AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Guggenhuber, Stephan ^a   Monory, Krisztina ^a   Lutz, Beat ^a   Klugmann, Matthias ^a,b  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CRE RECOMBINASE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; KAINIC ACID; PARVOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; INTEGRASE;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL STRAIN HEK293; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; EXCITOTOXICITY; GENE DOSAGE; GENE EXPRESSION; GENE OVEREXPRESSION; HIPPOCAMPAL MOSSY FIBER; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LOXP SITE; MORTALITY; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RECEPTOR UPREGULATION; SEIZURE; SIGNAL TRANSDUCTION; STEREOTACTIC PROCEDURE; TRANSGENE; TRANSGENICS; VIRUS RECOMBINANT; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC RECOMBINATION; GENETICS; METABOLISM; NERVE CELL;

ANIMALIA; MUS;

ANIMALS; BEHAVIOR, ANIMAL; DEPENDOVIRUS; GENE EXPRESSION REGULATION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; INTEGRASES; MICE; MICE, INBRED C57BL; NEURONS; RECEPTOR, CANNABINOID, CB1; RECOMBINATION, GENETIC; SEIZURES; TRANSGENES;

EID: 78650987060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015707     Document Type: Article

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