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Volumn 7, Issue 1, 2011, Pages 31-40

The role of inflammation in epilepsy

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CORTICOTROPIN; CYTOKINE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR;

EID: 78651369895     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2010.178     Document Type: Review
Times cited : (1434)

References (181)
  • 2
    • 34547828792 scopus 로고    scopus 로고
    • Development of new antiepileptic drugs: Challenges, incentives, and recent advances
    • Perucca, E., French, J. & Bialer, M. Development of new antiepileptic drugs: challenges, incentives, and recent advances. Lancet Neurol. 6, 793-804 (2007).
    • (2007) Lancet Neurol. , vol.6 , pp. 793-804
    • Perucca, E.1    French, J.2    Bialer, M.3
  • 3
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski, M. A. & Loscher, W. The neurobiology of antiepileptic drugs. Nat. Rev. Neurosci. 5, 553-564 (2004).
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 553-564
    • Rogawski, M.A.1    Loscher, W.2
  • 4
    • 0001490738 scopus 로고    scopus 로고
    • Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    • Pitkanen, A. & Sutula, T. P. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol. 1, 173-181 (2002).
    • (2002) Lancet Neurol. , vol.1 , pp. 173-181
    • Pitkanen, A.1    Sutula, T.P.2
  • 5
    • 33644625777 scopus 로고    scopus 로고
    • Brain inflammation in epilepsy: Experimental and clinical evidence
    • Vezzani, A. & Granata, T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46, 1724-1743 (2005).
    • (2005) Epilepsia , vol.46 , pp. 1724-1743
    • Vezzani, A.1    Granata, T.2
  • 6
    • 34848863567 scopus 로고    scopus 로고
    • New roles for interleukin-1 beta in the mechanisms of epilepsy
    • Vezzani, A. & Baram, T. Z. New roles for interleukin-1 beta in the mechanisms of epilepsy. Epilepsy Curr. 7, 45-50 (2007).
    • (2007) Epilepsy Curr. , vol.7 , pp. 45-50
    • Vezzani, A.1    Baram, T.Z.2
  • 7
    • 77950516194 scopus 로고    scopus 로고
    • Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability
    • Riazi, K., Galic, M. A. & Pittman, Q. J. Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability. Epilepsy Res. 89, 34-42 (2010).
    • (2010) Epilepsy Res. , vol.89 , pp. 34-42
    • Riazi, K.1    Galic, M.A.2    Pittman, Q.J.3
  • 8
    • 75649099305 scopus 로고    scopus 로고
    • Cellular injury and neuroinflammation in children with chronic intractable epilepsy
    • Choi, J., et al. Cellular injury and neuroinflammation in children with chronic intractable epilepsy. J. Neuroinflammation 6, 38 (2009).
    • (2009) J. Neuroinflammation , vol.6 , pp. 38
    • Choi, J.1
  • 9
    • 4544320221 scopus 로고    scopus 로고
    • Infantile spasms: Therapy and outcome
    • Riikonen, R. Infantile spasms: therapy and outcome. J. Child Neurol. 19, 401-404 (2004).
    • (2004) J. Child Neurol. , vol.19 , pp. 401-404
    • Riikonen, R.1
  • 11
    • 29044448545 scopus 로고    scopus 로고
    • The epileptic encephalopathies of infancy and childhood
    • Wirrell, E., Farrell, K. & Whiting, S. The epileptic encephalopathies of infancy and childhood. Can. J. Neurol. Sci. 32, 409-418 (2005).
    • (2005) Can. J. Neurol. Sci. , vol.32 , pp. 409-418
    • Wirrell, E.1    Farrell, K.2    Whiting, S.3
  • 13
    • 8344261590 scopus 로고    scopus 로고
    • Infection fever, and exogenous and endogenous pyrogens: Some concepts have changed
    • Dinarello, C. A. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J. Endotoxin Res. 10, 201-222 (2004).
    • (2004) J. Endotoxin Res. , vol.10 , pp. 201-222
    • Dinarello, C.A.1
  • 14
    • 84902014898 scopus 로고
    • Focal seizures due to chronic localized encephalitis
    • Rasmussen, T., Olsewski, J. & Lloyd-Smith, D. Focal seizures due to chronic localized encephalitis. Neurology 8, 435-445 (1958).
    • (1958) Neurology , vol.8 , pp. 435-445
    • Rasmussen, T.1    Olsewski, J.2    Lloyd-Smith, D.3
  • 15
    • 34548725094 scopus 로고    scopus 로고
    • Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy
    • Bien, C. G., et al. Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. Neurology 69, 1236-1244 (2007).
    • (2007) Neurology , vol.69 , pp. 1236-1244
    • Bien, C.G.1
  • 16
    • 55549135314 scopus 로고    scopus 로고
    • Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies
    • Dalmau, J., et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 7, 1091-1098 (2008).
    • (2008) Lancet Neurol. , vol.7 , pp. 1091-1098
    • Dalmau, J.1
  • 17
    • 55549097085 scopus 로고    scopus 로고
    • Anti-NMDA-receptor encephalitis: A cause of psychiatric, seizure, and movement disorders in young adults
    • Vincent, A. & Bien, C. G. Anti-NMDA-receptor encephalitis: a cause of psychiatric, seizure, and movement disorders in young adults. Lancet Neurol. 7, 1074-1075 (2008).
    • (2008) Lancet Neurol. , vol.7 , pp. 1074-1075
    • Vincent, A.1    Bien, C.G.2
  • 18
    • 0033667848 scopus 로고    scopus 로고
    • Epilepsy and the immune system
    • Aarli, J. A. Epilepsy and the immune system. Arch. Neurol. 57, 1689-1692 (2000).
    • (2000) Arch. Neurol. , vol.57 , pp. 1689-1692
    • Aarli, J.A.1
  • 20
    • 0027433102 scopus 로고
    • Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
    • Campbell, I. L., et al. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl Acad. Sci. USA 90, 10061-10065 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10061-10065
    • Campbell, I.L.1
  • 21
    • 12944273495 scopus 로고    scopus 로고
    • Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice
    • Vezzani, A., et al. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl Acad. Sci. USA 97, 11534-11539 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11534-11539
    • Vezzani, A.1
  • 22
    • 20444379573 scopus 로고    scopus 로고
    • Tumor necrosis factor-α inhibits seizures in mice via p75 receptors
    • Balosso, S., et al. Tumor necrosis factor-α inhibits seizures in mice via p75 receptors. Ann. Neurol. 57, 804-812 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 804-812
    • Balosso, S.1
  • 23
    • 33746145901 scopus 로고    scopus 로고
    • Inactivation of caspase-1 in rodent brain: A novel anticonvulsive strategy
    • Ravizza, T., et al. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia 47, 1160-1168 (2006).
    • (2006) Epilepsia , vol.47 , pp. 1160-1168
    • Ravizza, T.1
  • 24
    • 0037829339 scopus 로고    scopus 로고
    • Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6
    • Samland, H., et al. Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J. Neurosci. Res. 73, 176-187 (2003).
    • (2003) J. Neurosci. Res. , vol.73 , pp. 176-187
    • Samland, H.1
  • 25
    • 0030639621 scopus 로고    scopus 로고
    • Astrocyte-specific but not neuronspecific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    • Akassoglou, K., Probert, L., Kontogeorgos, G. & Kollias, G. Astrocyte-specific but not neuronspecific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J. Immunol. 158, 438-445 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 438-445
    • Akassoglou, K.1    Probert, L.2    Kontogeorgos, G.3    Kollias, G.4
  • 26
    • 0032887341 scopus 로고    scopus 로고
    • Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2
    • Kelley, K. A., et al. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am. J. Pathol. 155, 995-1004 (1999).
    • (1999) Am. J. Pathol. , vol.155 , pp. 995-1004
    • Kelley, K.A.1
  • 27
    • 1942423710 scopus 로고    scopus 로고
    • Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice
    • De Sarro, G., et al. Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice. Pharmacol. Biochem. Behav. 77, 761-766 (2004).
    • (2004) Pharmacol. Biochem. Behav. , vol.77 , pp. 761-766
    • De Sarro, G.1
  • 28
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff, R. M., Kivisakk, P. & Kidd, G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3, 569-581 (2003).
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 29
    • 70449529633 scopus 로고    scopus 로고
    • The blood-brain barrier and immune function and dysfunction
    • Banks, W. A. & Erickson, M. A. The blood-brain barrier and immune function and dysfunction. Neurobiol. Dis. 37, 26-32 (2010).
    • (2010) Neurobiol. Dis. , vol.37 , pp. 26-32
    • Banks, W.A.1    Erickson, M.A.2
  • 30
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C. & Gage, F. H. Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934 (2010).
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 31
    • 0036518997 scopus 로고    scopus 로고
    • Innate immunity: The missing link in neuroprotection and neurodegeneration?
    • Nguyen, M. D., Julien, J. P. & Rivest, S. Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216-227 (2002).
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 216-227
    • Nguyen, M.D.1    Julien, J.P.2    Rivest, S.3
  • 32
    • 73149116008 scopus 로고    scopus 로고
    • Cell-microglial dialog in Parkinsons disease and amyotrophic lateral sclerosis: Are we listening?
    • Appel, S. H., Beers, D. R. & Henkel, J. S. T cell-microglial dialog in Parkinsons disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol. 31, 7-17 (2009).
    • (2009) Trends Immunol. , vol.31 , pp. 7-17
    • Appel, S.H.1    Beers, D.R.2    Henkel, J.S.T.3
  • 34
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 35
    • 35548985825 scopus 로고    scopus 로고
    • Interleukin-1 system in CNS stress: Seizures, fever, and neurotrauma
    • Bartfai, T., et al. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Ann. N. Y. Acad. Sci. 1113, 173-177 (2007).
    • (2007) Ann. N. Y. Acad. Sci. , vol.1113 , pp. 173-177
    • Bartfai, T.1
  • 36
    • 0035487313 scopus 로고    scopus 로고
    • Cytokines and acute neurodegeneration
    • Allan, S. M. & Rothwell, N. J. Cytokines and acute neurodegeneration. Nat. Rev. Neurosci. 2, 734-744 (2001).
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 734-744
    • Allan, S.M.1    Rothwell, N.J.2
  • 37
    • 0027207998 scopus 로고
    • Cytokines in neuronal cell types
    • Bartfai, T. & Schultzberg, M. Cytokines in neuronal cell types. Neurochem. Int. 22, 435-444 (1993).
    • (1993) Neurochem. Int. , vol.22 , pp. 435-444
    • Bartfai, T.1    Schultzberg, M.2
  • 38
    • 77951837763 scopus 로고    scopus 로고
    • Trafficking of immune cells in the central nervous system
    • Wilson, E. H., Weninger, W. & Hunter, C. A. Trafficking of immune cells in the central nervous system. J. Clin. Invest. 120, 1368-1379 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1368-1379
    • Wilson, E.H.1    Weninger, W.2    Hunter, C.A.3
  • 40
    • 77649273140 scopus 로고    scopus 로고
    • Role of chemokines in CNS health and pathology: A focus on the CCL2/ CCR2 and CXCL8/CXCR2 networks
    • Semple, B. D., Kossmann, T. & Morganti- Kossmann, M. C. Role of chemokines in CNS health and pathology: a focus on the CCL2/ CCR2 and CXCL8/CXCR2 networks. J. Cereb. Blood Flow Metab. 30, 459-473 (2010).
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 459-473
    • Semple, B.D.1    Kossmann, T.2    Morganti-Kossmann, M.C.3
  • 41
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello, C. A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 42
    • 0034919056 scopus 로고    scopus 로고
    • Decoy receptors: A strategy to regulate inflammatory cytokines and chemokines
    • Mantovani, A., Locati, M., Vecchi, A., Sozzani, S. & Allavena, P. Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol. 22, 328-336 (2001).
    • (2001) Trends Immunol. , vol.22 , pp. 328-336
    • Mantovani, A.1    Locati, M.2    Vecchi, A.3    Sozzani, S.4    Allavena, P.5
  • 43
    • 68149147407 scopus 로고    scopus 로고
    • SOCS1 and SOCS3 in the control of CNS immunity
    • Baker, B. J., Akhtar, L. N. & Benveniste, E. N. SOCS1 and SOCS3 in the control of CNS immunity. Trends Immunol. 30, 392-400 (2009).
    • (2009) Trends Immunol. , vol.30 , pp. 392-400
    • Baker, B.J.1    Akhtar, L.N.2    Benveniste, E.N.3
  • 44
    • 33751331444 scopus 로고    scopus 로고
    • Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages
    • Khuu, C. H., Barrozo, R. M., Hai, T. & Weinstein, S. L. Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages. Mol. Immunol. 44, 1598-1605 (2007).
    • (2007) Mol. Immunol. , vol.44 , pp. 1598-1605
    • Khuu, C.H.1    Barrozo, R.M.2    Hai, T.3    Weinstein, S.L.4
  • 45
    • 55149096344 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-α via superinduction of ATF-3 and suppression of AP-1
    • Ho, H. H., Antoniv, T. T., Ji, J. D. & Ivashkiv, L. B. Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-α via superinduction of ATF-3 and suppression of AP-1. J. Immunol. 181, 5089-5097 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 5089-5097
    • Ho, H.H.1    Antoniv, T.T.2    Ji, J.D.3    Ivashkiv, L.B.4
  • 46
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor ? in human disease
    • Blobe, G. C., Schiemann, W. P. & Lodish, H. F. Role of transforming growth factor ? in human disease. N. Engl. J. Med. 342, 1350-1358 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 47
    • 0023276493 scopus 로고
    • Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
    • Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P. & Vale, W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238, 522-524 (1987).
    • (1987) Science , vol.238 , pp. 522-524
    • Sapolsky, R.1    Rivier, C.2    Yamamoto, G.3    Plotsky, P.4    Vale, W.5
  • 48
    • 0024505181 scopus 로고
    • CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat
    • Rothwell, N. J. CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat. Am. J. Physiol. 256, E111-E115 (1989).
    • (1989) Am. J. Physiol. , vol.256
    • Rothwell, N.J.1
  • 49
    • 0032789711 scopus 로고    scopus 로고
    • Stress corticotropin-releasing hormone, glucocorticoids, and the immune/ inflammatory response: Acute and chronic effects
    • Elenkov, I. J., Webster, E. L., Torpy, D. J. & Chrousos, G. P. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/ inflammatory response: acute and chronic effects. Ann. N. Y. Acad. Sci. 876, 1-13 (1999).
    • (1999) Ann. N. Y. Acad. Sci. , vol.876 , pp. 1-13
    • Elenkov, I.J.1    Webster, E.L.2    Torpy, D.J.3    Chrousos, G.P.4
  • 50
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • Tracey, K. J. The inflammatory reflex. Nature 420, 853-859 (2002).
    • (2002) Nature , vol.420 , pp. 853-859
    • Tracey, K.J.1
  • 52
    • 0028095257 scopus 로고
    • Autoantibodies to glutamate receptor GluR3 in Rasmussens encephalitis
    • Rogers, S. W., et al. Autoantibodies to glutamate receptor GluR3 in Rasmussens encephalitis. Science 265, 648-651 (1994).
    • (1994) Science , vol.265 , pp. 648-651
    • Rogers, S.W.1
  • 53
    • 0036791046 scopus 로고    scopus 로고
    • Antibodies against GluR3 peptides are not specific for Rasmussens encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures
    • Mantegazza, R., et al. Antibodies against GluR3 peptides are not specific for Rasmussens encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures. J. Neuroimmunol. 131, 179-185 (2002).
    • (2002) J. Neuroimmunol. , vol.131 , pp. 179-185
    • Mantegazza, R.1
  • 54
    • 3242676920 scopus 로고    scopus 로고
    • Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis
    • Watson, R., et al. Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis. Neurology 63, 43-50 (2004).
    • (2004) Neurology , vol.63 , pp. 43-50
    • Watson, R.1
  • 55
    • 0036198111 scopus 로고    scopus 로고
    • Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in Rasmussens encephalitis
    • Bien, C. G., et al. Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussens encephalitis. Ann. Neurol. 51, 311-318 (2002).
    • (2002) Ann. Neurol. , vol.51 , pp. 311-318
    • Bien, C.G.1
  • 56
    • 0036293865 scopus 로고    scopus 로고
    • Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussens) encephalitis
    • Baranzini, S. E., Laxer, K., Bollen, A. & Oksenberg, J. R. Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussens) encephalitis. J. Neuroimmunol. 128, 9-15 (2002).
    • (2002) J. Neuroimmunol. , vol.128 , pp. 9-15
    • Baranzini, S.E.1    Laxer, K.2    Bollen, A.3    Oksenberg, J.R.4
  • 57
    • 2342516129 scopus 로고    scopus 로고
    • The pathology of Rasmussen syndrome: Stages of cortical involvement and neuropathological studies in 45 hemispherectomies
    • Pardo, C. A., et al. The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomies. Epilepsia 45, 516-526 (2004).
    • (2004) Epilepsia , vol.45 , pp. 516-526
    • Pardo, C.A.1
  • 58
    • 67349226155 scopus 로고    scopus 로고
    • Increased activation of Iba1+ microglia in pediatric epilepsy patients with Rasmussens encephalitis compared with cortical dysplasia and tuberous sclerosis complex
    • Wirenfeldt, M., et al. Increased activation of Iba1+ microglia in pediatric epilepsy patients with Rasmussens encephalitis compared with cortical dysplasia and tuberous sclerosis complex. Neurobiol. Dis. 34, 432-440 (2009).
    • (2009) Neurobiol. Dis. , vol.34 , pp. 432-440
    • Wirenfeldt, M.1
  • 59
    • 66849087660 scopus 로고    scopus 로고
    • A substantial number of Rasmussen syndrome patients have increased IgG, CD4+ T cells, TNF, and granzyme B in CSF
    • Takahashi, Y., Mine, J., Kubota, Y., Yamazaki, E. & Fujiwara, T. A substantial number of Rasmussen syndrome patients have increased IgG, CD4+ T cells, TNF, and granzyme B in CSF. Epilepsia 50, 1419-1431 (2009).
    • (2009) Epilepsia , vol.50 , pp. 1419-1431
    • Takahashi, Y.1    Mine, J.2    Kubota, Y.3    Yamazaki, E.4    Fujiwara, T.5
  • 60
    • 77949347358 scopus 로고    scopus 로고
    • The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins
    • Vincent, A., Irani, S. R. & Lang, B. The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins. Curr. Opin. Neurol. 23, 144-150 (2010).
    • (2010) Curr. Opin. Neurol. , vol.23 , pp. 144-150
    • Vincent, A.1    Irani, S.R.2    Lang, B.3
  • 61
    • 0037131063 scopus 로고    scopus 로고
    • Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis
    • Crespel, A., et al. Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis. Brain Res. 952, 159-169 (2002).
    • (2002) Brain Res. , vol.952 , pp. 159-169
    • Crespel, A.1
  • 62
    • 34248563861 scopus 로고    scopus 로고
    • Complement activation in experimental and human temporal lobe epilepsy
    • Aronica, E., et al. Complement activation in experimental and human temporal lobe epilepsy. Neurobiol. Dis. 26, 497-511 (2007).
    • (2007) Neurobiol. Dis. , vol.26 , pp. 497-511
    • Aronica, E.1
  • 63
    • 36549071601 scopus 로고    scopus 로고
    • Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy
    • Ravizza, T., et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol. Dis. 29, 142-160 (2008).
    • (2008) Neurobiol. Dis. , vol.29 , pp. 142-160
    • Ravizza, T.1
  • 64
    • 44849128027 scopus 로고    scopus 로고
    • Possible role of the innate immunity in temporal lobe epilepsy
    • van Gassen, K. L., et al. Possible role of the innate immunity in temporal lobe epilepsy. Epilepsia 49, 1055-1065 (2008).
    • (2008) Epilepsia , vol.49 , pp. 1055-1065
    • Van Gassen, K.L.1
  • 65
    • 0142157634 scopus 로고    scopus 로고
    • Expression of ICAM-1, β, NFB, and MAP kinase in tubers of the tuberous sclerosis complex
    • Maldonado, M., et al. Expression of ICAM-1, β, NFB, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol. Dis. 14, 279-290 (2003).
    • (2003) Neurobiol. Dis. , vol.14 , pp. 279-290
    • Maldonado, M.1
  • 66
    • 37349064173 scopus 로고    scopus 로고
    • Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex
    • Boer, K., et al. Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. Epilepsy Res. 78, 7-21 (2008).
    • (2008) Epilepsy Res. , vol.78 , pp. 7-21
    • Boer, K.1
  • 67
    • 77953199739 scopus 로고    scopus 로고
    • Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors
    • Boer, K., et al. Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors. Brain Pathol. 20, 704-719 (2010).
    • (2010) Brain Pathol. , vol.20 , pp. 704-719
    • Boer, K.1
  • 68
    • 77951281887 scopus 로고    scopus 로고
    • Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies
    • Iyer, A. M., et al. Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies. Neuroscience 19, 929-945 (2010).
    • (2010) Neuroscience , vol.19 , pp. 929-945
    • Iyer, A.M.1
  • 69
    • 77956318202 scopus 로고    scopus 로고
    • Evaluation of the innate and adaptive immunity in type i and type II focal cortical dysplasias
    • Iyer, A., et al. Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias. Epilepsia 51, 1763-1773 (2010).
    • (2010) Epilepsia , vol.51 , pp. 1763-1773
    • Iyer, A.1
  • 70
    • 33748789581 scopus 로고    scopus 로고
    • The IL-1 system in epilepsyassociated malformations of cortical development
    • Ravizza, T., et al. The IL-1 system in epilepsyassociated malformations of cortical development. Neurobiol. Dis. 24, 128-143 (2006).
    • (2006) Neurobiol. Dis. , vol.24 , pp. 128-143
    • Ravizza, T.1
  • 71
    • 0025844833 scopus 로고
    • Effects of kainic acid on messenger RNA levels of IL-1, IL-6, β and LIF in the rat brain
    • Minami, M., Kuraishi, Y. & Satoh, M. Effects of kainic acid on messenger RNA levels of IL-1, IL-6, β and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176, 593-598 (1991).
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 593-598
    • Minami, M.1    Kuraishi, Y.2    Satoh, M.3
  • 72
    • 0033563321 scopus 로고    scopus 로고
    • Interleukin-1 immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures
    • Vezzani, A., et al. Interleukin-1 immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J. Neurosci. 19, 5054-5065 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 5054-5065
    • Vezzani, A.1
  • 73
    • 0033943296 scopus 로고    scopus 로고
    • Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
    • De Simoni, M. G., et al. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur. J. Neurosci. 12, 2623-2633 (2000).
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 2623-2633
    • De Simoni, M.G.1
  • 74
    • 2942555126 scopus 로고    scopus 로고
    • Innate immune reaction in response to seizures: Implications for the neuropathology associated with epilepsy
    • Turrin, N. P. & Rivest, S. Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol. Dis. 16, 321-334 (2004).
    • (2004) Neurobiol. Dis. , vol.16 , pp. 321-334
    • Turrin, N.P.1    Rivest, S.2
  • 75
    • 0034656403 scopus 로고    scopus 로고
    • Increased expression of mRNA encoding interleukin-1 and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration
    • Eriksson, C., Tehranian, R., Iverfeldt, K., Winblad, B. & Schultzberg, M. Increased expression of mRNA encoding interleukin-1 and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration. J. Neurosci. Res. 60, 266-279 (2000).
    • (2000) J. Neurosci. Res. , vol.60 , pp. 266-279
    • Eriksson, C.1    Tehranian, R.2    Iverfeldt, K.3    Winblad, B.4    Schultzberg, M.5
  • 76
    • 9644289382 scopus 로고    scopus 로고
    • Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    • Voutsinos-Porche, B., et al. Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy. Neurobiol. Dis. 17, 385-402 (2004).
    • (2004) Neurobiol. Dis. , vol.17 , pp. 385-402
    • Voutsinos-Porche, B.1
  • 77
    • 33746263652 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus
    • Jung, K. H., et al. Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Neurobiol. Dis. 23, 237-246 (2006).
    • (2006) Neurobiol. Dis. , vol.23 , pp. 237-246
    • Jung, K.H.1
  • 78
    • 33751169109 scopus 로고    scopus 로고
    • CRE-mediated transcription and COX-2 expression in the pilocarpine model of status epilepticus
    • Lee, B., Dziema, H., Lee, K. H., Choi, Y. S. & Obrietan, K. CRE-mediated transcription and COX-2 expression in the pilocarpine model of status epilepticus. Neurobiol. Dis. 25, 80-91 (2007).
    • (2007) Neurobiol. Dis. , vol.25 , pp. 80-91
    • Lee, B.1    Dziema, H.2    Lee, K.H.3    Choi, Y.S.4    Obrietan, K.5
  • 79
    • 33751099302 scopus 로고    scopus 로고
    • Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
    • Gorter, J. A., et al. Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J. Neurosci. 26, 11083-11110 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 11083-11110
    • Gorter, J.A.1
  • 80
    • 77953707753 scopus 로고    scopus 로고
    • The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy
    • Polascheck, N., Bankstahl, M. & Loscher, W. The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. Exp. Neurol. 224, 219-233 (2010).
    • (2010) Exp. Neurol. , vol.224 , pp. 219-233
    • Polascheck, N.1    Bankstahl, M.2    Loscher, W.3
  • 81
    • 60949104467 scopus 로고    scopus 로고
    • Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy
    • Holtman, L., et al. Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. Epilepsy Res. 84, 56-66 (2009).
    • (2009) Epilepsy Res. , vol.84 , pp. 56-66
    • Holtman, L.1
  • 82
    • 34547770719 scopus 로고    scopus 로고
    • Prolonged inflammatory gene response following soman-induced seizures in mice
    • Dhote, F., et al. Prolonged inflammatory gene response following soman-induced seizures in mice. Toxicology 238, 166-176 (2007).
    • (2007) Toxicology , vol.238 , pp. 166-176
    • Dhote, F.1
  • 83
    • 33744955628 scopus 로고    scopus 로고
    • Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: Dual phase regulation and differential involvement of COX-1 and COX-2
    • Yoshikawa, K., Kita, Y., Kishimoto, K. & Shimizu, T. Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2. J. Biol. Chem. 281, 14663-14669 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 14663-14669
    • Yoshikawa, K.1    Kita, Y.2    Kishimoto, K.3    Shimizu, T.4
  • 84
    • 0028134829 scopus 로고
    • Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro
    • Rozovsky, I., et al. Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro. Neuroscience 62, 741-758 (1994).
    • (1994) Neuroscience , vol.62 , pp. 741-758
    • Rozovsky, I.1
  • 85
    • 66249132320 scopus 로고    scopus 로고
    • Cyclooxygenase in epilepsy: From perception to application
    • Kulkarni, S. K. & Dhir, A. Cyclooxygenase in epilepsy: from perception to application. Drugs Today (Barc.) 45, 135-154 (2009).
    • (2009) Drugs Today (Barc.) , vol.45 , pp. 135-154
    • Kulkarni, S.K.1    Dhir, A.2
  • 86
    • 46049103354 scopus 로고    scopus 로고
    • The role of cytokines in the pathophysiology of epilepsy
    • Vezzani, A., Balosso, S. & Ravizza, T. The role of cytokines in the pathophysiology of epilepsy. Brain Behav. Immun. 22, 797-803 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 797-803
    • Vezzani, A.1    Balosso, S.2    Ravizza, T.3
  • 88
    • 69949145443 scopus 로고    scopus 로고
    • CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpineinduced status epilepticus (PISE)
    • Xu, J. H., et al. CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpineinduced status epilepticus (PISE). Neuropathol. Appl. Neurobiol. 35, 496-514 (2009).
    • (2009) Neuropathol. Appl. Neurobiol. , vol.35 , pp. 496-514
    • Xu, J.H.1
  • 89
    • 74549199252 scopus 로고    scopus 로고
    • Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus
    • Foresti, M. L., et al. Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. J. Neuroinflammation 6, 40 (2009).
    • (2009) J. Neuroinflammation , vol.6 , pp. 40
    • Foresti, M.L.1
  • 90
    • 36049000222 scopus 로고    scopus 로고
    • Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus
    • Manley, N. C., Bertrand, A. A., Kinney, K. S., Hing, T. C. & Sapolsky, R. M. Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus. Brain Res. 1182, 138-143 (2007).
    • (2007) Brain Res. , vol.1182 , pp. 138-143
    • Manley, N.C.1    Bertrand, A.A.2    Kinney, K.S.3    Hing, T.C.4    Sapolsky, R.M.5
  • 91
    • 41149139537 scopus 로고    scopus 로고
    • Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy
    • Wu, Y., et al. Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy. Clin. Neuropathol. 27, 55-63 (2008).
    • (2008) Clin. Neuropathol. , vol.27 , pp. 55-63
    • Wu, Y.1
  • 92
    • 57349141812 scopus 로고    scopus 로고
    • A role for leukocyte-endothelial adhesion mechanisms in epilepsy
    • Fabene, P. F., et al. A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat. Med. 14, 1377-1383 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1377-1383
    • Fabene, P.F.1
  • 93
    • 34247176722 scopus 로고    scopus 로고
    • Expression of adhesion factors induced by epileptiform activity in the endothelium of the isolated guinea pig brain in vitro
    • Librizzi, L., et al. Expression of adhesion factors induced by epileptiform activity in the endothelium of the isolated guinea pig brain in vitro. Epilepsia 48, 743-751 (2007).
    • (2007) Epilepsia , vol.48 , pp. 743-751
    • Librizzi, L.1
  • 95
    • 77953217352 scopus 로고    scopus 로고
    • Epileptogenesis provoked by prolonged experimental febrile seizures: Mechanisms and biomarkers
    • Dub C. M., et al. Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J. Neurosci. 30, 7484-7494 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 7484-7494
    • Dub, C.M.1
  • 96
    • 33846629927 scopus 로고    scopus 로고
    • Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    • van Vliet, E. A., et al. Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 130, 521-534 (2007).
    • (2007) Brain , vol.130 , pp. 521-534
    • Van Vliet, E.A.1
  • 97
    • 34247151602 scopus 로고    scopus 로고
    • Seizure-promoting effect of blood-brain barrier disruption
    • Marchi, N., et al. Seizure-promoting effect of blood-brain barrier disruption. Epilepsia 48, 732-742 (2007).
    • (2007) Epilepsia , vol.48 , pp. 732-742
    • Marchi, N.1
  • 98
    • 33750924816 scopus 로고    scopus 로고
    • The blood-brain barrier and epilepsy
    • Oby, E. & Janigro, D. The blood-brain barrier and epilepsy. Epilepsia 47, 1761-1774 (2006).
    • (2006) Epilepsia , vol.47 , pp. 1761-1774
    • Oby, E.1    Janigro, D.2
  • 99
    • 62549139615 scopus 로고    scopus 로고
    • Age-dependent vascular changes induced by status epilepticus in rat forebrain: Implications for epileptogenesis
    • Marcon, J., et al. Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis Neurobiol. Dis. 34, 121-132 (2009).
    • (2009) Neurobiol Dis. , vol.34 , pp. 121-132
    • Marcon, J.1
  • 100
    • 8444234236 scopus 로고    scopus 로고
    • Molecular profiling of temporal lobe epilepsy: Comparison of data from human tissue samples and animal models
    • Majores, M., Eils, J., Wiestler, O. D. & Becker, A. J. Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models. Epilepsy Res. 60, 173-178 (2004).
    • (2004) Epilepsy Res. , vol.60 , pp. 173-178
    • Majores, M.1    Eils, J.2    Wiestler, O.D.3    Becker, A.J.4
  • 102
    • 0037322558 scopus 로고    scopus 로고
    • Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration
    • Xiong, Z. Q., Qian, W., Suzuki, K. & McNamara, J. O. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. J. Neurosci. 23, 955-960 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 955-960
    • Xiong, Z.Q.1    Qian, W.2    Suzuki, K.3    McNamara, J.O.4
  • 103
    • 0031931216 scopus 로고    scopus 로고
    • Seizures with fever after unprovoked seizures: An analysis in children followed from the time of a first febrile seizure
    • Berg, A. T., Darefsky, A. S., Holford, T. R. & Shinnar, S. Seizures with fever after unprovoked seizures: an analysis in children followed from the time of a first febrile seizure. Epilepsia 39, 77-80 (1998).
    • (1998) Epilepsia , vol.39 , pp. 77-80
    • Berg, A.T.1    Darefsky, A.S.2    Holford, T.R.3    Shinnar, S.4
  • 105
    • 3242875620 scopus 로고    scopus 로고
    • Ch. 12 (eds Baram, T. Z. & Shinnar, S.) Academic Press, San Diego
    • Gatti, S., Vezzani, A. & Bartfai, T. in Febrile Seizures Ch. 12 (eds Baram, T. Z. & Shinnar, S.) 169-184 (Academic Press, San Diego, 2002).
    • (2002) Febrile Seizures , pp. 169-184
    • Gatti, S.1    Vezzani, A.2    Bartfai, T.3
  • 106
    • 0033565290 scopus 로고    scopus 로고
    • Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat
    • Cartmell, T., Luheshi, G. N. & Rothwell, N. J. Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J. Physiol. 518, 585-594 (1999).
    • (1999) J. Physiol. , vol.518 , pp. 585-594
    • Cartmell, T.1    Luheshi, G.N.2    Rothwell, N.J.3
  • 107
    • 11144237593 scopus 로고    scopus 로고
    • Interleukin-1 contributes to the generation of experimental febrile seizures
    • Dub C., Vezzani, A., Behrens, M., Bartfai, T. & Baram, T. Z. Interleukin-1 contributes to the generation of experimental febrile seizures. Ann. Neurol. 57, 152-155 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 152-155
    • Dub, C.1    Vezzani, A.2    Behrens, M.3    Bartfai, T.4    Baram, T.Z.5
  • 108
    • 0036340601 scopus 로고    scopus 로고
    • Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures
    • Virta, M., Hurme, M. & Helminen, M. Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia 43, 920-923 (2002).
    • (2002) Epilepsia , vol.43 , pp. 920-923
    • Virta, M.1    Hurme, M.2    Helminen, M.3
  • 109
    • 0036772091 scopus 로고    scopus 로고
    • Interleukin-1, tumor necrosis factor-α, and nitrite levels in febrile seizures
    • Haspolat, S., et al. Interleukin-1, tumor necrosis factor-α, and nitrite levels in febrile seizures. J. Child Neurol. 17, 749-751 (2002).
    • (2002) J. Child Neurol. , vol.17 , pp. 749-751
    • Haspolat, S.1
  • 110
    • 0031934336 scopus 로고    scopus 로고
    • Tumor necrosis factor-α, interleukin-1, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy
    • Ichiyama, T., Nishikawa, M., Yoshitomi, T., Hayashi, T. & Furukawa, S. Tumor necrosis factor-α, interleukin-1, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy. Neurology 50, 407-411 (1998).
    • (1998) Neurology , vol.50 , pp. 407-411
    • Ichiyama, T.1    Nishikawa, M.2    Yoshitomi, T.3    Hayashi, T.4    Furukawa, S.5
  • 111
    • 0030612597 scopus 로고    scopus 로고
    • Interleukin-1 levels in serum and cerebrospinal fluid of children with febrile seizures
    • Lahat, E., Livne, M., Barr, J. & Katz, Y. Interleukin-1 levels in serum and cerebrospinal fluid of children with febrile seizures. Pediatr. Neurol. 17, 34-36 (1997).
    • (1997) Pediatr. Neurol. , vol.17 , pp. 34-36
    • Lahat, E.1    Livne, M.2    Barr, J.3    Katz, Y.4
  • 112
    • 33644794932 scopus 로고    scopus 로고
    • Causal links between brain cytokines and experimental febrile convulsions in the rat
    • Heida, J. G. & Pittman, Q. J. Causal links between brain cytokines and experimental febrile convulsions in the rat. Epilepsia 46, 1906-1913 (2005).
    • (2005) Epilepsia , vol.46 , pp. 1906-1913
    • Heida, J.G.1    Pittman, Q.J.2
  • 113
    • 0027430322 scopus 로고
    • Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination
    • French, J. A., et al. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann. Neurol. 34, 774-780 (1993).
    • (1993) Ann. Neurol. , vol.34 , pp. 774-780
    • French, J.A.1
  • 114
    • 77950521028 scopus 로고    scopus 로고
    • Febrile seizures and temporal lobe epileptogenesis
    • Scantlebury, M. H. & Heida, J. G. Febrile seizures and temporal lobe epileptogenesis. Epilepsy Res. 89, 27-33 (2010).
    • (2010) Epilepsy Res. , vol.89 , pp. 27-33
    • Scantlebury, M.H.1    Heida, J.G.2
  • 115
    • 33645061779 scopus 로고    scopus 로고
    • Temporal lobe epilepsy after experimental prolonged febrile seizures: Prospective analysis
    • Dub C., et al Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain 129 911-922 (2006).
    • (2006) Brain , vol.129 , pp. 911-922
    • Dub, C.1
  • 116
    • 0345304249 scopus 로고    scopus 로고
    • The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: Involvement of proinflammatory factors: Nitric oxide and prostaglandins
    • Sayyah, M., Javad-Pour, M. & Ghazi-Khansari, M. The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins. Neuroscience 122, 1073-1080 (2003).
    • (2003) Neuroscience , vol.122 , pp. 1073-1080
    • Sayyah, M.1    Javad-Pour, M.2    Ghazi-Khansari, M.3
  • 117
    • 49049097966 scopus 로고    scopus 로고
    • Postnatal inflammation increases seizure susceptibility in adult rats
    • Galic, M. A., et al. Postnatal inflammation increases seizure susceptibility in adult rats. J. Neurosci. 28, 6904-6913 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 6904-6913
    • Galic, M.A.1
  • 118
    • 70349484628 scopus 로고    scopus 로고
    • Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitability
    • Auvin, S., et al. Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitability. Epilepsy Res. 86, 124-130 (2009).
    • (2009) Epilepsy Res. , vol.86 , pp. 124-130
    • Auvin, S.1
  • 119
    • 77955845563 scopus 로고    scopus 로고
    • Inflammation enhances epileptogenesis in the developing rat brain
    • Auvin, S., Mazarati, A. Shin, D. & Sankar, R. Inflammation enhances epileptogenesis in the developing rat brain. Neurobiol. Dis. 40, 303-310 (2010).
    • (2010) Neurobiol. Dis. , vol.40 , pp. 303-310
    • Auvin, S.1    Mazarati Shin, A.D.2    Sankar, R.3
  • 120
    • 33646510267 scopus 로고    scopus 로고
    • Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats
    • Kovacs, Z., et al. Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats. Neuroscience 140, 731-742 (2006).
    • (2006) Neuroscience , vol.140 , pp. 731-742
    • Kovacs, Z.1
  • 121
    • 77953512334 scopus 로고    scopus 로고
    • Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways
    • Mouihate, A., et al. Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways. J. Neurosci. 30, 7975-7983 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 7975-7983
    • Mouihate, A.1
  • 122
    • 39049133870 scopus 로고    scopus 로고
    • Neonatal inflammation produces selective behavioral deficits and alters N-methyl-d-aspartate receptor subunit mRNA in the adult rat brain
    • Harre, E. M., Galic, M. A., Mouihate, A., Noorbakhsh, F. & Pittman, Q. J. Neonatal inflammation produces selective behavioral deficits and alters N-methyl-d-aspartate receptor subunit mRNA in the adult rat brain. Eur. J. Neurosci. 27, 644-653 (2008).
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 644-653
    • Harre, E.M.1    Galic, M.A.2    Mouihate, A.3    Noorbakhsh, F.4    Pittman, Q.J.5
  • 123
    • 77950539231 scopus 로고    scopus 로고
    • Toll-like receptor 4 and highmobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    • Maroso, M., et al. Toll-like receptor 4 and highmobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat. Med. 16, 413-419 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 413-419
    • Maroso, M.1
  • 124
    • 1842298190 scopus 로고    scopus 로고
    • Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization
    • Buckmaster, P. S. & Dudek, F. E. Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization. J. Neurophysiol. 77, 2685-2696 (1997).
    • (1997) J. Neurophysiol. , vol.77 , pp. 2685-2696
    • Buckmaster, P.S.1    Dudek, F.E.2
  • 125
    • 10744232929 scopus 로고    scopus 로고
    • Glia activation and cytokine increase in rat hippocampus by kainic acidinduced status epilepticus during postnatal development
    • Rizzi, M., et al. Glia activation and cytokine increase in rat hippocampus by kainic acidinduced status epilepticus during postnatal development. Neurobiol. Dis. 14, 494-503 (2003).
    • (2003) Neurobiol. Dis. , vol.14 , pp. 494-503
    • Rizzi, M.1
  • 126
    • 29744460702 scopus 로고    scopus 로고
    • Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type i in the rat limbic system
    • Ravizza, T. & Vezzani, A. Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system. Neuroscience 137, 301-308 (2006).
    • (2006) Neuroscience , vol.137 , pp. 301-308
    • Ravizza, T.1    Vezzani, A.2
  • 127
    • 0033964181 scopus 로고    scopus 로고
    • Kindling modulates the IL-1 system, β, TGF-?1, and neuropeptide mRNAs in specific brain regions
    • Plata-Salaman, C. R., et al. Kindling modulates the IL-1 system, β, TGF-?1, and neuropeptide mRNAs in specific brain regions. Brain Res. Mol. Brain Res. 75, 248-258 (2000).
    • (2000) Brain Res. Mol. Brain Res. , vol.75 , pp. 248-258
    • Plata-Salaman, C.R.1
  • 128
    • 49349112122 scopus 로고    scopus 로고
    • Interleukin converting enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1 production
    • Ravizza, T., et al. Interleukin converting enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1 production. Neurobiol. Dis. 31, 327-333 (2008).
    • (2008) Neurobiol. Dis. , vol.31 , pp. 327-333
    • Ravizza, T.1
  • 129
    • 67650398286 scopus 로고    scopus 로고
    • C1-inhibitor attenuates neurobehavioral deficits and reduces contusion volume after controlled cortical impact brain injury in mice
    • Longhi, L., et al. C1-inhibitor attenuates neurobehavioral deficits and reduces contusion volume after controlled cortical impact brain injury in mice. Crit. Care Med. 37, 659-665 (2009).
    • (2009) Crit. Care Med. , vol.37 , pp. 659-665
    • Longhi, L.1
  • 130
    • 68249103676 scopus 로고    scopus 로고
    • Neutralization of interleukin-1 modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
    • Clausen, F., et al. Neutralization of interleukin-1 modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice. Eur. J. Neurosci. 30, 385-396 (2009).
    • (2009) Eur. J. Neurosci. , vol.30 , pp. 385-396
    • Clausen, F.1
  • 131
    • 48449095239 scopus 로고    scopus 로고
    • Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury
    • Lloyd, E., Somera-Molina, K., Van Eldik, L. J., Watterson, D. M. & Wainwright, M. S. Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J. Neuroinflammation 5, 28 (2008).
    • (2008) J. Neuroinflammation , vol.5 , pp. 28
    • Lloyd, E.1    Somera-Molina, K.2    Van Eldik, L.J.3    Watterson, D.M.4    Wainwright, M.S.5
  • 132
    • 77954865635 scopus 로고    scopus 로고
    • Systemic inflammatory cells fight off neurodegenerative disease
    • Schwartz, M. & Shechter, R. Systemic inflammatory cells fight off neurodegenerative disease. Nat. Rev. Neurol. 6, 405-410 (2010).
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 405-410
    • Schwartz, M.1    Shechter, R.2
  • 133
    • 59649123881 scopus 로고    scopus 로고
    • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
    • Liesz, A., et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat. Med. 15, 192-199 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 192-199
    • Liesz, A.1
  • 134
    • 70349108297 scopus 로고    scopus 로고
    • Seizures in patients with multiple sclerosis: Epidemiology, pathophysiology and management
    • Kelley, B. J. & Rodriguez, M. Seizures in patients with multiple sclerosis: epidemiology, pathophysiology and management. CNS Drugs 23, 805-815 (2009).
    • (2009) CNS Drugs , vol.23 , pp. 805-815
    • Kelley, B.J.1    Rodriguez, M.2
  • 135
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signaling pathways with NF-B and IKK function
    • Perkins, N. D. Integrating cell-signaling pathways with NF-B and IKK function. Nat. Rev. Mol. Cell. Biol. 8, 49-62 (2007).
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 136
    • 41349100214 scopus 로고    scopus 로고
    • Forward genetic analysis of TLR-signaling pathways: An evaluation
    • Hoebe, K. & Beutler, B. Forward genetic analysis of TLR-signaling pathways: an evaluation. Adv. Drug Deliv. Rev. 60, 824-829 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 824-829
    • Hoebe, K.1    Beutler, B.2
  • 137
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-B: Players, pathways, perspectives
    • Gilmore, T. D. Introduction to NF-B: players, pathways, perspectives. Oncogene 25, 6680-6684 (2006).
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 138
    • 0031172065 scopus 로고    scopus 로고
    • NF-B: A crucial transcription factor for glial and neuronal cell function
    • ONeill, L. A. & Kaltschmidt, C. NF-B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20, 252-258 (1997).
    • (1997) Trends Neurosci. , vol.20 , pp. 252-258
    • Oneill, L.A.1    Kaltschmidt, C.2
  • 139
    • 55749104050 scopus 로고    scopus 로고
    • Molecular and cellular basis of epileptogenesis in symptomatic epilepsy
    • Pitkanen, A. & Lukasiuk, K. Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. Epilepsy Behav. 14 (Suppl. 1), 16-25 (2009).
    • (2009) Epilepsy Behav. , vol.14 , Issue.SUPPL. 1 , pp. 16-25
    • Pitkanen, A.1    Lukasiuk, K.2
  • 140
    • 58149105502 scopus 로고    scopus 로고
    • A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1
    • Balosso, S., et al. A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1. Brain 131, 3256-3265 (2008).
    • (2008) Brain , vol.131 , pp. 3256-3265
    • Balosso, S.1
  • 141
    • 0141535180 scopus 로고    scopus 로고
    • Interleukin-1 enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
    • Viviani, B., et al. Interleukin-1 enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci. 23, 8692-8700 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 8692-8700
    • Viviani, B.1
  • 142
    • 33746927145 scopus 로고    scopus 로고
    • IL-1 induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons
    • Davis, C. N., Tabarean, I., Gaidarova, S., Behrens, M. M. & Bartfai, T. IL-1 induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J. Neurochem. 98, 1379-1389 (2006).
    • (2006) J. Neurochem. , vol.98 , pp. 1379-1389
    • Davis, C.N.1    Tabarean, I.2    Gaidarova, S.3    Behrens, M.M.4    Bartfai, T.5
  • 144
    • 33747175900 scopus 로고    scopus 로고
    • Interleukin-1 induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons
    • Tabarean, I. V., Korn, H. & Bartfai, T. Interleukin-1 induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. Neuroscience 141, 1685-1695 (2006).
    • (2006) Neuroscience , vol.141 , pp. 1685-1695
    • Tabarean, I.V.1    Korn, H.2    Bartfai, T.3
  • 145
    • 77549084791 scopus 로고    scopus 로고
    • Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1
    • Zhang, R., et al. Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1. Neurobiol. Dis. 38, 68-77 (2010).
    • (2010) Neurobiol. Dis. , vol.38 , pp. 68-77
    • Zhang, R.1
  • 146
    • 34547279579 scopus 로고    scopus 로고
    • Cytokines and neuronal ion channels in health and disease
    • Viviani, B., Gardoni, F. & Marinovich, M. Cytokines and neuronal ion channels in health and disease. Int. Rev. Neurobiol. 82, 247-263 (2007).
    • (2007) Int. Rev. Neurobiol. , vol.82 , pp. 247-263
    • Viviani, B.1    Gardoni, F.2    Marinovich, M.3
  • 147
    • 0034960228 scopus 로고    scopus 로고
    • CXCR4-activated astrocyte glutamate release via β: Amplification by microglia triggers neurotoxicity
    • Bezzi, P., et al. CXCR4-activated astrocyte glutamate release via β: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 4, 702-710 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 702-710
    • Bezzi, P.1
  • 149
    • 16244376446 scopus 로고    scopus 로고
    • Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-α
    • Stellwagen, D., Beattie, E. C., Seo, J. Y. & Malenka, R. C. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-α. J. Neurosci. 25, 3219-3228 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 3219-3228
    • Stellwagen, D.1    Beattie, E.C.2    Seo, J.Y.3    Malenka, R.C.4
  • 150
    • 56149092503 scopus 로고    scopus 로고
    • Cell death after spinal cord injury is exacerbated by rapid TNF-induced trafficking of GluR2-lacking AMPARs to the plasma membrane
    • Ferguson, A. R., et al. Cell death after spinal cord injury is exacerbated by rapid TNF-induced trafficking of GluR2-lacking AMPARs to the plasma membrane. J. Neurosci. 28, 11391-11400 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 11391-11400
    • Ferguson, A.R.1
  • 151
    • 23644451669 scopus 로고    scopus 로고
    • Lipid signaling: Sleep, synaptic plasticity, and neuroprotection
    • Chen, C. & Bazan, N. G. Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Prostaglandins Other Lipid Mediat. 77, 65-76 (2005).
    • (2005) Prostaglandins Other Lipid Mediat. , vol.77 , pp. 65-76
    • Chen, C.1    Bazan, N.G.2
  • 152
    • 23944475831 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus
    • Slanina, K. A. & Schweitzer, P. Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus. Neuropharmacology 49, 653-659 (2005).
    • (2005) Neuropharmacology , vol.49 , pp. 653-659
    • Slanina, K.A.1    Schweitzer, P.2
  • 153
    • 69449102409 scopus 로고    scopus 로고
    • Astrocytic dysfunction in epileptogenesis: Consequence of altered potassium and glutamate homeostasis? J
    • David, Y., et al. Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? J. Neurosci. 29, 10588-10599 (2009).
    • (2009) Neurosci. , vol.29 , pp. 10588-10599
    • David, Y.1
  • 154
    • 67650739168 scopus 로고    scopus 로고
    • Transcriptome profiling reveals TGF-? signaling involvement in epileptogenesis
    • Cacheaux, L. P., et al. Transcriptome profiling reveals TGF-? signaling involvement in epileptogenesis. J. Neurosci. 29, 8927-8935 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 8927-8935
    • Cacheaux, L.P.1
  • 155
    • 33746303035 scopus 로고    scopus 로고
    • Cytokine sickness behavior, and depression
    • Dantzer, R. Cytokine, sickness behavior, and depression. Neurol. Clin. 24, 441-460 (2006).
    • (2006) Neurol. Clin. , vol.24 , pp. 441-460
    • Dantzer, R.1
  • 156
    • 52949117520 scopus 로고    scopus 로고
    • Malaise in the water maze: Untangling the effects of LPS and IL-1 on learning and memory
    • Cunningham, C. & Sanderson, D. J. Malaise in the water maze: untangling the effects of LPS and IL-1 on learning and memory. Brain Behav. Immun. 22, 1117-1127 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 1117-1127
    • Cunningham, C.1    Sanderson, D.J.2
  • 157
    • 70349481275 scopus 로고    scopus 로고
    • Treatment of Rasmussen encephalitis half a century after its initial description: Promising prospects and a dilemma
    • Bien, C. G. & Schramm, J. Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma. Epilepsy Res. 86, 101-112 (2009).
    • (2009) Epilepsy Res. , vol.86 , pp. 101-112
    • Bien, C.G.1    Schramm, J.2
  • 158
    • 67349151166 scopus 로고    scopus 로고
    • The neuro-symphony of stress
    • Joels, M. & Baram, T. Z. The neuro-symphony of stress. Nat. Rev. Neurosci. 10, 459-466 (2009).
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 459-466
    • Joels, M.1    Baram, T.Z.2
  • 159
    • 0035094278 scopus 로고    scopus 로고
    • Corticotropin (ACTH) acts directly on amygdala neurons to downregulate corticotropinreleasing hormone gene expression
    • Brunson, K. L., Khan, N., Eghbal-Ahmadi, M. & Baram, T. Z. Corticotropin (ACTH) acts directly on amygdala neurons to downregulate corticotropinreleasing hormone gene expression. Ann. Neurol. 49, 304-312 (2001).
    • (2001) Ann. Neurol. , vol.49 , pp. 304-312
    • Brunson, K.L.1    Khan, N.2    Eghbal-Ahmadi, M.3    Baram, T.Z.4
  • 160
    • 0032212674 scopus 로고    scopus 로고
    • Neuropeptidemediated excitability: A key triggering mechanism for seizure generation in the developing brain
    • Baram, T. Z. & Hatalski, C. G. Neuropeptidemediated excitability: a key triggering mechanism for seizure generation in the developing brain. Trends Neurosci. 21, 471-476 (1998).
    • (1998) Trends Neurosci. , vol.21 , pp. 471-476
    • Baram, T.Z.1    Hatalski, C.G.2
  • 161
    • 78649241016 scopus 로고    scopus 로고
    • Infantile spasms: A U S. consensus report
    • Pellock, J. M., et al. Infantile spasms: a U. S. consensus report. Epilepsia 51, 2175-2189 (2010).
    • (2010) Epilepsia , vol.51 , pp. 2175-2189
    • Pellock, J.M.1
  • 162
    • 0036368031 scopus 로고    scopus 로고
    • ACTH treatment of infantile spasms: Mechanisms of its effects in modulation of neuronal excitability
    • Brunson, K. L., Avishai-Eliner, S. & Baram, T. Z. ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. Int. Rev. Neurobiol. 49, 185-197 (2002).
    • (2002) Int. Rev. Neurobiol. , vol.49 , pp. 185-197
    • Brunson, K.L.1    Avishai-Eliner, S.2    Baram, T.Z.3
  • 163
    • 0037950645 scopus 로고    scopus 로고
    • Prednisone therapy in pediatric epilepsy
    • Sinclair, D. B. Prednisone therapy in pediatric epilepsy. Pediatr. Neurol. 28, 194-198 (2003).
    • (2003) Pediatr. Neurol. , vol.28 , pp. 194-198
    • Sinclair, D.B.1
  • 164
    • 72949122335 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy in intractable childhood epilepsy: Open-label study and review of the literature
    • Mikati, M. A., Kurdi, R., El-Khoury, Z., Rahi, A. & Raad, W. Intravenous immunoglobulin therapy in intractable childhood epilepsy: open-label study and review of the literature. Epilepsy Behav. 17, 90-94 (2010).
    • (2010) Epilepsy Behav. , vol.17 , pp. 90-94
    • Mikati, M.A.1    Kurdi, R.2    El-Khoury, Z.3    Rahi, A.4    Raad, W.5
  • 165
    • 0025684724 scopus 로고
    • Landau-Kleffner syndrome: A pharmacologic study of five cases
    • Marescaux, C., et al. Landau-Kleffner syndrome: a pharmacologic study of five cases. Epilepsia 31, 768-777 (1990).
    • (1990) Epilepsia , vol.31 , pp. 768-777
    • Marescaux, C.1
  • 166
    • 0036266629 scopus 로고    scopus 로고
    • The use of immunoglobulins in the treatment of human epilepsy
    • Villani, F. & Avanzini, G. The use of immunoglobulins in the treatment of human epilepsy. Neurol. Sci. 23 (Suppl. 1), S33-S37 (2002).
    • (2002) Neurol. Sci. , vol.23 , Issue.SUPPL. 1
    • Villani, F.1    Avanzini, G.2
  • 167
    • 43749097619 scopus 로고    scopus 로고
    • Efficacy and prognosis of a short course of prednisolone therapy for pediatric epilepsy
    • You, S. J., Jung, D. E., Kim, H. D., Lee, H. S. & Kang, H. C. Efficacy and prognosis of a short course of prednisolone therapy for pediatric epilepsy. Eur. J. Paediatr. Neurol. 12, 314-320 (2008).
    • (2008) Eur. J. Paediatr. Neurol. , vol.12 , pp. 314-320
    • You, S.J.1    Jung, D.E.2    Kim, H.D.3    Lee, H.S.4    Kang, H.C.5
  • 168
    • 0036234372 scopus 로고    scopus 로고
    • Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome
    • Mikati, M. A., Saab, R., Fayad, M. N. & Choueiri, R. N. Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome. Pediatr. Neurol. 26, 298-300 (2002).
    • (2002) Pediatr. Neurol. , vol.26 , pp. 298-300
    • Mikati, M.A.1    Saab, R.2    Fayad, M.N.3    Choueiri, R.N.4
  • 169
    • 23944503013 scopus 로고    scopus 로고
    • Steroids in intractable childhood epilepsy: Clinical experience and review of the literature
    • Verhelst, H., et al. Steroids in intractable childhood epilepsy: clinical experience and review of the literature. Seizure 14, 412-421 (2005).
    • (2005) Seizure , vol.14 , pp. 412-421
    • Verhelst, H.1
  • 170
    • 0029916006 scopus 로고    scopus 로고
    • High-dose corticotropin (ACTH) versus prednisone for infantile spasms: A prospective, randomized, blinded study
    • Baram, T. Z., et al. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics 97, 375-379 (1996).
    • (1996) Pediatrics , vol.97 , pp. 375-379
    • Baram, T.Z.1
  • 171
    • 2442641463 scopus 로고    scopus 로고
    • Practice parameter: Medical treatment of infantile spasms: Report of the American Academy of Neurology and the Child Neurology Society
    • Mackay, M. T., et al. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology 62, 1668-1681 (2004).
    • (2004) Neurology , vol.62 , pp. 1668-1681
    • MacKay, M.T.1
  • 172
    • 26844507605 scopus 로고    scopus 로고
    • The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: A multicenter randomised trial
    • Lux, A. L., et al. The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicenter randomised trial. Lancet Neurol. 4, 712-717 (2005).
    • (2005) Lancet Neurol. , vol.4 , pp. 712-717
    • Lux, A.L.1
  • 173
    • 44949208631 scopus 로고    scopus 로고
    • Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms
    • Art. No.: CD005222, doi:10.1002/14651858. CD005222.pub2
    • Gayatri, N. A., Ferrie, C. D. & Cross, H. Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms. Cochrane Database of Systematic Reviews, Issue 1. Art. No.: CD005222. doi:10.1002/14651858. CD005222.pub2 (2007).
    • (2007) Cochrane Database of Systematic Reviews , vol.1
    • Gayatri, N.A.1    Ferrie, C.D.2    Cross, H.3
  • 174
    • 33845976292 scopus 로고    scopus 로고
    • A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
    • Crow, A. R., Song, S., Semple, J. W., Freedman, J. & Lazarus, A. H. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109, 155-158 (2007).
    • (2007) Blood , vol.109 , pp. 155-158
    • Crow, A.R.1    Song, S.2    Semple, J.W.3    Freedman, J.4    Lazarus, A.H.5
  • 175
    • 55349122596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha and the ketogenic diet
    • Cullingford, T. Peroxisome proliferator-activated receptor alpha and the ketogenic diet. Epilepsia 49 (Suppl. 8), 70-72 (2008).
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 8 , pp. 70-72
    • Cullingford, T.1
  • 177
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of Tolllike receptors
    • Tsan, M. F. & Gao, B. Endogenous ligands of Tolllike receptors. J. Leukoc. Biol. 76, 514-519 (2004).
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 514-519
    • Tsan, M.F.1    Gao, B.2
  • 178
    • 77954862661 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
    • Shlosberg, D., Benifla, M., Kaufer, D. & Friedman, A. Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat. Rev. Neurol. 6, 393-403 (2010).
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 393-403
    • Shlosberg, D.1    Benifla, M.2    Kaufer, D.3    Friedman, A.4
  • 179
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins, B. T. & Davis, T. P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57, 173-185 (2005).
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 180
    • 77949313388 scopus 로고    scopus 로고
    • Endocytosis and recycling of tight junction proteins in inflammation
    • Utech, M., Mennigen, R. & Bruewer, M. Endocytosis and recycling of tight junction proteins in inflammation. J. Biomed. Biotechnol. 2010, 484987 (2010).
    • (2010) J. Biomed. Biotechnol. 2010 , pp. 484987
    • Utech, M.1    Mennigen, R.2    Bruewer, M.3
  • 181
    • 0034750810 scopus 로고    scopus 로고
    • Molecular and cellular permeability control at the blood-brain barrier
    • Gloor, S. M., et al. Molecular and cellular permeability control at the blood-brain barrier. Brain Res. Brain Res. Rev. 36, 258-264 (2001).
    • (2001) Brain Res. Brain Res. Rev. , vol.36 , pp. 258-264
    • Gloor, S.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.