Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects

European Journal of Pharmacology

Volumn 428, Issue 1, 2001, Pages 51-57

  Wallace, Melisa J ^a,b   Wiley, Jenny L ^a   Martin, Billy R ^a   DeLorenzo, Robert J ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cannabinoid; Cannabinoid CB1 receptor; Epilepsy; Maximal electroshock; Seizure

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ANTICONVULSIVE AGENT; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CANNABINOL; RIMONABANT; TETRAHYDROCANNABINOL; CANNABIDIOL; CANNABINOID; CANNABINOID RECEPTOR; DRUG RECEPTOR; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTRIC SHOCK; FOCAL EPILEPSY; GRAND MAL SEIZURE; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SEIZURE THRESHOLD; ANIMAL; ANIMAL BEHAVIOR; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CANNABIDIOL; CANNABINOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; MALE; MICE; MORPHOLINES; NAPHTHALENES; PIPERIDINES; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0035964576     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01243-2     Document Type: Article

References (36)

1. Cannabis: Pharmacology and toxicology in animals and humans
2. Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices
3. Anticonvulsant-convulsant effects of delta-9-tetrahydrocannabinol
4. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice
5. + current in cultured hippocampal neurons
6. + A-current in hippocampal neurons via a cAMP-dependent process
7. The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests
8. 2 receptors
9. Watching the pot boil [news]
10. Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A
11. + "A-current" in cultured rat hippocampal neurons
12. Cannabinoid receptor localization in brain
13. Cannabis: Finally a therapeutic agent?
14. Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes
15. 1 receptors on peripheral sympathetic nerves
16. The anticonvulsant activity of cannabidiol and cannabinol
17. Anticonvulsant properties of delta 9-tetrahydrocannabinol and other cannabinoids
18. 1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
19. 1 cannabinoid receptors inhibits neurotransmitter release from identified synaptic sites in rat hippocampal cultures
20. Antiepiletic drug development: II. Anticonvulsant drug screening
21. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action
22. A simplified method of evaluating dose effect experiments
23. 2+ currents in AtT20 cells transfected with rat brain cannabinoid receptor
24. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
25. Molecular characterization of a peripheral receptor for cannabinoids
26. 2+ channels in a neuronal expression system
27. Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: Involvement of mu-and kappa-opioid receptors
28. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
29. Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture
30. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures
31. Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats
32. Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats
33. Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells
34. Comparative receptor binding analyses of cannabinoid agonists and antagonists
35. 1 receptors in the rat central nervous system
36. Incidence of epileptic syndromes in Rochester, Minnesota: 1980-1984