Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

Drug Metabolism and Disposition

Volumn 40, Issue 11, 2012, Pages 2212-2218

  Scheer, Nico ^a   Balimane, Praveen ^b   Hayward, Michael D ^c   Buechel, Sandra ^a   Kauselmann, Gunther ^a   Wolf, C Roland ^d,e  

^a TaconicArtemis   (Germany)

^b BRISTOL MYERS SQUIBB   (United States)

^c Taconic Farms Inc   (United States)

^d CXR Biosciences Ltd   (United Kingdom)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; COMPLEMENTARY DNA; CYTOCHROME P450; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENE SEQUENCE; GENE TARGETING; GENETIC ENGINEERING; GENETIC STABILITY; HOMOLOGOUS RECOMBINATION; HOMOZYGOSITY; HUMAN; HYPERBILIRUBINEMIA; INTESTINE; KIDNEY; KNOCKOUT MOUSE; LIVER; MALE; MOUSE; MRP2 GENE; NONHUMAN; NULL ALLELE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BILIRUBIN; BIOLOGICAL TRANSPORT; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; EMBRYONIC STEM CELLS; GENE KNOCK-IN TECHNIQUES; HUMANS; INTESTINES; KIDNEY; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RNA, MESSENGER;

EID: 84867672704     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.047605     Document Type: Article

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