Effects of chronic treatment with Δ9-tetrahydrocannabinol on cannabinoid-stimulated [35S]GTPγS autoradiography in rat brain

Journal of Neuroscience

Volumn 16, Issue 24, 1996, Pages 8057-8066

  Sim, Laura J ^b   Hampson, Robert E ^b   Deadwyler, Sam A ^b   Childers, Steven R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

cannabinoid receptor; G protein; GABA(B) receptor; 35S GTP S autoradiography; 9 THC

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 AMINOBUTYRIC ACID B RECEPTOR; CANNABINOID; CANNABINOID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); TETRAHYDROCANNABINOL;

ARTICLE; AUTORADIOGRAPHY; BRAIN; BRAIN CORTEX; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GLOBUS PALLIDUS; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

EID: 0029829841     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-24-08057.1996     Document Type: Article

References (38)

1. 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain. Pharmacol Biochem Behav 46:575-579.
2. Aceto MD, Scates SM, Lowe JA, Martin BR (1995) Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A. Eur J Pharmacol 282:R1-R2.
3. Carlini EA (1968) Tolerance to chronic administration of cannabis sativa (marijuana) in rats. Pharmacology 1:135-142.
4. Compton DR, Rice KC, DeCosta BR, Razdan RK, Melvin LS, Johnson MR, Martin BR (1993) Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities. J Pharmacol Exp Ther 265:218-226.
5. 9-tetrahydrocannabinol treatment. Pharmacol Biochem Behav 47:33-40.
6. Deadwyler SA, Hampson RE, Bennett BA, Edwards TA, Mu J, Pacheco MA, Ward SJ, Childers SR (1993) Cannabinoids modulate potassium current in cultured hippocampal neurons. Receptors Channels 1:121-134.
7. Deadwyler SA, Hampson RE, Childers SR (1995a) Functional significance of cannabinoid receptors in brain. In: Cannabinoid receptors (Pertwee RG, ed), pp 206-231. New York: Academic.
8. Deadwyler SA, Heyser CJ, Hampson RE (1995b) Complete adaptation to the memory disruptive effects of delta-9-THC following 35 days of exposure. Neurosci Res Commun 17:9-18.
9. Devane WA, Dysarz FAI, Johnson MR, Melvin LS, Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613.
10. Dewey WL (1986) Cannabinoid pharmacology. Pharmacol Rev 48:151-174.
11. Dill JA, Howlett AC (1988) Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs. J Pharmacol Exp Ther 244:1157-1163.
12. Fan F, Tao Q, Abood ME, Martin BR (1996) Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice. Brain Res 706:13-20.
13. Gaoni Y, Mechoulam R (1964) Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 86:1646-1647.
14. Hampson RE, Byrd D, Konstantopolous J, Bunn T, Jarrard LE, Deadwyler SA (1995a) Proactive interference and short term memory during performance of a DNMS task in normal rats and rats with hippocampus removed. Soc Neurosci Abstr 21:1215.
15. Hampson RE, Evans GJO, Mu J, Zhuang S, King VC, Childers SR, Deadwyler SA (1995b) Role of cyclic AMP dependent protein kinase in cannabinoid receptor modulation of potassium "A-current" in cultured rat hippocampal neurons. Life Sci 56:2081-2088.
16. Herkenham M, Lynn AB, de Costa BR, Richfield EK (1991a) Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res 547:267-274.
17. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991b) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11:563-583.
18. Heyser CJ, Hampson RE, Deadwyler SA (1993) Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. J Pharmacol Exp Ther 264:294-307.
19. Hilf G, Gierschik P, Jakobs KH (1989) Muscarinic acetylcholine receptor-stimulated binding of guanosine 5′-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur J Biochem 186:725-731.
20. Howlett AC (1985) Cannabinoid inhibition of adenylate cyclase: biochemistry of the response in neuroblastoma cell membranes. Mol Pharmacol 27:429-436.
21. Howlett AC, Qualy JM, Khachatrian LL (1986) Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol Pharmacol 29:307-313.
22. Jansen EM, Haycock DA, Ward SJ, Seybold VS (1992) Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res 575:93-102.
23. Kenakin T (1993) Efficacy. In: Pharmacologic analysis of drug-receptor interaction (Kenakin T, ed), pp 249-277. New York: Raven.
24. Mackie K, Hille B (1992) Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc Natl Acad Sci USA 89:3825-3829.
25. Matsuda LA, Lolait SJ, Brownstein MJ, Young AL, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
26. Nestler EJ, Alreja M, Aghajanian GK (1994) Molecular and cellular mechanisms of opiate action: studies in the locus coeruleus. Brain Res Bull 35:521-528.
27. Oviedo A, Glowa J, Herkenham M (1993) Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain Res 616:293-302.
28. Pacheco M, Childers SR, Arnold R, Casiano F, Ward SJ (1991) Amino-alkylindoles: actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257:170-183.
29. Pacheco M, Ward SJ, Childers SR (1993) Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. Brain Res 603:102-110.
30. Rubino T, Massi P, Patrini G, Venier I, Giagnoni G, Parolaro D (1994) Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: an in situ hybridization study. NeuroReport 5:2493-2496.
31. Selley DE, Nestler EJ, Breivogel CS, Childers SR (1996a) Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: decrease in activity after chronic morphine treatment. Brain Res, in press.
32. 35S]thio)triphosphate binding in rat brain membranes. Life Sci 59:659-668.
33. 35S]thio]-triphosphate binding. Proc Natl Acad Sci USA 92:7242-7246.
34. 35S]GTPγS autoradiography in rat brain. J Neurosci 16:2684-2692.
35. Sim LJ, Selley DE, Xiao R, Childers SR (1996b) Differences in G-protein activation by mu and delta opioid, and Cannabinoid, receptors in rat striatum. Eur J Pharmacol 307:95-107.
36. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol Pharmacol 47:848-854.
37. Tsou K, Patrick SL, Walker JM (1995) Physical withdrawal in rats tolerant to Δ9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. Eur J Pharmacol 280:R13-R15.
38. 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. Brain Res 544:145-149.