A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity

Drug Discovery Today

Volumn 21, Issue 2, 2016, Pages 250-263

  Scheer, Nico ^a   Wilson, Ian D ^b  

^a Imperial College London ^*  (Germany)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; CHIMERA; CONTROLLED STUDY; DRUG DISPOSITION; DRUG METABOLISM; DRUG TOXICITY; GENETIC ANALYSIS; IMMUNE SYSTEM; LIVER; MOUSE; NONHUMAN; REVIEW; ADVERSE DRUG REACTION; ANIMAL; ANIMAL MODEL; DRUG DEVELOPMENT; HUMAN; METABOLISM; TRANSGENIC MOUSE;

DRUG;

ANIMALS; CHIMERA; DRUG DISCOVERY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HUMANS; LIVER; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS;

EID: 84969256254     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.09.002     Document Type: Review

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