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Volumn 145, Issue 6, 2013, Pages 1209-1214

Mice with human livers

Author keywords

Animal Model; Chimera; Hepatocyte; Humanization; Liver

Indexed keywords

XENOBIOTIC AGENT;

EID: 84888233058     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.09.009     Document Type: Review
Times cited : (110)

References (57)
  • 1
    • 0014649888 scopus 로고
    • Heterotransplantation of a human malignant tumour to "nude" mice
    • J. Rygaard, and C.O. Povlsen Heterotransplantation of a human malignant tumour to "nude" mice Acta Pathol Microbiol Scand 77 1969 758 760
    • (1969) Acta Pathol Microbiol Scand , vol.77 , pp. 758-760
    • Rygaard, J.1    Povlsen, C.O.2
  • 2
    • 0031956277 scopus 로고    scopus 로고
    • Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras
    • M. Ramirez, G.A. Rottman, and L.D. Shultz Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras Exp Hematol 26 1998 332 344
    • (1998) Exp Hematol , vol.26 , pp. 332-344
    • Ramirez, M.1    Rottman, G.A.2    Shultz, L.D.3
  • 3
    • 1842588698 scopus 로고    scopus 로고
    • Development of a human adaptive immune system in cord blood cell-transplanted mice
    • E. Traggiai, L. Chicha, and L. Mazzucchelli Development of a human adaptive immune system in cord blood cell-transplanted mice Science 304 2004 104 107
    • (2004) Science , vol.304 , pp. 104-107
    • Traggiai, E.1    Chicha, L.2    Mazzucchelli, L.3
  • 4
    • 0028353410 scopus 로고
    • Replacement of disease mouse liver by hepatic cell transplantation
    • J.A. Rhim, E.P. Sandgren, and J.L. Degen Replacement of disease mouse liver by hepatic cell transplantation Science 263 1994 1149 1152
    • (1994) Science , vol.263 , pp. 1149-1152
    • Rhim, J.A.1    Sandgren, E.P.2    Degen, J.L.3
  • 5
    • 34547730702 scopus 로고    scopus 로고
    • Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice
    • H. Azuma, N. Paulk, and A. Ranade Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice Nat Biotechnol 25 2007 903 910
    • (2007) Nat Biotechnol , vol.25 , pp. 903-910
    • Azuma, H.1    Paulk, N.2    Ranade, A.3
  • 6
    • 79951576827 scopus 로고    scopus 로고
    • The reconstituted 'humanized liver' in TK-NOG mice is mature and functional
    • M. Hasegawa, K. Kawai, and T. Mitsui The reconstituted 'humanized liver' in TK-NOG mice is mature and functional Biochem Biophys Res Commun 405 2011 405 410
    • (2011) Biochem Biophys Res Commun , vol.405 , pp. 405-410
    • Hasegawa, M.1    Kawai, K.2    Mitsui, T.3
  • 7
    • 79953196869 scopus 로고    scopus 로고
    • A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease
    • M.L. Washburn, M.T. Bility, and L. Zhang A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease Gastroenterology 140 2011 1334 1344
    • (2011) Gastroenterology , vol.140 , pp. 1334-1344
    • Washburn, M.L.1    Bility, M.T.2    Zhang, L.3
  • 8
    • 84876891474 scopus 로고    scopus 로고
    • Can 'humanized' mice improve drug development in the 21st century?
    • G. Peltz Can 'humanized' mice improve drug development in the 21st century? Trends Pharmacol Sci 34 2013 255 260
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 255-260
    • Peltz, G.1
  • 9
    • 84881142146 scopus 로고    scopus 로고
    • Response to "can 'humanized' mice improve drug development in the 21st century?"
    • K.D. Bissig, and M. Grompe Response to "can 'humanized' mice improve drug development in the 21st century?" Trends Pharmacol Sci 34 2013 425
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 425
    • Bissig, K.D.1    Grompe, M.2
  • 10
    • 0036352728 scopus 로고    scopus 로고
    • Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type i
    • M. Al-Dhalimy, K. Overturf, and M. Finegold Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type I Mol Genet Metab 75 2002 38 45
    • (2002) Mol Genet Metab , vol.75 , pp. 38-45
    • Al-Dhalimy, M.1    Overturf, K.2    Finegold, M.3
  • 11
    • 77957288391 scopus 로고    scopus 로고
    • Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice
    • R. Utoh, C. Tateno, and M. Kataoka Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice Am J Pathol 177 2010 654 665
    • (2010) Am J Pathol , vol.177 , pp. 654-665
    • Utoh, R.1    Tateno, C.2    Kataoka, M.3
  • 12
    • 84866130619 scopus 로고    scopus 로고
    • Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis
    • M.T. Bility, L. Zhang, and M.L. Washburn Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis Nat Protoc 7 2012 1608 1617
    • (2012) Nat Protoc , vol.7 , pp. 1608-1617
    • Bility, M.T.1    Zhang, L.2    Washburn, M.L.3
  • 13
    • 17744378552 scopus 로고    scopus 로고
    • Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
    • M. Dandri, M.R. Burda, and E. Torok Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus Hepatology 33 2001 981 988
    • (2001) Hepatology , vol.33 , pp. 981-988
    • Dandri, M.1    Burda, M.R.2    Torok, E.3
  • 14
    • 77949725830 scopus 로고    scopus 로고
    • Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
    • K.D. Bissig, S.F. Wieland, and P. Tran Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment J Clin Invest 120 2010 924 930
    • (2010) J Clin Invest , vol.120 , pp. 924-930
    • Bissig, K.D.1    Wieland, S.F.2    Tran, P.3
  • 15
    • 84858191432 scopus 로고    scopus 로고
    • Mice with liver composed of human hepatocytes as an animal model for drug testing
    • K. Yoshizato, C. Tateno, and R. Utoh Mice with liver composed of human hepatocytes as an animal model for drug testing Curr Drug Discov Technol 9 2012 63 76
    • (2012) Curr Drug Discov Technol , vol.9 , pp. 63-76
    • Yoshizato, K.1    Tateno, C.2    Utoh, R.3
  • 16
    • 78049374383 scopus 로고    scopus 로고
    • Chimeric mice with humanized liver: Tools for the study of drug metabolism, excretion, and toxicity
    • S.C. Strom, J. Davila, and M. Grompe Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity Methods Mol Biol 640 2010 491 509
    • (2010) Methods Mol Biol , vol.640 , pp. 491-509
    • Strom, S.C.1    Davila, J.2    Grompe, M.3
  • 17
    • 84860287115 scopus 로고    scopus 로고
    • Animal models for the study of hepatitis C virus infection and related liver disease
    • J. Bukh Animal models for the study of hepatitis C virus infection and related liver disease Gastroenterology 142 2012 1279 1287.e3
    • (2012) Gastroenterology , vol.142
    • Bukh, J.1
  • 18
    • 17944379233 scopus 로고    scopus 로고
    • Hepatitis C virus replication in mice with chimeric human livers
    • D.F. Mercer, D.E. Schiller, and J.F. Elliott Hepatitis C virus replication in mice with chimeric human livers Nat Med 7 2001 927 933
    • (2001) Nat Med , vol.7 , pp. 927-933
    • Mercer, D.F.1    Schiller, D.E.2    Elliott, J.F.3
  • 19
    • 33645347305 scopus 로고    scopus 로고
    • Liver-stage development of Plasmodium falciparum, in a humanized mouse model
    • S. Morosan, S. Hez-Deroubaix, and F. Lunel Liver-stage development of Plasmodium falciparum, in a humanized mouse model J Infect Dis 193 2006 996 1004
    • (2006) J Infect Dis , vol.193 , pp. 996-1004
    • Morosan, S.1    Hez-Deroubaix, S.2    Lunel, F.3
  • 20
    • 77954155771 scopus 로고    scopus 로고
    • Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor
    • N. Kamiya, E. Iwao, and N. Hiraga Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor J Gen Virol 91 2010 1668 1677
    • (2010) J Gen Virol , vol.91 , pp. 1668-1677
    • Kamiya, N.1    Iwao, E.2    Hiraga, N.3
  • 21
    • 84857442747 scopus 로고    scopus 로고
    • Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
    • M. Lutgehetmann, L.V. Mancke, and T. Volz Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation Hepatology 55 2012 685 694
    • (2012) Hepatology , vol.55 , pp. 685-694
    • Lutgehetmann, M.1    Mancke, L.V.2    Volz, T.3
  • 22
    • 84867154422 scopus 로고    scopus 로고
    • Complete Plasmodium falciparum liver-stage development in liver-chimeric mice
    • A.M. Vaughan, S.A. Mikolajczak, and E.M. Wilson Complete Plasmodium falciparum liver-stage development in liver-chimeric mice J Clin Invest 122 2012 3618 3628
    • (2012) J Clin Invest , vol.122 , pp. 3618-3628
    • Vaughan, A.M.1    Mikolajczak, S.A.2    Wilson, E.M.3
  • 23
    • 35648968164 scopus 로고    scopus 로고
    • Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice
    • J.G. Kuruvilla, R.M. Troyer, and S. Devi Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice Virology 369 2007 143 152
    • (2007) Virology , vol.369 , pp. 143-152
    • Kuruvilla, J.G.1    Troyer, R.M.2    Devi, S.3
  • 24
    • 84871600580 scopus 로고    scopus 로고
    • SiRNA therapeutics in the treatment of diseases
    • S. Bakhtiyari, K. Haghani, and G. Basati siRNA therapeutics in the treatment of diseases Ther Deliv 4 2013 45 57
    • (2013) Ther Deliv , vol.4 , pp. 45-57
    • Bakhtiyari, S.1    Haghani, K.2    Basati, G.3
  • 25
    • 36849087968 scopus 로고    scopus 로고
    • Therapeutic application of RNAi: Is mRNA targeting finally ready for prime time?
    • D. Grimm, and M.A. Kay Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? J Clin Invest 117 2007 3633 3641
    • (2007) J Clin Invest , vol.117 , pp. 3633-3641
    • Grimm, D.1    Kay, M.A.2
  • 26
    • 84888249912 scopus 로고    scopus 로고
    • A species restricted AAV obtained from viral capsid shuffling
    • L. Lisowski, K. Chu, and M.A. Kay A species restricted AAV obtained from viral capsid shuffling Mol Ther 21 2013 S3
    • (2013) Mol Ther , vol.21 , pp. 3
    • Lisowski, L.1    Chu, K.2    Kay, M.A.3
  • 27
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • E. Lagasse, H. Connors, and M. Al-Dhalimy Purified hematopoietic stem cells can differentiate into hepatocytes in vivo Nat Med 6 2000 1229 1234
    • (2000) Nat Med , vol.6 , pp. 1229-1234
    • Lagasse, E.1    Connors, H.2    Al-Dhalimy, M.3
  • 28
    • 0141594641 scopus 로고    scopus 로고
    • The origin and liver repopulating capacity of murine oval cells
    • X. Wang, M. Foster, and M. Al-Dhalimy The origin and liver repopulating capacity of murine oval cells Proc Natl Acad Sci U S A 100 Suppl 1 2003 11881 11888
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.SUPPL. 1 , pp. 11881-11888
    • Wang, X.1    Foster, M.2    Al-Dhalimy, M.3
  • 29
    • 77956354626 scopus 로고    scopus 로고
    • Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
    • S. Espejel, G.R. Roll, and K.J. McLaughlin Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice J Clin Invest 120 2010 3120 3126
    • (2010) J Clin Invest , vol.120 , pp. 3120-3126
    • Espejel, S.1    Roll, G.R.2    McLaughlin, K.J.3
  • 30
    • 0035132173 scopus 로고    scopus 로고
    • Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells
    • X. Wang, M. Al-Dhalimy, and E. Lagasse Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells Am J Pathol 158 2001 571 579
    • (2001) Am J Pathol , vol.158 , pp. 571-579
    • Wang, X.1    Al-Dhalimy, M.2    Lagasse, E.3
  • 31
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
    • K. Yusa, S.T. Rashid, and H. Strick-Marchand Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells Nature 478 2011 391 394
    • (2011) Nature , vol.478 , pp. 391-394
    • Yusa, K.1    Rashid, S.T.2    Strick-Marchand, H.3
  • 32
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derived organ bud transplant
    • T. Takebe, K. Sekine, and M. Enomura Vascularized and functional human liver from an iPSC-derived organ bud transplant Nature 499 2013 481 484
    • (2013) Nature , vol.499 , pp. 481-484
    • Takebe, T.1    Sekine, K.2    Enomura, M.3
  • 33
    • 79955904906 scopus 로고    scopus 로고
    • In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins
    • H. Liu, Y. Kim, and S. Sharkis In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins Sci Transl Med 3 2011 82ra39
    • (2011) Sci Transl Med , vol.3
    • Liu, H.1    Kim, Y.2    Sharkis, S.3
  • 34
    • 4344574035 scopus 로고    scopus 로고
    • Near completely humanized liver in mice shows human-type metabolic responses to drugs
    • C. Tateno, Y. Yoshizane, and N. Saito Near completely humanized liver in mice shows human-type metabolic responses to drugs Am J Pathol 165 2004 901 912
    • (2004) Am J Pathol , vol.165 , pp. 901-912
    • Tateno, C.1    Yoshizane, Y.2    Saito, N.3
  • 35
    • 9444259317 scopus 로고    scopus 로고
    • Expression of human cytochromes P450 in chimeric mice with humanized liver
    • M. Katoh, T. Matsui, and M. Nakajima Expression of human cytochromes P450 in chimeric mice with humanized liver Drug Metab Dispos 32 2004 1402 1410
    • (2004) Drug Metab Dispos , vol.32 , pp. 1402-1410
    • Katoh, M.1    Matsui, T.2    Nakajima, M.3
  • 36
    • 18844441734 scopus 로고    scopus 로고
    • In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver
    • M. Katoh, T. Matsui, and M. Nakajima In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver Drug Metab Dispos 33 2005 754 763
    • (2005) Drug Metab Dispos , vol.33 , pp. 754-763
    • Katoh, M.1    Matsui, T.2    Nakajima, M.3
  • 37
    • 33847034231 scopus 로고    scopus 로고
    • In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver
    • M. Katoh, T. Sawada, and Y. Soeno In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver J Pharm Sci 96 2007 428 437
    • (2007) J Pharm Sci , vol.96 , pp. 428-437
    • Katoh, M.1    Sawada, T.2    Soeno, Y.3
  • 38
    • 34447568362 scopus 로고    scopus 로고
    • Humanization of excretory pathway in chimeric mice with humanized liver
    • H. Okumura, M. Katoh, and T. Sawada Humanization of excretory pathway in chimeric mice with humanized liver Toxicol Sci 97 2007 533 538
    • (2007) Toxicol Sci , vol.97 , pp. 533-538
    • Okumura, H.1    Katoh, M.2    Sawada, T.3
  • 39
    • 84872743384 scopus 로고    scopus 로고
    • Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction
    • T. Nishimura, Y. Hu, and M. Wu Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction J Pharmacol Exp Ther 344 2013 388 396
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 388-396
    • Nishimura, T.1    Hu, Y.2    Wu, M.3
  • 40
    • 78951482519 scopus 로고    scopus 로고
    • In vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice
    • C. Yamasaki, M. Kataoka, and Y. Kato In vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice Drug Metab Pharmacokinet 25 2010 539 550
    • (2010) Drug Metab Pharmacokinet , vol.25 , pp. 539-550
    • Yamasaki, C.1    Kataoka, M.2    Kato, Y.3
  • 41
    • 84877314691 scopus 로고    scopus 로고
    • New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants
    • R. Gramignoli, V. Tahan, and K. Dorko New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants Stem Cell Res 11 2013 563 573
    • (2013) Stem Cell Res , vol.11 , pp. 563-573
    • Gramignoli, R.1    Tahan, V.2    Dorko, K.3
  • 42
    • 84873097181 scopus 로고    scopus 로고
    • Human pharmacogenetic analysis in chimeric mice with 'humanized livers'
    • Y. Hu, M. Wu, and T. Nishimura Human pharmacogenetic analysis in chimeric mice with 'humanized livers' Pharmacogenet Genomics 23 2013 78 83
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 78-83
    • Hu, Y.1    Wu, M.2    Nishimura, T.3
  • 43
    • 79960034141 scopus 로고    scopus 로고
    • Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
    • T. Li, S. Huang, and X. Zhao Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes Nucleic Acids Res 39 2011 6315 6325
    • (2011) Nucleic Acids Res , vol.39 , pp. 6315-6325
    • Li, T.1    Huang, S.2    Zhao, X.3
  • 44
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • H. Wang, H. Yang, and C.S. Shivalila One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering Cell 153 2013 910 918
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3
  • 45
    • 81155162423 scopus 로고    scopus 로고
    • Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer
    • R.D. Hickey, J.B. Lillegard, and J.E. Fisher Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer Hepatology 54 2011 1351 1359
    • (2011) Hepatology , vol.54 , pp. 1351-1359
    • Hickey, R.D.1    Lillegard, J.B.2    Fisher, J.E.3
  • 46
    • 84864564708 scopus 로고    scopus 로고
    • Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies
    • Y. Yu, H. Liu, and Y. Ikeda Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies Stem Cell Res 9 2012 196 207
    • (2012) Stem Cell Res , vol.9 , pp. 196-207
    • Yu, Y.1    Liu, H.2    Ikeda, Y.3
  • 47
    • 84881120386 scopus 로고    scopus 로고
    • Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development
    • A.V. Parent, H.A. Russ, and I.S. Khan Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development Cell Stem Cell 13 2013 219 229
    • (2013) Cell Stem Cell , vol.13 , pp. 219-229
    • Parent, A.V.1    Russ, H.A.2    Khan, I.S.3
  • 48
    • 3042518936 scopus 로고    scopus 로고
    • HIV and hepatitis C virus co-infection
    • J.K. Rockstroh, and U. Spengler HIV and hepatitis C virus co-infection Lancet Infect Dis 4 2004 437 444
    • (2004) Lancet Infect Dis , vol.4 , pp. 437-444
    • Rockstroh, J.K.1    Spengler, U.2
  • 49
    • 84865504141 scopus 로고    scopus 로고
    • Sterile inflammation in the liver
    • P. Kubes, and W.Z. Mehal Sterile inflammation in the liver Gastroenterology 143 2012 1158 1172
    • (2012) Gastroenterology , vol.143 , pp. 1158-1172
    • Kubes, P.1    Mehal, W.Z.2
  • 51
    • 84885159847 scopus 로고    scopus 로고
    • Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes
    • C. Tanoue, K. Sugihara, and N. Uramaru Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes Xenobiotica 43 2013 956 962
    • (2013) Xenobiotica , vol.43 , pp. 956-962
    • Tanoue, C.1    Sugihara, K.2    Uramaru, N.3
  • 52
    • 84455171514 scopus 로고    scopus 로고
    • Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes
    • S Sanoh, K Nozaki, and H Murai Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes Drug Metab Dispos 40 2012 76 82
    • (2012) Drug Metab Dispos , vol.40 , pp. 76-82
    • Sanoh, S.1    Nozaki, K.2    Murai, H.3
  • 53
    • 26644459708 scopus 로고    scopus 로고
    • Efficient in vivo xenogeneic retroviral vector-mediated gene transduction into human hepatocytes
    • K Emoto, C Tateno, and H Hino Efficient in vivo xenogeneic retroviral vector-mediated gene transduction into human hepatocytes Hum Gene Ther 16 2005 1168 1674
    • (2005) Hum Gene Ther , vol.16 , pp. 1168-1674
    • Emoto, K.1    Tateno, C.2    Hino, H.3
  • 54
    • 28744432193 scopus 로고    scopus 로고
    • In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver
    • M Katoh, M Watanabe, and T Tabata In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver Xenobiotica 35 2005 863 875
    • (2005) Xenobiotica , vol.35 , pp. 863-875
    • Katoh, M.1    Watanabe, M.2    Tabata, T.3
  • 55
    • 84865480870 scopus 로고    scopus 로고
    • Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury
    • M Kakuni, M Morita, and K Matsuo Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury Toxicol Lett 214 2012 9 18
    • (2012) Toxicol Lett , vol.214 , pp. 9-18
    • Kakuni, M.1    Morita, M.2    Matsuo, K.3
  • 56
    • 84857404544 scopus 로고    scopus 로고
    • Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver
    • M Hasegawa, H Tahara, and R Inoue Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver Drug Metab Dispos 40 2012 474 480
    • (2012) Drug Metab Dispos , vol.40 , pp. 474-480
    • Hasegawa, M.1    Tahara, H.2    Inoue, R.3
  • 57
    • 84878788641 scopus 로고    scopus 로고
    • Human cytomegalovirus infection in humanized liver chimeric mice
    • T. Kawahara, L.F. Lisboa, and S. Cader Human cytomegalovirus infection in humanized liver chimeric mice Hepatol Res 43 2013 679 684
    • (2013) Hepatol Res , vol.43 , pp. 679-684
    • Kawahara, T.1    Lisboa, L.F.2    Cader, S.3


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