Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

Journal of Clinical Investigation

Volumn 120, Issue 3, 2010, Pages 924-930

  Bissig, Karl Dimiter ^a   Wieland, Stefan F ^b   Tran, Phu ^a   Isogawa, Masanori ^b   Le, Tam T ^a   Chisari, Francis V ^b   Verma, Inder M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR DIPIVOXIL; CYCLOSPORIN A [3 N METHYL DEXTRO ALANINE 4 N ETHYLVALINE]; CYTOKERATIN 18; ENZYME; FUMARYL ACETOACETATE HYDROLASE; HUMAN SERUM ALBUMIN; PEGINTERFERON ALPHA2A; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS DNA;

ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL THERAPY; ARTICLE; BLOOD ANALYSIS; CELL POPULATION; CELL TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA EXTRACTION; DNA REPLICATION; DRUG SCREENING; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN LIVER CHIMERISM; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INOCULATION; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROLOGY; VIRUS DETECTION; VIRUS ISOLATION; VIRUS TITRATION;

ANIMALS; DISEASE MODELS, ANIMAL; HEPACIVIRUS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, KNOCKOUT; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HETEROLOGOUS;

EID: 77949725830     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40094     Document Type: Article

References (26)

1. Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev. 2000;64(1):51-68.
2. Wieland SF, Chisari FV. Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol. 2005; 79(15):9369-9380.
3. Dienstag JL. Hepatitis B virus infection. N Engl J Med. 2008;359(14):1486-1500.
4. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003;362(9399):1907-1917.
5. Barker LF, et al. Transmission of type B viral hepatitis to chimpanzees. J Infect Dis. 1973;127(6):648-662.
6. Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV. Viral clearance without destruction of infected cells during acute HBV infection. Science. 1999;284(5415):825-829.
7. Abe K, Inchauspe G, Shikata T, Prince AM. Three different patterns of hepatitis C virus infection in chimpanzees. Hepatology. 1992;15(4):690-695.
8. Mason WS, Seal G, Summers J. Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. J Virol. 1980;36(3):829-836.
9. Summers J, Smolec JM, Snyder R. A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci U S A. 1978;75(9):4533-4537.
10. Marion PL, Oshiro LS, Regnery DC, Scullard GH, Robinson WS. A virus in Beechey ground squirrels that is related to hepatitis B virus of humans. Proc Natl Acad Sci U S A. 1980;77(5):2941-2945.
11. Yang PL, Althage A, Chung J, Chisari FV. Hydro dynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci U S A. 2002;99(21):13825-13830.
12. Heckel JL, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell. 1990;62(3):447-456.
13. Dandri M, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology. 2001;33(4):981-988.
14. Mercer DF, et al. Hepatitis C virus replication in mice with chimeric human livers. Nat Med. 2001; 7(8):927-933.
15. -/-) mice. Nat Biotechnol. 2007;25(8):903-910.
16. Bissig KD, Le TT, Woods NB, Verma IM. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci U S A. 2007;104(51):20507-20511.
17. Grompe M, et al. Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev. 1993;7(12A):2298-2307.
18. Pietschmann T, et al. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A. 2006;103(19):7408-7413.
19. Goldsmith LA, Laberge C. 1989. Tyrosinemia and related disorders. In: Scriver CR, Beaudet AL, Sly AS, Valle D, eds. The Metabolic Basis of Inherited Disease. New York: McGraw-Hill. 547-562.
20. Flisiak R, et al. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology. 2009;49(5):1460-1468.
21. Murray JM, Wieland SF, Purcell RH, Chisari FV. Dynamics of hepatitis B virus clearance in chimpanzees. Proc Natl Acad Sci U S A. 2005; 102(49):17780-17785.
22. Zhong J, et al. Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2005; 102(26):9294-9299.
23. Wieland SF, Guidotti LG, Chisari FV. Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J Virol. 2000;74(9):4165-4173.
24. Wieland SF, Spangenberg HC, Thimme R, Purcell RH, Chisari FV. Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees. Proc Natl Acad Sci U S A. 2004;101(7):2129-2134.
25. Meuleman P, et al. Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus. J Virol. 2006;80(6):2797-2807.
26. Guidotti LG, Matzke B, Schaller H, Chisari FV. High-level hepatitis B virus replication in transgenic mice. J Virol. 1995;69(10):6158-6169.