Chronic Δ9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain

Journal of Neurochemistry

Volumn 73, Issue 6, 1999, Pages 2447-2459

  Breivogel, Christopher S ^b   Childers, Steven R ^a   Deadwyler, Sam A ^a   Hampson, Robert E ^a   Vogt, Leslie J ^a   Sim Selley, Laura J ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

35S GTP S autoradiography; CB1 receptor; Desensitization; Down regulation; Guanosine 5' O (3 thiotriphosphate)

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID RECEPTOR; DRONABINOL; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; DRUG RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; TETRAHYDROCANNABINOL;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DESENSITIZATION; DOWN REGULATION; DRUG TOLERANCE; GLOBUS PALLIDUS; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PUTAMEN; RAT; ANIMAL; BRAIN; CELL MEMBRANE; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ANIMALS; BRAIN; CELL MEMBRANE; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MORPHOLINES; NAPHTHALENES; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0032589999     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0732447.x     Document Type: Article

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