Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

Human Molecular Genetics

Volumn 22, Issue 3, 2013, Pages 578-592

  Kazuki, Yasuhiro ^a,b   Kobayashi, Kaoru ^c   Aueviriyavit, Sasitorn ^c   Oshima, Takeshi ^d   Kuroiwa, Yoshimi ^d,g   Tsukazaki, Yasuko ^e   Senda, Naoto ^e   Kawakami, Hiroki ^f   Ohtsuki, Sumio ^f   Abe, Satoshi ^a   Takiguchi, Masato ^a   Hoshiya, Hidetoshi ^a   Kajitani, Naoyo ^b   Takehara, Shoko ^b   Kubo, Kinya ^b   Terasaki, Tetsuya ^f   Chiba, Kan ^c   Tomizuka, Kazuma ^d   Oshimura, Mitsuo ^a,b  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

^e LSI MEDIENCE CORPORATION   (Japan)

^f TOHOKU UNIVERSITY   (Japan)

^g Hematech Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; PRASTERONE; TRIAZOLAM;

ANIMAL TISSUE; ARTICLE; ARTIFICIAL CHROMOSOME; CHIMERA; CHROMOSOME TRANSLOCATION; DRUG METABOLISM; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; GENE LOCUS; GENETIC TRANSFECTION; HOMOZYGOSITY; INTESTINE; LIVER; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOBIOTIC METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, SOUTHERN; CELL LINE; CHO CELLS; CHROMOSOMES, ARTIFICIAL, HUMAN; CHROMOSOMES, HUMAN, PAIR 7; CLONING, MOLECULAR; CRICETINAE; CYTOCHROME P-450 CYP3A; DEHYDROEPIANDROSTERONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC LOCI; HUMANS; INTESTINES; LIVER; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; MICROSOMES; MULTIGENE FAMILY; TRIAZOLAM; XENOBIOTICS;

MUS; MUS MUSCULUS;

EID: 84872385005     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds468     Document Type: Article

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