메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages

A novel mouse model for stable engraftment of a human immune system and human hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; DENDRITIC CELL; ENGRAFTMENT; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VIVO STUDY; LIVER CELL; MOUSE; NATURAL KILLER CELL; NEWBORN; NONHUMAN; PLASMODIUM; SPLEEN CELL; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; KINETICS; LIVER DISEASE; NONOBESE DIABETIC MOUSE; PARASITOLOGY; PHYSIOLOGY; TRANSPLANTATION; VIROLOGY;

EID: 84925004629     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119820     Document Type: Article
Times cited : (67)

References (40)
  • 1
    • 2542530063 scopus 로고    scopus 로고
    • A critical role for the chimpanzee model in the study of hepatitis C
    • PMID: 15185284
    • Bukh J. A critical role for the chimpanzee model in the study of hepatitis C. Hepatology. 2004; 39: 1469-75. doi: 10.1002/hep.20268 PMID: 15185284
    • (2004) Hepatology , vol.39 , pp. 1469-1475
    • Bukh, J.1
  • 2
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • PMID: 18039107
    • Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol. 2006; 1: 23-61. PMID: 18039107
    • (2006) Annu Rev Pathol , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 3
    • 79958268921 scopus 로고    scopus 로고
    • Animal models in the study of hepatitis C virus-associated liver pathologies
    • PMID: 21651352
    • Lerat H, Higgs M, Pawlotsky J-M. Animal models in the study of hepatitis C virus-associated liver pathologies. Expert Rev Gastroenterol Hepatol. 2011; 5: 341-352. doi: 10.1586/egh.11.14 PMID: 21651352
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , pp. 341-352
    • Lerat, H.1    Higgs, M.2    Pawlotsky, J.-M.3
  • 4
    • 84860287115 scopus 로고    scopus 로고
    • Animal Models for the Study of Hepatitis C Virus Infection and Related Liver Disease
    • PMID: 22537434
    • Bukh J. Animal Models for the Study of Hepatitis C Virus Infection and Related Liver Disease. Gastroenterology. 2012; 142: 1279-1287.e3. doi: 10.1053/j.gastro.2012.02.016 PMID: 22537434
    • (2012) Gastroenterology , vol.142 , pp. 1279-1287.e3
    • Bukh, J.1
  • 5
    • 84872370948 scopus 로고    scopus 로고
    • Experimental models and therapeutic approaches for HBV
    • PMID: 22898798
    • Dandri M, Lutgehetmann M, Petersen J. Experimental models and therapeutic approaches for HBV. Semin Immunopathol. 2013; 35: 7-21. doi: 10.1007/s00281-012-0335-7 PMID: 22898798
    • (2013) Semin Immunopathol , vol.35 , pp. 7-21
    • Dandri, M.1    Lutgehetmann, M.2    Petersen, J.3
  • 6
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • PMID: 14978070
    • Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol. 2004; 172: 2731-8. PMID: 14978070
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 7
    • 84875548150 scopus 로고    scopus 로고
    • Human hemato-lymphoid system mice: Current use and future potential for medicine
    • PMID: 23330956
    • Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, et al. Human hemato-lymphoid system mice: current use and future potential for medicine. Annu Rev Immunol. 2013; 31: 635-74. doi: 10.1146/annurev-immunol-032712-095921 PMID: 23330956
    • (2013) Annu Rev Immunol , vol.31 , pp. 635-674
    • Rongvaux, A.1    Takizawa, H.2    Strowig, T.3    Willinger, T.4    Eynon, E.E.5    Flavell, R.A.6
  • 8
    • 64249129778 scopus 로고    scopus 로고
    • Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens
    • PMID: 19048074
    • Brezillon N, Kremsdorf D, Weiss MC. Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens. Model Mech. 2008; 1: 113-30. doi: 10.1242/dmm.000463 PMID: 19048074
    • (2008) Model Mech , vol.1 , pp. 113-130
    • Brezillon, N.1    Kremsdorf, D.2    Weiss, M.C.3
  • 9
    • 56349163205 scopus 로고    scopus 로고
    • The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV
    • PMID: 18706933
    • Meuleman P, Leroux-Roels G. The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV. Antivir Res. 2008; 80: 231-8. doi: 10.1016/j.antiviral.2008.07.006 PMID: 18706933
    • (2008) Antivir Res , vol.80 , pp. 231-238
    • Meuleman, P.1    Leroux-Roels, G.2
  • 10
    • 0025144417 scopus 로고
    • Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
    • PMID: 1696178
    • Heckel JL, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell. 1990; 62: 447-56. PMID: 1696178
    • (1990) Cell , vol.62 , pp. 447-456
    • Heckel, J.L.1    Sandgren, E.P.2    Degen, J.L.3    Palmiter, R.D.4    Brinster, R.L.5
  • 11
    • 0025781894 scopus 로고
    • Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
    • PMID: 1713128
    • Sandgren EP, Palmiter RD, Heckel JL, Daughert CC, Brinster RL, Degen JL. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell. 1991; 66: 245-256. PMID: 1713128
    • (1991) Cell , vol.66 , pp. 245-256
    • Sandgren, E.P.1    Palmiter, R.D.2    Heckel, J.L.3    Daughert, C.C.4    Brinster, R.L.5    Degen, J.L.6
  • 12
    • 17744378552 scopus 로고    scopus 로고
    • Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
    • PMID: 11283864
    • Dandri M, Burda MR, Torok E, Pollok JM, Iwanska A, Sommer G, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology. 2001; 33: 981-8. PMID: 11283864
    • (2001) Hepatology , vol.33 , pp. 981-988
    • Dandri, M.1    Burda, M.R.2    Torok, E.3    Pollok, J.M.4    Iwanska, A.5    Sommer, G.6
  • 13
  • 14
    • 34547730702 scopus 로고    scopus 로고
    • Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice
    • PMID: 17664939
    • Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, et al. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol. 2007; 25: 903-10. PMID: 17664939
    • (2007) Nat Biotechnol , vol.25 , pp. 903-910
    • Azuma, H.1    Paulk, N.2    Ranade, A.3    Dorrell, C.4    Al-Dhalimy, M.5    Ellis, E.6
  • 15
    • 77949725830 scopus 로고    scopus 로고
    • Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
    • PMID: 20179355
    • Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest. 2010; 120: 924-30. doi: 10.1172/JCI40094 PMID: 20179355
    • (2010) J Clin Invest , vol.120 , pp. 924-930
    • Bissig, K.D.1    Wieland, S.F.2    Tran, P.3    Isogawa, M.4    Le, T.T.5    Chisari, F.V.6
  • 16
    • 79955010744 scopus 로고    scopus 로고
    • IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo
    • PMID: 21444793
    • Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, et al. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U A. 2011; 108: 6217-22. doi: 10.1073/pnas.1019167108 PMID: 21444793
    • (2011) Proc Natl Acad Sci U A , vol.108 , pp. 6217-6222
    • Huntington, N.D.1    Alves, N.L.2    Legrand, N.3    Lim, A.4    Strick-Marchand, H.5    Mention, J.J.6
  • 17
    • 80051982736 scopus 로고    scopus 로고
    • Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo
    • PMID: 21788504
    • Legrand N, Huntington ND, Nagasawa M, Bakker AQ, Schotte R, Strick-Marchand H, et al. Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U A. 2011; 108: 13224-9. doi: 10.1073/pnas.1101398108 PMID: 21788504
    • (2011) Proc Natl Acad Sci U A , vol.108 , pp. 13224-13229
    • Legrand, N.1    Huntington, N.D.2    Nagasawa, M.3    Bakker, A.Q.4    Schotte, R.5    Strick-Marchand, H.6
  • 18
    • 84867898654 scopus 로고    scopus 로고
    • Humanized mice for immune system investigation: Progress, promise and challenges
    • PMID: 23059428
    • Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol. 2012; 12: 786-98. doi: 10.1038/nri3311 PMID: 23059428
    • (2012) Nat Rev Immunol , vol.12 , pp. 786-798
    • Shultz, L.D.1    Brehm, M.A.2    Garcia-Martinez, J.V.3    Greiner, D.L.4
  • 19
    • 10244237695 scopus 로고    scopus 로고
    • Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: Functional inactivation of p53 in developing T cells
    • PMID: 15319293
    • Gimeno R, Weijer K, Voordouw A, Uittenbogaart CH, Legrand N, Alves NL, et al. Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells. Blood. 2004; 104: 3886-93. PMID: 15319293
    • (2004) Blood , vol.104 , pp. 3886-3893
    • Gimeno, R.1    Weijer, K.2    Voordouw, A.3    Uittenbogaart, C.H.4    Legrand, N.5    Alves, N.L.6
  • 20
    • 1842588698 scopus 로고    scopus 로고
    • Development of a human adaptive immune system in cord blood cell-transplanted mice
    • PMID: 15064419
    • Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004; 304: 104-7. PMID: 15064419
    • (2004) Science , vol.304 , pp. 104-107
    • Traggiai, E.1    Chicha, L.2    Mazzucchelli, L.3    Bronz, L.4    Piffaretti, J.C.5    Lanzavecchia, A.6
  • 21
    • 79953196869 scopus 로고    scopus 로고
    • A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease
    • PMID: 21237170
    • Washburn ML, Bility MT, Zhang L, Kovalev GI, Buntzman A, Frelinger JA, et al. A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease. Gastroenterology. 2011; 140: 1334-44. doi: 10.1053/j.gastro.2011.01.001 PMID: 21237170
    • (2011) Gastroenterology , vol.140 , pp. 1334-1344
    • Washburn, M.L.1    Bility, M.T.2    Zhang, L.3    Kovalev, G.I.4    Buntzman, A.5    Frelinger, J.A.6
  • 22
    • 84890386754 scopus 로고    scopus 로고
    • Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice
    • PMID: 24200850
    • Gutti TL, Knibbe JS, Makarov E, Zhang J, Yannam GR, Gorantla S, et al. Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice. Am J Pathol. 2014; 184: 101-109. doi: 10.1016/j.ajpath.2013.09.008 PMID: 24200850
    • (2014) Am J Pathol , vol.184 , pp. 101-109
    • Gutti, T.L.1    Knibbe, J.S.2    Makarov, E.3    Zhang, J.4    Yannam, G.R.5    Gorantla, S.6
  • 23
    • 84908027919 scopus 로고    scopus 로고
    • Extensive double humanization of both liver and hematopoiesis in FRGN mice
    • PMID: 25310256
    • Wilson EM, Bial J, Tarlow B, Bial G, Jensen B, Greiner DL, et al. Extensive double humanization of both liver and hematopoiesis in FRGN mice. Stem Cell Res. 2014; 13: 404-412. doi: 10.1016/j.scr.2014.08.006 PMID: 25310256
    • (2014) Stem Cell Res , vol.13 , pp. 404-412
    • Wilson, E.M.1    Bial, J.2    Tarlow, B.3    Bial, G.4    Jensen, B.5    Greiner, D.L.6
  • 24
    • 67651102866 scopus 로고    scopus 로고
    • Humanized mice for modeling human infectious disease: Challenges, progress, and outlook
    • PMID: 19616761
    • Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, et al. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe. 2009; 6: 5-9. doi: 10.1016/j.chom.2009.06.006 PMID: 19616761
    • (2009) Cell Host Microbe , vol.6 , pp. 5-9
    • Legrand, N.1    Ploss, A.2    Balling, R.3    Becker, P.D.4    Borsotti, C.5    Brezillon, N.6
  • 25
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
    • PMID: 21993621
    • Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, et al. Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011; 478: 391-4. doi: 10.1038/nature10424 PMID: 21993621
    • (2011) Nature , vol.478 , pp. 391-394
    • Yusa, K.1    Rashid, S.T.2    Strick-Marchand, H.3    Varela, I.4    Liu, P.Q.5    Paschon, D.E.6
  • 26
    • 60549117539 scopus 로고    scopus 로고
    • IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    • PMID: 19103877
    • Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, et al. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med. 2009; 206: 25-34. doi: 10.1084/jem.20082013 PMID: 19103877
    • (2009) J Exp Med , vol.206 , pp. 25-34
    • Huntington, N.D.1    Legrand, N.2    Alves, N.L.3    Jaron, B.4    Weijer, K.5    Plet, A.6
  • 27
    • 84924934025 scopus 로고    scopus 로고
    • Animal Models to Test hiPS-Derived Hepatocytes in the Context of Inherited Metabolic Liver Diseases
    • PMID: 25173376
    • Dusséaux M, Darche S, Strick-Marchand H. Animal Models to Test hiPS-Derived Hepatocytes in the Context of Inherited Metabolic Liver Diseases. Methods Mol Biol. 2014; 1213: 81-88. doi: 10.1007/978-1-4939-1453-1-8 PMID: 25173376
    • (2014) Methods Mol Biol , vol.1213 , pp. 81-88
    • Dusséaux, M.1    Darche, S.2    Strick-Marchand, H.3
  • 28
    • 53149130614 scopus 로고    scopus 로고
    • Lymphocytes support oval cell-dependent liver regeneration
    • PMID: 18684967
    • Strick-Marchand H, Masse GX, Weiss MC, Di Santo JP. Lymphocytes support oval cell-dependent liver regeneration. J Immunol. 2008; 181: 2764-71. PMID: 18684967
    • (2008) J Immunol , vol.181 , pp. 2764-2771
    • Strick-Marchand, H.1    Masse, G.X.2    Weiss, M.C.3    Di Santo, J.P.4
  • 29
    • 73549083003 scopus 로고    scopus 로고
    • Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice
    • PMID: 19717639
    • Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, et al. Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice. Am J Pathol. 2009; 175: 1483-92. doi: 10.2353/ajpath.2009.090117 PMID: 19717639
    • (2009) Am J Pathol , vol.175 , pp. 1483-1492
    • Haridass, D.1    Yuan, Q.2    Becker, P.D.3    Cantz, T.4    Iken, M.5    Rothe, M.6
  • 30
    • 77955853940 scopus 로고    scopus 로고
    • Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice
    • PMID: 20591528
    • Vanwolleghem T, Libbrecht L, Hansen BE, Desombere I, Roskams T, Meuleman P, et al. Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice. J Hepatol. 2010; 53: 468-76. doi: 10.1016/j.jhep.2010.03.024 PMID: 20591528
    • (2010) J Hepatol , vol.53 , pp. 468-476
    • Vanwolleghem, T.1    Libbrecht, L.2    Hansen, B.E.3    Desombere, I.4    Roskams, T.5    Meuleman, P.6
  • 31
    • 0028341024 scopus 로고
    • Cell adhesion molecules in liver function and pattern formation
    • PMID: 8168692
    • Stamatoglou SC, Hughes RC. Cell adhesion molecules in liver function and pattern formation. FASEB J. 1994; 8: 420-427. PMID: 8168692
    • (1994) FASEB J , vol.8 , pp. 420-427
    • Stamatoglou, S.C.1    Hughes, R.C.2
  • 32
    • 46749145393 scopus 로고    scopus 로고
    • Which in vitro models could be best used to study hepatocyte polarity?
    • PMID: 18549352
    • Decaens C, Durand M, Grosse B, Cassio D. Which in vitro models could be best used to study hepatocyte polarity? Biol Cell. 2008; 100: 387-398. doi: 10.1042/BC20070127 PMID: 18549352
    • (2008) Biol Cell , vol.100 , pp. 387-398
    • Decaens, C.1    Durand, M.2    Grosse, B.3    Cassio, D.4
  • 33
    • 84874223600 scopus 로고    scopus 로고
    • Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation
    • PMID: 23335750
    • Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, et al. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013; 190: 2090-101. doi: 10.4049/jimmunol.1202810 PMID: 23335750
    • (2013) J Immunol , vol.190 , pp. 2090-2101
    • Lang, J.1    Kelly, M.2    Freed, B.M.3    McCarter, M.D.4    Kedl, R.M.5    Torres, R.M.6
  • 34
    • 84881429352 scopus 로고    scopus 로고
    • Characterization of Human Antiviral Adaptive Immune Responses during Hepatotropic Virus Infection in HLA-Transgenic Human Immune System Mice
    • PMID: 23833235
    • Billerbeck E, Horwitz JA, Labitt RN, Donovan BM, Vega K, Budell WC, et al. Characterization of Human Antiviral Adaptive Immune Responses during Hepatotropic Virus Infection in HLA-Transgenic Human Immune System Mice. J Immunol. 2013; 191: 1753-64. doi: 10.4049/jimmunol.1201518 PMID: 23833235
    • (2013) J Immunol , vol.191 , pp. 1753-1764
    • Billerbeck, E.1    Horwitz, J.A.2    Labitt, R.N.3    Donovan, B.M.4    Vega, K.5    Budell, W.C.6
  • 35
    • 84896724294 scopus 로고    scopus 로고
    • FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo
    • PMID: 24453245
    • Ding Y, Wilkinson A, Idris A, Fancke B, O'Keeffe M, Khalil D, et al. FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo. J Immunol. 2014; 192: 1982-1989. doi: 10.4049/jimmunol.1302391 PMID: 24453245
    • (2014) J Immunol , vol.192 , pp. 1982-1989
    • Ding, Y.1    Wilkinson, A.2    Idris, A.3    Fancke, B.4    O'Keeffe, M.5    Khalil, D.6
  • 36
    • 84862596451 scopus 로고    scopus 로고
    • Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice
    • PMID: 22611244
    • Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, et al. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. J Immunol. 2012; 188: 6145-6155. doi: 10.4049/jimmunol.1103660 PMID: 22611244
    • (2012) J Immunol , vol.188 , pp. 6145-6155
    • Tanaka, S.1    Saito, Y.2    Kunisawa, J.3    Kurashima, Y.4    Wake, T.5    Suzuki, N.6
  • 37
    • 33645347305 scopus 로고    scopus 로고
    • Liver-stage development of Plasmodium falciparum, in a humanized mouse model
    • PMID: 16518762
    • Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, Van Rooijen N, et al. Liver-stage development of Plasmodium falciparum, in a humanized mouse model. J Infect Dis. 2006; 193: 996-1004. PMID: 16518762
    • (2006) J Infect Dis , vol.193 , pp. 996-1004
    • Morosan, S.1    Hez-Deroubaix, S.2    Lunel, F.3    Renia, L.4    Giannini, C.5    Van Rooijen, N.6
  • 38
    • 4344574035 scopus 로고    scopus 로고
    • Near completely humanized liver in mice shows human-type metabolic responses to drugs
    • PMID: 15331414
    • Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol. 2004; 165: 901-12. PMID: 15331414
    • (2004) Am J Pathol , vol.165 , pp. 901-912
    • Tateno, C.1    Yoshizane, Y.2    Saito, N.3    Kataoka, M.4    Utoh, R.5    Yamasaki, C.6
  • 39
    • 84893102530 scopus 로고    scopus 로고
    • Chimeric rodents with humanized liver: Bridging the preclinical/clinical trial gap in ADME/toxicity studies
    • PMID: 24320885
    • Foster JR, Lund G, Sapelnikova S, Tyrrell DL, Kneteman NM. Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies. Xenobiotica. 2013; 44: 109-122. doi: 10.3109/00498254.2013.867553 PMID: 24320885
    • (2013) Xenobiotica , vol.44 , pp. 109-122
    • Foster, J.R.1    Lund, G.2    Sapelnikova, S.3    Tyrrell, D.L.4    Kneteman, N.M.5
  • 40
    • 84869747235 scopus 로고    scopus 로고
    • GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation
    • PMID: 23089398
    • Chen Q, He F, Kwang J, Chan JKY, Chen J. GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation. J Immunol. 2012; 189: 5223-5229. doi: 10.4049/jimmunol.1201789 PMID: 23089398
    • (2012) J Immunol , vol.189 , pp. 5223-5229
    • Chen, Q.1    He, F.2    Kwang, J.3    Chan, J.K.Y.4    Chen, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.