Protein kinase-dependent phosphorylation and cannabinoid receptor modulation of potassium a current (I(A)) in cultured rat hippocampal neurons

Pflugers Archiv European Journal of Physiology

Volumn 439, Issue 5, 2000, Pages 541-546

  Mu, Jian ^a   Zhuang, Shou Yuan ^a   Hampson, Robert E ^a   Deadwyler, Sam A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

cAMP dependent protein kinase; Cannabinoid; Cyclic adenosine monophosphate; G protein; Hippocampus; Okadaic acid; Phosphorylation; Potassium current

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID RECEPTOR; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; OKADAIC ACID; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; HIPPOCAMPUS; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; RAT; REGULATORY MECHANISM; STEADY STATE;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME INHIBITORS; FETUS; FORSKOLIN; GTP-BINDING PROTEINS; HIPPOCAMPUS; ION CHANNEL GATING; MORPHOLINES; NAPHTHALENES; NEURONS; OKADAIC ACID; PEPTIDES; PHOSPHORYLATION; PIPERIDINES; POTASSIUM; PYRAZOLES; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0034058480     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050975     Document Type: Article

References (46)

1. 1. Bidaut-Russell M, Howlett AC (1991) Cannabinoid receptor-regulated cyclic AMP accumulation in the rat striatum. J Neurochem 57:1769-1773
2. 2. Bidaut-Russell M, Devane WA, Howlett AC (1990) Cannabinoid receptors modulation of cyclic AMP accumulation in the rat brain. J Neurochem 55:21-26
3. 3. Browning MD, Huganir R, Greengard P (1985) Protein phosphorylation and neuronal function. J Neurochem 45:11-23
4. + channels by protein kinase A and phosphatase inhibitors. Am J Physiol 261 :C387-C392
5. 5. Cheng HC, Van Patten SM, Smith AJ, Walsh DA (1985) An active twenty-amino-acid-residue peptide derived from the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J 231:655-661
6. 6. Cheng HC, Kemp BE, Pearson RB, Smith AJ, Misconi L, Van Patten SM, Walsh DA (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem 261: 989-992
7. 7. Childers SR, Deadwyler SA (1996) Role of cyclic AMP in the actions of cannabinoid receptors. Biochem Pharmacol 52: 819-827
8. 8. Childers SR, Fleming L, Konkoy C, Marckel D, Pacheco M, Sexton T, Ward S (1992) Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain. Ann NY Acad Sci 654:33-51
9. 9. Deadwyler SA, Hampson RE, Bennett BA, Edwards TA, Mu J, Pacheco MA, Ward SJ, Childers SR (1993) Cannabinoids modulate potassium current in cultured hippocampal neurons. Receptors Channels 1:121-134
10. 10. Deadwyler SA, Hampson RE, Mu J, Whyte A, Childers SR (1995) Cannabinoids modulate voltage-sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process. J Pharmacol Exp Ther 273:734-743
11. 11. Dill JA, Howlett AC (1988) Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs. J Pharmacol Exp Ther 244:1157-1163
12. 12. Dolphin AC (1992) The effect of phosphatase inhibitors and agents increasing cyclic-AMP-dependent phosphorylation on calcium channel currents in cultured rat dorsal root ganglion neurones: interaction with the effect of G protein activation. Pflügers Arch 421:138-145
13. 13. Egan TM, Dagan D, Levitan IB (1993) Properties and modulation of a calcium-activated potassium channel in rat olfactory bulb neurons. J Neurophysiol 69:1433-1442
14. 14. Fadool DA, Levitan IB (1998) Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation. J Neurosci 18:6126-6137
15. 15. Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB (1997) Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol 78:1563-1573
16. 16. Felder CC, Joyce KE, Briley EM, Glass M, Mackie KP, Fahey KJ, Cullinan GJ, Hunden DC, Johnson DW, Chaney MO, Koppel GA, Brownstein M (1998) LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther 284:291-297
17. 17. Glass M, Felder CC (1997) Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J Neurosci 17:5327-5333
18. 18. Glass DB, Cheng HC, Mende-Mueller L, Reed J, Walsh DA (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J Biol Chem 264:8802-8810
19. 19. Hampson RE, Deadwyler SA (1998) Role of cannabinoid receptors in memory storage. Neurobiol Dis Exp Neurol [B] 5: 474-482
20. 20. Hampson RE, Mu J, Evans GJO, Zhuang S-Y, Childers SR, Deadwyler SA (1995) Role of cAMP-dependent protein kinase in cannabinoid receptor modulation of potassium A-current in cultured rat hippocampal neurons. Life Sci 56:2081-2088
21. 21. Hampson RE, Mu J, Kirby MT, Zhuang S-Y, Deadwyler SA (1998) Role of cannabinoid receptors on GABAergic neurons in the rat hippocampus (abstract). Soc Neurosci Abstr 24:1245
22. 22. Hampson RE, Mu J, Zhuang S-Y, Kirby MT, Deadwyler SA (1998) Cannabinoid receptor antagonist SR141716A reveals interaction between GABA-B and CB1 receptors on potassium A-current in cultured rat hippocampal neurons. J Neurosci
23. + channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 18: 3521-3528
24. 24. Howlett AC (1995) Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35:607-634
25. 25. Huganir RL (1990) Protein phosphorylation in the nervous system. In: Ritchie JM, Magistretti PJ, Bolis L (eds) Control of membrane function: short-term and long-term. Elsevier, Amsterdam, pp 21-32
26. 26. Jan LY, Jan YN (1994) Potassium channels and their evolving gates. Nature 371:119-122
27. 27. Levitan IB (1994) Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu Rev Physiol 56:193-212
28. 28. Little PJ, Martin BR (1989) Cannabinoid modulation of cyclic AMP accumulation in synaptosomes. NIDA Res Monogr 95: 282-283
29. 29. Marrion NV (1996) Calcineurin regulates M channel modal gating in sympathetic neurons. Neuron 16:163-173
30. 30. Mathie A, Wooltorton JR, Watkins CS (1998) Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen Pharmacol 30:13-24
31. 31. Mei YA, Louiset E, Vaudry H, Cazin L (1995) A-type potassium current modulated by Al adenosine receptor in frog melanotrophs. J Physiol (Lond) 489:431-442
32. 32. Mironov SL, Lux HD (1991) Calmodulin antagonists and protein phosphatase inhibitor okadaic acid fasten the 'run-up' of high-voltage activated calcium current in rat hippocampal neurones. Neurosci Lett 133:175-178
33. 33. Reference deleted
34. + current underlying the slow spike frequency adaptation in hippocampal neurons [published erratum appears in Neuron 1994 12(4): following 934] Neuron 11:1023-1035
35. + channels in the squid giant axon. II. Nonstationary conditions. J Gen Physiol 98:19-34
36. + channel modulation by G-protein and second messengers. In: Cook N (ed) Potassium channels: structure, classification, function and therapeutic potential. Wiley, New York, pp 118-153
37. A receptor in cerebellar granule cells in culture: differential involvement of kinase activities. Neuroscience 53:131-138
38. 38. Rosenmund C, Carr DW, Bergeson SE, Nilaver G, Scott JD, Westbrook GL (1994) Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature 368:853-856
39. 39. Segal M, Barker JL (1984) Rat hippocampal neurons in culture: potassium conductances. J Neurophysiol 51:1409-1433
40. 40. Segal M, Rogawski MA, Barker JL (1984) A transient potassium conductance regulates the excitability of cultured hippocampal and spinal neurons. J Neurosci 4:604-609
41. 41. Simmons ML, Chavkin C (1996) κ-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. Mol Pharmacol 50:80-85
42. 42. Storm JF (1990) Potassium currents in hippocampal pyramidal cells. Prog Brain Res 83:161-187
43. 43. Takano K, Stanfield PR, Nakajima S, Nakajima Y (1995) Protein kinase C-mediated inhibition of an inward rectifier potassium channel by substance P in nucleus basalis neurons. Neuron 14:999-1008
44. 44. Taschenberger H, Grantyn R (1998) Interaction of calcium-permeable non-N-methyl-D-aspartate receptor channels with voltage-activated potassium and calcium currents in rat retinal ganglion cells in vitro. Neuroscience 84:877-896
45. + channel by protein kinases A and C. Proc Natl Acad Sci USA 88:9722-9725
46. 46. Wimpey TL, Chavkin C (1992) 8-Bromo-cAMP blocks opioid activation of a voltage-gated potassium current in isolated hippocampal neurons. Neuroscience Lett 137:137-140