Seizure exacerbation in two patients with focal epilepsy following marijuana cessation

Epilepsy and Behavior

Volumn 25, Issue 4, 2012, Pages 563-566

  Hegde, Manu ^a,b   Santos Sanchez, Carlos ^a   Hess, Christopher P ^a   Kabir, Arif A ^b   Garcia, Paul A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cannabidiol; Cannabis; Epilepsy, partial; Marijuana smoking; Tetrahydocannabinol

Indexed keywords

ANTICONVULSIVE AGENT; CANNABIS; CARBAMAZEPINE; ETIRACETAM; HYDROCHLOROTHIAZIDE; LISINOPRIL; LORAZEPAM; OMEPRAZOLE; PHENYTOIN; PRAVASTATIN; VALPROIC ACID;

ABDOMINAL PAIN; ADULT; AMNESIA; ARTICLE; BRAIN PERFUSION; CANNABIS ADDICTION; CANNABIS SMOKING; CASE REPORT; CORTICAL DYSPLASIA; DISEASE EXACERBATION; DRUG DOSE INCREASE; ELECTROCORTICOGRAPHY; ELECTROENCEPHALOGRAPHY; FOCAL EPILEPSY; FRONTAL OPERCULUM; HOSPITAL ADMISSION; HUMAN; MALE; MULTIPLE TRAUMA; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTPATIENT CARE; PATIENT MONITORING; RISK FACTOR; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOKING CESSATION; SUPERIOR TEMPORAL GYRUS; SYMPTOM; TELEMETRY; VIDEORECORDING; WITHDRAWAL SYNDROME;

ADULT; BRAIN; CANNABIS; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROIMAGING; PHYTOTHERAPY; SEIZURES; SUBSTANCE WITHDRAWAL SYNDROME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84871839209     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2012.09.024     Document Type: Article

References (17)

1. Katona I., Freund T.F. Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nat Med 2008, 14:923-930.
2. World Health Organization Epilepsy: aetiogy [sic], epidemiology and prognosis February. Archived from the original on 2007-05-18, Accessed March 8, 2012. http://web.archive.org/web/20070518073641/http://www.who.int/mediacentre/factsheets/fs165/en/.
3. Gross D.W., Hamm J., Ashworth N.L., Quigley D. Marijuana use and epilepsy: prevalence in patients of a tertiary care epilepsy center. Neurology 2004, 62:2095-2097.
4. Gordon E., Devinsky O. Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy. Epilepsia 2001, 42:1266-1272.
5. Cunha J.M., Carlini E.A., Pereira A.E., et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 1980, 21:175-185.
6. Ames F.R., Cridland S. Anticonvulsant effect of cannabidiol. S Afr Med J 1986, 69:14.
7. Abrams D.I., Jay C.A., Shade S.B., et al. Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology 2007, 68:515-521.
8. Jones N.A., Hill A.J., Smith I., et al. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. J Pharmacol Exp Ther 2010, 332:569-577.
9. Lutz B. On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures. Biochem Pharmacol 2004, 68:1691-1698.
10. Ludányi A., Eross L., Czirják S., et al. Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. J Neurosci 2008, 28:2976-2990.
11. Panikashvili D., Simeonidou C., Ben-Shabat S., et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 2001, 413:527-531.
12. Wallace M.J., Blair R.E., Falenski K.W., Martin B.R., DeLorenzo R.J. The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther 2003, 307:129-137.
13. Wendt H., Soerensen J., Wotjak C.T., Potschka H. Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice. Epilepsia 2011, 52:e62-e65.
14. Romigi A., Bari M., Placidi F., et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. Epilepsia 2009, 51:768-772.
15. Goffin K., Van Paesschen W., Van Laere K. In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis. Brain 2011, 134:1033-1040.
16. Budney A.J., Hughes J.R. The cannabis withdrawal syndrome. Curr Opin Psychiatry 2006, 19:233-238.
17. Roth M.D., Marques-Magallanes J.A., Yuan M., Sun W., Tashkin D.P., Hankinson O. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. Am J Respir Cell Mol Biol 2001, 24:339-344.