Neuroprotection by Δ9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity

Journal of Neuroscience

Volumn 21, Issue 17, 2001, Pages 6475-6479

  Van Der Stelt, M ^a   Veldhuis, W B ^b,c   Bar P R ^c   Veldink, G A ^a   Vliegenthart, J F G ^a   Nicolay, K ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Anandamide; Astrogliosis; Cannabinoid; Excitotoxicity; Magnetic resonance imaging; Neonatal rat; Neuroprotection; Ouabain; THC

Indexed keywords

CANNABINOID RECEPTOR ANTAGONIST; CANNABIS; DRONABINOL; OUABAIN; RIMONABANT; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CANNABINOID RECEPTOR; DRUG RECEPTOR; ENZYME INHIBITOR; NEUROPROTECTIVE AGENT; TETRAHYDROCANNABINOL; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL VOLUME; DRUG EFFECT; DRUG MECHANISM; IN VIVO STUDY; INJECTION; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; ACUTE DISEASE; ANIMAL; BRAIN; BRAIN EDEMA; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; CORPUS STRIATUM; DOSE RESPONSE; DRUG ANTAGONISM; LONGITUDINAL STUDY; METABOLISM; MICROINJECTION; PATHOLOGY; WISTAR RAT;

ACUTE DISEASE; ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN EDEMA; CANNABIS; CHRONIC DISEASE; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MICROINJECTIONS; NA(+)-K(+)-EXCHANGING ATPASE; NEUROPROTECTIVE AGENTS; OUABAIN; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL; WATER;

EID: 0035437865     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-17-06475.2001     Document Type: Article

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