Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716

Archives of General Psychiatry

Volumn 58, Issue 4, 2001, Pages 322-328

  Huestis, Marilyn A ^a   Gorelick, David A ^a   Heishman, Stephen J ^a   Preston, Kenzie L ^a   Nelson, Richard A ^a   Moolchan, Eric T ^a   Frank, Richard A ^b   Dsouza, Deepak C ^c   Kosten, Thomas R ^c  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b Sanofi Synthelabo Inc   (United Kingdom)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; RIMONABANT;

ADULT; ARTICLE; CANNABIS ADDICTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEART RATE; HUMAN; MALE; PSYCHOLOGICAL ASPECT; RANDOMIZED CONTROLLED TRIAL;

EID: 0035048803     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.58.4.322     Document Type: Article

References (43)

1. Cannabis: Pharmacology and toxicology in animals and humans
2. Unresponsiveness to cannabinoids reduced addictive effects of opiates in CB1 receptor knockout mice
3. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
4. Molecular cloning of a human cannabinoid receptor which is also expressed in testis
5. Molecular characterization of a peripheral receptor for cannabinoids
6. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor
7. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
8. "Endocannabinoids" and other fatty acid derivatives with cannabimimetic properties: Biochemistry and possible physiopathological relevance
9. SR141716, a potent selective antagonist of the brain cannabinoid receptor
10. Biochemical and pharmacological characterization of SR141716A, the first potent and selective brain cannabinoid receptor antagonist
11. Dependence on delta-9-tetrahydrocannabinol: Studies on precipitated and abrupt withdrawal
12. Characterization of the absorption phase of marijuana smoking
13. Comparative effects of alcohol and marijuana on mood, memory, and performance
14. "Hangover" effects the morning after marijuana smoking
15. Quantitative measurement of delta-9-tetrahydrocannabinol and two major metabolites in physiological specimens using capillary column gas chromatography negative ion chemical ionization mass spectrometry
16. Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats
17. Central mediation of the cannabinoid cue: Activity of a selective CB1 antagonist, SR 141716A
18. Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats
19. Antagonism of the discriminative stimulus effects of delta-9-tetrahydrocannabinol in rats and rhesus monkeys
20. Cardiovascular effects of prolonged delta-9-tetrahydrocannabinol ingestion
21. Clinical studies of cannabis tolerance and dependence
22. Tolerance to marijuana: Heart rate and subjective "high"
23. Abstinence symptoms following smoked marijuana in humans
24. Abstinence symptoms following oral THC administration in humans
25. Selective inhibition of sucrose and ethanol intake by SR141716, an antagonist of central cannabinoid (CB1) receptors
26. In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): Inhibition of delta-9-tetrahydrocannabinol-induced responses and apparent agonist activity
27. SR141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice
28. Acute administration of the CB1, cannabinoid receptor antagonist SR141716A induces anxiety-like responses in the rat
29. Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR141716A in rats as assessed by electroencephalographic spectral sleep-waking cycle analysis
30. Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR141716
31. SR141716A is an inverse agonist at the human cannabinoid CB1 receptor
32. Cannabinoid receptor interactions with the antagonist SR141716A and SR144528
33. The CB1 cannabinoid receptor can sequester G-proteins, making them unavailable to couple to other receptors
34. Cardiovascular effects of marijuana and cannabinoids
35. Cardiovascular effects of cannabinoids
36. Cannabinoids, hippocampal function and memory
37. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
38. Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal neonatal and adult human brain
39. Cannabinoid ligands and their effects on learning performance in rhesus monkeys
40. Anandamide induces overeating: Mediation by central cannabinoid (CB1) receptors
41. Cannabinoid/anandamide system and schizophrenia: Is there evidence for association?
42. Elevated endogenous cannabinoids in schizophrenia