;

FORBRAIN NEURONS;

NEUROLOGY;

CANNABINOID 1 RECEPTOR; KAINIC ACID;

DEFENSE MECHANISM; TOXICITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CELL PROTECTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FOREBRAIN; HIPPOCAMPUS; IN VITRO STUDY; MOUSE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RECEPTOR INTRINSIC ACTIVITY; SEIZURE; SPIKE WAVE; WILD TYPE;

ANIMALIA;

EID: 0141865717     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088208     Document Type: Article

References (42)

1. Y. Ben Ari, R. Cossart, Trends Neurosci. 23, 580 (2000).
2. A. C. Howlett et al., Pharmacol. Rev. 54, 161 (2002).
3. V. Di Marzo, D. Melck, T. Bisogno, L. De Petrocellis, Trends Neurosci. 21, 521 (1998).
4. M. van der Stelt et al., Mol. Neurobiol. 26, 317 (2002).
5. R. Mechoulam, M. Spatz, E. Shohami, Sci. STKE 2002, re1 (2002).
6. J. L. Croxford, CNS Drugs 17, 179 (2003).
7. W. B. Veldhuis et al., J. Neurosci. 23, 4127 (2003).
8. H. Cadas, S. Gaillet, M. Beltramo, L. Venance, D. Piomelli, J. Neurosci. 16, 3934 (1996).
9. G. C. Chan, T. R. Hinds, S. Impey, D. R. Storm, J. Neurosci. 18, 5322 (1998).
10. A. B. Clement, E. G. Hawkins, A. H. Lichtman, B. F. Cravatt, J. Neurosci. 23, 3916 (2003).
11. H. H. Hansen et al., J. Neurochem. 82, 154 (2002).
12. G. Marsicano et al., Nature 418, 530 (2002).
13. Materials and methods are available as supporting material on Science Online.
14. G. Marsicano et al., unpublished data.
15. D. E. Selley et al., J. Neurochem. 77, 1048 (2001).
16. E. de Lago et al., Eur. J. Pharmacol. 449, 99 (2002).
17. G. Marsicano, B. Lutz, Eur. J. Neurosci. 11, 4213 (1999).
18. I. Katona et al., J. Neurosci. 19, 4544 (1999).
19. L. A. Matsuda, T. I. Bonner, S. J. Lolait, J. Comp. Neurol. 327, 535 (1993).
20. E. Casanova et al., Genesis 31, 37 (2001).
21. I. Ferrer et al., Acta Neuropathol. 103, 391 (2002).
22. K. J. O'Donovan, W. G. Tourtellotte, J. Millbrandt, J. M. Baraban, Trends Neurosci. 22, 167 (1999).
23. T. Herdegen, J. D. Leah, Brain Res. Rev. 28, 370 (1998).
24. J. Zhang et al., Nature Genet. 30, 416 (2002).
25. P. Derkinderen et al., J. Neurosci. 23, 2371 (2003).
26. P. Tandon, Y. Yang, K. Das, G. L. Holmes, C. E. Stafstrom, Neuroscience 91, 293 (1999).
27. E. Gratacos, E. Perez-Navarro, E. Tolosa, E. Arenas, J. Alberch, J. Neurochem. 78, 1287 (2001).
28. R. Sattler, M. Tymianski, Mol. Neurobiol. 24, 107 (2001).
29. B. Moesgaard, H. H. Hansen, S. L. Hansen, S. H. Hansen, G. Petersen, H. S. Hansen, Lipids 38, 387 (2003).
30. S. Parmentier-Batteur, K. Jin, X. O. Mao, L. Xie, D. A. Greenberg, J. Neurosci. 22, 9771 (2002).
31. D. Panikashvili et al., Nature 413, 527 (2001).
32. M. Wallace, B. Martin, R. DeLorenzo, Eur. J. Pharmacol. 452, 295 (2002).
33. D. Baker et al., FASEB J. 15, 300 (2001).
34. M. van der Stelt et al., J. Neurosci. 21, 8765 (2001).
35. H. H. Hansen, C. Ikonomidou, P. Bittigau, S. H. Hansen, H. S. Hansen, J. Neurochem. 76, 39 (2001).
36. V. Di Marzo, L. De Petrocellis, F. Fezza, A. Ligresti, T. Bisogno, Prostaglandins Leukot. Essent. Fatty Acids 66, 377 (2002).
37. H. H. Hansen et al., J. Neurochem. 78, 1415 (2001).
38. Y. Ben Ari, Nature Rev. Neurosci. 3, 728 (2002).
39. D. W. Choi, Neuron 1, 623 (1988).
40. J. T. Coyle, P. Puttfarcken, Science 262, 689 (1993).
41. J. O. McNamara, Nature 399, A15 (1999).
42. We thank B. Wölfel, A. Daschner, N. Franke, and B. Fackelmeier for technical assistance, mouse breeding, and genotyping; S. Dymecki for providing the FLP recombinase deleter mouse line; K. Becker for programming an application for the analysis of electrophysiological data; D. Monory for help with computer graphics; H.-U. Dodt for supporting M.E.; F. Holsboer for continuous support; and C. Wotjak for critical reading of the manuscript and valuable suggestions. Supported by grants from the Deutsche Forschungsgemeinschaft (DFG) to C.B. (no. Be1475/2-2, Alzheimer Priority Program), B.L. (no. LU755/1-1), G.S. (no. SFB488), and W.Z. (no. SFB391); from the Ministerio de Ciencia y Tecnologia to M.L.L.R. and S.O.G. (no. BQU 2001-1459); and from the Fondo Italiano per la Ricerca di Base to V.D.M. and by a scholarship from the Hertie Foundation to B.L.