Early identification of refractory epilepsy

New England Journal of Medicine

Volumn 342, Issue 5, 2000, Pages 314-319

  Kwan, Patrick ^a   Brodie, Martin J ^a  

^a WESTERN INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENYTOIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; DRUG EFFECT; EPILEPSY; FEMALE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; CHILD; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REMISSION INDUCTION; TREATMENT FAILURE;

EID: 0034598762     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200002033420503     Document Type: Article

References (41)

1. Brodie MJ, Shorvon SD, Canger R, et al. Commission on European Affairs: appropriate standards of epilepsy care across Europe: ILEA. Epilepsia 1997;38:1245-50.
2. ILEA Commission report: the epidemiology of the epilepsies: future directions. Epilepsia 1997;38:614-8.
3. Sander JWAS. Some aspects of prognosis in the epilepsies: a review. Epilepsia 1993;34:1007-16.
4. Schmidt D, Gram L. Monotherapy versus polytherapy in epilepsy: a reappraisal. CNS Drugs 1995;3:194-208.
5. Brodie MJ, Dichter MA. Antiepileptic drugs. N Engl J Med 1996;334: 168-75. [Erratum, N Engl J Med 1996;334:479.]
6. Devinsky O. Patients with refractory seizures. N Engl J Med 1999;340: 1565-70.
7. Shorvon SD. The epidemiology and treatment of chronic and refractory epilepsy. Epilepsia 1996;37:Suppl 2:S1-S3.
8. Perucca E. Pharmacoresistance in epilepsy: how should it be defined? CNS Drugs 1998;10:171-9.
9. Brodie MJ. Antiepileptic drugs, clinical trials, and the marketplace. Lancet 1996;347:777-9.
10. McKee PJW, Wilson EA, Dawson JA, Larkin JG, Brodie MJ. Managing seizures in the casualty department. BMJ 1990;300:978-9.
11. Tobias ES, Brodie AF, Brodie MJ. An outcome audit at the epilepsy clinic: results from 1000 consecutive referrals. Seizure 1994;3:37-43.
12. Brodie MJ. Monostars: an aid to choosing an antiepileptic drug as monotherapy. Epilepsia 1999;40:Suppl 6:S17-S22.
13. McKee PJW, Larkin JG, Brodie AF, Percy-Robb IW, Brodie MJ. Five years of anticonvulsant monitoring on site at the epilepsy clinic. Ther Drug Monit 1993;15:83-90.
14. Engel J Jr. Surgery for seizures. N Engl J Mod 1996;334:647-52.
15. Wieser HG. Epilepsy surgery: past, present and future. Seizure 1998; 7:173-84.
16. Dreifuss FE. Classification of epileptic seizures. In: Engel J Jr, Pedley TA, eds. Epilepsy: a comprehensive textbook. Vol. I. Philadelphia: Lippincott-Raven, 1998:517-24.
17. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-99.
18. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Guidelines for epidemiologic studies on epilepsy. Epilepsia 1993;34:592-6.
19. Wolf P. International classification of the epilepsies. In: Engel J Jr, Pedley TA, eds. Epilepsy: a comprehensive textbook. Vol. 1. Philadelphia: Lippincott-Raven, 1998:773-7.
20. Collaborative Group for the Study of Epilepsy. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia 1992;33:45-51.
21. Sillanpää M, Jalava M, Kaleva O, Shinnar S. Long-term prognosis of seizures with onset in childhood. N Engl J Mcd 1998;338:1715-22.
22. Cockerell OC, Johnson AL, Sander JWAS, Hart YM, Shorvon SD. Remission of epilepsy: results from the National General Practice Study of Epilepsy. Lancet 1995;346:140-4.
23. Cockercll OC, Eckle I, Goodridge DMG, Sander JWA, Shorvon SD. Epilepsy in a population of 6000 re-examined: secular trends in first attendance rates, prevalence, and prognosis. J Neurol Ncurosurg Psychiatry 1995;58:570-6. [Erratum, J Neurol Neurosurg Psychiatry 1996;60:247.]
24. Shafer SQ, Hauser WA, Annegers JF, Klass DW. EEG and other early predictors of epilepsy remission: a community study. Epilepsia 1988;29: 590-600.
25. Semah F, Picot M-C, Adam C, et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology 1998;51:1256-62.
26. Berg AT, Levy SR, Novotny EJ, Shinnar S. Predictors of intractable epilepsy in childhood: a case-control study. Epilepsia 1996;37:24-30.
27. Annegers JF, Hauser WA, Elveback LR. Remission of seizures and relapse in patients with epilepsy. Epilepsia 1979;20:729-37.
28. Sillanpää M. Remission of seizures and predictors of intractability in long-term follow-up. Epilepsia 1993;34:930-6.
29. Reynolds EH. Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as possible. BMJ 1995;310:176-7.
30. Musicco M, Beghi E, Solari A, Viani F. Treatment of first tonic-clonic seizure docs not improve the prognosis of epilepsy. Neurology 1997;49: 991-8.
31. Camfield C, Cimfield P, Gordon K, Dooley J. Does the number of seizures before treatment influence ease of control or remission of childhood epilepsy? Not if the number is 10 or less. Neurology 1996;46:41-4.
32. Berg AT, Shinnar S. Do seizures beget seizures? An assessment of the clinical evidence in humans. J Clin Neurophysiol 1997;14:102-10.
33. Elwes RDC, Johnson AL, Shorvon SD, Reynolds EH. The prognosis for seizure control in newly diagnosed epilepsy. N Engl J Med 1984;311:944-7.
34. Keranen T, Riekkinen PJ. Remission of seizures in untreated epilepsy. BMJ 1993;307:483.
35. Watts AE. The natural history of untreated epilepsy in a rural community in Africa. Epilepsia 1992;33:464-8.
36. Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet 1995;345: 476-9. [Erratum, Lancet 1995;345:662.]
37. Brodie MJ, Overstall PW, Giorgi L, UK Lamotrigine Elderly Study Group. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Res 1999;37:81-7.
38. Brodie MJ, Yuen AWC, 105 Study Group. Lamotrigine substitution study: evidence for synergism with sodium valproate? Epilepsy Res 1997; 26:423-32.
39. Brodie MJ, Mumford JP, 012 Study Group. Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. Epilepsy Res 1999;34:199-205.
40. Ling V. Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol 1997;40:Suppl:S3-S8.
41. Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995;36:1-6.