Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver

Drug Metabolism and Disposition

Volumn 40, Issue 2, 2012, Pages 322-328

  Sanoh, Seigo ^a   Horiguchi, Aya ^a   Sugihara, Kazumi ^g   Kotake, Yaichiro ^a   Tayama, Yoshitaka ^c   Ohshita, Hiroki ^d   Tateno, Chise ^b,e   Horie, Toru ^f   Kitamura, Shigeyuki ^c   Ohta, Shigeru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^c PXB Mouse Production Department   (Japan)

^d R and D Department   (Japan)

^e PhoenixBio USA Corporation   (Japan)

^f DeThree Research Laboratories   (Japan)

^g NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 DEOXYPENCICLOVIR; ALDEHYDE OXIDASE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DAPSONE; DICLOFENAC; FASUDIL; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; IBUPROFEN; KETOPROFEN; LAMOTRIGINE; MIRTAZAPINE; NAPROXEN; SALBUTAMOL; SULFOTRANSFERASE; SULINDAC; WARFARIN; ZALEPLON;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CLEARANCE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

ANIMALS; CELLS, CULTURED; CHILD, PRESCHOOL; CHIMERA; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; FEMALE; HALF-LIFE; HEPATOCYTES; HUMANS; IMMUNOMAGNETIC SEPARATION; LIVER; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, SCID; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

ANIMALIA; MUS;

EID: 84855997102     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.040923     Document Type: Article

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