Internalization and recycling of the CB1 cannabinoid receptor

Journal of Neurochemistry

Volumn 73, Issue 2, 1999, Pages 493-501

  Hsieh, C ^a   Brown, S ^a   Derleth, C ^a   Mackie, K ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cannabimimetic drugs; CB1 cannabinoid receptor; Internalization; Receptor regulation; Recycling; Tolerance

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; DEXANABINOL; DRONABINOL; EMETINE; GUANINE NUCLEOTIDE BINDING PROTEIN; METHANANDAMIDE; OKADAIC ACID; PERTUSSIS TOXIN; RIMONABANT; SUCROSE; TACROLIMUS;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOSOME; INTERNALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RECEPTOR BINDING; RECYCLING;

ACIDS; AMMONIUM CHLORIDE; ANIMALS; ARACHIDONIC ACIDS; CALCIUM CHANNEL BLOCKERS; CANNABINOIDS; CELLS, CULTURED; CLATHRIN; COATED VESICLES; CYCLOHEXANOLS; DRUG TOLERANCE; ENDOCYTOSIS; ENDOSOMES; EXCITATORY AMINO ACID ANTAGONISTS; GTP-BINDING PROTEINS; IMMUNOSUPPRESSIVE AGENTS; MORPHOLINES; MUTAGENESIS; NAPHTHALENES; PHOSPHORYLATION; PIPERIDINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL; TRANSFECTION; UP-REGULATION; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA; CANNABIS;

EID: 0032771955     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0730493.x     Document Type: Article

References (43)

1. Bathon J. M., Faussner A., Proud D., and Towns M. (1998) Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction. J. Biol. Chem. 273, 2617-2623.
2. 2-radrenergic receptor. J. Biol. Chem. 273, 6976-6981.
3. 35S]GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity. J. Biol. Chem. 273, 16865-16873.
4. Caron M. G., Ferguson S. S., Downey W. E. III, Colapietro A. M., Barak L. S., and Menard L. (1996) Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. J. Biol. Chem. 271, 18302-18305.
5. Chu P., Murray S., Lissin D., and von Zastrow M. (1997) Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J. Biol. Chem. 272, 27124-27130.
6. Consroe P., Musty R., Rein J., Tillery W., and Pertwee R. (1997) The perceived effects of smoked cannabis on patients with multiple sclerosis. Eur. Neurol. 38, 44-48.
7. Devi L. A., Trapaidze N., Keith D. E., Cvejic S., and Evans C. J. (1996a) Sequestration of the δ opioid receptor. J. Biol. Chem. 271, 29279-29285.
8. 353, located within the COOH-terminal tail of the δ opiate receptor, is involved in receptor down-regulation. J. Biol. Chem. 271, 4073-4076.
9. Ferguson S. S. G., Zhang J., Barak L. S., and Caron M. G. (1996) G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration. Biochem. Soc. Trans. 24, 953-959.
10. Gagnon A. W., Kallal L., and Benovic J. L. (1998) Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor. J. Biol. Chem. 273, 6976-6981.
11. Garcia D. E., Brown S., Hille B., and Mackie K. (1998) Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor. J. Neurosci. 18, 2834-2841.
12. Garland A. M., Grady E. F., Lovett M., Vigna S. R., Frucht M. M., Krause J. E., and Bunnett N. W. (1996) Mechanisms of desensitization and resensitization of G protein-coupled NK1 and NK2 receptors. Mol. Pharmacol. 49, 438-446.
13. Glass M. and Felder C. C. (1997) Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J. Neurosci. 17, 5327-5333.
14. Grady E. F., Garland A. M., Gamp P. D., Lovett M., Payan D. G., and Bunnett N. W. (1995) Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol. Biol. Cell 6, 509-524.
15. Hein L., Ishii K., Coughlin S. R., and Kobilka B. K. (1994) Intracellular targeting and trafficking of thrombin receptors. J. Biol. Chem. 269, 27719-27726.
16. Herning R. I., Jones R. T., and Benowitz N. L. (1981) Clinical relevance of cannabis tolerance and dependence. J. Clin. Pharmacol. 8-9 (Suppl.), 143S-152S.
17. Heuser J. E. and Anderson R. G. (1989) Hyptertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J. Cell Biol. 108, 389-400.
18. Hollister L. E. (1986) Health aspects of cannabis. Pharmacol. Rev. 38, 1-20.
19. Kobilka B. K. and von Zastrow M. (1992) Ligand-regulated internalization and recycling of human beta-2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J. Biol. Chem. 267, 3530-3538.
20. Krueger K. M., Daaka Y., Pitcher J. A., and Lefkowitz R. J. (1997) The role of sequestration in G protein-coupled receptor re-sensitization. Regulation of β2-adrenergic receptor dephosphorylation by vesicular acidification. J. Biol. Chem. 272, 5-8.
21. Ledent C., Valverde O., Cossu G., Petitet F., Aubert J.-F., Beslot F., Böhme G. A., Imperato A., Pedrazzini T., Roques B. P., Vassart G., Fratta W., and Parmentier M. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283, 401-404.
22. Lee K. B., Pals-Rylaarsdam R., Benovic J. L., and Hosey M. M. (1998) Arrestin-independent internalization of the m1, m3, m4 subtypes of muscarinic cholinergic receptors. J. Biol. Chem. 273, 12967-12972.
23. Lefkowitz R. J. (1996) G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. Nat. Biotechnol. 14, 283-286.
24. Lefkowitz R. J., Pitcher J., Krueger K., and Daaka Y. (1997) Mechanisms of β-adrenergic receptor desensitization and resensilization. Adv. Pharmacol. 42, 416-420.
25. Liggett S. B., Ostrowski J., Chesnut L. C., Kurose H., Raymond J. R., Caron M. G., and Lefkowitz R. J. (1992) Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. J. Biol. Chem. 267, 4740-4746.
26. Matsuda L. A. (1997) Molecular aspects of cannabinoid receptors. Crit. Rev. Neurobiol. 11, 143-166.
27. Moya M., Dautry-Varsat A., Goud B., Louvard D., and Boquet P. (1985) Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin. J. Cell Biol. 101, 548-559.
28. 9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. J. Palliat. Care 10, 14-18.
29. Pals-Rylaarsdam R. and Hosey M. M. (1997) Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor. J. Biol. Chem. 272, 14152-14158.
30. Pertwee R. G. (1991) Tolerance to and dependence on psychotropic cannabinoids, in The Biological Bases of Drug Tolerance and Dependence (Pratt J., ed), pp. 231-263. Academic Press, London.
31. Pertwee R. G. (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther. 74, 129-180.
32. Pippig S., Andexinger S., and Lohse M. J. (1995) Sequestration and recycling of beta-2-adrenergic receptors permit receptor resensitization. Mol. Pharmacol. 47, 666-676.
33. Pitcher J. A., Payne E. S., Csortos C., DePaoli-Roach A. A., and Lefkowitz R. J. (1995) The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc. Natl. Acad. Sci. USA 92, 8343-8347.
34. Roth A., Kreienkamp H. J., Meyerhof W., and Richter D. (1997) Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. J. Biol. Chem. 272, 23769-23774.
35. Sadée W., Tsuga H., Kameyama K., Haga T., Honma T., and Lameh J. (1998) Internalization and down-regulation of the human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G-protein-coupled receptor kinase 2. J. Biol. Chem. 273, 5323-5330.
36. Segredo V., Burford N. T., Lameh J., and Sadée W. (1997) A constitutively internalizing and recycling mutant of the μ-opioid receptor. J. Neurochem. 68, 2395-2404.
37. Shimizu T., Ishii I., Saito E., Izumi T., and Ui M. (1998) Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process. J. Biol. Chem. 273, 9878-9885.
38. Sternini C., Spann M., Anton B., Keith D. E. Jr., Bunnett N. W., von Zastrow M., Evans C., and Brecha N. C. (1996) Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proc. Natl. Acad. Sci. USA 93, 9241-9246.
39. Tsou K., Brown S., Sanudo-Pena M. C., Mackie K., and Walker J. M. (1998) Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83, 393-411.
40. Twitchell W., Brown S., and Mackie K. (1997) Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J. Neurophysiol. 78, 43-50.
41. Van Koppen C. J., Sell A., Lenz W., and Jakobs K. H. (1994) Deletion analysis of the m4 muscarinic acetylcholine receptor. Molecular determinants for activation of but not coupling to the Gi guanine-nucleotide-binding regulatory protein regulate receptor internalization. Eur. J. Biochem. 222, 525-531.
42. Vogler O., Bogatkewitsch G. S., Wriske C., Krummenerl P., Jakobs K. H., and van Koppen C. J. (1998) Receptor subtype-specific regulation of muscarinic acetylcholine receptor sequestration by dynamin. Distinct sequestration of m2 receptors. J. Biol. Chem. 273, 12155-12160.
43. Voth E. A. and Schwartz R. H. (1997) Medicinal applications of delta-9-tetrahydrocannabinol and marijuana. Ann. Intern. Med. 126, 791-798.