Cannabidiol and (-)Δ9-tetrahydrocannabinol are neuroprotective antioxidants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 14, 1998, Pages 8268-8273

  Hampson, A J ^a   Grimaldi, M ^b   Axelrod, J ^a   Wink, D ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CALCIUM; CALCIUM CHANNEL; CANNABIDIOL; CANNABINOID RECEPTOR ANTAGONIST; CANNABIS; DRONABINOL; GLUTAMIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; CANNABINOID RECEPTOR; DRUG RECEPTOR; TETRAHYDROCANNABINOL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; FETUS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CELL DEATH; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CANNABIDIOL; CELL DEATH; CELLS, CULTURED; DRUG ANTAGONISM; GLUTAMIC ACID; NEURONS; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0032493197     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.14.8268     Document Type: Article

References (29)

1. Welch, S. P. & Stevens, D. L. (1992) J. Pharmacol. Exp.Ther. 262, 8-10.
2. Merritt, J. C., Crawford, W. J., Alexander, P. C., Anduze, A. L. & Gelbart, S. S. (1980) Ophthalmology 87, 222-228.
3. Abrahamov, A. & Mechoulam R. (1995) Life Sci. 56, 2097-2102.
4. Choi, D. W., Koh, J. Y. & Peters, S. (1988) J. Neurosci. 8, 185-196.
5. Ciani, E., Groneng, L., Voltattorni, M., Rolseth, V., Contestabile, A. & Paulsen, R. E. (1996) Brain Res. 728, 1-6.
6. MacGregor, D. G., Higgins, M. J., Jones, P. A., Maxwell, W. L., Watson, M. W., Graham, D. I. & Stone, T. W. (1996) Brain Res. 727, 133-144.
7. Skaper, S. D., Buriani, A., Dal Toso, R., Petrell, I. L., Romanello, L., Facci, L. & Leon, A (1996) Proc. Natl. Acad. Sci. USA 93, 3984-3989.
8. Hampson, A. J., Bornheim, L. M., Scanziani, M., Yost, C. S, Gray, A. T., Hansen, B. M, Leonoudakis, D. J. & Bickler, P. E. (1998) J. Neurochem. 70, 671-676.
9. Twitchell, W., Brown, S. & Mackie, K. (1997) J. Neurophysiol. 78, 43-50.
10. Biegon, A. (1995) Ann. N.Y. Acad. Sci. 765, 314.
11. Eshhar, N., Striem, S., Kohen, R., Tirosh, O. & Biegon, A (1995) Eur. J. Pharmacol. 283(1-3), 19-29.
12. Mansbach, R. S., Rovetti, C. C., Winston, E. N. & Lowe, J. A., III (1996) Psychopharmacol. 124, 315-22.
13. Ventra, C, Porcellini, A., Feliciello, A. R., Gallo, A., Paolillo, M., Mele, E., Avedimento, V. E. & Schettini, G. (1996) J. Neurochem. 66, 1752-1761.
14. Grimaldi, M., Pozzoli, G., Navarra, P., Preziosi, P. & Schettini, G. (1994) J. Neurochem. 63, 344-350.
15. Zhou, L. M., Gu, Z. Q., Costa, A. M., Yamada, K. A., Mansson, P. E., Giordano, T., Skolnick, P. & Jones, K. A (1997) J. Pharmacol. Exp. Ther. 280, 422-427.
16. Amin, N. & Pearce, B. (1997) Neurochem. Int. 30, 271-276.
17. Holopainen, I., Saransaari, P. & Oja, S. S. (1994) Neurochem. Res. 19, 111-115.
18. Van Bockstaele, E. J. & Colago, E. E. J. (1996) J. Comp. Neurol. 369, 483-496.
19. David, J. C., Yamada, K. A., Bagwe, M. R. & Goldberg, M. P. (1996) J. Neurosci. 16, 200-209.
20. Roehm, N. W., Rodgers, G. H., Hatfield, S. M. & Glasebrook, A. L. (1991) J. Immunol. Methods 142, 257-265.
21. Hack, N. & Balazs, R (1995) J. Neurochem. 65, 1077-1084.
22. Berman, F. W. & Murray, T. F. J. (1996) J. Biochem. Toxicol. 11, 111-119.
23. Deupree, D. L., Tang, X. W., Yarom, M., Dickman, E., Kirch, R. D., Schloss, J. V. & Wu, J. Y. (1996) Neurochem. Int. 29, 255-261.
24. Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Hewlett, A. C. (1988) Mol. Pharmacol. 34, 605-613.
25. Thompson, J. A., Bolton, J. L. & Malkinson, A. M. (1991) Exp. Lung Res. 17, 439-453.
26. Lindenschmidt, R. C., Tryka, A. F., Goad, M. E. & Witschi, H. P. (1986) Toxicology 38, 151-160.
27. Auer, R. N (1994) Psychopharmacol. Bull. 30, 585-591.
28. Cunha, J. M., Carlini, E. A., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R., Sanvito, W. L., Lander, N. & Mechoulam, R. (1980) Pharmacology 21, 175-185.
29. Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K. & Schram, K. (1991) Pharmacol. Biochem. Behav. 40, 701-708.