Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver

Toxicological Sciences

Volumn 142, Issue 1, 2014, Pages 137-157

  Yamada, Tomoya ^a   Okuda, Yu ^a   Kushida, Masahiko ^a   Sumida, Kayo ^a   Takeuchi, Hayato ^a   Nagahori, Hirohisa ^a   Fukuda, Takako ^a   Lake, Brian G ^b   Cohen, Samuel M ^c   Kawamura, Satoshi ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cell proliferation; Cytochrome P450; Human risk assessment; Humanized mice; Liver tumors; Mode of action; Sodium phenobarbital

Indexed keywords

CYTOCHROME P450 2B; DNA; GAMMA UROGASTRONE; PHENOBARBITAL; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP2B6 PROTEIN, HUMAN; CYTOCHROME P450 2B6; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER CARCINOGENESIS; LIVER CELL; LIVER TUMOR; LIVER WEIGHT; MALE; METABOLOMICS; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPECIES DIFFERENCE; TRANSCRIPTOMICS; WISTAR HANNOVER RAT; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CHIMERA; DNA REPLICATION; DRUG EFFECTS; ENZYMOLOGY; EXPERIMENTAL LIVER NEOPLASM; GENE EXPRESSION PROFILING; INBRED MOUSE STRAIN; INBRED RAT STRAIN; METABOLISM; ORGAN SIZE; PATHOLOGY;

ANIMALS; CELLS, CULTURED; CHIMERA; CYTOCHROME P-450 CYP2B6; DNA REPLICATION; GENE EXPRESSION PROFILING; HEPATOCYTES; HUMANS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE, INBRED STRAINS; ORGAN SIZE; PHENOBARBITAL; RATS, INBRED STRAINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SPECIES SPECIFICITY; TRANSCRIPTOME;

EID: 84931054243     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu173     Document Type: Article

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