Generation and utility of genetically humanized mouse models

Drug Discovery Today

Volumn 18, Issue 23-24, 2013, Pages 1200-1211

  Scheer, Nico ^a   Snaith, Mike ^b   Wolf, C Roland ^c   Seibler, Jost ^a  

^a TaconicArtemis   (Germany)

^b MEDIMMUNE   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ARYLAMINE ACETYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE 2; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B7; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B ANTIGEN; HLA C ANTIGEN; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER 1B3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

ANEUPLOIDY; BACTERIAL ARTIFICIAL CHROMOSOME; CANCER RESEARCH; CELL TYPE; CHROMOSOME REARRANGEMENT; DNA END JOINING REPAIR; DNA MODIFICATION; DRUG DISPOSITION; DRUG EFFICACY; DRUG METABOLISM; DRUG TARGETING; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; FERTILIZATION; GENE EXPRESSION; GENE INSERTION; GENE TARGETING; GENETIC CODE; GENETICALLY ENGINEERED MOUSE STRAIN; GENOME; HEMATOPOIETIC SYSTEM; HUMAN; HUMAN CHROMOSOME; IMMUNE SYSTEM; INFECTION; INTRACYTOPLASMIC SPERM INJECTION; MOUSE; MOUSE MODEL; NONHUMAN; PROTO ONCOGENE; REGULATORY SEQUENCE; REVIEW; RNA EDITING; SPERMATOGONIUM; TRANSGENIC MOUSE; TRANSLATIONAL RESEARCH; TUMOR SUPPRESSOR GENE; WILD TYPE; YEAST ARTIFICIAL CHROMOSOME; ADVERSE DRUG REACTION; ANIMAL; ANIMAL MODEL; DRUG DESIGN; DRUG DEVELOPMENT; GENETIC ENGINEERING; PROCEDURES; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DRUG DESIGN; DRUG DISCOVERY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENETIC ENGINEERING; HUMANS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84889084878     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.07.007     Document Type: Review

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