Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to Δ9- tetrahydrocannabinol

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Volumn 30, Issue 3, 1998, Pages 298-308

  Romero, Julián ^a   Berrendero, Fernando ^a   Manzanares, Jorge ^a   Perez, Alberto ^a   Corchero, Javier ^a   Fuentes, J Angel ^a   Fernandez Ruiz, J Javier ^a   Ramos, J Antonio ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

9 tetrahydrocannabinol; Autoradiography; Cannabinoid receptor binding; Cannabinoid receptor mRNA levels; Chronic exposure; Down regulation; In situ hybridization

Indexed keywords

CANNABINOID RECEPTOR; DRONABINOL;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CAUDATE NUCLEUS; DRUG RECEPTOR BINDING; IN SITU HYBRIDIZATION; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION;

ANIMALS; AUTORADIOGRAPHY; BRAIN; DOWN-REGULATION; MALE; MORPHOLINES; NAPHTHALENES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RNA, MESSENGER; TETRAHYDROCANNABINOL; TIME FACTORS; TRANSCRIPTION, GENETIC; TRITIUM;

EID: 0031669975     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199811)30:3<298::AID-SYN7>3.0.CO;2-6     Document Type: Article

References (15)

1. 9-tetrahydrocannabinol without alteration of cannabinoid receptor binding or mRNA levels in whole brain. Pharmacol. Biochem. Behav., 46:575-579.
2. 9-THC on cannabinoid receptors and G-protein activation in rat brain. Proc. Soc. Neurosci., 911:13.
3. de Miguel, R., Romero, J., Muñoz, R.M., García-Gil, L., González, S., Villanua, M.A., Makriyannis, A., Ramos, J.A., and Fernández-Ruiz, J.J. (1998) Effects of cannabinoids on prolactin and gonadotrophin secretion: Involvement of changes in hypothalamic GABAergic inputs. Biochem. Pharmacol. (in press).
4. Dewey, W.L. (1986) Cannabinoid pharmacology. Pharmacol. Rev., 38:151-178.
5. Jansen, E.M., Haycock, D.A., Ward, S.J., and Seybold, U.S. (1992) Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res., 575:93-102.
6. Oviedo, A., Glowa, J., and Herkenham, M. (1993) Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: A quantitative autoradiographic study. Brain Res., 616:293-302.
7. Paxinos, G., and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
8. Pertwee, R.G. (1991) Tolerance and dependence on psychotropic cannabinoids. In: The Biological Bases of Drug Tolerance and Dependence. Pratt, J., ed., Academic Press, New York, pp. 231-254.
9. Pertwee, R.G. (1995) Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors. In: Cannabinoid Receptors. Pertwee, R.G., ed. Academic Press, New York, pp. 1-34.
10. 9- tetrahydrocannabinol. Pharmacol. Biochem. Behav., 47:33-40.
11. 9-tetrahydrocannabinol. Pharmacol. Biochem. Behav. 51:731-737.
12. 9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions. Mol. Brain Res. 46:100-108.
13. Rubino, T., Massi, P., Patrini, G., Venier, I., Giagnoni, G., and Parolaro, D. (1994) Chronic CP-55,940 alters cannabinoid receptor-mRNA in the rat brain: An in situ hybridization study. Neuroreport, 5:2493-2496.
14. 35S]-GTPγS autoradiography in rat brain. J. Neurosci., 16:8057-8066.
15. 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptor. Brain Res. 544:145-149.