WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges

Epilepsia

Volumn 51, Issue 8, 2010, Pages 1511-1521

  Van Rijn, Clementina M ^a   Gaetani, Silvana ^b   Santolini, Ines ^c   Badura, Aleksandra ^a   Gabova, Aleksandra ^d   Fu, Jin ^e   Watanabe, Masashiko ^f   Cuomo, Vincenzo ^b   Van Luijtelaar, Gilles ^a   Nicoletti, Ferdinando ^b,c   Ngomba, Richard T ^c  

^a RADBOUD UNIVERSITY   (Netherlands)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS NEUROMED   (Italy)

^d INSTITUTE OF HIGHER NERVOUS ACTIVITY AND NEUROPHYSIOLOGY   (Russian Federation)

^e XIAMEN UNIVERSITY   (China)

^f HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Absence epilepsy; Endocannabinoid system; RTN

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; BENZOXAZINE DERIVATIVE; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; IN SITU HYBRIDIZATION; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE; SPIKE; SPIKE WAVE; THALAMUS NUCLEUS; WESTERN BLOTTING; WISTAR ALBINO GLAXO RAT; ABSENCE; ANALYSIS OF VARIANCE; ANIMAL; AUGUST COPENHAGEN IRISH RAT; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; ELECTROENCEPHALOGRAPHY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MOVEMENT (PHYSIOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; RAT STRAIN;

ANALYSIS OF VARIANCE; ANIMALS; BENZOXAZINES; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; GENE EXPRESSION REGULATION; MALE; MORPHOLINES; MOVEMENT; NAPHTHALENES; PIPERIDINES; PYRAZOLES; RATS; RATS, INBRED ACI; RATS, MUTANT STRAINS; RECEPTOR, CANNABINOID, CB1; THALAMIC NUCLEI;

EID: 77955338455     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2009.02510.x     Document Type: Article

References (46)

1. Angerer LM, Cox KH, Angerer RC 1987) Demonstration of tissue-specific gene expression by in situ hybridization. Methods Enzymol 152:649 661.
2. Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Huffman JW, Layward L 2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404:84 87.
3. Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ 1999) Self-sustained rhythmic activity in the thalamic reticular nucleus mediated by depolarizing GABAA receptor potentials. Nat Neurosci 2:168 174.
4. Blumenfeld H. (2005) Cellular and network mechanisms of spike-wave seizures. Epilepsia 46 (suppl 9 21 33.
5. Chemin J, Monteil A, Perez-Reyes E, Nargeot J, Lory P 2001) Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. EMBO J 20 (24 7033 7040.
6. Crunelli V, Leresche N 1991) A role for GABAB receptors in excitation and inhibition of thalamocortical cells. Trends Neurosci 14:16 21.
7. Falenski KW, Blair RE, Sim-Selley LJ, Martin BR, DeLorenzo RJ 2007) Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy. Neuroscience 146:1232 1244.
8. Freund TF, Katona I, Piomelli D 2003) Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83:1017 1066.
9. Fukudome Y, Ohno-Shosaku T, Matsui M, Omori Y, Fukaya M, Taketo M, Watanabe M, Manabe M, Kano M 2004) Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1M3-mediated indirect suppression through endocannabinoid signaling. Eur J Neurosci 19:2682 2692.
10. Hájos N, Katona I, Naiem SS, MacKie K, Ledent C, Mody I, Freund TF 2000) Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations. Eur J Neurosci 12:3239 3249.
11. Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, Rice KC 1990) Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A 87:1932 1936.
12. Inaba Y, D'Antuono M, Bertazzoni G, Biagini G, Avoli M 2009) Diminished presynaptic GABA(B) receptor function in the neocortex of a genetic model of absence epilepsy. Neurosignals 17:121 131.
13. Inoue M, Peeters BW, van Luijtelaar EL, Vossen JM, Coenen AM 1990) Spontaneous occurrence of spike-wave discharges in five inbred strains of rats. Physiol Behav 48:199 201.
14. Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M 2006) The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum. J Neurosci 26:2991 3001.
15. Lastres-Becker I, Hansen HH, Berrendero F, De Miguel R, Pérez-Rosado A, Manzanares J, Ramos JA, Fernández-Ruiz J 2002) Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease. Synapse 44:23 35.
16. Liu XB, Coble J, van Luijtelaar G, Jones EG 2007) Reticular nucleus-specific changes in alpha3 subunit protein at GABA synapses in genetically epilepsy-prone rats. Proc Natl Acad Sci U S A 104:12512 12517.
17. Ludányi A, Eross L, Czirják S, Vajda J, Halász P, Watanabe M, Palkovits M, Maglóczky Z, Freund TF, Katona I 2008) Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. J Neurosci 28:2976 2990.
18. McCormick DA, Bal T 1997) Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 20:185 215.
19. Merlo D, Mollinari C, Inaba Y, Cardinale A, Rinaldi AM, D'Antuono M, D'Arcangelo G, Tancredi V, Ragsdale D, Avoli M 2007) Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures. Neurobiol Dis 25:631 641.
20. Miller JA 1991) The calibration of 35S or 32P with 14C-labeled brain paste or 14C-plastic standards for quantitative autoradiography using LKB Ultrofilm or Amersham Hyperfilm. Neurosci Lett 121:211 214.
21. Naderi N, Aziz Ahari F, Shafaghi B, Najarkolaei AH, Motamedi F 2008) Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice. J Neural Transm 115:1501 1511.
22. Ngomba RT, Biagioni F, Casciato S, Willems-van Bree E, Battaglia G, Bruno V, Nicoletti F, van Luijtelaar EL 2005) The preferential mGlu23 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAGRij rat model of absence epilepsy. Neuropharmacology 49:89 103.
23. Ngomba RT, Ferraguti F, Badura A, Citraro R, Santolini I, Battaglia G, Bruno V, De Sarro G, Simonyi A, van Luijtelaar G, Nicoletti F 2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology 54:344 354.
24. Nowycky MC, Fox AP, Tsien RW 1985) Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316:440 443.
25. Ohno-Shosaku T, Tsubokawa H, Mizushima I, Yoneda N, Zimmer A, Kano M 2002) Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses. J Neurosci 22:3864 3872.
26. Onaivi ES, Ishiguro H, Gong JP, Patel S, Perchuk A, Meozzi PA, Myers L, Mora Z, Tagliaferro P, Gardner E, Brusco A, Akinshola BE, Liu QR, Hope B, Iwasaki S, Arinami T, Teasenfitz L, Uhl GR 2006) Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci 1074:514 536.
27. Paxinos G, Watson C 1998) The rat brain atlas in stereotaxic coordinates. Academic Press, London, U.K.
28. Piomelli D 2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873 884.
29. Pitler TA, Alger BE 1994) Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism. Neuron 13:1447 1455.
30. Raza M, Pal S, Rafiq A, DeLorenzo RJ 2001) Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy. Brain Res 903:1 12.
31. Romero J, de Miguel R, García-Palomero E, Fernández-Ruiz JJ, Ramos JA 1995) Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function. Brain Res 694:223 232.
32. Schridde U, van Luijtelaar G 2004) The influence of strain and housing on two types of spike-wave discharges in rats. Genes Brain Behav 3:1 7.
33. Stella N, Schweitzer P, Piomelli D 1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature 388:773 778.
34. Storozhuk MV, Ivanova SY, Piomelli D 2006) Presence of depolarization-induced suppression of inhibition in a fraction of GABAergic synaptic connections in rat neocortical cultures. Neurosci Behav Physiol 36:709 713.
35. Tolmacheva EA, van Luijtelaar G 2007) Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAGRij rats. Neurosci Lett 416 (1 17 21.
36. van de Bovenkamp-Janssen MC, Akhmadeev A, Kalimullina L, Nagaeva DV, van Luijtelaar EL, Roubos EW 2004) Synaptology of the rostral reticular thalamic nucleus of absence epileptic WAGRij rats. Neurosci Res 48:21 31.
37. van Luijtelaar EL, Coenen AM 1986) Two types of electrocortical paroxysms in an inbred strain of rats. Neurosci Lett 70:393 397.
38. van Luijtelaar El, Coenen AM 1988) Circadian rhythmicity in absence epilepsy in rats. Epilepsy Res 2:331 336.
39. van Luijtelaar G, Sitnikova E 2006) Global and focal aspects of absence epilepsy: the contribution of genetic models. Neurosci Biobehav Rev 30:983 1003.
40. van Rijn CM, Sun MS, Deckers CL, Edelbroek PM, Keyser A, Renier W, Meinardi H 2004) Effects of the combination of valproate and ethosuximide on spike wave discharges in WAGRij rats. Epilepsy Res 59:181 189.
41. Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA 2005) Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310:329 332.
42. Wallace MJ, Wiley JL, Martin BR, DeLorenzo RJ 2001) Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. Eur J Pharmacol 428:51 57.
43. Wallace MJ, Martin BR, DeLorenzo RJ 2002) Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. Eur J Pharmacol 452:295 301.
44. Wallace MJ, Blair RE, Falenski KW, Martin BR, DeLorenzo RJ 2003) The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther 307:129 137.
45. Wilson RI, Nicoll RA 2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 410:588 592.
46. Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M 2002) The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J Neurosci 22:1690 1697.