Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 20, 2006, Pages 7895-7900

  Carrier, Erica J ^a   Auchampach, John A ^a   Hillard, Cecilia J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Adenosine; Lipopolysaccharide; Tetrahydrocannabinol; Thymidine tumor necrosis factor

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ADENOSINE; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR STIMULATING AGENT; CANNABIDIOL; CANNABINOID; CANNABINOID 2 RECEPTOR; DEXANABINOL; DNA; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; LIPOPOLYSACCHARIDE; RIMONABANT; TETRAHYDROCANNABINOL; THYMIDINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN RAW264.7; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SYNTHESIS INHIBITION; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; IMMUNE DEFICIENCY; IN VIVO STUDY; KNOCKOUT MOUSE; MACROPHAGE; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOSINE; ANIMALS; BORNANES; CANNABIDIOL; CELL LINE; CELL PROLIFERATION; DNA; IMMUNOSUPPRESSION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NUCLEOSIDE TRANSPORT PROTEINS; PIPERIDINES; PSYCHOTROPIC DRUGS; PYRAZOLES; TETRAHYDROCANNABINOL; THYMIDINE; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 33646734889     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0511232103     Document Type: Article

References (40)

1. Croxford, J. L. & Yamamura, T. (2005) J. Neuroimmunol. 166, 3-18.
2. Wade, D. T., Makela, P., Robson, P., House, H. & Bateman, C. (2004) Mult. Scler. 10, 434-441.
3. Buckley, N. E., McCoy, K. L., Mezey, E., Bonner, T., Zimmer, A., Felder, C. C. & Glass, M. (2000) Eur. J. Pharmacol. 396, 141-149.
4. Mechoulam, R., Parker, L. A. & Gallily, R. (2002) J. Clin. Pharmacol. 42, 11S-19S.
5. Belgrave, B. E., Bird, K. D., Chesher, G. B., Jackson, D. M., Lubbe, K. E., Starmer, G. A. & Teo, R. K. (1979) Psychopharmacology (Berlin) 64, 243-246.
6. Razdan, R. K. (1986) Pharmacol. Rev. 38, 75-149.
7. Pertwee, R. G. (2004) in Cannabinoids, ed. Di Marzo, V. (Kluwer Academic/Plenum Publishers, New York), pp. 32-83.
8. Costa, B., Colleoni, M., Conti, S., Parolaro, D., Franke, C., Trovato, A. E. & Giagnoni, G. (2004) Naunyn-Schmiedeberg's Arch. Pharmacol. 369, 294-299.
9. Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R. & Feldmann, M. (2000) Proc. Natl. Acad. Sci. USA 97, 9561-9566.
10. Steffens, S., Veillard, N. R., Arnaud, C., Pelli, G., Burger, F., Staub, C., Karsak, M., Zimmer, A., Frossard, J. L. & Mach, F. (2005) Nature 434, 782-786.
11. Streit, W. J., Walter, S. A. & Pennell, N. A. (1999) Prog. Neurobiol. 57, 563-581.
12. Hasko, G. & Cronstein, B. N. (2004) Trends Immunol. 25, 33-39.
13. Noji, T., Takayama, M., Mizutani, M., Okamura, Y., Takai, H., Karasawa, A. & Kusaka, H. (2002) J. Pharmacol. Exp. Ther. 300, 200-205.
14. Erdmann, A. A., Gao, Z.-G., Jung, U., Foley, J., Borenstein, T., Jacobson, K. A. & Fowler, D. H. (2005) Blood 105, 4707-4714.
15. Klein, T. W., Newton, C., Larsen, K., Lu, L., Perkins, I., Nong, L. & Friedman, H. (2003) J. Leukocyte Biol. 74, 486-496.
16. Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) Pharmacol. Rev. 54, 161-202.
17. Glass, M. & Northup, J. K. (1999) Mol. Pharmacol. 56, 1362-1369.
18. Howlett, A. C., Qualy, J. M. & Khachatrian, L. L. (1986) Mol. Pharmacol. 29, 307-313.
19. Carrier, E. J., Kearn, C. S., Barkmeier, A. J., Breese, N. M., Yang, W., Nithipatikom, K., Pfister, S. L., Campbell, W. B. & Hillard, C. J. (2004) Mol. Pharmacol. 65, 999-1007.
20. Kong, W., Engel, K. & Wang, J. (2004) Curr. Drug Metab. 5, 63-84.
21. Hyde, R. J., Cass, C. E., Young, J. D. & Baldwin, S. A. (2001) Mol. Membr. Biol. 18, 53-63.
22. Desoize, B., Leger, C., Jardillier, J. C. & Nahas, G. (1978) Adv. Biosci. 22-23, 145-159.
23. Desoize, B., Leger, C. & Nahas, G. (1978) C. R. Hebd. Seances Acad. Sci. D 287, 1441-1444.
24. Massi, P., Vaccani, A., Ceruti, S., Colombo, A., Abbracchio, M. P. & Parolaro, D. (2004) J. Pharmacol. Exp. Ther. 308, 838-845.
25. Kiss, A., Farah, K., Kim, J., Garriock, R. J., Drysdale, T. A. & Hammond, J. R. (2000) Biochem. J. 352, 363-372.
26. Hong, M., Schlichter, L. & Bendayan, R. (2000) J. Pharmacol. Exp. Ther. 292, 366-374.
27. Martin, C., Leone, M., Viviand, X., Ayem, M. L. & Guieu, R. (2000) Crit. Care Med. 28, 3198-3202.
28. Sottofattori, E., Anzaldi, M. & Ottonello, L. (2001) J. Pharm. Biomed. Anal. 24, 1143-1146.
29. Dar, M. S. & Mustafa, S. J. (2002) Brain Res. 957, 53-60.
30. Selley, D. E., Cassidy, M. P., Martin, B. R. & Sim-Selley, L. J. (2004) Mol. Pharmacol. 66, 1275-1284.
31. Soria, G., Castane, A., Berrendero, F., Ledent, C., Parmentier, M., Maldonado, R. & Valverde, O. (2004) Eur. J. Neurosci. 20, 2203-2213.
32. Hirai, K. & Ashraf, M. (1998) J. Mol. Cell. Cardiol. 30, 1803-1815.
33. Boison, D. (2005) Neuroscientist 11, 25-36.
34. Smith, P. G., Thomas, H. D., Barlow, H. C., Griffin, R. J., Golding, B. T., Calvert, H., Newell, D. R. & Curtin, N. J. (2001) Clin. Cancer Res. 7, 2105-2113.
35. Cunha, J. M., Carlini, E. A., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R., Sanvito, W. L., Lander, N. & Mechoulam, R. (1980) Pharmacology 21, 175-185.
36. Baldwin, S. J., Mackey, J. R., Cass, C. E. & Young, J. D. (1999) Mol. Med. Today 5, 216-224.
37. Mackey, J. R., Baldwin, S. A., Young, J. D. & Cass, C. E. (1998) Drug Resist. Updat. 1, 310-324.
38. Gordon, A. S., Nagy, L., Mochly-Rosen, D. & Diamond, I. (1990) Biochem. Soc. Symp. 56, 117-136.
39. Sklar, M. D., Tereba, A., Chen, B. D. & Walker, W. S. (1985) J. Cell. Physiol. 125, 403-412.
40. Cheng, Y. C. & Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3110.