Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway

EMBO Journal

Volumn 33, Issue 7, 2014, Pages 668-685

  Tortoriello, Giuseppe ^a   Morris, Claudia V ^b   Alpar, Alan ^a   Fuzik, Janos ^a,c   Shirran, Sally L ^d   Calvigioni, Daniela ^a   Keimpema, Erik ^a,c   Botting, Catherine H ^d   Reinecke, Kirstin ^e   Herdegen, Thomas ^e   Courtney, Michael ^f   Hurd, Yasmin L ^b   Harkany, Tibor ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^f UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

axon; growth cone; marijuana; neurite outgrowth; synaptogenesis

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; DRONABINOL; MICROTUBULE PROTEIN; STATHMIN 2 PROTEIN; SUPERIOR CERVICAL GANGLION 10 PROTEIN; UNCLASSIFIED DRUG; MESSENGER RNA; PSYCHOTROPIC AGENT; SIGNAL PEPTIDE; STMN2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; BRAIN MAPPING; CANNABIS USE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; FETUS; GROWTH CONE; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; METABOLISM; NERVE FIBER; PHOSPHORYLATION; PREGNANCY; PROTEOMICS; TIME;

ANIMALS; AXONS; CELL DIFFERENTIATION; CEREBRAL CORTEX; DRONABINOL; FEMALE; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MATERNAL EXPOSURE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PREGNANCY; PROTEOMICS; PSYCHOTROPIC DRUGS; RECEPTOR, CANNABINOID, CB1; RNA, MESSENGER; TIME FACTORS;

EID: 84898620219     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201386035     Document Type: Article

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