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Volumn 133, Issue 1, 2012, Pages 79-97

Phytocannabinoids as novel therapeutic agents in CNS disorders

Author keywords

Cannabinoids; Electrophysiology; Endocannabinoid system; Epilepsy; Feeding

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABIDIOL; CANNABIDIVARIN; CANNABIGEROL; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; CANNABIS; CARBAMAZEPINE; CHLORDIAZEPOXIDE; CLONAZEPAM; DELTA 9 TETRAHYDROCANNABIVARIN; DIAZEPAM; DRONABINOL; ETHOSUXIMIDE; NABILONE; NABIXIMOLS; PHENOBARBITAL; PHENYTOIN; RIMONABANT; TRIMETHADIONE; UNCLASSIFIED DRUG;

EID: 83555174546     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.09.002     Document Type: Review
Times cited : (256)

References (319)
  • 1
    • 0035979606 scopus 로고    scopus 로고
    • Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity
    • M.E. Abood, G. Rizvi, N. Sallapudi, and S.D. Mcallister Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity Neurosci Lett 309 2001 197 201
    • (2001) Neurosci Lett , vol.309 , pp. 197-201
    • Abood, M.E.1    Rizvi, G.2    Sallapudi, N.3    McAllister, S.D.4
  • 2
    • 0036444375 scopus 로고    scopus 로고
    • Rates of psychiatric comorbidity among U.S. residents with lifetime cannabis dependence
    • V. Agosti, E. Nunes, and F. Levin Rates of psychiatric comorbidity among U.S. residents with lifetime cannabis dependence Am J Drug Alcohol Abuse 28 2002 643 652
    • (2002) Am J Drug Alcohol Abuse , vol.28 , pp. 643-652
    • Agosti, V.1    Nunes, E.2    Levin, F.3
  • 3
    • 59549106886 scopus 로고    scopus 로고
    • The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-beta glycine receptor function
    • J. Ahrens, R. Demir, M. Leuwer, J. De La Roche, K. Krampfl, and N. Foadi The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-beta glycine receptor function Pharmacology 83 2009 217 222
    • (2009) Pharmacology , vol.83 , pp. 217-222
    • Ahrens, J.1    Demir, R.2    Leuwer, M.3    De La Roche, J.4    Krampfl, K.5    Foadi, N.6
  • 4
    • 79957551226 scopus 로고    scopus 로고
    • Supply and demand for endocannabinoids
    • B.E. Alger, and J. Kim Supply and demand for endocannabinoids Trends Neurosci 34 2011 304 315
    • (2011) Trends Neurosci , vol.34 , pp. 304-315
    • Alger, B.E.1    Kim, J.2
  • 5
    • 0023041272 scopus 로고
    • Anticonvulsant effect of cannabidiol
    • F.R. Ames, and S. Cridland Anticonvulsant effect of cannabidiol S Afr Med J 69 1986 14
    • (1986) S Afr Med J , vol.69 , pp. 14
    • Ames, F.R.1    Cridland, S.2
  • 6
    • 38349141837 scopus 로고    scopus 로고
    • CB2 cannabinoid receptors as an emerging target for demyelinating diseases: From neuroimmune interactions to cell replacement strategies
    • A. Arevalo-Martin, D. Garcia-Ovejero, O. Gomez, A. Rubio-Araiz, B. Navarro-Galve, and C. Guaza CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies Br J Pharmacol 153 2008 216 225
    • (2008) Br J Pharmacol , vol.153 , pp. 216-225
    • Arevalo-Martin, A.1    Garcia-Ovejero, D.2    Gomez, O.3    Rubio-Araiz, A.4    Navarro-Galve, B.5    Guaza, C.6
  • 8
    • 0035205651 scopus 로고    scopus 로고
    • Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats
    • J.C. Arnold, G.E. Hunt, and I.S. Mcgregor Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats Life Sci 70 2001 97 108
    • (2001) Life Sci , vol.70 , pp. 97-108
    • Arnold, J.C.1    Hunt, G.E.2    McGregor, I.S.3
  • 9
    • 0035138027 scopus 로고    scopus 로고
    • Pharmacology and effects of cannabis: A brief review
    • C.H. Ashton Pharmacology and effects of cannabis: a brief review Br J Psychiatry 178 2001 101 106
    • (2001) Br J Psychiatry , vol.178 , pp. 101-106
    • Ashton, C.H.1
  • 10
    • 0019404107 scopus 로고
    • The seed and the soil: Effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man
    • H. Ashton, J. Golding, V.R. Marsh, J.E. Millman, and J.W. Thompson The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man Br J Clin Pharmacol 12 1981 705 720
    • (1981) Br J Clin Pharmacol , vol.12 , pp. 705-720
    • Ashton, H.1    Golding, J.2    Marsh, V.R.3    Millman, J.E.4    Thompson, J.W.5
  • 11
  • 12
    • 33645816506 scopus 로고    scopus 로고
    • Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
    • M.P. Barnes Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain Expert Opin Pharmacother 7 2006 607 615
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 607-615
    • Barnes, M.P.1
  • 15
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • T. Bisogno, L. Hanus, L. De Petrocellis, S. Tchilibon, D.E. Ponde, and I. Brandi Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide Br J Pharmacol 134 2001 845 852
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 16
    • 53649087673 scopus 로고    scopus 로고
    • Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats
    • R.M. Bitencourt, F.A. Pamplona, and R.N. Takahashi Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats Eur Neuropsychopharmacol 18 2008 849 859
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 849-859
    • Bitencourt, R.M.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 17
    • 78650694548 scopus 로고    scopus 로고
    • Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
    • C. Blazquez, A. Chiarlone, O. Sagredo, T. Aguado, M.R. Pazos, and E. Resel Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease Brain 134 2011 119 136
    • (2011) Brain , vol.134 , pp. 119-136
    • Blazquez, C.1    Chiarlone, A.2    Sagredo, O.3    Aguado, T.4    Pazos, M.R.5    Resel, E.6
  • 18
    • 0015927103 scopus 로고
    • 9 -Tetrahydrocannabinol effect on audiogenic seizure susceptibility
    • W.O. Boggan, R.A. Steele, and D.X. Freedman 9 -Tetrahydrocannabinol effect on audiogenic seizure susceptibility Psychopharmacologia 29 1973 101 106
    • (1973) Psychopharmacologia , vol.29 , pp. 101-106
    • Boggan, W.O.1    Steele, R.A.2    Freedman, D.X.3
  • 19
    • 77952645077 scopus 로고    scopus 로고
    • The plant cannabinoid delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice
    • D. Bolognini, B. Costa, S. Maione, F. Comelli, P. Marini, and V. Di Marzo The plant cannabinoid delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice Br J Pharmacol 160 2010 677 687
    • (2010) Br J Pharmacol , vol.160 , pp. 677-687
    • Bolognini, D.1    Costa, B.2    Maione, S.3    Comelli, F.4    Marini, P.5    Di Marzo, V.6
  • 20
    • 0031773166 scopus 로고    scopus 로고
    • Characterization of cytochrome P450 3A inactivation by cannabidiol: Possible involvement of cannabidiol-hydroxyquinone as a P450 inactivator
    • L.M. Bornheim, and M.P. Grillo Characterization of cytochrome P450 3A inactivation by cannabidiol: possible involvement of cannabidiol-hydroxyquinone as a P450 inactivator Chem Res Toxicol 11 1998 1209 1216
    • (1998) Chem Res Toxicol , vol.11 , pp. 1209-1216
    • Bornheim, L.M.1    Grillo, M.P.2
  • 21
    • 0003753476 scopus 로고    scopus 로고
    • British Medical Association, Harwood Academic Australia
    • British Medical Association Therapeutic uses of cannabis 1997 Harwood Academic Australia
    • (1997) Therapeutic Uses of Cannabis
  • 22
    • 3042542729 scopus 로고    scopus 로고
    • Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels
    • S.P. Brown, P.K. Safo, and W.G. Regehr Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels J Neurosci 24 2004 5623 5631
    • (2004) J Neurosci , vol.24 , pp. 5623-5631
    • Brown, S.P.1    Safo, P.K.2    Regehr, W.G.3
  • 23
    • 50549098159 scopus 로고    scopus 로고
    • Marijuana effect expectancies: Relations to social anxiety and marijuana use problems
    • J.D. Buckner, and N.B. Schmidt Marijuana effect expectancies: relations to social anxiety and marijuana use problems Addict Behav 33 2008 1477 1483
    • (2008) Addict Behav , vol.33 , pp. 1477-1483
    • Buckner, J.D.1    Schmidt, N.B.2
  • 24
    • 63049105150 scopus 로고    scopus 로고
    • Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation
    • G.A. Cabral, and L. Griffin-Thomas Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation Expert Rev Mol Med 11 2009 e3
    • (2009) Expert Rev Mol Med , vol.11 , pp. 3
    • Cabral, G.A.1    Griffin-Thomas, L.2
  • 25
    • 0019604414 scopus 로고
    • Hypnotic and antiepileptic effects of cannabidiol
    • E.A. Carlini, and J.M. Cunha Hypnotic and antiepileptic effects of cannabidiol J Clin Pharmacol 21 1981 417S 427S
    • (1981) J Clin Pharmacol , vol.21
    • Carlini, E.A.1    Cunha, J.M.2
  • 26
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • E.J. Carrier, J.A. Auchampach, and C.J. Hillard Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression Proc Natl Acad Sci U S A 103 2006 7895 7900
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 27
    • 1842428537 scopus 로고    scopus 로고
    • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    • E.J. Carrier, C.S. Kearn, A.J. Barkmeier, N.M. Breese, W. Yang, and K. Nithipatikom Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism Mol Pharmacol 65 2004 999 1007
    • (2004) Mol Pharmacol , vol.65 , pp. 999-1007
    • Carrier, E.J.1    Kearn, C.S.2    Barkmeier, A.J.3    Breese, N.M.4    Yang, W.5    Nithipatikom, K.6
  • 28
    • 20844441058 scopus 로고    scopus 로고
    • Cannabis for dyskinesia in Parkinson disease: A randomized double-blind crossover study
    • C.B. Carroll, P.G. Bain, L. Teare, X. Liu, C. Joint, and C. Wroath Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study Neurology 63 2004 1245 1250
    • (2004) Neurology , vol.63 , pp. 1245-1250
    • Carroll, C.B.1    Bain, P.G.2    Teare, L.3    Liu, X.4    Joint, C.5    Wroath, C.6
  • 29
    • 74549138165 scopus 로고    scopus 로고
    • Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
    • M.G. Cascio, L.A. Gauson, L.A. Stevenson, R.A. Ross, and R.G. Pertwee Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist Br J Pharmacol 159 2010 129 141
    • (2010) Br J Pharmacol , vol.159 , pp. 129-141
    • Cascio, M.G.1    Gauson, L.A.2    Stevenson, L.A.3    Ross, R.A.4    Pertwee, R.G.5
  • 30
    • 0028273994 scopus 로고
    • Treatment for HIV wasting syndrome
    • L.K. Cat, and R.L. Coleman Treatment for HIV wasting syndrome Ann Pharmacother 28 1994 595 597
    • (1994) Ann Pharmacother , vol.28 , pp. 595-597
    • Cat, L.K.1    Coleman, R.L.2
  • 31
    • 0031780582 scopus 로고    scopus 로고
    • Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats
    • F. Chaperon, P. Soubrie, A.J. Puech, and M.H. Thiebot Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats Psychopharmacology (Berl) 135 1998 324 332
    • (1998) Psychopharmacology (Berl) , vol.135 , pp. 324-332
    • Chaperon, F.1    Soubrie, P.2    Puech, A.J.3    Thiebot, M.H.4
  • 32
    • 0034046970 scopus 로고    scopus 로고
    • Cannabinoids protect cells from oxidative cell death: A receptor-independent mechanism
    • Y. Chen, and J. Buck Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism J Pharmacol Exp Ther 293 2000 807 812
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 807-812
    • Chen, Y.1    Buck, J.2
  • 34
    • 0012748550 scopus 로고
    • The present position of hemp drug addiction in India
    • R.N. Chopra, and G.S. Chopra The present position of hemp drug addiction in India Ind Med Res Mem 31 1939 1 119
    • (1939) Ind Med Res Mem , vol.31 , pp. 1-119
    • Chopra, R.N.1    Chopra, G.S.2
  • 35
    • 0016590028 scopus 로고
    • The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption
    • P. Chiu, R. Karler, C. Craven, D.M. Olsen, and S.A. Turkanis The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption Res Commun Chem Pathol Pharmacol 12 1975 267 286
    • (1975) Res Commun Chem Pathol Pharmacol , vol.12 , pp. 267-286
    • Chiu, P.1    Karler, R.2    Craven, C.3    Olsen, D.M.4    Turkanis, S.A.5
  • 36
    • 0018363904 scopus 로고
    • The influence of cannabidiol and delta9-tetrahydrocannabinol on cobalt epilepsy in rats
    • P. Chiu, D.M. Olsen, H.K. Borys, R. Karler, and S.A. Turkanis The influence of cannabidiol and delta9-tetrahydrocannabinol on cobalt epilepsy in rats Epilepsia 20 1979 365 375
    • (1979) Epilepsia , vol.20 , pp. 365-375
    • Chiu, P.1    Olsen, D.M.2    Borys, H.K.3    Karler, R.4    Turkanis, S.A.5
  • 37
    • 36048995288 scopus 로고    scopus 로고
    • Efficacy and safety of the weight-loss drug rimonabant: A meta-analysis of randomised trials
    • R. Christensen, P.K. Kristensen, E.M. Bartels, H. Bliddal, and A. Astrup Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials Lancet 370 2007 1706 1713
    • (2007) Lancet , vol.370 , pp. 1706-1713
    • Christensen, R.1    Kristensen, P.K.2    Bartels, E.M.3    Bliddal, H.4    Astrup, A.5
  • 38
    • 83555162674 scopus 로고    scopus 로고
    • Clinical Neurology Research Group, Exeter & Plymotuh CNRG
    • Clinical Neurology Research Group CUPID 2009 Exeter & Plymotuh CNRG
    • (2009) CUPID
  • 39
    • 0020083061 scopus 로고
    • Effects of marihuana cannabinoids on seizure activity in cobalt-epileptic rats
    • B.K. Colasanti, C. Lindamood III, and C.R. Craig Effects of marihuana cannabinoids on seizure activity in cobalt-epileptic rats Pharmacol Biochem Behav 16 1982 573 578
    • (1982) Pharmacol Biochem Behav , vol.16 , pp. 573-578
    • Colasanti, B.K.1    Lindamood Iii, C.2    Craig, C.R.3
  • 40
    • 33847766180 scopus 로고    scopus 로고
    • Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis
    • C. Collin, P. Davies, I.K. Mutiboko, and S. Ratcliffe Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis Eur J Neurol 14 2007 290 296
    • (2007) Eur J Neurol , vol.14 , pp. 290-296
    • Collin, C.1    Davies, P.2    Mutiboko, I.K.3    Ratcliffe, S.4
  • 41
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • A. Compston, and A. Coles Multiple sclerosis Lancet 372 2008 1502 1517
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 42
    • 0019929137 scopus 로고
    • Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice
    • P. Consroe, M.A. Benedito, J.R. Leite, E.A. Carlini, and R. Mechoulam Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice Eur J Pharmacol 83 1982 293 298
    • (1982) Eur J Pharmacol , vol.83 , pp. 293-298
    • Consroe, P.1    Benedito, M.A.2    Leite, J.R.3    Carlini, E.A.4    Mechoulam, R.5
  • 43
    • 0019272074 scopus 로고
    • Behavioral pharmacology of tetrahydrocannabinol convulsions in rabbits
    • P. Consroe, and B.S. Fish Behavioral pharmacology of tetrahydrocannabinol convulsions in rabbits Commun Psychopharmacol 4 1980 287 291
    • (1980) Commun Psychopharmacol , vol.4 , pp. 287-291
    • Consroe, P.1    Fish, B.S.2
  • 45
    • 0019605564 scopus 로고
    • Antiepileptic potential of cannabidiol analogs
    • P. Consroe, A. Martin, and V. Singh Antiepileptic potential of cannabidiol analogs J Clin Pharmacol 21 1981 428S 436S
    • (1981) J Clin Pharmacol , vol.21
    • Consroe, P.1    Martin, A.2    Singh, V.3
  • 46
    • 0023496402 scopus 로고
    • Anticonvulsant and neurotoxic effects of tetrahydrocannabinol stereoisomers
    • P. Consroe, and R. Mechoulam Anticonvulsant and neurotoxic effects of tetrahydrocannabinol stereoisomers NIDA Res Monogr 79 1987 59 66
    • (1987) NIDA Res Monogr , vol.79 , pp. 59-66
    • Consroe, P.1    Mechoulam, R.2
  • 47
    • 0022818369 scopus 로고
    • Open label evaluation of cannabidiol in dystonic movement disorders
    • P. Consroe, R. Sandyk, and S.R. Snider Open label evaluation of cannabidiol in dystonic movement disorders Int J Neurosci 30 1986 277 282
    • (1986) Int J Neurosci , vol.30 , pp. 277-282
    • Consroe, P.1    Sandyk, R.2    Snider, S.R.3
  • 48
    • 0017595939 scopus 로고
    • Cannabidiol-antiepileptic drug comparisons and interactions in experimentally induced seizures in rats
    • P. Consroe, and A. Wolkin Cannabidiol-antiepileptic drug comparisons and interactions in experimentally induced seizures in rats J Pharmacol Exp Ther 201 1977 26 32
    • (1977) J Pharmacol Exp Ther , vol.201 , pp. 26-32
    • Consroe, P.1    Wolkin, A.2
  • 49
    • 0017389448 scopus 로고
    • Anticonvulsant interaction of cannabidiol and ethosuximide in rats
    • P.F. Consroe, and A.L. Wolkin Anticonvulsant interaction of cannabidiol and ethosuximide in rats J Pharm Pharmacol 29 1977 500 501
    • (1977) J Pharm Pharmacol , vol.29 , pp. 500-501
    • Consroe, P.F.1    Wolkin, A.L.2
  • 50
    • 0016858146 scopus 로고
    • Anticonvulsant nature of marihuana smoking
    • P.F. Consroe, G.C. Wood, and H. Buchsbaum Anticonvulsant nature of marihuana smoking JAMA 234 1975 306 307
    • (1975) JAMA , vol.234 , pp. 306-307
    • Consroe, P.F.1    Wood, G.C.2    Buchsbaum, H.3
  • 51
    • 1242305688 scopus 로고    scopus 로고
    • Differential effects of medical marijuana based on strain and route of administration: A three-year observational study
    • V. Corral Differential effects of medical marijuana based on strain and route of administration: a three-year observational study J Cannabis Ther 1 2001 43 59
    • (2001) J Cannabis Ther , vol.1 , pp. 43-59
    • Corral, V.1
  • 52
    • 4744372178 scopus 로고    scopus 로고
    • Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    • B. Costa, G. Giagnoni, C. Franke, A.E. Trovato, and M. Colleoni Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation Br J Pharmacol 143 2004 247 250
    • (2004) Br J Pharmacol , vol.143 , pp. 247-250
    • Costa, B.1    Giagnoni, G.2    Franke, C.3    Trovato, A.E.4    Colleoni, M.5
  • 54
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    • B.F. Cravatt, D.K. Giang, S.P. Mayfield, D.L. Boger, R.A. Lerner, and N.B. Gilula Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides Nature 384 1996 83 87
    • (1996) Nature , vol.384 , pp. 83-87
    • Cravatt, B.F.1    Giang, D.K.2    Mayfield, S.P.3    Boger, D.L.4    Lerner, R.A.5    Gilula, N.B.6
  • 55
    • 78650625479 scopus 로고    scopus 로고
    • Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: A preliminary report
    • J.A. Crippa, G.N. Derenusson, T.B. Ferrari, L. Wichert-Ana, F.L. Duran, and R. Martin-Santos Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report J Psychopharmacol 25 2011 121 130
    • (2011) J Psychopharmacol , vol.25 , pp. 121-130
    • Crippa, J.A.1    Derenusson, G.N.2    Ferrari, T.B.3    Wichert-Ana, L.4    Duran, F.L.5    Martin-Santos, R.6
  • 58
    • 39149131360 scopus 로고    scopus 로고
    • Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain
    • L. Cristino, K. Starowicz, L. De Petrocellis, J. Morishita, N. Ueda, and V. Guglielmotti Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain Neuroscience 151 2008 955 968
    • (2008) Neuroscience , vol.151 , pp. 955-968
    • Cristino, L.1    Starowicz, K.2    De Petrocellis, L.3    Morishita, J.4    Ueda, N.5    Guglielmotti, V.6
  • 59
    • 0037397037 scopus 로고    scopus 로고
    • Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212
    • J.L. Croxford, and S.D. Miller Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212 J Clin Invest 111 2003 1231 1240
    • (2003) J Clin Invest , vol.111 , pp. 1231-1240
    • Croxford, J.L.1    Miller, S.D.2
  • 60
    • 72849149551 scopus 로고    scopus 로고
    • A pilot study using nabilone for symptomatic treatment in Huntington's disease
    • A. Curtis, I. Mitchell, S. Patel, N. Ives, and H. Rickards A pilot study using nabilone for symptomatic treatment in Huntington's disease Mov Disord 24 2009 2254 2259
    • (2009) Mov Disord , vol.24 , pp. 2254-2259
    • Curtis, A.1    Mitchell, I.2    Patel, S.3    Ives, N.4    Rickards, H.5
  • 61
    • 0002467306 scopus 로고
    • Antiepileptic action of marijuana-active substances
    • J.P. Davis, and H.H. Ramsey Antiepileptic action of marijuana-active substances Fed Proc Baltimore 8 1949 284 285
    • (1949) Fed Proc Baltimore , vol.8 , pp. 284-285
    • Davis, J.P.1    Ramsey, H.H.2
  • 63
    • 28944453205 scopus 로고    scopus 로고
    • Cannabinoid signalling
    • D.G. Demuth, and A. Molleman Cannabinoid signalling Life Sci 78 2006 549 563
    • (2006) Life Sci , vol.78 , pp. 549-563
    • Demuth, D.G.1    Molleman, A.2
  • 64
    • 79960328574 scopus 로고    scopus 로고
    • Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    • L. De Petrocellis, A. Ligresti, A.S. Moriello, M. Allara, T. Bisogno, and S. Petrosino Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes Br J Pharmacol 163 2011 1479 1494
    • (2011) Br J Pharmacol , vol.163 , pp. 1479-1494
    • De Petrocellis, L.1    Ligresti, A.2    Moriello, A.S.3    Allara, M.4    Bisogno, T.5    Petrosino, S.6
  • 65
    • 44249117614 scopus 로고    scopus 로고
    • Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
    • L. De Petrocellis, V. Vellani, A. Schiano-Moriello, P. Marini, P.C. Magherini, and P. Orlando Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8 J Pharmacol Exp Ther 325 2008 1007 1015
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 1007-1015
    • De Petrocellis, L.1    Vellani, V.2    Schiano-Moriello, A.3    Marini, P.4    Magherini, P.C.5    Orlando, P.6
  • 66
    • 47249142379 scopus 로고    scopus 로고
    • Effects of delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes
    • I. Dennis, B.J. Whalley, and G.J. Stephens Effects of delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes Br J Pharmacol 154 2008 1349 1358
    • (2008) Br J Pharmacol , vol.154 , pp. 1349-1358
    • Dennis, I.1    Whalley, B.J.2    Stephens, G.J.3
  • 67
    • 33645233785 scopus 로고    scopus 로고
    • Decreased depression in marijuana users
    • T.F. Denson, and M. Earleywine Decreased depression in marijuana users Addict Behav 31 2006 738 742
    • (2006) Addict Behav , vol.31 , pp. 738-742
    • Denson, T.F.1    Earleywine, M.2
  • 68
    • 0034802989 scopus 로고    scopus 로고
    • SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats
    • V. Deroche-Gamonet, M. Le Moal, P.V. Piazza, and P. Soubrie SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats Psychopharmacology (Berl) 157 2001 254 259
    • (2001) Psychopharmacology (Berl) , vol.157 , pp. 254-259
    • Deroche-Gamonet, V.1    Le Moal, M.2    Piazza, P.V.3    Soubrie, P.4
  • 69
    • 0034988827 scopus 로고    scopus 로고
    • Cannabinoid-induced motor incoordination through the cerebellar CB(1) receptor in mice
    • K.P. Desanty, and M.S. Dar Cannabinoid-induced motor incoordination through the cerebellar CB(1) receptor in mice Pharmacol Biochem Behav 69 2001 251 259
    • (2001) Pharmacol Biochem Behav , vol.69 , pp. 251-259
    • Desanty, K.P.1    Dar, M.S.2
  • 70
    • 0035968051 scopus 로고    scopus 로고
    • Involvement of the cerebellar adenosine A1 receptor in cannabinoid-induced motor incoordination in the acute and tolerant state in mice
    • K.P. Desanty, and M.S. Dar Involvement of the cerebellar adenosine A1 receptor in cannabinoid-induced motor incoordination in the acute and tolerant state in mice Brain Res 905 2001 178 187
    • (2001) Brain Res , vol.905 , pp. 178-187
    • Desanty, K.P.1    Dar, M.S.2
  • 71
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • W.A. Devane, L. Hanus, A. Breuer, R.G. Pertwee, L.A. Stevenson, and G. Griffin Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 258 1992 1946 1949
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 73
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • V. Di Marzo Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 7 2008 438 455
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 74
    • 67449119913 scopus 로고    scopus 로고
    • The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
    • V. Di Marzo The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation Pharmacol Res 60 2009 77 84
    • (2009) Pharmacol Res , vol.60 , pp. 77-84
    • Di Marzo, V.1
  • 75
    • 33645794041 scopus 로고    scopus 로고
    • The biosynthesis, fate and pharmacological properties of endocannabinoids
    • V. Di Marzo, L. De Petrocellis, and T. Bisogno The biosynthesis, fate and pharmacological properties of endocannabinoids Handb Exp Pharmacol 2005 147 185
    • (2005) Handb Exp Pharmacol , pp. 147-185
    • Di Marzo, V.1    De Petrocellis, L.2    Bisogno, T.3
  • 76
    • 0029031421 scopus 로고
    • Anandamide, an endogenous cannabinomimetic eicosanoid: 'Killing two birds with one stone'
    • V. Di Marzo, and A. Fontana Anandamide, an endogenous cannabinomimetic eicosanoid: 'killing two birds with one stone' Prostaglandins Leukot Essent Fatty Acids 53 1995 1 11
    • (1995) Prostaglandins Leukot Essent Fatty Acids , vol.53 , pp. 1-11
    • Di Marzo, V.1    Fontana, A.2
  • 77
    • 67649563560 scopus 로고    scopus 로고
    • The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation
    • V. Di Marzo, A. Ligresti, and L. Cristino The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation Int J Obes (Lond) 33 Suppl 2 2009 S18 S24
    • (2009) Int J Obes (Lond) , vol.33 , Issue.SUPPL. 2
    • Di Marzo, V.1    Ligresti, A.2    Cristino, L.3
  • 78
    • 33947583201 scopus 로고    scopus 로고
    • Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation
    • F. Docagne, V. Muneton, D. Clemente, C. Ali, F. Loria, and F. Correa Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation Mol Cell Neurosci 34 2007 551 561
    • (2007) Mol Cell Neurosci , vol.34 , pp. 551-561
    • Docagne, F.1    Muneton, V.2    Clemente, D.3    Ali, C.4    Loria, F.5    Correa, F.6
  • 79
  • 80
    • 77955922748 scopus 로고    scopus 로고
    • Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice
    • M.J. Dowie, M.L. Howard, L.F. Nicholson, R.L. Faull, A.J. Hannan, and M. Glass Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice Neuroscience 170 2010 324 336
    • (2010) Neuroscience , vol.170 , pp. 324-336
    • Dowie, M.J.1    Howard, M.L.2    Nicholson, L.F.3    Faull, R.L.4    Hannan, A.J.5    Glass, M.6
  • 81
    • 80051665640 scopus 로고    scopus 로고
    • Neuroprotective strategies involving ROS in Alzheimer disease
    • M. Dumont, and M.F. Beal Neuroprotective strategies involving ROS in Alzheimer disease Free Radic Biol Med 51 2011 1014 1026
    • (2011) Free Radic Biol Med , vol.51 , pp. 1014-1026
    • Dumont, M.1    Beal, M.F.2
  • 82
    • 67349209246 scopus 로고    scopus 로고
    • Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model
    • J. Echegoyen, C. Armstrong, R.J. Morgan, and I. Soltesz Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model Epilepsy Res 85 2009 123 127
    • (2009) Epilepsy Res , vol.85 , pp. 123-127
    • Echegoyen, J.1    Armstrong, C.2    Morgan, R.J.3    Soltesz, I.4
  • 83
    • 29244478635 scopus 로고    scopus 로고
    • Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
    • J. Ehrhart, D. Obregon, T. Mori, H. Hou, N. Sun, and Y. Bai Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation J Neuroinflammation 2 2005 29
    • (2005) J Neuroinflammation , vol.2 , pp. 29
    • Ehrhart, J.1    Obregon, D.2    Mori, T.3    Hou, H.4    Sun, N.5    Bai, Y.6
  • 84
    • 77952551436 scopus 로고    scopus 로고
    • Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
    • A.T. El-Alfy, K. Ivey, K. Robinson, S. Ahmed, M. Radwan, and D. Slade Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L Pharmacol Biochem Behav 95 2010 434 442
    • (2010) Pharmacol Biochem Behav , vol.95 , pp. 434-442
    • El-Alfy, A.T.1    Ivey, K.2    Robinson, K.3    Ahmed, S.4    Radwan, M.5    Slade, D.6
  • 85
    • 0142151067 scopus 로고    scopus 로고
    • Neuroprotective effect of (-)delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: Involvement of peroxynitrite
    • A.B. El-Remessy, I.E. Khalil, S. Matragoon, G. Abou-Mohamed, N.J. Tsai, and P. Roon Neuroprotective effect of (-)delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite Am J Pathol 163 2003 1997 2008
    • (2003) Am J Pathol , vol.163 , pp. 1997-2008
    • El-Remessy, A.B.1    Khalil, I.E.2    Matragoon, S.3    Abou-Mohamed, G.4    Tsai, N.J.5    Roon, P.6
  • 86
    • 18044383529 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in the treatment of dementia
    • J.M. Ellis Cholinesterase inhibitors in the treatment of dementia J Am Osteopath Assoc 105 2005 145 158
    • (2005) J Am Osteopath Assoc , vol.105 , pp. 145-158
    • Ellis, J.M.1
  • 87
    • 27844525479 scopus 로고    scopus 로고
    • Chemical constituents of marijuana: The complex mixture of natural cannabinoids
    • M.A. Elsohly, and D. Slade Chemical constituents of marijuana: the complex mixture of natural cannabinoids Life Sci 78 2005 539 548
    • (2005) Life Sci , vol.78 , pp. 539-548
    • Elsohly, M.A.1    Slade, D.2
  • 88
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • G. Esposito, D. De Filippis, M.C. Maiuri, D. De Stefano, R. Carnuccio, and T. Iuvone Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement Neurosci Lett 399 2006 91 95
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 89
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
    • G. Esposito, C. Scuderi, C. Savani, L. Steardo Jr., D. De Filippis, and P. Cottone Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression Br J Pharmacol 151 2007 1272 1279
    • (2007) Br J Pharmacol , vol.151 , pp. 1272-1279
    • Esposito, G.1    Scuderi, C.2    Savani, C.3    Steardo, Jr.L.4    De Filippis, D.5    Cottone, P.6
  • 90
  • 91
    • 77955570050 scopus 로고    scopus 로고
    • Cannabis constituents modulate delta9-tetrahydrocannabinol-induced hyperphagia in rats
    • J.A. Farrimond, A.J. Hill, B.J. Whalley, and C.M. Williams Cannabis constituents modulate delta9-tetrahydrocannabinol-induced hyperphagia in rats Psychopharmacology (Berl) 210 2010 97 106
    • (2010) Psychopharmacology (Berl) , vol.210 , pp. 97-106
    • Farrimond, J.A.1    Hill, A.J.2    Whalley, B.J.3    Williams, C.M.4
  • 92
    • 79551662698 scopus 로고    scopus 로고
    • Cannabis sativa and the endogenous cannabinoid system: Therapeutic potential for appetite regulation
    • J.A. Farrimond, M.S. Mercier, B.J. Whalley, and C.M. Williams Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation Phytother Res 25 2011 170 188
    • (2011) Phytother Res , vol.25 , pp. 170-188
    • Farrimond, J.A.1    Mercier, M.S.2    Whalley, B.J.3    Williams, C.M.4
  • 93
    • 78651410455 scopus 로고    scopus 로고
    • A low-delta9tetrahydrocannabinol cannabis extract induces hyperphagia in rats
    • J.A. Farrimond, B.J. Whalley, and C.M. Williams A low- delta9tetrahydrocannabinol cannabis extract induces hyperphagia in rats Behav Pharmacol 21 2010 769 772
    • (2010) Behav Pharmacol , vol.21 , pp. 769-772
    • Farrimond, J.A.1    Whalley, B.J.2    Williams, C.M.3
  • 94
    • 0027185227 scopus 로고
    • Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
    • C.C. Felder, E.M. Briley, J. Axelrod, J.T. Simpson, K. Mackie, and W.A. Devane Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction Proc Natl Acad Sci U S A 90 1993 7656 7660
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7656-7660
    • Felder, C.C.1    Briley, E.M.2    Axelrod, J.3    Simpson, J.T.4    MacKie, K.5    Devane, W.A.6
  • 95
    • 0030893338 scopus 로고    scopus 로고
    • Early onset cannabis use and psychosocial adjustment in young adults
    • D.M. Fergusson, and L.J. Horwood Early onset cannabis use and psychosocial adjustment in young adults Addiction 92 1997 279 296
    • (1997) Addiction , vol.92 , pp. 279-296
    • Fergusson, D.M.1    Horwood, L.J.2
  • 96
    • 0020537267 scopus 로고
    • Convulsant-anticonvulsant properties of delta-9-tetrahydrocannabinol in rabbits
    • B.S. Fish, P. Consroe, and R.R. Fox Convulsant-anticonvulsant properties of delta-9-tetrahydrocannabinol in rabbits Behav Genet 13 1983 205 211
    • (1983) Behav Genet , vol.13 , pp. 205-211
    • Fish, B.S.1    Consroe, P.2    Fox, R.R.3
  • 98
    • 0022900093 scopus 로고
    • Behavioral analysis of marijuana effects on food intake in humans
    • R.W. Foltin, J.V. Brady, and M.W. Fischman Behavioral analysis of marijuana effects on food intake in humans Pharmacol Biochem Behav 25 1986 577 582
    • (1986) Pharmacol Biochem Behav , vol.25 , pp. 577-582
    • Foltin, R.W.1    Brady, J.V.2    Fischman, M.W.3
  • 99
    • 0023794545 scopus 로고
    • Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory
    • R.W. Foltin, M.W. Fischman, and M.F. Byrne Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory Appetite 11 1988 1 14
    • (1988) Appetite , vol.11 , pp. 1-14
    • Foltin, R.W.1    Fischman, M.W.2    Byrne, M.F.3
  • 101
    • 0036868444 scopus 로고    scopus 로고
    • Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease
    • S.H. Fox, B. Henry, M. Hill, A. Crossman, and J. Brotchie Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease Mov Disord 17 2002 1180 1187
    • (2002) Mov Disord , vol.17 , pp. 1180-1187
    • Fox, S.H.1    Henry, B.2    Hill, M.3    Crossman, A.4    Brotchie, J.5
  • 103
    • 0032901227 scopus 로고    scopus 로고
    • The motivation for beer in rats: Effects of ritanserin, naloxone and SR 141716
    • J.E. Gallate, and I.S. Mcgregor The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716 Psychopharmacology (Berl) 142 1999 302 308
    • (1999) Psychopharmacology (Berl) , vol.142 , pp. 302-308
    • Gallate, J.E.1    McGregor, I.S.2
  • 104
    • 0032952420 scopus 로고    scopus 로고
    • Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist
    • J.E. Gallate, T. Saharov, P.E. Mallet, and I.S. Mcgregor Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist Eur J Pharmacol 370 1999 233 240
    • (1999) Eur J Pharmacol , vol.370 , pp. 233-240
    • Gallate, J.E.1    Saharov, T.2    Mallet, P.E.3    McGregor, I.S.4
  • 105
    • 0015221354 scopus 로고
    • The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish
    • Y. Gaoni, and R. Mechoulam The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish J Am Chem Soc 93 1971 217 224
    • (1971) J Am Chem Soc , vol.93 , pp. 217-224
    • Gaoni, Y.1    Mechoulam, R.2
  • 106
    • 43549124297 scopus 로고    scopus 로고
    • Enhanced striatal glutamate release after the administration of rimonabant to 6-hydroxydopamine-lesioned rats
    • M. Garcia-Arencibia, L. Ferraro, S. Tanganelli, and J. Fernandez-Ruiz Enhanced striatal glutamate release after the administration of rimonabant to 6-hydroxydopamine-lesioned rats Neurosci Lett 438 2008 10 13
    • (2008) Neurosci Lett , vol.438 , pp. 10-13
    • Garcia-Arencibia, M.1    Ferraro, L.2    Tanganelli, S.3    Fernandez-Ruiz, J.4
  • 107
    • 33846401540 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties
    • M. Garcia-Arencibia, S. Gonzalez, E. De Lago, J.A. Ramos, R. Mechoulam, and J. Fernandez-Ruiz Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties Brain Res 1134 2007 162 170
    • (2007) Brain Res , vol.1134 , pp. 162-170
    • Garcia-Arencibia, M.1    Gonzalez, S.2    De Lago, E.3    Ramos, J.A.4    Mechoulam, R.5    Fernandez-Ruiz, J.6
  • 108
  • 110
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • J.M. Gil, and A.C. Rego Mechanisms of neurodegeneration in Huntington's disease Eur J Neurosci 27 2008 2803 2820
    • (2008) Eur J Neurosci , vol.27 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 111
    • 33846066404 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
    • G.L. Gilbert, H.J. Kim, J.J. Waataja, and S.A. Thayer Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity Brain Res 1128 2007 61 69
    • (2007) Brain Res , vol.1128 , pp. 61-69
    • Gilbert, G.L.1    Kim, H.J.2    Waataja, J.J.3    Thayer, S.A.4
  • 113
    • 33644952242 scopus 로고    scopus 로고
    • Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease
    • S. Gonzalez, C. Scorticati, M. Garcia-Arencibia, R. De Miguel, J.A. Ramos, and J. Fernandez-Ruiz Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease Brain Res 1073-1074 2006 209 219
    • (2006) Brain Res , vol.1073-1074 , pp. 209-219
    • Gonzalez, S.1    Scorticati, C.2    Garcia-Arencibia, M.3    De Miguel, R.4    Ramos, J.A.5    Fernandez-Ruiz, J.6
  • 117
    • 2942555598 scopus 로고    scopus 로고
    • Marijuana use and epilepsy: Prevalence in patients of a tertiary care epilepsy center
    • D.W. Gross, J. Hamm, N.L. Ashworth, and D. Quigley Marijuana use and epilepsy: prevalence in patients of a tertiary care epilepsy center Neurology 62 2004 2095 2097
    • (2004) Neurology , vol.62 , pp. 2095-2097
    • Gross, D.W.1    Hamm, J.2    Ashworth, N.L.3    Quigley, D.4
  • 118
    • 0038792188 scopus 로고    scopus 로고
    • Survey on the medical use of cannabis and THC in Germany
    • F. Grotenhermen, and M. Schnelle Survey on the medical use of cannabis and THC in Germany J Cannabis Ther 3 2003 17 40
    • (2003) J Cannabis Ther , vol.3 , pp. 17-40
    • Grotenhermen, F.1    Schnelle, M.2
  • 119
    • 78650987060 scopus 로고    scopus 로고
    • AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity
    • S. Guggenhuber, K. Monory, B. Lutz, and M. Klugmann AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity PLoS One 5 2010 e15707
    • (2010) PLoS One , vol.5 , pp. 15707
    • Guggenhuber, S.1    Monory, K.2    Lutz, B.3    Klugmann, M.4
  • 122
    • 78650961973 scopus 로고    scopus 로고
    • The interplay of cannabinoid and NMDA glutamate receptor systems in humans: Preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects
    • J.E. Hallak, S.M. Dursun, D.C. Bosi, L.R. De Macedo, J.P. Machado-De-Sousa, and J. Abrao The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects Prog Neuropsychopharmacol Biol Psychiatry 35 2011 198 202
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 198-202
    • Hallak, J.E.1    Dursun, S.M.2    Bosi, D.C.3    De MacEdo, L.R.4    MacHado-De-Sousa, J.P.5    Abrao, J.6
  • 123
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • A.J. Hampson, M. Grimaldi, J. Axelrod, and D. Wink Cannabidiol and (-)delta9-tetrahydrocannabinol are neuroprotective antioxidants Proc Natl Acad Sci U S A 95 1998 8268 8273
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 124
    • 77950106481 scopus 로고    scopus 로고
    • Neuroprotection without immunomodulation is not sufficient to reduce first relapse severity in experimental autoimmune encephalomyelitis
    • H. Hasseldam, and F.F. Johansen Neuroprotection without immunomodulation is not sufficient to reduce first relapse severity in experimental autoimmune encephalomyelitis Neuroimmunomodulation 17 2010 252 264
    • (2010) Neuroimmunomodulation , vol.17 , pp. 252-264
    • Hasseldam, H.1    Johansen, F.F.2
  • 126
    • 30944438671 scopus 로고    scopus 로고
    • Malnutrition in ageing
    • M. Hickson Malnutrition in ageing Postgrad Med J 82 2006 2 8
    • (2006) Postgrad Med J , vol.82 , pp. 2-8
    • Hickson, M.1
  • 127
    • 0037320209 scopus 로고    scopus 로고
    • Cannabinoid influences on palatability: Microstructural analysis of sucrose drinking after delta9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716
    • S. Higgs, C.M. Williams, and T.C. Kirkham Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716 Psychopharmacology (Berl) 165 2003 370 377
    • (2003) Psychopharmacology (Berl) , vol.165 , pp. 370-377
    • Higgs, S.1    Williams, C.M.2    Kirkham, T.C.3
  • 128
    • 77955327987 scopus 로고    scopus 로고
    • Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats
    • A.J. Hill, S.E. Weston, N.A. Jones, I. Smith, S.A. Bevan, and E.M. Williamson Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats Epilepsia 51 2010 1522 1532
    • (2010) Epilepsia , vol.51 , pp. 1522-1532
    • Hill, A.J.1    Weston, S.E.2    Jones, N.A.3    Smith, I.4    Bevan, S.A.5    Williamson, E.M.6
  • 130
    • 77949407188 scopus 로고    scopus 로고
    • Ageing, neurodegeneration and Parkinson's disease
    • J.V. Hindle Ageing, neurodegeneration and Parkinson's disease Age Ageing 39 2010 156 161
    • (2010) Age Ageing , vol.39 , pp. 156-161
    • Hindle, J.V.1
  • 131
    • 0014975470 scopus 로고
    • Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine
    • L.E. Hollister Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine Clin Pharmacol Ther 12 1971 44 49
    • (1971) Clin Pharmacol Ther , vol.12 , pp. 44-49
    • Hollister, L.E.1
  • 132
    • 35648985647 scopus 로고    scopus 로고
    • PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats
    • J.G. Horswill, U. Bali, S. Shaaban, J.F. Keily, P. Jeevaratnam, and A.J. Babbs PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats Br J Pharmacol 152 2007 805 814
    • (2007) Br J Pharmacol , vol.152 , pp. 805-814
    • Horswill, J.G.1    Bali, U.2    Shaaban, S.3    Keily, J.F.4    Jeevaratnam, P.5    Babbs, A.J.6
  • 135
    • 0345490815 scopus 로고    scopus 로고
    • Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain
    • M.J. Hurley, D.C. Mash, and P. Jenner Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain J Neural Transm 110 2003 1279 1288
    • (2003) J Neural Transm , vol.110 , pp. 1279-1288
    • Hurley, M.J.1    Mash, D.C.2    Jenner, P.3
  • 136
    • 78751700934 scopus 로고    scopus 로고
    • Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors
    • B. Ignatowska-Jankowska, M.M. Jankowski, and A.H. Swiergiel Cannabidiol decreases body weight gain in rats: involvement of CB2 receptors Neurosci Lett 490 2011 82 84
    • (2011) Neurosci Lett , vol.490 , pp. 82-84
    • Ignatowska-Jankowska, B.1    Jankowski, M.M.2    Swiergiel, A.H.3
  • 137
    • 45149096740 scopus 로고    scopus 로고
    • Cannabis use and the risk behavior syndrome in Italian university students: Are they related to suicide risk?
    • M. Innamorati, M. Pompili, V. Ferrari, P. Girardi, R. Tatarelli, and A. Tamburello Cannabis use and the risk behavior syndrome in Italian university students: are they related to suicide risk? Psychol Rep 102 2008 577 594
    • (2008) Psychol Rep , vol.102 , pp. 577-594
    • Innamorati, M.1    Pompili, M.2    Ferrari, V.3    Girardi, P.4    Tatarelli, R.5    Tamburello, A.6
  • 138
    • 0036198117 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: Current issues in research and management
    • A. Inui Cancer anorexia-cachexia syndrome: current issues in research and management CA Cancer J Clin 52 2002 72 91
    • (2002) CA Cancer J Clin , vol.52 , pp. 72-91
    • Inui, A.1
  • 139
    • 33846662156 scopus 로고    scopus 로고
    • Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
    • M. Iskedjian, B. Bereza, A. Gordon, C. Piwko, and T.R. Einarson Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain Curr Med Res Opin 23 2007 17 24
    • (2007) Curr Med Res Opin , vol.23 , pp. 17-24
    • Iskedjian, M.1    Bereza, B.2    Gordon, A.3    Piwko, C.4    Einarson, T.R.5
  • 140
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • T. Iuvone, G. Esposito, R. Esposito, R. Santamaria, M. Di Rosa, and A.A. Izzo Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells J Neurochem 89 2004 134 141
    • (2004) J Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 141
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb
    • A.A. Izzo, F. Borrelli, R. Capasso, V. Di Marzo, and R. Mechoulam Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb Trends Pharmacol Sci 30 2009 515 527
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 144
    • 0034883101 scopus 로고    scopus 로고
    • Medicinal use of cannabis: History and current status
    • H. Kalant Medicinal use of cannabis: history and current status Pain Res Manag 6 2001 80 91
    • (2001) Pain Res Manag , vol.6 , pp. 80-91
    • Kalant, H.1
  • 145
    • 0015869627 scopus 로고
    • The anticonvulsant activity of cannabidiol and cannabinol
    • R. Karler, W. Cely, and S.A. Turkanis The anticonvulsant activity of cannabidiol and cannabinol Life Sci 13 1973 1527 1531
    • (1973) Life Sci , vol.13 , pp. 1527-1531
    • Karler, R.1    Cely, W.2    Turkanis, S.A.3
  • 146
    • 0016139631 scopus 로고
    • Anticonvulsant activity of delta9-tetrahydrocannabilol and its 11-hydroxy and 8alpha, 11-dihydroxy metabolites in the frog
    • R. Karler, W. Cely, and S.A. Turkanis Anticonvulsant activity of delta9-tetrahydrocannabilol and its 11-hydroxy and 8alpha, 11-dihydroxy metabolites in the frog Res Commun Chem Pathol Pharmacol 9 1974 441 452
    • (1974) Res Commun Chem Pathol Pharmacol , vol.9 , pp. 441-452
    • Karler, R.1    Cely, W.2    Turkanis, S.A.3
  • 147
    • 0016301179 scopus 로고
    • Anticonvulsant properties of delta 9-tetrahydrocannabinol and other cannabinoids
    • R. Karler, W. Cely, and S.A. Turkanis Anticonvulsant properties of delta 9-tetrahydrocannabinol and other cannabinoids Life Sci 15 1974 931 947
    • (1974) Life Sci , vol.15 , pp. 931-947
    • Karler, R.1    Cely, W.2    Turkanis, S.A.3
  • 149
    • 0018866833 scopus 로고
    • Subacute cannabinoid treatment: Anticonvulsant activity and withdrawal excitability in mice
    • R. Karler, and S.A. Turkanis Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice Br J Pharmacol 68 1980 479 484
    • (1980) Br J Pharmacol , vol.68 , pp. 479-484
    • Karler, R.1    Turkanis, S.A.2
  • 150
    • 0019604856 scopus 로고
    • The cannabinoids as potential antiepileptics
    • R. Karler, and S.A. Turkanis The cannabinoids as potential antiepileptics J Clin Pharmacol 21 1981 437S 448S
    • (1981) J Clin Pharmacol , vol.21
    • Karler, R.1    Turkanis, S.A.2
  • 151
    • 67649644733 scopus 로고    scopus 로고
    • The CB1 antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease
    • J.E. Kelsey, O. Harris, and J. Cassin The CB1 antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease Behav Brain Res 203 2009 304 307
    • (2009) Behav Brain Res , vol.203 , pp. 304-307
    • Kelsey, J.E.1    Harris, O.2    Cassin, J.3
  • 152
    • 49449090467 scopus 로고    scopus 로고
    • Endocannabinoids and the neurochemistry of gluttony
    • T.C. Kirkham Endocannabinoids and the neurochemistry of gluttony J Neuroendocrinol 20 2008 1099 1100
    • (2008) J Neuroendocrinol , vol.20 , pp. 1099-1100
    • Kirkham, T.C.1
  • 153
    • 0015593002 scopus 로고
    • 9 -Tetrahydrocannabinol in depressed patients
    • J. Kotin, R.M. Post, and F.K. Goodwin 9 -Tetrahydrocannabinol in depressed patients Arch Gen Psychiatry 28 1973 345 348
    • (1973) Arch Gen Psychiatry , vol.28 , pp. 345-348
    • Kotin, J.1    Post, R.M.2    Goodwin, F.K.3
  • 154
    • 67649967402 scopus 로고    scopus 로고
    • The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats
    • R. Kozan, M. Ayyildiz, and E. Agar The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats Epilepsia 50 2009 1760 1767
    • (2009) Epilepsia , vol.50 , pp. 1760-1767
    • Kozan, R.1    Ayyildiz, M.2    Agar, E.3
  • 155
    • 76249095734 scopus 로고    scopus 로고
    • Cannabinoids delta9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells
    • E. Kozela, M. Pietr, A. Juknat, N. Rimmerman, R. Levy, and Z. Vogel Cannabinoids delta9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells J Biol Chem 285 2010 1616 1626
    • (2010) J Biol Chem , vol.285 , pp. 1616-1626
    • Kozela, E.1    Pietr, M.2    Juknat, A.3    Rimmerman, N.4    Levy, R.5    Vogel, Z.6
  • 156
    • 64249138218 scopus 로고    scopus 로고
    • The therapeutic potential of novel cannabinoid receptors
    • F.R. Kreitzer, and N. Stella The therapeutic potential of novel cannabinoid receptors Pharmacol Ther 122 2009 83 96
    • (2009) Pharmacol Ther , vol.122 , pp. 83-96
    • Kreitzer, F.R.1    Stella, N.2
  • 158
    • 77950857170 scopus 로고    scopus 로고
    • Huntington's disease: Pathogenesis to animal models
    • P. Kumar, H. Kalonia, and A. Kumar Huntington's disease: pathogenesis to animal models Pharmacol Rep 62 2010 1 14
    • (2010) Pharmacol Rep , vol.62 , pp. 1-14
    • Kumar, P.1    Kalonia, H.2    Kumar, A.3
  • 159
    • 72549092256 scopus 로고    scopus 로고
    • Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: A systematic review
    • S.E. Lakhan, and M. Rowland Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review BMC Neurol 9 2009 59
    • (2009) BMC Neurol , vol.9 , pp. 59
    • Lakhan, S.E.1    Rowland, M.2
  • 161
    • 17444370570 scopus 로고    scopus 로고
    • Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease
    • I. Lastres-Becker, F. Molina-Holgado, J.A. Ramos, R. Mechoulam, and J. Fernandez-Ruiz Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease Neurobiol Dis 19 2005 96 107
    • (2005) Neurobiol Dis , vol.19 , pp. 96-107
    • Lastres-Becker, I.1    Molina-Holgado, F.2    Ramos, J.A.3    Mechoulam, R.4    Fernandez-Ruiz, J.5
  • 162
    • 78650145243 scopus 로고    scopus 로고
    • Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways
    • C.J. Ledgerwood, S.M. Greenwood, R.R. Brett, J.A. Pratt, and T.J. Bushell Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways Br J Pharmacol 162 2011 286 294
    • (2011) Br J Pharmacol , vol.162 , pp. 286-294
    • Ledgerwood, C.J.1    Greenwood, S.M.2    Brett, R.R.3    Pratt, J.A.4    Bushell, T.J.5
  • 163
    • 68949209293 scopus 로고    scopus 로고
    • The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents
    • H.K. Lee, E.B. Choi, and C.S. Pak The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents Curr Top Med Chem 9 2009 482 503
    • (2009) Curr Top Med Chem , vol.9 , pp. 482-503
    • Lee, H.K.1    Choi, E.B.2    Pak, C.S.3
  • 166
    • 37049229957 scopus 로고
    • Marihuana: Tetrahydrocannabinol and Related Compounds
    • M. Lerner Marihuana: Tetrahydrocannabinol and Related Compounds Science 140 1963 175 176
    • (1963) Science , vol.140 , pp. 175-176
    • Lerner, M.1
  • 167
    • 0002649325 scopus 로고
    • An archaeological and historical account of cannabis in China
    • H.L. Li, and H. Lin An archaeological and historical account of cannabis in China Econ Bot 28 4 1974 437 447
    • (1974) Econ Bot , vol.28 , Issue.4 , pp. 437-447
    • Li, H.L.1    Lin, H.2
  • 168
    • 58149269741 scopus 로고    scopus 로고
    • Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor
    • G.I. Liou, J.A. Auchampach, C.J. Hillard, G. Zhu, B. Yousufzai, and S. Mian Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor Invest Ophthalmol Vis Sci 49 2008 5526 5531
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 5526-5531
    • Liou, G.I.1    Auchampach, J.A.2    Hillard, C.J.3    Zhu, G.4    Yousufzai, B.5    Mian, S.6
  • 169
    • 3242813125 scopus 로고    scopus 로고
    • On the application of cannabis in paediatrics and epileptology
    • R. Lorenz On the application of cannabis in paediatrics and epileptology Neuro Endocrinol Lett 25 2004 40 44
    • (2004) Neuro Endocrinol Lett , vol.25 , pp. 40-44
    • Lorenz, R.1
  • 170
    • 0343990077 scopus 로고    scopus 로고
    • Animal models of intractable epilepsy
    • W. Loscher Animal models of intractable epilepsy Prog Neurobiol 53 1997 239 258
    • (1997) Prog Neurobiol , vol.53 , pp. 239-258
    • Loscher, W.1
  • 171
    • 84947769162 scopus 로고    scopus 로고
    • The therapeutic use of Cannabis sativa L. in Arabic medicine
    • I. Lozano The therapeutic use of Cannabis sativa L. in Arabic medicine J Cannabis Ther 1 2001 63 70
    • (2001) J Cannabis Ther , vol.1 , pp. 63-70
    • Lozano, I.1
  • 172
    • 77957028140 scopus 로고    scopus 로고
    • Microglial activation and chronic neurodegeneration
    • M.E. Lull, and M.L. Block Microglial activation and chronic neurodegeneration Neurotherapeutics 7 2010 354 365
    • (2010) Neurotherapeutics , vol.7 , pp. 354-365
    • Lull, M.E.1    Block, M.L.2
  • 173
    • 4644278264 scopus 로고    scopus 로고
    • On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures
    • B. Lutz On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures Biochem Pharmacol 68 2004 1691 1698
    • (2004) Biochem Pharmacol , vol.68 , pp. 1691-1698
    • Lutz, B.1
  • 174
    • 0024596492 scopus 로고
    • Delta 9-tetrahydrocannabinol: A novel treatment for experimental autoimmune encephalomyelitis
    • W.D. Lyman, J.R. Sonett, C.F. Brosnan, R. Elkin, and M.B. Bornstein Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis J Neuroimmunol 23 1989 73 81
    • (1989) J Neuroimmunol , vol.23 , pp. 73-81
    • Lyman, W.D.1    Sonett, J.R.2    Brosnan, C.F.3    Elkin, R.4    Bornstein, M.B.5
  • 175
    • 42949162068 scopus 로고    scopus 로고
    • The phytocannabinoid delta9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum
    • Y.L. Ma, S.E. Weston, B.J. Whalley, and G.J. Stephens The phytocannabinoid delta9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum Br J Pharmacol 154 2008 204 215
    • (2008) Br J Pharmacol , vol.154 , pp. 204-215
    • Ma, Y.L.1    Weston, S.E.2    Whalley, B.J.3    Stephens, G.J.4
  • 176
    • 68049129534 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation
    • I. Magen, Y. Avraham, Z. Ackerman, L. Vorobiev, R. Mechoulam, and E.M. Berry Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation J Hepatol 51 2009 528 534
    • (2009) J Hepatol , vol.51 , pp. 528-534
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 177
    • 77249134168 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
    • I. Magen, Y. Avraham, Z. Ackerman, L. Vorobiev, R. Mechoulam, and E.M. Berry Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation Br J Pharmacol 159 2010 950 957
    • (2010) Br J Pharmacol , vol.159 , pp. 950-957
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 178
    • 67649274432 scopus 로고    scopus 로고
    • Cannabidiol reverses the reduction in social interaction produced by low dose delta9-tetrahydrocannabinol in rats
    • D.T. Malone, D. Jongejan, and D.A. Taylor Cannabidiol reverses the reduction in social interaction produced by low dose delta9-tetrahydrocannabinol in rats Pharmacol Biochem Behav 93 2009 91 96
    • (2009) Pharmacol Biochem Behav , vol.93 , pp. 91-96
    • Malone, D.T.1    Jongejan, D.2    Taylor, D.A.3
  • 179
    • 34147165471 scopus 로고    scopus 로고
    • Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    • K. Maresz, G. Pryce, E.D. Ponomarev, G. Marsicano, J.L. Croxford, and L.P. Shriver Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells Nat Med 13 2007 492 497
    • (2007) Nat Med , vol.13 , pp. 492-497
    • Maresz, K.1    Pryce, G.2    Ponomarev, E.D.3    Marsicano, G.4    Croxford, J.L.5    Shriver, L.P.6
  • 180
    • 79956293339 scopus 로고    scopus 로고
    • Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: Relevance to Alzheimers' disease
    • A.M. Martin-Moreno, D. Reigada, B.G. Ramirez, R. Mechoulam, N. Innamorato, and A. Cuadrado Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease Mol Pharmacol 79 2011 964 973
    • (2011) Mol Pharmacol , vol.79 , pp. 964-973
    • Martin-Moreno, A.M.1    Reigada, D.2    Ramirez, B.G.3    Mechoulam, R.4    Innamorato, N.5    Cuadrado, A.6
  • 182
    • 0018200736 scopus 로고
    • Tolerance to delta9-tetrahydrocannabinol in adapted and nonadapted rabbits
    • P. Martin, and P. Consroe Tolerance to delta9-tetrahydrocannabinol in adapted and nonadapted rabbits Pharmacol Biochem Behav 9 1978 753 758
    • (1978) Pharmacol Biochem Behav , vol.9 , pp. 753-758
    • Martin, P.1    Consroe, P.2
  • 183
    • 0028950529 scopus 로고
    • Nabilone in the treatment of multiple sclerosis
    • C.N. Martyn, L.S. Illis, and J. Thom Nabilone in the treatment of multiple sclerosis Lancet 345 1995 579
    • (1995) Lancet , vol.345 , pp. 579
    • Martyn, C.N.1    Illis, L.S.2    Thom, J.3
  • 184
    • 77950609949 scopus 로고    scopus 로고
    • Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus
    • R. Mason, and J.F. Cheer Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus Front Integr Neurosci 3 2009 13
    • (2009) Front Integr Neurosci , vol.3 , pp. 13
    • Mason, R.1    Cheer, J.F.2
  • 185
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • L.A. Matsuda, S.J. Lolait, M.J. Brownstein, A.C. Young, and T.I. Bonner Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 1990 561 564
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 186
    • 0036120657 scopus 로고    scopus 로고
    • Reflections on nutritional issues associated with cancer therapy
    • P. Mcgrath Reflections on nutritional issues associated with cancer therapy Cancer Pract 10 2002 94 101
    • (2002) Cancer Pract , vol.10 , pp. 94-101
    • McGrath, P.1
  • 187
    • 83555167391 scopus 로고
    • Cannabis indica in convulsions
    • R.R. McMeens Cannabis indica in convulsions West Lancet 1856 327 331
    • (1856) West Lancet , pp. 327-331
    • McMeens, R.R.1
  • 190
    • 28444487445 scopus 로고    scopus 로고
    • Plant cannabinoids: A neglected pharmacological treasure trove
    • R. Mechoulam Plant cannabinoids: a neglected pharmacological treasure trove Br J Pharmacol 146 2005 913 915
    • (2005) Br J Pharmacol , vol.146 , pp. 913-915
    • Mechoulam, R.1
  • 191
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • R. Mechoulam, S. Ben-Shabat, L. Hanus, M. Ligumsky, N.E. Kaminski, and A.R. Schatz Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors Biochem Pharmacol 50 1995 83 90
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3    Ligumsky, M.4    Kaminski, N.E.5    Schatz, A.R.6
  • 193
    • 77952314867 scopus 로고    scopus 로고
    • Potency trends of Delta9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008
    • Z. Mehmedic, S. Chandra, D. Slade, H. Denham, S. Foster, and A.S. Patel Potency trends of Delta9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008 J Forensic Sci 55 2010 1209 1217
    • (2010) J Forensic Sci , vol.55 , pp. 1209-1217
    • Mehmedic, Z.1    Chandra, S.2    Slade, D.3    Denham, H.4    Foster, S.5    Patel, A.S.6
  • 194
    • 0034942985 scopus 로고    scopus 로고
    • Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates
    • J.P. Meschler, A.C. Howlett, and B.K. Madras Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5, 6-tetrahydropyridine (MPTP)-treated non-human primates Psychopharmacology (Berl) 156 2001 79 85
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 79-85
    • Meschler, J.P.1    Howlett, A.C.2    Madras, B.K.3
  • 195
    • 0036317453 scopus 로고    scopus 로고
    • The legalization of Cannabis for medical use
    • A.C. Moffat The legalization of Cannabis for medical use Sci Justice 42 2002 55 57
    • (2002) Sci Justice , vol.42 , pp. 55-57
    • Moffat, A.C.1
  • 196
    • 33746913292 scopus 로고    scopus 로고
    • The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    • K. Monory, F. Massa, M. Egertova, M. Eder, H. Blaudzun, and R. Westenbroek The endocannabinoid system controls key epileptogenic circuits in the hippocampus Neuron 51 2006 455 466
    • (2006) Neuron , vol.51 , pp. 455-466
    • Monory, K.1    Massa, F.2    Egertova, M.3    Eder, M.4    Blaudzun, H.5    Westenbroek, R.6
  • 198
    • 33746610118 scopus 로고    scopus 로고
    • Nutritional management of individuals with Alzheimer's disease and other progressive dementias
    • J. Morris, and L. Volicer Nutritional management of individuals with Alzheimer's disease and other progressive dementias Nutr Clin Care 4 2001 148 155
    • (2001) Nutr Clin Care , vol.4 , pp. 148-155
    • Morris, J.1    Volicer, L.2
  • 199
    • 34347331251 scopus 로고    scopus 로고
    • Marijuana: An effective antiepileptic treatment in partial epilepsy? A case report and review of the literature
    • K. Mortati, B. Dworetzky, and O. Devinsky Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature Rev Neurol Dis 4 2007 103 106
    • (2007) Rev Neurol Dis , vol.4 , pp. 103-106
    • Mortati, K.1    Dworetzky, B.2    Devinsky, O.3
  • 200
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • S. Munro, K.L. Thomas, and M. Abu-Shaar Molecular characterization of a peripheral receptor for cannabinoids Nature 365 1993 61 65
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 202
    • 78649689791 scopus 로고    scopus 로고
    • GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?
    • T. Nevalainen, and A.J. Irving GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity? Curr Top Med Chem 10 2010 799 813
    • (2010) Curr Top Med Chem , vol.10 , pp. 799-813
    • Nevalainen, T.1    Irving, A.J.2
  • 203
    • 0025340938 scopus 로고
    • Illicit drug use and the risk of new-onset seizures
    • S.K. Ng, J.C. Brust, W.A. Hauser, and M. Susser Illicit drug use and the risk of new-onset seizures Am J Epidemiol 132 1990 47 57
    • (1990) Am J Epidemiol , vol.132 , pp. 47-57
    • Ng, S.K.1    Brust, J.C.2    Hauser, W.A.3    Susser, M.4
  • 204
    • 0031408313 scopus 로고    scopus 로고
    • Clinical experience with nabilone for chronic pain
    • W. Notcutt, M. Price, and G. Chapman Clinical experience with nabilone for chronic pain Pharm Sci 3 1997 551 555
    • (1997) Pharm Sci , vol.3 , pp. 551-555
    • Notcutt, W.1    Price, M.2    Chapman, G.3
  • 205
    • 79953822342 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
    • A. Novotna, J. Mares, S. Ratcliffe, I. Novakova, M. Vachova, and O. Zapletalova A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis Eur J Neurol 2011
    • (2011) Eur J Neurol
    • Novotna, A.1    Mares, J.2    Ratcliffe, S.3    Novakova, I.4    Vachova, M.5    Zapletalova, O.6
  • 206
    • 3843066799 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study
    • E. Nunez, C. Benito, M.R. Pazos, A. Barbachano, O. Fajardo, and S. Gonzalez Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study Synapse 53 2004 208 213
    • (2004) Synapse , vol.53 , pp. 208-213
    • Nunez, E.1    Benito, C.2    Pazos, M.R.3    Barbachano, A.4    Fajardo, O.5    Gonzalez, S.6
  • 207
    • 0001210566 scopus 로고
    • On the preparations of the Indian hemp, or gunjah (Cannabis indica)
    • W.B. O'Shaughnessy On the preparations of the Indian hemp, or gunjah (Cannabis indica) Trans Med Phys Soc Bengal 1840 71 102
    • (1840) Trans Med Phys Soc Bengal , pp. 71-102
    • O'Shaughnessy, W.B.1
  • 208
    • 33749544716 scopus 로고    scopus 로고
    • Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
    • E.S. Onaivi, H. Ishiguro, J.P. Gong, S. Patel, A. Perchuk, and P.A. Meozzi Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain Ann N Y Acad Sci 1074 2006 514 536
    • (2006) Ann N y Acad Sci , vol.1074 , pp. 514-536
    • Onaivi, E.S.1    Ishiguro, H.2    Gong, J.P.3    Patel, S.4    Perchuk, A.5    Meozzi, P.A.6
  • 209
    • 33646872652 scopus 로고    scopus 로고
    • Receptor-independent actions of cannabinoids on cell membranes: Focus on endocannabinoids
    • M. Oz Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids Pharmacol Ther 111 2006 114 144
    • (2006) Pharmacol Ther , vol.111 , pp. 114-144
    • Oz, M.1
  • 210
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • U. Pagotto, G. Marsicano, D. Cota, B. Lutz, and R. Pasquali The emerging role of the endocannabinoid system in endocrine regulation and energy balance Endocr Rev 27 2006 73 100
    • (2006) Endocr Rev , vol.27 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3    Lutz, B.4    Pasquali, R.5
  • 212
    • 0035037811 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice
    • S. Patel, and C.J. Hillard Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice J Pharmacol Exp Ther 297 2001 629 637
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 629-637
    • Patel, S.1    Hillard, C.J.2
  • 213
    • 0035918511 scopus 로고    scopus 로고
    • Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase
    • M.P. Patricelli, and B.F. Cravatt Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase Biochemistry 40 2001 6107 6115
    • (2001) Biochemistry , vol.40 , pp. 6107-6115
    • Patricelli, M.P.1    Cravatt, B.F.2
  • 214
    • 70349105130 scopus 로고    scopus 로고
    • The spinocerebellar ataxias
    • H.L. Paulson The spinocerebellar ataxias J Neuroophthalmol 29 2009 227 237
    • (2009) J Neuroophthalmol , vol.29 , pp. 227-237
    • Paulson, H.L.1
  • 215
    • 75649135280 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease
    • D.P. Perl Neuropathology of Alzheimer's disease Mt Sinai J Med 77 2010 32 42
    • (2010) Mt Sinai J Med , vol.77 , pp. 32-42
    • Perl, D.P.1
  • 216
    • 32944469658 scopus 로고    scopus 로고
    • Sativex for the management of multiple sclerosis symptoms
    • C. Perras Sativex for the management of multiple sclerosis symptoms Issues Emerg Health Technol 2005 1 4
    • (2005) Issues Emerg Health Technol , pp. 1-4
    • Perras, C.1
  • 217
    • 36448995830 scopus 로고    scopus 로고
    • GPR55: A new member of the cannabinoid receptor clan?
    • R.G. Pertwee GPR55: a new member of the cannabinoid receptor clan? Br J Pharmacol 152 2007 984 986
    • (2007) Br J Pharmacol , vol.152 , pp. 984-986
    • Pertwee, R.G.1
  • 218
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9- tetrahydrocannabivarin
    • R.G. Pertwee The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9- tetrahydrocannabivarin Br J Pharmacol 153 2008 199 215
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 219
    • 78650120798 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB and CB
    • R.G. Pertwee, A.C. Howlett, M.E. Abood, S.P. Alexander, V. Di Marzo, and M.R. Elphick International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB Pharmacol Rev 62 2010 588 631
    • (2010) Pharmacol Rev , vol.62 , pp. 588-631
    • Pertwee, R.G.1    Howlett, A.C.2    Abood, M.E.3    Alexander, S.P.4    Di Marzo, V.5    Elphick, M.R.6
  • 220
    • 0037027935 scopus 로고    scopus 로고
    • (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens
    • R.G. Pertwee, R.A. Ross, S.J. Craib, and A. Thomas (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens Eur J Pharmacol 456 2002 99 106
    • (2002) Eur J Pharmacol , vol.456 , pp. 99-106
    • Pertwee, R.G.1    Ross, R.A.2    Craib, S.J.3    Thomas, A.4
  • 221
  • 223
    • 22144447474 scopus 로고    scopus 로고
    • Strong increase in total delta-THC in cannabis preparations sold in Dutch coffee shops
    • F.T. Pijlman, S.M. Rigter, J. Hoek, H.M. Goldschmidt, and R.J. Niesink Strong increase in total delta-THC in cannabis preparations sold in Dutch coffee shops Addict Biol 10 2005 171 180
    • (2005) Addict Biol , vol.10 , pp. 171-180
    • Pijlman, F.T.1    Rigter, S.M.2    Hoek, J.3    Goldschmidt, H.M.4    Niesink, R.J.5
  • 226
    • 77956958953 scopus 로고    scopus 로고
    • Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy
    • L. Qian, P.M. Flood, and J.S. Hong Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy J Neural Transm 117 2010 971 979
    • (2010) J Neural Transm , vol.117 , pp. 971-979
    • Qian, L.1    Flood, P.M.2    Hong, J.S.3
  • 227
    • 46749129338 scopus 로고    scopus 로고
    • TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons
    • N. Qin, M.P. Neeper, Y. Liu, T.L. Hutchinson, M.L. Lubin, and C.M. Flores TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons J Neurosci 28 2008 6231 6238
    • (2008) J Neurosci , vol.28 , pp. 6231-6238
    • Qin, N.1    Neeper, M.P.2    Liu, Y.3    Hutchinson, T.L.4    Lubin, M.L.5    Flores, C.M.6
  • 228
    • 0034054679 scopus 로고    scopus 로고
    • Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells
    • F. Rakhshan, T.A. Day, R.D. Blakely, and E.L. Barker Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells J Pharmacol Exp Ther 292 2000 960 967
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 960-967
    • Rakhshan, F.1    Day, T.A.2    Blakely, R.D.3    Barker, E.L.4
  • 229
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • B.G. Ramirez, C. Blazquez, T. Gomez Del Pulgar, M. Guzman, and M.L. De Ceballos Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation J Neurosci 25 2005 1904 1913
    • (2005) J Neurosci , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez Del Pulgar, T.3    Guzman, M.4    De Ceballos, M.L.5
  • 230
    • 0002135271 scopus 로고
    • 9-THC as an effective antidepressant and appetite stimulating agent in advanced cancer patients
    • M.C. Braude, S. Szara, Raven Press New York, NY
    • 9-THC as an effective antidepressant and appetite stimulating agent in advanced cancer patients M.C. Braude, S. Szara, The Pharmacology of Marihuana 1976 Raven Press New York, NY 763 776
    • (1976) The Pharmacology of Marihuana , pp. 763-776
    • Regelson, W.1    Butler, J.R.2
  • 231
    • 0031861639 scopus 로고    scopus 로고
    • Long-term cannabis use: Characteristics of users in an Australian rural area
    • D. Reilly, P. Didcott, W. Swift, and W. Hall Long-term cannabis use: characteristics of users in an Australian rural area Addiction 93 1998 837 846
    • (1998) Addiction , vol.93 , pp. 837-846
    • Reilly, D.1    Didcott, P.2    Swift, W.3    Hall, W.4
  • 232
    • 33746647403 scopus 로고    scopus 로고
    • Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats
    • L.B. Resstel, S.R. Joca, F.A. Moreira, F.M. Correa, and F.S. Guimaraes Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats Behav Brain Res 172 2006 294 298
    • (2006) Behav Brain Res , vol.172 , pp. 294-298
    • Resstel, L.B.1    Joca, S.R.2    Moreira, F.A.3    Correa, F.M.4    Guimaraes, F.S.5
  • 233
    • 65549106424 scopus 로고    scopus 로고
    • 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
    • L.B. Resstel, R.F. Tavares, S.F. Lisboa, S.R. Joca, F.M. Correa, and F.S. Guimaraes 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats Br J Pharmacol 156 2009 181 188
    • (2009) Br J Pharmacol , vol.156 , pp. 181-188
    • Resstel, L.B.1    Tavares, R.F.2    Lisboa, S.F.3    Joca, S.R.4    Correa, F.M.5    Guimaraes, F.S.6
  • 234
    • 0001314102 scopus 로고
    • Therapeutical uses and toxic effects of Cannabis indica
    • J.R. Reynolds Therapeutical uses and toxic effects of Cannabis indica Lancet 1 1868 637 638
    • (1868) Lancet , vol.1 , pp. 637-638
    • Reynolds, J.R.1
  • 235
    • 67649856310 scopus 로고    scopus 로고
    • Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
    • G. Riedel, P. Fadda, S. Mckillop-Smith, R.G. Pertwee, B. Platt, and L. Robinson Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice Br J Pharmacol 156 2009 1154 1166
    • (2009) Br J Pharmacol , vol.156 , pp. 1154-1166
    • Riedel, G.1    Fadda, P.2    McKillop-Smith, S.3    Pertwee, R.G.4    Platt, B.5    Robinson, L.6
  • 236
    • 77951100273 scopus 로고    scopus 로고
    • The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies
    • J.R. Rivers, and J.C. Ashton The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies Cent Nerv Syst Agents Med Chem 10 2010 47 64
    • (2010) Cent Nerv Syst Agents Med Chem , vol.10 , pp. 47-64
    • Rivers, J.R.1    Ashton, J.C.2
  • 237
    • 0035135376 scopus 로고    scopus 로고
    • Therapeutic aspects of cannabis and cannabinoids
    • P. Robson Therapeutic aspects of cannabis and cannabinoids Br J Psychiatry 178 2001 107 115
    • (2001) Br J Psychiatry , vol.178 , pp. 107-115
    • Robson, P.1
  • 238
    • 77954177297 scopus 로고    scopus 로고
    • Cannabis-based medicines in multiple sclerosis - A review of clinical studies
    • D.J. Rog Cannabis-based medicines in multiple sclerosis-a review of clinical studies Immunobiology 215 2010 658 672
    • (2010) Immunobiology , vol.215 , pp. 658-672
    • Rog, D.J.1
  • 239
    • 25444530723 scopus 로고    scopus 로고
    • Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
    • D.J. Rog, T.J. Nurmikko, T. Friede, and C.A. Young Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis Neurology 65 2005 812 819
    • (2005) Neurology , vol.65 , pp. 812-819
    • Rog, D.J.1    Nurmikko, T.J.2    Friede, T.3    Young, C.A.4
  • 240
    • 36849070991 scopus 로고    scopus 로고
    • Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial
    • D.J. Rog, T.J. Nurmikko, and C.A. Young Oromucosal delta9- tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial Clin Ther 29 2007 2068 2079
    • (2007) Clin Ther , vol.29 , pp. 2068-2079
    • Rog, D.J.1    Nurmikko, T.J.2    Young, C.A.3
  • 241
    • 47049091502 scopus 로고    scopus 로고
    • Inhibition of recombinant human T-type calcium channels by delta9-tetrahydrocannabinol and cannabidiol
    • H.R. Ross, I. Napier, and M. Connor Inhibition of recombinant human T-type calcium channels by delta9-tetrahydrocannabinol and cannabidiol J Biol Chem 283 2008 16124 16134
    • (2008) J Biol Chem , vol.283 , pp. 16124-16134
    • Ross, H.R.1    Napier, I.2    Connor, M.3
  • 242
    • 61349143694 scopus 로고    scopus 로고
    • The enigmatic pharmacology of GPR55
    • R.A. Ross The enigmatic pharmacology of GPR55 Trends Pharmacol Sci 30 2009 156 163
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 156-163
    • Ross, R.A.1
  • 243
    • 78651456305 scopus 로고    scopus 로고
    • Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: An intravital microscopy study
    • L. Ruiz-Valdepenas, J.A. Martinez-Orgado, C. Benito, A. Millan, R.M. Tolon, and J. Romero Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study J Neuroinflammation 8 2011 5
    • (2011) J Neuroinflammation , vol.8 , pp. 5
    • Ruiz-Valdepenas, L.1    Martinez-Orgado, J.A.2    Benito, C.3    Millan, A.4    Tolon, R.M.5    Romero, J.6
  • 244
    • 33645098642 scopus 로고    scopus 로고
    • Cannabis in India: Ancient lore and modern medicine
    • R. Mechoulam, Birkhäuser Verlag Basel, Switzerland
    • E.B. Russo Cannabis in India: Ancient lore and modern medicine R. Mechoulam, Cannabinoids as therapeutics 2005 Birkhäuser Verlag Basel, Switzerland 1 22
    • (2005) Cannabinoids As Therapeutics , pp. 1-22
    • Russo, E.B.1
  • 245
    • 28844489930 scopus 로고    scopus 로고
    • A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
    • E. Russo, and G.W. Guy A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol Med Hypotheses 66 2006 234 246
    • (2006) Med Hypotheses , vol.66 , pp. 234-246
    • Russo, E.1    Guy, G.W.2
  • 246
    • 34548523508 scopus 로고    scopus 로고
    • History of cannabis and its preparations in saga, science, and sobriquet
    • E.B. Russo History of cannabis and its preparations in saga, science, and sobriquet Chem Biodivers 4 2007 1614 1648
    • (2007) Chem Biodivers , vol.4 , pp. 1614-1648
    • Russo, E.B.1
  • 247
    • 79960306559 scopus 로고    scopus 로고
    • Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
    • E.B. Russo Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects Br J Pharmacol 163 2011 1344 1364
    • (2011) Br J Pharmacol , vol.163 , pp. 1344-1364
    • Russo, E.B.1
  • 248
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • E.B. Russo, A. Burnett, B. Hall, and K.K. Parker Agonistic properties of cannabidiol at 5-HT1a receptors Neurochem Res 30 2005 1037 1043
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 250
    • 79952269285 scopus 로고    scopus 로고
    • Association between psychopathology and substance use among school-going adolescents in Cape Town, South Africa
    • A. Saban, A.J. Flisher, and G. Distiller Association between psychopathology and substance use among school-going adolescents in Cape Town, South Africa J Psychoactive Drugs 42 2010 467 476
    • (2010) J Psychoactive Drugs , vol.42 , pp. 467-476
    • Saban, A.1    Flisher, A.J.2    Distiller, G.3
  • 251
    • 0025558976 scopus 로고
    • Case report: The effect of tetrahydrocannabinol on food intake during chemotherapy
    • N. Sacks, J.R. Hutcheson Jr., J.M. Watts, and R.E. Webb Case report: the effect of tetrahydrocannabinol on food intake during chemotherapy J Am Coll Nutr 9 1990 630 632
    • (1990) J Am Coll Nutr , vol.9 , pp. 630-632
    • Sacks, N.1    Hutcheson, Jr.J.R.2    Watts, J.M.3    Webb, R.E.4
  • 252
    • 34547984234 scopus 로고    scopus 로고
    • Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    • O. Sagredo, J.A. Ramos, A. Decio, R. Mechoulam, and J. Fernandez-Ruiz Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors Eur J Neurosci 26 2007 843 851
    • (2007) Eur J Neurosci , vol.26 , pp. 843-851
    • Sagredo, O.1    Ramos, J.A.2    Decio, A.3    Mechoulam, R.4    Fernandez-Ruiz, J.5
  • 254
    • 80051785860 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, crossover study to evaluate the abuse potential of nabiximols oromucosal spray in subjects with a history of recreational cannabis use
    • Jun 13 [Epub ahead of print]
    • K.A. Schoedel, N. Chen, A. Hilliard, L. White, C. Stott, and E. Russo A randomized, double-blind, placebo-controlled, crossover study to evaluate the abuse potential of nabiximols oromucosal spray in subjects with a history of recreational cannabis use Hum Psychopharmacol 2011 Jun 13 [Epub ahead of print]
    • (2011) Hum Psychopharmacol
    • Schoedel, K.A.1    Chen, N.2    Hilliard, A.3    White, L.4    Stott, C.5    Russo, E.6
  • 255
    • 79551647321 scopus 로고    scopus 로고
    • Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists
    • A.A. Scopinho, F.S. Guimaraes, F.M. Correa, and L.B. Resstel Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists Pharmacol Biochem Behav 98 2011 268 272
    • (2011) Pharmacol Biochem Behav , vol.98 , pp. 268-272
    • Scopinho, A.A.1    Guimaraes, F.S.2    Correa, F.M.3    Resstel, L.B.4
  • 256
    • 77952950690 scopus 로고    scopus 로고
    • Pharmacological characterization of GPR55, a putative cannabinoid receptor
    • H. Sharir, and M.E. Abood Pharmacological characterization of GPR55, a putative cannabinoid receptor Pharmacol Ther 126 2010 301 313
    • (2010) Pharmacol Ther , vol.126 , pp. 301-313
    • Sharir, H.1    Abood, M.E.2
  • 257
    • 0032589801 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture
    • M. Shen, and S.A. Thayer Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture Mol Pharmacol 55 1999 8 13
    • (1999) Mol Pharmacol , vol.55 , pp. 8-13
    • Shen, M.1    Thayer, S.A.2
  • 259
    • 0035846577 scopus 로고    scopus 로고
    • Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study
    • K.A. Sieradzan, S.H. Fox, M. Hill, J.P. Dick, A.R. Crossman, and J.M. Brotchie Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study Neurology 57 2001 2108 2111
    • (2001) Neurology , vol.57 , pp. 2108-2111
    • Sieradzan, K.A.1    Fox, S.H.2    Hill, M.3    Dick, J.P.4    Crossman, A.R.5    Brotchie, J.M.6
  • 260
    • 0034982493 scopus 로고    scopus 로고
    • Striatal cannabinoid CB1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease
    • M.A. Silverdale, S. Mcguire, A. Mcinnes, A.R. Crossman, and J.M. Brotchie Striatal cannabinoid CB1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease Exp Neurol 169 2001 400 406
    • (2001) Exp Neurol , vol.169 , pp. 400-406
    • Silverdale, M.A.1    McGuire, S.2    McInnes, A.3    Crossman, A.R.4    Brotchie, J.M.5
  • 261
    • 0034949246 scopus 로고    scopus 로고
    • Current perspectives on the development of non-biogenic amine-based antidepressants
    • P. Skolnick, B. Legutko, X. Li, and F.P. Bymaster Current perspectives on the development of non-biogenic amine-based antidepressants Pharmacol Res 43 2001 411 423
    • (2001) Pharmacol Res , vol.43 , pp. 411-423
    • Skolnick, P.1    Legutko, B.2    Li, X.3    Bymaster, F.P.4
  • 263
    • 0017187470 scopus 로고
    • Comparative effects of various naturally occurring cannabinoids on food, sucrose and water consumption by rats
    • R.D. Sofia, and L.C. Knobloch Comparative effects of various naturally occurring cannabinoids on food, sucrose and water consumption by rats Pharmacol Biochem Behav 4 1976 591 599
    • (1976) Pharmacol Biochem Behav , vol.4 , pp. 591-599
    • Sofia, R.D.1    Knobloch, L.C.2
  • 264
    • 78650172976 scopus 로고    scopus 로고
    • Inflammation, demyelination, and degeneration - Recent insights from MS pathology
    • C. Stadelmann, C. Wegner, and W. Bruck Inflammation, demyelination, and degeneration - recent insights from MS pathology Biochim Biophys Acta 1812 2011 275 282
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 275-282
    • Stadelmann, C.1    Wegner, C.2    Bruck, W.3
  • 265
    • 77954406421 scopus 로고    scopus 로고
    • Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    • N. Stella Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas Glia 58 2010 1017 1030
    • (2010) Glia , vol.58 , pp. 1017-1030
    • Stella, N.1
  • 266
    • 33746793870 scopus 로고    scopus 로고
    • Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group
    • F. Strasser, D. Luftner, K. Possinger, G. Ernst, T. Ruhstaller, and W. Meissner Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group J Clin Oncol 24 2006 3394 3400
    • (2006) J Clin Oncol , vol.24 , pp. 3394-3400
    • Strasser, F.1    Luftner, D.2    Possinger, K.3    Ernst, G.4    Ruhstaller, T.5    Meissner, W.6
  • 268
    • 4043096916 scopus 로고    scopus 로고
    • Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial
    • K.B. Svendsen, T.S. Jensen, and F.W. Bach Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial BMJ 329 2004 253
    • (2004) BMJ , vol.329 , pp. 253
    • Svendsen, K.B.1    Jensen, T.S.2    Bach, F.W.3
  • 269
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • A. Thomas, G.L. Baillie, A.M. Phillips, R.K. Razdan, R.A. Ross, and R.G. Pertwee Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro Br J Pharmacol 150 2007 613 623
    • (2007) Br J Pharmacol , vol.150 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3    Razdan, R.K.4    Ross, R.A.5    Pertwee, R.G.6
  • 270
    • 28444433385 scopus 로고    scopus 로고
    • Evidence that the plant cannabinoid delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist
    • A. Thomas, L.A. Stevenson, K.N. Wease, M.R. Price, G. Baillie, and R.A. Ross Evidence that the plant cannabinoid delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist Br J Pharmacol 2005
    • (2005) Br J Pharmacol
    • Thomas, A.1    Stevenson, L.A.2    Wease, K.N.3    Price, M.R.4    Baillie, G.5    Ross, R.A.6
  • 271
    • 0015621246 scopus 로고
    • Barbiturate-induced transmitter release at a frog neuromuscular junction
    • T.D. Thomson, and S.A. Turkanis Barbiturate-induced transmitter release at a frog neuromuscular junction Br J Pharmacol 48 1973 48 58
    • (1973) Br J Pharmacol , vol.48 , pp. 48-58
    • Thomson, T.D.1    Turkanis, S.A.2
  • 272
    • 77949389645 scopus 로고    scopus 로고
    • THC Prevents MDMA Neurotoxicity in Mice
    • C. Tourino, A. Zimmer, and O. Valverde THC Prevents MDMA Neurotoxicity in Mice PLoS One 5 2010 e9143
    • (2010) PLoS One , vol.5 , pp. 9143
    • Tourino, C.1    Zimmer, A.2    Valverde, O.3
  • 273
    • 0019456423 scopus 로고
    • The religious and medicinal uses of Cannabis in China, India and Tibet
    • M. Touw The religious and medicinal uses of Cannabis in China, India and Tibet J Psychoactive Drugs 13 1981 23 34
    • (1981) J Psychoactive Drugs , vol.13 , pp. 23-34
    • Touw, M.1
  • 275
    • 0031929438 scopus 로고    scopus 로고
    • Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
    • K. Tsou, S. Brown, M.C. Sanudo-Pena, K. Mackie, and J.M. Walker Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system Neuroscience 83 1998 393 411
    • (1998) Neuroscience , vol.83 , pp. 393-411
    • Tsou, K.1    Brown, S.2    Sanudo-Pena, M.C.3    MacKie, K.4    Walker, J.M.5
  • 277
    • 0017623002 scopus 로고
    • Influence of delta9-tetrahydrocannabinol and cannabidiol on photically evoked after-discharge potentials
    • S.A. Turkanis, P. Chiu, H.K. Borys, and R. Karler Influence of delta9-tetrahydrocannabinol and cannabidiol on photically evoked after-discharge potentials Psychopharmacology (Berl) 52 1977 207 212
    • (1977) Psychopharmacology (Berl) , vol.52 , pp. 207-212
    • Turkanis, S.A.1    Chiu, P.2    Borys, H.K.3    Karler, R.4
  • 278
    • 0016744453 scopus 로고
    • Influence of anticonvulsant cannabinoids on posttetanic potentiation at isolated bullfrog ganglia
    • S.A. Turkanis, and R. Karler Influence of anticonvulsant cannabinoids on posttetanic potentiation at isolated bullfrog ganglia Life Sci 17 1975 569 578
    • (1975) Life Sci , vol.17 , pp. 569-578
    • Turkanis, S.A.1    Karler, R.2
  • 279
    • 0019604278 scopus 로고
    • Electrophysiologic properties of the cannabinoids
    • S.A. Turkanis, and R. Karler Electrophysiologic properties of the cannabinoids J Clin Pharmacol 21 1981 449S 463S
    • (1981) J Clin Pharmacol , vol.21
    • Turkanis, S.A.1    Karler, R.2
  • 280
    • 0019848101 scopus 로고
    • Excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat
    • S.A. Turkanis, and R. Karler Excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat Psychopharmacology (Berl) 75 1981 294 298
    • (1981) Psychopharmacology (Berl) , vol.75 , pp. 294-298
    • Turkanis, S.A.1    Karler, R.2
  • 281
    • 0020086336 scopus 로고
    • Central excitatory properties of delta9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats
    • S.A. Turkanis, and R. Karler Central excitatory properties of delta9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats Neuropharmacology 21 1982 7 13
    • (1982) Neuropharmacology , vol.21 , pp. 7-13
    • Turkanis, S.A.1    Karler, R.2
  • 282
    • 0023461472 scopus 로고
    • Different cannabinoids exhibit different electrophysiological properties
    • S.A. Turkanis, and R. Karler Different cannabinoids exhibit different electrophysiological properties NIDA Res Monogr 79 1987 67 81
    • (1987) NIDA Res Monogr , vol.79 , pp. 67-81
    • Turkanis, S.A.1    Karler, R.2
  • 283
    • 0026010616 scopus 로고
    • Differential effects of delta-9-tetrahydrocannabinol and its 11-hydroxy metabolite on sodium current in neuroblastoma cells
    • S.A. Turkanis, R. Karler, and L.M. Partlow Differential effects of delta-9-tetrahydrocannabinol and its 11-hydroxy metabolite on sodium current in neuroblastoma cells Brain Res 560 1991 245 250
    • (1991) Brain Res , vol.560 , pp. 245-250
    • Turkanis, S.A.1    Karler, R.2    Partlow, L.M.3
  • 284
    • 0018387160 scopus 로고
    • An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats
    • S.A. Turkanis, K.A. Smiley, H.K. Borys, D.M. Olsen, and R. Karler An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats Epilepsia 20 1979 351 363
    • (1979) Epilepsia , vol.20 , pp. 351-363
    • Turkanis, S.A.1    Smiley, K.A.2    Borys, H.K.3    Olsen, D.M.4    Karler, R.5
  • 285
    • 0035437865 scopus 로고    scopus 로고
    • Neuroprotection by delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity
    • M. Van Der Stelt, W.B. Veldhuis, P.R. Bar, G.A. Veldink, J.F. Vliegenthart, and K. Nicolay Neuroprotection by delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity J Neurosci 21 2001 6475 6479
    • (2001) J Neurosci , vol.21 , pp. 6475-6479
    • Van Der Stelt, M.1    Veldhuis, W.B.2    Bar, P.R.3    Veldink, G.A.4    Vliegenthart, J.F.5    Nicolay, K.6
  • 286
    • 59249107384 scopus 로고    scopus 로고
    • Does cannabis use affect treatment outcome in bipolar disorder? A longitudinal analysis
    • I. van Rossum, M. Boomsma, D. Tenback, C. Reed, and J. Van Os Does cannabis use affect treatment outcome in bipolar disorder? A longitudinal analysis J Nerv Ment Dis 197 2009 35 40
    • (2009) J Nerv Ment Dis , vol.197 , pp. 35-40
    • Van Rossum, I.1    Boomsma, M.2    Tenback, D.3    Reed, C.4    Van Os, J.5
  • 287
    • 26844504226 scopus 로고    scopus 로고
    • Identification and functional characterization of brainstem cannabinoid CB2 receptors
    • M.D. Van Sickle, M. Duncan, P.J. Kingsley, A. Mouihate, P. Urbani, and K. Mackie Identification and functional characterization of brainstem cannabinoid CB2 receptors Science 310 2005 329 332
    • (2005) Science , vol.310 , pp. 329-332
    • Van Sickle, M.D.1    Duncan, M.2    Kingsley, P.J.3    Mouihate, A.4    Urbani, P.5    MacKie, K.6
  • 289
    • 4344571664 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled, crossover study
    • C. Vaney, M. Heinzel-Gutenbrunner, P. Jobin, F. Tschopp, B. Gattlen, and U. Hagen Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study Mult Scler 10 2004 417 424
    • (2004) Mult Scler , vol.10 , pp. 417-424
    • Vaney, C.1    Heinzel-Gutenbrunner, M.2    Jobin, P.3    Tschopp, F.4    Gattlen, B.5    Hagen, U.6
  • 290
    • 39149092685 scopus 로고    scopus 로고
    • Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of delta9-tetrahydrocannabinol
    • R.E. Vann, T.F. Gamage, J.A. Warner, E.M. Marshall, N.L. Taylor, and B.R. Martin Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of delta9-tetrahydrocannabinol Drug Alcohol Depend 94 2008 191 198
    • (2008) Drug Alcohol Depend , vol.94 , pp. 191-198
    • Vann, R.E.1    Gamage, T.F.2    Warner, J.A.3    Marshall, E.M.4    Taylor, N.L.5    Martin, B.R.6
  • 291
    • 4644341666 scopus 로고    scopus 로고
    • Survey on cannabis use in Parkinson's disease: Subjective improvement of motor symptoms
    • K. Venderová, E. Růzicka, V. Vorísek, and P. Visnovský Survey on cannabis use in Parkinson's disease: Subjective improvement of motor symptoms Mov Disord 19 2004 1102 1106
    • (2004) Mov Disord , vol.19 , pp. 1102-1106
    • Venderová, K.1    Růzicka, E.2    Vorísek, V.3    Visnovský, P.4
  • 292
    • 0030966425 scopus 로고    scopus 로고
    • Dronabinol may help behaviour problems in Alzheimers disease
    • L. Volicer Dronabinol may help behaviour problems in Alzheimers disease Am Fam Physician 55 1997 1338
    • (1997) Am Fam Physician , vol.55 , pp. 1338
    • Volicer, L.1
  • 293
    • 4344582253 scopus 로고    scopus 로고
    • Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients
    • D.T. Wade, P. Makela, P. Robson, H. House, and C. Bateman Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients Mult Scler 10 2004 434 441
    • (2004) Mult Scler , vol.10 , pp. 434-441
    • Wade, D.T.1    Makela, P.2    Robson, P.3    House, H.4    Bateman, C.5
  • 294
    • 33745025055 scopus 로고    scopus 로고
    • Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis
    • D.T. Wade, P.M. Makela, H. House, C. Bateman, and P. Robson Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis Mult Scler 12 2006 639 645
    • (2006) Mult Scler , vol.12 , pp. 639-645
    • Wade, D.T.1    Makela, P.M.2    House, H.3    Bateman, C.4    Robson, P.5
  • 295
    • 0345669751 scopus 로고    scopus 로고
    • A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms
    • D.T. Wade, P. Robson, H. House, P. Makela, and J. Aram A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms Clin Rehabil 17 2003 21 29
    • (2003) Clin Rehabil , vol.17 , pp. 21-29
    • Wade, D.T.1    Robson, P.2    House, H.3    Makela, P.4    Aram, J.5
  • 296
    • 0035964576 scopus 로고    scopus 로고
    • Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects
    • M.J. Wallace, J.L. Wiley, B.R. Martin, and R.J. Delorenzo Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects Eur J Pharmacol 428 2001 51 57
    • (2001) Eur J Pharmacol , vol.428 , pp. 51-57
    • Wallace, M.J.1    Wiley, J.L.2    Martin, B.R.3    Delorenzo, R.J.4
  • 297
    • 76749165654 scopus 로고    scopus 로고
    • Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine- induced nigrostriatal terminal lesion model of Parkinson's disease in the rat
    • S. Walsh, K. Mnich, K. Mackie, A.M. Gorman, D.P. Finn, and E. Dowd Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat Brain Res Bull 81 2010 543 548
    • (2010) Brain Res Bull , vol.81 , pp. 543-548
    • Walsh, S.1    Mnich, K.2    MacKie, K.3    Gorman, A.M.4    Finn, D.P.5    Dowd, E.6
  • 298
    • 33645453054 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
    • S. Walther, R. Mahlberg, U. Eichmann, and D. Kunz Delta-9- tetrahydrocannabinol for nighttime agitation in severe dementia Psychopharmacology (Berl) 185 2006 524 528
    • (2006) Psychopharmacology (Berl) , vol.185 , pp. 524-528
    • Walther, S.1    Mahlberg, R.2    Eichmann, U.3    Kunz, D.4
  • 299
    • 79953007668 scopus 로고    scopus 로고
    • Effects of the allosteric antagonist 1-(4-Chlorophenyl)-3-[3-(6- pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum
    • X. Wang, J.G. Horswill, B.J. Whalley, and G.J. Stephens Effects of the allosteric antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl) phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum Mol Pharmacol 79 2011 758 767
    • (2011) Mol Pharmacol , vol.79 , pp. 758-767
    • Wang, X.1    Horswill, J.G.2    Whalley, B.J.3    Stephens, G.J.4
  • 300
    • 0029745360 scopus 로고    scopus 로고
    • Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids
    • K. Watanabe, Y. Kayano, T. Matsunaga, I. Yamamoto, and H. Yoshimura Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids Biol Pharm Bull 19 1996 1109 1111
    • (1996) Biol Pharm Bull , vol.19 , pp. 1109-1111
    • Watanabe, K.1    Kayano, Y.2    Matsunaga, T.3    Yamamoto, I.4    Yoshimura, H.5
  • 301
    • 3242661071 scopus 로고    scopus 로고
    • A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro
    • B.J. Whalley, J.D. Wilkinson, E.M. Williamson, and A. Constanti A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro Neurosci Lett 365 2004 58 63
    • (2004) Neurosci Lett , vol.365 , pp. 58-63
    • Whalley, B.J.1    Wilkinson, J.D.2    Williamson, E.M.3    Constanti, A.4
  • 302
    • 77954127252 scopus 로고    scopus 로고
    • Neuroinflammation and the prospects for anti-inflammatory treatment of Parkinson's disease
    • P.S. Whitton Neuroinflammation and the prospects for anti-inflammatory treatment of Parkinson's disease Curr Opin Investig Drugs 11 2010 788 794
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 788-794
    • Whitton, P.S.1
  • 305
    • 0036607403 scopus 로고    scopus 로고
    • Observational analysis of feeding induced by delta9-THC and anandamide
    • C.M. Williams, and T.C. Kirkham Observational analysis of feeding induced by delta9-THC and anandamide Physiol Behav 76 2002 241 250
    • (2002) Physiol Behav , vol.76 , pp. 241-250
    • Williams, C.M.1    Kirkham, T.C.2
  • 306
    • 0036361973 scopus 로고    scopus 로고
    • Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
    • C.M. Williams, and T.C. Kirkham Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine Pharmacol Biochem Behav 71 2002 333 340
    • (2002) Pharmacol Biochem Behav , vol.71 , pp. 333-340
    • Williams, C.M.1    Kirkham, T.C.2
  • 307
    • 0031736282 scopus 로고    scopus 로고
    • Hyperphagia in pre-fed rats following oral delta9-THC
    • C.M. Williams, P.J. Rogers, and T.C. Kirkham Hyperphagia in pre-fed rats following oral delta9-THC Physiol Behav 65 1998 343 346
    • (1998) Physiol Behav , vol.65 , pp. 343-346
    • Williams, C.M.1    Rogers, P.J.2    Kirkham, T.C.3
  • 308
    • 34248173051 scopus 로고    scopus 로고
    • Anorexia of aging in long term care: Is dronabinol an effective appetite stimulant? - A pilot study
    • M.M. Wilson, C. Philpot, and J.E. Morley Anorexia of aging in long term care: is dronabinol an effective appetite stimulant?-a pilot study J Nutr Health Aging 11 2007 195 198
    • (2007) J Nutr Health Aging , vol.11 , pp. 195-198
    • Wilson, M.M.1    Philpot, C.2    Morley, J.E.3
  • 309
    • 77951037192 scopus 로고    scopus 로고
    • The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine 3A receptor-mediated currents in Xenopus laevis oocytes
    • K.H. Yang, S. Galadari, D. Isaev, G. Petroianu, T.S. Shippenberg, and M. Oz The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine 3A receptor-mediated currents in Xenopus laevis oocytes J Pharmacol Exp Ther 333 2010 547 554
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 547-554
    • Yang, K.H.1    Galadari, S.2    Isaev, D.3    Petroianu, G.4    Shippenberg, T.S.5    Oz, M.6
  • 310
    • 0242654882 scopus 로고    scopus 로고
    • Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): Multicentre randomised placebo-controlled trial
    • J. Zajicek, P. Fox, H. Sanders, D. Wright, J. Vickery, and A. Nunn Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial Lancet 362 2003 1517 1526
    • (2003) Lancet , vol.362 , pp. 1517-1526
    • Zajicek, J.1    Fox, P.2    Sanders, H.3    Wright, D.4    Vickery, J.5    Nunn, A.6
  • 312
    • 74549165354 scopus 로고    scopus 로고
    • Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors
    • T.V. Zanelati, C. Biojone, F.A. Moreira, F.S. Guimaraes, and S.R. Joca Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors Br J Pharmacol 159 2010 122 128
    • (2010) Br J Pharmacol , vol.159 , pp. 122-128
    • Zanelati, T.V.1    Biojone, C.2    Moreira, F.A.3    Guimaraes, F.S.4    Joca, S.R.5
  • 313
    • 36949015383 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors
    • A. Zani, D. Braida, V. Capurro, and M. Sala Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors Br J Pharmacol 152 2007 1301 1311
    • (2007) Br J Pharmacol , vol.152 , pp. 1301-1311
    • Zani, A.1    Braida, D.2    Capurro, V.3    Sala, M.4
  • 317
    • 0027263719 scopus 로고
    • Effect of cannabidiol on plasma prolactin, growth hormone and cortisol in human volunteers
    • A.W. Zuardi, F.S. Guimaraes, and A.C. Moreira Effect of cannabidiol on plasma prolactin, growth hormone and cortisol in human volunteers Braz J Med Biol Res 26 1993 213 217
    • (1993) Braz J Med Biol Res , vol.26 , pp. 213-217
    • Zuardi, A.W.1    Guimaraes, F.S.2    Moreira, A.C.3
  • 318
    • 0020509686 scopus 로고
    • Effects on variable-interval performance in rats of delta 9-tetrahydrocannabinol and cannabidiol, separately and in combination
    • A.W. Zuardi, and I.G. Karniol Effects on variable-interval performance in rats of delta 9-tetrahydrocannabinol and cannabidiol, separately and in combination Braz J Med Biol Res 16 1983 141 146
    • (1983) Braz J Med Biol Res , vol.16 , pp. 141-146
    • Zuardi, A.W.1    Karniol, I.G.2
  • 319
    • 0020079139 scopus 로고
    • Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
    • A.W. Zuardi, I. Shirakawa, E. Finkelfarb, and I.G. Karniol Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects Psychopharmacology (Berl) 76 1982 245 250
    • (1982) Psychopharmacology (Berl) , vol.76 , pp. 245-250
    • Zuardi, A.W.1    Shirakawa, I.2    Finkelfarb, E.3    Karniol, I.G.4


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